ITTO20010804A1 - Composizioni a base di aminoacidi, idonee alla terapia per la cicatrizzazione e/o riparazione di ferite e lesioni, in particolare per l'appl - Google Patents
Composizioni a base di aminoacidi, idonee alla terapia per la cicatrizzazione e/o riparazione di ferite e lesioni, in particolare per l'appl Download PDFInfo
- Publication number
- ITTO20010804A1 ITTO20010804A1 IT2001TO000804A ITTO20010804A ITTO20010804A1 IT TO20010804 A1 ITTO20010804 A1 IT TO20010804A1 IT 2001TO000804 A IT2001TO000804 A IT 2001TO000804A IT TO20010804 A ITTO20010804 A IT TO20010804A IT TO20010804 A1 ITTO20010804 A1 IT TO20010804A1
- Authority
- IT
- Italy
- Prior art keywords
- amino acids
- weight
- total
- threonine
- lysine
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 72
- 150000001413 amino acids Chemical class 0.000 title claims abstract description 60
- 238000002560 therapeutic procedure Methods 0.000 title claims abstract description 13
- 230000008439 repair process Effects 0.000 title claims description 11
- 230000006378 damage Effects 0.000 title description 3
- 229940024606 amino acid Drugs 0.000 claims abstract description 59
- 235000001014 amino acid Nutrition 0.000 claims abstract description 59
- 239000004480 active ingredient Substances 0.000 claims abstract description 28
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000004472 Lysine Substances 0.000 claims abstract description 27
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000004473 Threonine Substances 0.000 claims abstract description 27
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims abstract description 23
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims abstract description 22
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims abstract description 21
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229960000310 isoleucine Drugs 0.000 claims abstract description 21
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 230000035876 healing Effects 0.000 claims abstract description 14
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 12
- 230000003902 lesion Effects 0.000 claims abstract description 12
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims abstract description 11
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract description 10
- 206010052428 Wound Diseases 0.000 claims abstract description 10
- 229930182817 methionine Natural products 0.000 claims abstract description 10
- 206010011732 Cyst Diseases 0.000 claims abstract description 9
- 208000031513 cyst Diseases 0.000 claims abstract description 9
- 235000020776 essential amino acid Nutrition 0.000 claims abstract description 9
- 239000003797 essential amino acid Substances 0.000 claims abstract description 9
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims abstract description 8
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims abstract description 8
- 235000008729 phenylalanine Nutrition 0.000 claims abstract description 8
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims abstract description 8
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims abstract description 8
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims abstract description 7
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims abstract description 7
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims abstract description 7
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 claims abstract description 6
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims abstract description 6
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims abstract description 6
- 235000018417 cysteine Nutrition 0.000 claims abstract description 6
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960003067 cystine Drugs 0.000 claims abstract description 6
- 241000700647 Variola virus Species 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 102000008186 Collagen Human genes 0.000 claims description 4
- 108010035532 Collagen Proteins 0.000 claims description 4
- 229920001436 collagen Polymers 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract description 9
- 239000004471 Glycine Substances 0.000 abstract description 5
