JO3551B1 - تركيبة كبسولة مشتملة على المونتليوكاست و اللِّيفوسيتريزين - Google Patents
تركيبة كبسولة مشتملة على المونتليوكاست و اللِّيفوسيتريزينInfo
- Publication number
- JO3551B1 JO3551B1 JOP/2012/0182A JOP20120182A JO3551B1 JO 3551 B1 JO3551 B1 JO 3551B1 JO P20120182 A JOP20120182 A JO P20120182A JO 3551 B1 JO3551 B1 JO 3551B1
- Authority
- JO
- Jordan
- Prior art keywords
- levocetirizine
- montelukast
- capsule formulation
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
- ZKLPARSLTMPFCP-OAQYLSRUSA-N 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-OAQYLSRUSA-N 0.000 title abstract 3
- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 title abstract 3
- 239000007963 capsule composition Substances 0.000 title abstract 3
- 229960001508 levocetirizine Drugs 0.000 title abstract 3
- 229960005127 montelukast Drugs 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003679 aging effect Effects 0.000 abstract 1
- 201000009961 allergic asthma Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009257 reactivity Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
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- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
يتم الكشف عن تركيبة كبسولة لوقاية أو علاج التهاب الأنف الأرجي وداء الربو وتتألف التركيبة من طبقتين منفصلتين وهما: طبقة مونتيلوكاست التي تحتوي مونتيلوكاست أو ملحه المقبول صيدلانيا؛ و (2) طبقة ليفوسيتريزين تحتوي على ليفوسيتريزين أو ملحه المقبول صيدلانيا؛ وطريقة لإعدادهما. <br /> يمكن أن تفصل تركيبة الكبسولة حسب هذا الاختراع المكونين النشطين فصلا بالكامل مما يقلل من التفاعلية بينهما وتحسين من استقرار المنتج ضد آثار الشيخوخة، وبالتالي يحسن من الآثار العلاجية.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20110070680 | 2011-07-15 | ||
KR1020110111132A KR20130009553A (ko) | 2011-07-15 | 2011-10-28 | 몬테루카스트 또는 이의 약학적으로 허용가능한 염 및 레보세티리진 또는 이의 약학적으로 허용가능한 염을 함유하는 캡슐 제제 |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3551B1 true JO3551B1 (ar) | 2020-07-05 |
Family
ID=47839311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2012/0182A JO3551B1 (ar) | 2011-07-15 | 2012-07-08 | تركيبة كبسولة مشتملة على المونتليوكاست و اللِّيفوسيتريزين |
Country Status (21)
Country | Link |
---|---|
US (2) | US20140170213A1 (ar) |
EP (1) | EP2731594B1 (ar) |
JP (1) | JP2014520842A (ar) |
KR (2) | KR20130009553A (ar) |
CN (2) | CN107468667A (ar) |
AR (1) | AR087177A1 (ar) |
BR (1) | BR112014000943A2 (ar) |
CL (1) | CL2014000054A1 (ar) |
CO (1) | CO6880062A2 (ar) |
ES (1) | ES2727861T3 (ar) |
HK (1) | HK1246199A1 (ar) |
JO (1) | JO3551B1 (ar) |
MX (1) | MX366509B (ar) |
MY (1) | MY178890A (ar) |
PE (1) | PE20141200A1 (ar) |
RU (1) | RU2606857C2 (ar) |
SA (1) | SA112330689B1 (ar) |
TW (1) | TW201311241A (ar) |
UA (1) | UA112083C2 (ar) |
WO (1) | WO2013012199A1 (ar) |
ZA (1) | ZA201401143B (ar) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX352824B (es) | 2010-06-16 | 2017-12-11 | Inflammatory Response Res Inc | Uso de levocetirizina y montelukast en el tratamiento de influenza, resfriado común e inflamación. |
KR101418404B1 (ko) * | 2012-01-06 | 2014-07-10 | 한미약품 주식회사 | 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제 |
RU2677649C2 (ru) * | 2013-02-21 | 2019-01-18 | Глэнмарк Фармасьютикалс Лимитед | Фармацевтические композиции монтелукаста и левоцетиризина |
MX2015012315A (es) | 2013-03-13 | 2015-12-16 | Inflammatory Response Res Inc | Uso de levocetirizina y montelukast en el tratamiento de lesion traumatica. |
KR20160125283A (ko) | 2013-03-13 | 2016-10-31 | 인플래머토리 리스폰스 리서치, 아이엔씨. | 레보세티리진 및 몬테루카스트의 혈관염의 치료 용도 |
AU2014249456B2 (en) | 2013-03-13 | 2018-08-09 | IRR, Inc. | Use of levocetirizine and montelukast in the treatment of autoimmune disorders |
