MX2016011236A - Dispersiones solidas de bendamustina e infusion continua. - Google Patents
Dispersiones solidas de bendamustina e infusion continua.Info
- Publication number
- MX2016011236A MX2016011236A MX2016011236A MX2016011236A MX2016011236A MX 2016011236 A MX2016011236 A MX 2016011236A MX 2016011236 A MX2016011236 A MX 2016011236A MX 2016011236 A MX2016011236 A MX 2016011236A MX 2016011236 A MX2016011236 A MX 2016011236A
- Authority
- MX
- Mexico
- Prior art keywords
- solid dispersions
- continuous infusion
- bendamustine
- bendamustine hydrochloride
- degradants
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a composiciones farmacéuticas que comprenden mostaza de nitrógeno, por ejemplo, clorhidrato de bendamustina, dispersiones sólidas sustancialmente libres de degradantes. También se proporcionan métodos para producir y administrar mostazas de nitrógeno y en particular dispersiones sólidas e clorhidrato de bendamustina sustancialmente libres de degradantes. Las composiciones farmacéuticas pueden ser usadas para cualquier enfermedad que es sensible al tratamiento con clorhidrato de bendamustina, tal como enfermedades neoplásicas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461952624P | 2014-03-13 | 2014-03-13 | |
PCT/US2015/018725 WO2015138199A1 (en) | 2014-03-13 | 2015-03-04 | Bendamustine solid dispersions and continuous infusion |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016011236A true MX2016011236A (es) | 2017-04-06 |
Family
ID=52684713
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016011236A MX2016011236A (es) | 2014-03-13 | 2015-03-04 | Dispersiones solidas de bendamustina e infusion continua. |
MX2022006770A MX2022006770A (es) | 2014-03-13 | 2016-08-30 | Dispersiones solidas de bendamustina e infusion continua. |
MX2021002633A MX2021002633A (es) | 2014-03-13 | 2016-08-30 | Dispersiones solidas de bendamustina e infusion continua. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022006770A MX2022006770A (es) | 2014-03-13 | 2016-08-30 | Dispersiones solidas de bendamustina e infusion continua. |
MX2021002633A MX2021002633A (es) | 2014-03-13 | 2016-08-30 | Dispersiones solidas de bendamustina e infusion continua. |
Country Status (9)
Country | Link |
---|---|
US (5) | US9320730B2 (es) |
EP (1) | EP3116481A1 (es) |
JP (3) | JP6883428B2 (es) |
CN (2) | CN115350155A (es) |
AU (3) | AU2015229842B2 (es) |
CA (1) | CA2941632C (es) |
IL (1) | IL247739A0 (es) |
MX (3) | MX2016011236A (es) |
WO (1) | WO2015138199A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2922099C (en) | 2013-08-27 | 2022-11-29 | Vasilios VOUDOURIS | Bendamustine pharmaceutical compositions |
US20190231757A1 (en) * | 2016-07-13 | 2019-08-01 | Takeda Pharmaceutical Company Limited | Combination of spleen tyrosine kinase inhibitors and other therapeutic agents |
KR20200136997A (ko) | 2018-03-29 | 2020-12-08 | 프로젝트 파마슈틱스 게엠베하 | 액체 약학적 제형 |
CN108324691B (zh) * | 2018-04-11 | 2019-03-08 | 健进制药有限公司 | 一种注射用卡莫司汀冻干制剂及其制备方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5227374A (en) * | 1982-11-12 | 1993-07-13 | Mead Johnson & Company | Lyophilized cyclophosphamide |
DE19757224A1 (de) * | 1997-12-22 | 1999-07-01 | Bayer Ag | Verfahren und Vorrichtung zur in-situ-Formulierung einer Arzneistofflösung zur parenteralen Applikation |
JP2000281561A (ja) * | 1999-03-26 | 2000-10-10 | Ajinomoto Co Inc | 新規溶媒法固体分散体製剤 |
US6982253B2 (en) * | 2002-06-05 | 2006-01-03 | Supergen, Inc. | Liquid formulation of decitabine and use of the same |
MX2007005361A (es) * | 2004-11-05 | 2008-01-11 | Cephalon Inc | Tratamientos para cancer. |
US8436190B2 (en) * | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
JP2008534610A (ja) * | 2005-03-31 | 2008-08-28 | ブリストル−マイヤーズ スクイブ カンパニー | イクサベピロンの投与方法 |