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract description 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract description 2
- 229960005190 phenylalanine Drugs 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 231100000673 dose–response relationship Toxicity 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000036755 cellular response Effects 0.000 description 2
- 201000007717 corneal ulcer Diseases 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 230000003328 fibroblastic effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 206010011026 Corneal lesion Diseases 0.000 description 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 210000003683 corneal stroma Anatomy 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- -1 goine Chemical compound 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001TO000804A ITTO20010804A1 (it) | 2001-08-08 | 2001-08-08 | Composizioni a base di aminoacidi, idonee alla terapia per la cicatrizzazione e/o riparazione di ferite e lesioni, in particolare per l'appl |
| PCT/IB2002/002147 WO2003013487A2 (en) | 2001-08-08 | 2002-06-10 | Amino-acid-based compositions, suitable in therapy for the healing and/or mending of wounds and lesions, in particular for application in the ophthalmic field |
| CA2455776A CA2455776C (en) | 2001-08-08 | 2002-06-10 | Amino-acid-based compositions, suitable in therapy for the healing and/or mending of wounds and lesions, in particular for application in the ophthalmic field |
| AT02735772T ATE401070T1 (de) | 2001-08-08 | 2002-06-10 | Aminosäuren-enthaltende zusammensetzungen, geeignet zur wundheilung, insbesondere zur behandlung des auges |
| KR1020047001591A KR100894364B1 (ko) | 2001-08-08 | 2002-06-10 | 특히 안과 용도로 상처와 병소의 회복 및/또는 개선요법에 적합한 아미노산 기초한 조성물 |
| EP02735772A EP1414431B1 (en) | 2001-08-08 | 2002-06-10 | AMINO-ACID-BASED therapeutic COMPOSITIONS, FOR THE HEALING AND/OR MENDING OF WOUNDS AND LESIONS, IN PARTICULAR IN THE OPHTHALMIC FIELD |
| DE60227670T DE60227670D1 (de) | 2001-08-08 | 2002-06-10 | Aminosäuren-enthaltende zusammensetzungen, geeignet zur wundheilung, insbesondere zur behandlung des auges |
| US10/486,141 US20040192756A1 (en) | 2001-08-08 | 2002-06-10 | Amino-acid-based compositions, suitable in therapy for the healing and/or mending of wounds and lesions, in particular for application in the opthalmic field |
| JP2003518497A JP4366527B2 (ja) | 2001-08-08 | 2002-06-10 | 特に眼科分野における適用のための外傷および損傷の治癒および／または修復のための治療に適したアミノ酸組成物 |
| AU2002309121A AU2002309121A1 (en) | 2001-08-08 | 2002-06-10 | Amino-acid-based compositions, suitable in therapy for the healing and/or mending of wounds and lesions, in particular for application in the ophthalmic field |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001TO000804A ITTO20010804A1 (it) | 2001-08-08 | 2001-08-08 | Composizioni a base di aminoacidi, idonee alla terapia per la cicatrizzazione e/o riparazione di ferite e lesioni, in particolare per l'appl |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITTO20010804A0 ITTO20010804A0 (it) | 2001-08-08 |
| ITTO20010804A1 true ITTO20010804A1 (it) | 2003-02-08 |
Family
ID=11459143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2001TO000804A ITTO20010804A1 (it) | 2001-08-08 | 2001-08-08 | Composizioni a base di aminoacidi, idonee alla terapia per la cicatrizzazione e/o riparazione di ferite e lesioni, in particolare per l'appl |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20040192756A1 (enExample) |
| EP (1) | EP1414431B1 (enExample) |
| JP (1) | JP4366527B2 (enExample) |
| KR (1) | KR100894364B1 (enExample) |
| AT (1) | ATE401070T1 (enExample) |
| AU (1) | AU2002309121A1 (enExample) |
| CA (1) | CA2455776C (enExample) |
| DE (1) | DE60227670D1 (enExample) |
| IT (1) | ITTO20010804A1 (enExample) |
| WO (1) | WO2003013487A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITTO20030789A1 (it) | 2003-10-07 | 2005-04-08 | Professional Dietetics Srl | Composizione a base di amino acidi per il trattamento |
| ES2550608T3 (es) * | 2003-12-20 | 2015-11-11 | Nestec S.A. | Composición nutritiva para la curación de las heridas |
| CN101297390B (zh) * | 2005-09-13 | 2011-04-20 | 朗明科技公司 | 用于光刻法的系统、掩模和方法 |
| ITMI20052037A1 (it) * | 2005-10-26 | 2007-04-27 | Professional Dietetics Srl | Composizioni farmaceutiche cicatrizzanti sotto forma di polvere sterile a base di amminoacidi e sodio ialuronato |
