JO2373B1 - W-carboxy-aryl diphenyl urease substitutes used as RAV inhibitors - Google Patents

W-carboxy-aryl diphenyl urease substitutes used as RAV inhibitors

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Publication number
JO2373B1
JO2373B1 JO20003A JOP20000003A JO2373B1 JO 2373 B1 JO2373 B1 JO 2373B1 JO 20003 A JO20003 A JO 20003A JO P20000003 A JOP20000003 A JO P20000003A JO 2373 B1 JO2373 B1 JO 2373B1
Authority
JO
Jordan
Prior art keywords
kinease
raf
inhibitors
substituted diphenyl
diphenyl ureas
Prior art date
Application number
JO20003A
Other languages
Arabic (ar)
English (en)
Inventor
خير اودي
رايدل بيرند
بي. لاوينجر تيموثي
أي. وود جيل
جيه. سكوت ويليام
دوماس جاك
ايد. سميث روجير
مونهان ماري-كاثرين
ناتيرو رينا
ان سبيلي روبرت
رينيك جويل
Original Assignee
باير هيلثكير ال ال سي
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Publication date
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Application filed by باير هيلثكير ال ال سي filed Critical باير هيلثكير ال ال سي
Application granted granted Critical
Publication of JO2373B1 publication Critical patent/JO2373B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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NO2007002I1 (no) 2007-01-05
MA26038A1 (fr) 2004-04-01
HUP0300866A2 (hu) 2003-07-28
DE122006000059I1 (de) 2007-02-15
SK285532B6 (sk) 2007-03-01
CN1721397A (zh) 2006-01-18
NO20013463L (no) 2001-09-12
LU91280I9 (zh) 2019-01-02
BRPI0017535B1 (pt) 2018-02-14
NO2007002I2 (no) 2009-10-05
SK287419B6 (sk) 2010-09-07
HU230863B1 (hu) 2018-10-29
CN100522934C (zh) 2009-08-05
BG65945B1 (bg) 2010-06-30
EE04913B1 (et) 2007-10-15
PT1690853E (pt) 2010-04-23
HUP0300866A3 (en) 2006-04-28
KR20070020158A (ko) 2007-02-16
DE05028442T1 (de) 2007-02-22
CA2359510A1 (en) 2000-07-20
GT200000002A (es) 2002-01-09
KR100719166B1 (ko) 2007-05-17
KR101091101B1 (ko) 2011-12-09
KR20010103738A (ko) 2001-11-23
BRPI0017535B8 (pt) 2021-09-14
PL215029B1 (pl) 2013-10-31
AU2501600A (en) 2000-08-01
DK1140840T3 (da) 2006-07-31
IL144030A0 (en) 2002-04-21

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