CA2901411A1 (en) * | 2013-03-13 | 2014-10-09 | Bruce Chandler May | Use of levocetirizine and montelukast in the treatment of anaphylaxis |
KR102226833B1 (ko) * | 2013-06-28 | 2021-03-12 | 한미약품 주식회사 | 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형 |
WO2015069203A1 (en) * | 2013-11-06 | 2015-05-14 | Santa Farma Ilaç Sanayi A.Ş. | Capsule comprising rupatadine fumarate and montelukast sodium |
KR101669556B1 (ko) * | 2014-07-02 | 2016-10-28 | 한미약품 주식회사 | 몬테루카스트 또는 이의 약제학적으로 허용가능한 염의 경구투여용 액상제제 |
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BR112019021391A2 (pt) | 2017-04-14 | 2020-05-05 | Capsugel Belgium Nv | cápsulas de pululano |
EP3610028A1 (en) | 2017-04-14 | 2020-02-19 | Capsugel Belgium NV | Process for making pullulan |
KR20210152280A (ko) | 2020-06-08 | 2021-12-15 | 주식회사 경보제약 | 몬테루카스트와 레보세티리진을 포함하는 안정성이 향상된 단일 정제 및 이의 제조방법 |
KR102481517B1 (ko) | 2021-08-30 | 2022-12-27 | 주식회사 클라시아 | 약제학적 제제 |
CN117320697A (zh) | 2021-10-21 | 2023-12-29 | 韩和制药株式会社 | 包含孟鲁司特或其药学上可接受的盐和左西替利嗪或其药学上可接受的盐的稳定性提高的薄膜包衣片剂 |
KR20240045586A (ko) | 2022-09-30 | 2024-04-08 | 주식회사 제뉴원사이언스 | 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 포함하는 안정성이 향상된 이층정 정제 및 그의 제조방법 |
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2011
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- 2012-07-08 JO JOP/2012/0182A patent/JO3551B1/ar active
- 2012-07-11 US US14/232,433 patent/US20140170213A1/en not_active Abandoned
- 2012-07-11 CN CN201710839356.8A patent/CN107468667A/zh active Pending
- 2012-07-11 EP EP12814306.2A patent/EP2731594B1/en not_active Not-in-force
- 2012-07-11 PE PE2014000056A patent/PE20141200A1/es not_active Application Discontinuation
- 2012-07-11 CN CN201280035070.XA patent/CN103687591A/zh active Pending
- 2012-07-11 RU RU2014105577A patent/RU2606857C2/ru not_active IP Right Cessation
- 2012-07-11 WO PCT/KR2012/005506 patent/WO2013012199A1/en active Application Filing
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- 2012-07-11 MY MYPI2014700043A patent/MY178890A/en unknown
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- 2012-07-13 AR ARP120102542A patent/AR087177A1/es not_active Application Discontinuation
- 2012-07-14 SA SA112330689A patent/SA112330689B1/ar unknown
- 2012-11-07 UA UAA201401447A patent/UA112083C2/uk unknown
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2014
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- 2014-02-11 CO CO14028388A patent/CO6880062A2/es unknown
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- 2014-08-29 HK HK18105848.3A patent/HK1246199A1/zh unknown
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Also Published As
Publication number | Publication date |
---|---|
HK1246199A1 (zh) | 2018-09-07 |
UA112083C2 (uk) | 2016-07-25 |
AR087177A1 (es) | 2014-02-26 |
ZA201401143B (en) | 2015-04-29 |
KR20180090966A (ko) | 2018-08-14 |
CN103687591A (zh) | 2014-03-26 |
KR20130009553A (ko) | 2013-01-23 |
MX366509B (es) | 2019-07-11 |
RU2014105577A (ru) | 2015-08-27 |
EP2731594A1 (en) | 2014-05-21 |
CL2014000054A1 (es) | 2014-07-11 |
KR102006000B1 (ko) | 2019-08-01 |
MY178890A (en) | 2020-10-21 |
CO6880062A2 (es) | 2014-02-28 |
RU2606857C2 (ru) | 2017-01-10 |
PE20141200A1 (es) | 2014-09-29 |
EP2731594A4 (en) | 2014-12-31 |
US20160089339A1 (en) | 2016-03-31 |
JP2014520842A (ja) | 2014-08-25 |
MX2014000312A (es) | 2014-02-19 |
SA112330689B1 (ar) | 2017-03-02 |
BR112014000943A2 (pt) | 2017-02-14 |
EP2731594B1 (en) | 2019-04-24 |
WO2013012199A8 (en) | 2014-02-06 |
TW201311241A (zh) | 2013-03-16 |
ES2727861T3 (es) | 2019-10-21 |
CN107468667A (zh) | 2017-12-15 |
WO2013012199A1 (en) | 2013-01-24 |
US20140170213A1 (en) | 2014-06-19 |
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