| ITMI20052036A1 (it) * | 2005-10-26 | 2007-04-27 | Professional Dietetics Srl | Composizioni farmaceutiche oftalmiche a base di amminoacidi e sodio ialuronato |
| ITMI20052035A1 (it) * | 2005-10-26 | 2007-04-27 | Professional Dietetics Srl | Composizioni farmaceutiche cicatrizzanti sotto forma di crema a base di amminoacidi e sodio ialuronato |
| ITTO20080443A1 (it) | 2008-06-06 | 2009-12-07 | Professional Dietetics Srl | Composizioni comprendenti amminoacidi, con attivita' pro-angiogenica |
| CH699182B1 (fr) * | 2008-07-17 | 2012-03-15 | Care Cosmeceuticals Sarl | Mélanges de miel d'abeilles pour le traitement dermatologique des plaies chroniques. |
| IT1397446B1 (it) * | 2010-01-12 | 2013-01-10 | Professional Dietetics Srl | Compositions comprising amino acids for prevention and/or treatment of renal disorders. |
| IT201700087376A1 (it) | 2017-07-28 | 2019-01-28 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nel trattamento di malattie associate a disfunzione mitocondriale |
| IT201700087359A1 (it) | 2017-07-28 | 2019-01-28 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nel trattamento di malattie associate a disfunzione mitocondriale |
| IT201800006725A1 (it) | 2018-06-27 | 2019-12-27 | Composizioni comprendenti aminoacidi per l'uso nella prevenzione e nel trattamento di malattie epatiche | |
| AU2019370363B2 (en) * | 2018-10-30 | 2025-07-10 | University Of Florida Research Foundation, Incorporated | Amino acid compositions and methods for treating cystic fibrosis |
| IT202000000442A1 (it) | 2020-01-13 | 2021-07-13 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nella prevenzione e nel trattamento di effetti collaterali della chemioterapia |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1050756A (enExample) * | 1964-09-10 | 1900-01-01 | ||
| DE2531204C2 (de) * | 1975-07-12 | 1987-01-22 | Fresenius AG, 6380 Bad Homburg | L-Aminosäuregemische für die parenterale oder orale Ernährung |
| JPS5536457A (en) * | 1978-09-08 | 1980-03-14 | Ajinomoto Co Inc | Amino acid infusion |
| CA1165243A (en) * | 1980-02-19 | 1984-04-10 | Anthony N. Silvetti | Method and composition for treatment of wounds |
| EP0057209A4 (en) * | 1980-07-31 | 1982-11-25 | George L Blackburn | NEW PREPARATION OF AMINO ACID AND THERAPY FOR THE TREATMENT OF "STRESS" AND INJURIES. |
| JPS59137422A (ja) * | 1983-01-26 | 1984-08-07 | Kenko Igakushiya:Kk | 創傷の治癒促進液剤 |
| US5198465A (en) * | 1991-06-19 | 1993-03-30 | Dioguardi Francesco S | Compositions based on amino acids for preventing and treating precursor deficiencies in the synthesis of collagen |
| IT1304191B1 (it) * | 1998-12-18 | 2001-03-08 | Solartium Establishment | Composizione farmaceutica a base di prolina, glicina e lisina utilenella terapia odontoiatrica sia sotto forma iniettabile che in |
-
2001
- 2001-08-08 IT IT2001TO000804A patent/ITTO20010804A1/it unknown
-
2002
- 2002-06-10 US US10/486,141 patent/US20040192756A1/en not_active Abandoned
- 2002-06-10 AU AU2002309121A patent/AU2002309121A1/en not_active Abandoned
- 2002-06-10 EP EP02735772A patent/EP1414431B1/en not_active Expired - Lifetime
- 2002-06-10 AT AT02735772T patent/ATE401070T1/de not_active IP Right Cessation
- 2002-06-10 CA CA2455776A patent/CA2455776C/en not_active Expired - Fee Related
- 2002-06-10 KR KR1020047001591A patent/KR100894364B1/ko not_active Expired - Fee Related
- 2002-06-10 DE DE60227670T patent/DE60227670D1/de not_active Expired - Lifetime
- 2002-06-10 WO PCT/IB2002/002147 patent/WO2003013487A2/en not_active Ceased
- 2002-06-10 JP JP2003518497A patent/JP4366527B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1414431A2 (en) | 2004-05-06 |
| US20040192756A1 (en) | 2004-09-30 |
| KR100894364B1 (ko) | 2009-04-22 |
| AU2002309121A1 (en) | 2003-02-24 |
| ITTO20010804A0 (it) | 2001-08-08 |
| WO2003013487A3 (en) | 2003-05-30 |
| CA2455776C (en) | 2012-08-28 |
| KR20040020077A (ko) | 2004-03-06 |
| JP4366527B2 (ja) | 2009-11-18 |
| DE60227670D1 (de) | 2008-08-28 |
| JP2005501068A (ja) | 2005-01-13 |
| ATE401070T1 (de) | 2008-08-15 |
| CA2455776A1 (en) | 2003-02-20 |
| EP1414431B1 (en) | 2008-07-16 |
| WO2003013487A2 (en) | 2003-02-20 |
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