AR072777A1 (es) * | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
CN102149715A (zh) * | 2008-09-17 | 2011-08-10 | Cj第一制糖株式会社 | 肝适能的稳定化固态分散物及其制备方法 |
EP2889029A1 (en) * | 2008-09-25 | 2015-07-01 | Cephalon, Inc. | Liquid formulations of bendamustine |
MX2011011109A (es) * | 2009-04-28 | 2011-11-18 | Cephalon Inc | Formulaciones orales de bendamustina. |
US8609707B2 (en) * | 2010-01-28 | 2013-12-17 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
WO2011103150A2 (en) | 2010-02-18 | 2011-08-25 | Cephalon, Inc. | Lyophilized preparations of bendamustine |
WO2012103226A2 (en) * | 2011-01-25 | 2012-08-02 | Dr. Reddy's Laboratories Ltd. | Bendamustine formulations |
WO2013102920A1 (en) * | 2011-11-18 | 2013-07-11 | Astron Research Limited | Stable lyophilized formulation of bendamustine |
US20130172271A1 (en) * | 2012-01-04 | 2013-07-04 | Cynthia Fragale | Pharmaceutical Spray Drying |
WO2013112762A1 (en) * | 2012-01-24 | 2013-08-01 | Innopharma, Inc. | Bendamustine compositions and methods therefore |
EP2811984B1 (en) * | 2012-02-06 | 2015-08-26 | Fresenius Kabi Oncology Limited | Process for preparing stable pharmaceutical compositions of compounds susceptible to hydrolysis |
EP2641592A1 (en) * | 2012-03-23 | 2013-09-25 | Salmon Pharma GmbH | Pharmaceutical formulation comprising bendamustine |
CA2922099C (en) * | 2013-08-27 | 2022-11-29 | Vasilios VOUDOURIS | Bendamustine pharmaceutical compositions |
-
2015
- 2015-03-04 CA CA2941632A patent/CA2941632C/en active Active
- 2015-03-04 WO PCT/US2015/018725 patent/WO2015138199A1/en active Application Filing
- 2015-03-04 EP EP15710366.4A patent/EP3116481A1/en active Pending
- 2015-03-04 JP JP2016555955A patent/JP6883428B2/ja active Active
- 2015-03-04 AU AU2015229842A patent/AU2015229842B2/en active Active
- 2015-03-04 MX MX2016011236A patent/MX2016011236A/es unknown
- 2015-03-04 CN CN202210568961.7A patent/CN115350155A/zh active Pending
- 2015-03-04 US US14/638,543 patent/US9320730B2/en active Active
- 2015-03-04 CN CN201580012656.8A patent/CN106102722A/zh active Pending
-
2016
- 2016-04-20 US US15/134,122 patent/US9907752B2/en active Active
- 2016-08-30 MX MX2022006770A patent/MX2022006770A/es unknown
- 2016-08-30 MX MX2021002633A patent/MX2021002633A/es unknown
- 2016-09-11 IL IL247739A patent/IL247739A0/en unknown
-
2018
- 2018-02-26 US US15/905,640 patent/US20180185279A1/en not_active Abandoned
-
2019
- 2019-11-29 JP JP2019217619A patent/JP2020055831A/ja active Pending
-
2020
- 2020-09-17 AU AU2020233707A patent/AU2020233707A1/en not_active Abandoned
-
2021
- 2021-07-20 US US17/381,054 patent/US20210346289A1/en not_active Abandoned
-
2022
- 2022-04-18 JP JP2022068104A patent/JP2022095923A/ja active Pending
- 2022-08-05 AU AU2022211893A patent/AU2022211893A1/en active Pending
-
2023
- 2023-07-20 US US18/224,232 patent/US20230364017A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2941632C (en) | 2023-10-24 |
IL247739A0 (en) | 2016-11-30 |
AU2020233707A1 (en) | 2020-10-15 |
AU2015229842A1 (en) | 2016-09-15 |
CA2941632A1 (en) | 2015-09-17 |
CN106102722A (zh) | 2016-11-09 |
JP2017507958A (ja) | 2017-03-23 |
US9320730B2 (en) | 2016-04-26 |
AU2022211893A1 (en) | 2022-09-15 |
MX2021002633A (es) | 2021-05-12 |
US20180185279A1 (en) | 2018-07-05 |
US20230364017A1 (en) | 2023-11-16 |
JP6883428B2 (ja) | 2021-06-09 |
JP2022095923A (ja) | 2022-06-28 |
US20150258069A1 (en) | 2015-09-17 |
US20210346289A1 (en) | 2021-11-11 |
US9907752B2 (en) | 2018-03-06 |
US20160310422A1 (en) | 2016-10-27 |
AU2015229842B2 (en) | 2020-06-25 |
WO2015138199A1 (en) | 2015-09-17 |
EP3116481A1 (en) | 2017-01-18 |
JP2020055831A (ja) | 2020-04-09 |
MX2022006770A (es) | 2022-06-22 |
CN115350155A (zh) | 2022-11-18 |
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