MX2021002633A - Dispersiones solidas de bendamustina e infusion continua. - Google Patents

Dispersiones solidas de bendamustina e infusion continua.

Info

Publication number
MX2021002633A
MX2021002633A MX2021002633A MX2021002633A MX2021002633A MX 2021002633 A MX2021002633 A MX 2021002633A MX 2021002633 A MX2021002633 A MX 2021002633A MX 2021002633 A MX2021002633 A MX 2021002633A MX 2021002633 A MX2021002633 A MX 2021002633A
Authority
MX
Mexico
Prior art keywords
solid dispersions
continuous infusion
bendamustine
bendamustine hydrochloride
degradants
Prior art date
Application number
MX2021002633A
Other languages
English (en)
Inventor
Vasilios Voudouris
Original Assignee
Vasilios Voudouris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vasilios Voudouris filed Critical Vasilios Voudouris
Publication of MX2021002633A publication Critical patent/MX2021002633A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a composiciones farmacéuticas que comprenden mostaza de nitrógeno, por ejemplo, clorhidrato de bendamustina, dispersiones sólidas sustancialmente libres de degradantes. También se proporcionan métodos para producir y administrar mostazas de nitrógeno y en particular dispersiones sólidas e clorhidrato de bendamustina sustancialmente libres de degradantes. Las composiciones farmacéuticas pueden ser usadas para cualquier enfermedad que es sensible al tratamiento con clorhidrato de bendamustina, tal como enfermedades neoplásicas.
MX2021002633A 2014-03-13 2016-08-30 Dispersiones solidas de bendamustina e infusion continua. MX2021002633A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461952624P 2014-03-13 2014-03-13

Publications (1)

Publication Number Publication Date
MX2021002633A true MX2021002633A (es) 2021-05-12

Family

ID=52684713

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2016011236A MX2016011236A (es) 2014-03-13 2015-03-04 Dispersiones solidas de bendamustina e infusion continua.
MX2022006770A MX2022006770A (es) 2014-03-13 2016-08-30 Dispersiones solidas de bendamustina e infusion continua.
MX2021002633A MX2021002633A (es) 2014-03-13 2016-08-30 Dispersiones solidas de bendamustina e infusion continua.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2016011236A MX2016011236A (es) 2014-03-13 2015-03-04 Dispersiones solidas de bendamustina e infusion continua.
MX2022006770A MX2022006770A (es) 2014-03-13 2016-08-30 Dispersiones solidas de bendamustina e infusion continua.

Country Status (9)

Country Link
US (5) US9320730B2 (es)
EP (1) EP3116481A1 (es)
JP (3) JP6883428B2 (es)
CN (2) CN106102722A (es)
AU (3) AU2015229842B2 (es)
CA (1) CA2941632C (es)
IL (1) IL247739A0 (es)
MX (3) MX2016011236A (es)
WO (1) WO2015138199A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3043648B1 (en) 2013-08-27 2023-09-20 Vasilios VOUDOURIS Bendamustine pharmaceutical compositions
EP3484466A1 (en) * 2016-07-13 2019-05-22 Takeda Pharmaceutical Company Limited Combination of spleen tyrosine kinase inhibitors and other therapeutic agents
JP7464995B2 (ja) * 2018-03-29 2024-04-10 プロジェクト ファーマシューティクス ゲーエムベーハー 液体薬学的製剤
CN108324691B (zh) * 2018-04-11 2019-03-08 健进制药有限公司 一种注射用卡莫司汀冻干制剂及其制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19757224A1 (de) * 1997-12-22 1999-07-01 Bayer Ag Verfahren und Vorrichtung zur in-situ-Formulierung einer Arzneistofflösung zur parenteralen Applikation
JP2000281561A (ja) * 1999-03-26 2000-10-10 Ajinomoto Co Inc 新規溶媒法固体分散体製剤
US6982253B2 (en) * 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
CN101933923A (zh) * 2004-11-05 2011-01-05 赛福伦公司 癌症治疗
US8436190B2 (en) * 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
WO2006105399A1 (en) * 2005-03-31 2006-10-05 Bristol-Myers Squibb Company Methods for administering ixabepilone
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
CN102149715A (zh) * 2008-09-17 2011-08-10 Cj第一制糖株式会社 肝适能的稳定化固态分散物及其制备方法
MX2011002936A (es) * 2008-09-25 2011-04-11 Cephalon Inc Formulaciones liquidas de bendamustina.
CN102413816A (zh) 2009-04-28 2012-04-11 赛福伦公司 苯达莫司汀的口服制剂
PL3158991T3 (pl) * 2010-01-28 2021-09-27 Eagle Pharmaceuticals, Inc. Preparaty bendamustyny
WO2011103150A2 (en) * 2010-02-18 2011-08-25 Cephalon, Inc. Lyophilized preparations of bendamustine
US20140142153A1 (en) 2011-01-25 2014-05-22 Dr. Reddy's Laboratories, Inc. Bendamustine formulations
WO2013102920A1 (en) * 2011-11-18 2013-07-11 Astron Research Limited Stable lyophilized formulation of bendamustine
WO2013103801A1 (en) * 2012-01-04 2013-07-11 Hospira, Inc. Pharmaceutical spray drying
US20130210878A1 (en) * 2012-01-24 2013-08-15 Innopharma, Inc. Bendamustine compositions and methods therefore
IN2012DE00337A (es) * 2012-02-06 2015-04-10 Fresenius Kabi Oncology Ltd
EP2641592A1 (en) * 2012-03-23 2013-09-25 Salmon Pharma GmbH Pharmaceutical formulation comprising bendamustine
EP3043648B1 (en) * 2013-08-27 2023-09-20 Vasilios VOUDOURIS Bendamustine pharmaceutical compositions

Also Published As

Publication number Publication date
US20230364017A1 (en) 2023-11-16
CA2941632A1 (en) 2015-09-17
US20180185279A1 (en) 2018-07-05
MX2022006770A (es) 2022-06-22
US9907752B2 (en) 2018-03-06
AU2015229842B2 (en) 2020-06-25
US9320730B2 (en) 2016-04-26
JP2022095923A (ja) 2022-06-28
AU2022211893A1 (en) 2022-09-15
CA2941632C (en) 2023-10-24
JP6883428B2 (ja) 2021-06-09
US20160310422A1 (en) 2016-10-27
US20150258069A1 (en) 2015-09-17
MX2016011236A (es) 2017-04-06
WO2015138199A1 (en) 2015-09-17
CN106102722A (zh) 2016-11-09
EP3116481A1 (en) 2017-01-18
CN115350155A (zh) 2022-11-18
JP2020055831A (ja) 2020-04-09
IL247739A0 (en) 2016-11-30
AU2020233707A1 (en) 2020-10-15
AU2015229842A1 (en) 2016-09-15
JP2017507958A (ja) 2017-03-23
US20210346289A1 (en) 2021-11-11

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