ITRM20010465A0 - Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam - Google Patents
Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicamInfo
- Publication number
- ITRM20010465A0 ITRM20010465A0 IT2001RM000465A ITRM20010465A ITRM20010465A0 IT RM20010465 A0 ITRM20010465 A0 IT RM20010465A0 IT 2001RM000465 A IT2001RM000465 A IT 2001RM000465A IT RM20010465 A ITRM20010465 A IT RM20010465A IT RM20010465 A0 ITRM20010465 A0 IT RM20010465A0
- Authority
- IT
- Italy
- Prior art keywords
- triazolylpurines
- medicam
- imidazopyridine
- triazolyl
- adenosine
- Prior art date
Links
- 102000007471 Adenosine A2A receptor Human genes 0.000 title 1
- 108010085277 Adenosine A2A receptor Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001RM000465A ITRM20010465A1 (it) | 2001-07-31 | 2001-07-31 | Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam |
AT02760555T ATE325796T1 (de) | 2001-07-31 | 2002-07-25 | Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente |
US10/484,491 US7230102B2 (en) | 2001-07-31 | 2002-07-25 | Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligandsof the adenosine a2a receptor and their use as medicaments |
AU2002326146A AU2002326146B2 (en) | 2001-07-31 | 2002-07-25 | Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligands of the adenosine A2a receptor and their use as medicaments |
PCT/IT2002/000489 WO2003011864A1 (en) | 2001-07-31 | 2002-07-25 | DERIVATIVES OF TRIAZOLYL-IMIDAZOPYRIDINE AND OF THE TRIAZOLYLPURINES USEFUL AS LIGANDS OF THE ADENOSINE A2a RECEPTOR AND THEIR USE AS MEDICAMENTS |
JP2003517056A JP4366186B2 (ja) | 2001-07-31 | 2002-07-25 | アデノシンA2a受容体のリガンドとして有用なトリアゾリル−イミダゾピリジンおよびトリアゾリルプリンの誘導体およびその薬物としての使用 |
DE60211343T DE60211343T2 (de) | 2001-07-31 | 2002-07-25 | Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente |
ES02760555T ES2263810T3 (es) | 2001-07-31 | 2002-07-25 | Derivados de triazolil-imidazopiridina y de triazolilpurinas utiles como ligandos del receptor de adenosina a2a y su uso com medicamentos. |
PT02760555T PT1412354E (pt) | 2001-07-31 | 2002-07-25 | Derivados de triazolil-imidazopiridina e de triazolilpurinas uteis como ligandos do receptor a2a da adenosina e sua utilizacao como medicamentos |
KR1020047000173A KR100884818B1 (ko) | 2001-07-31 | 2002-07-25 | 아데노신 A2a 수용체의 리간드로서 유용한트리아졸릴-이미다조피리딘 및 트리아졸릴퓨린의 유도체,및 약제로서 그의 용도 |
CA2451279A CA2451279C (en) | 2001-07-31 | 2002-07-25 | Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligands of the adenosine a2a receptor and their use as medicaments |
PL368409A PL217269B1 (pl) | 2001-07-31 | 2002-07-25 | Pochodne triazoliloimidazopirydyny i triazolilopuryny, zawierająca je kompozycja farmaceutyczna, ich zastosowanie, sposób ich otrzymywania oraz związki pośrednie wykorzystywane w tym sposobie |
BR0211550-6A BR0211550A (pt) | 2001-07-31 | 2002-07-25 | Derivados de triazolil-imidazopiridina e das triazolilpurinas úteis como ligandos do receptor a2a da adenosina, e seu uso como medicamentos |
MXPA04000886A MXPA04000886A (es) | 2001-07-31 | 2002-07-25 | Derivados de triazolil-imidazopiridina y triazolilpurinas empledos como ligandos del receptor de adenosina a2a y su uso como medicamentos. |
HU0401987A HU228985B1 (en) | 2001-07-31 | 2002-07-25 | Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligands of the adenosine a2a receptor and their use as medicaments |
DK02760555T DK1412354T3 (da) | 2001-07-31 | 2002-07-25 | Derivater af triazolylimidazopyridin og af triazolylpurinerne, der er egnede som ligander for adenosin A2a?-receptoren og deres anvendelse som medikamenter |
CNB028138481A CN1271070C (zh) | 2001-07-31 | 2002-07-25 | 用作腺苷A2α受体的配体的三唑基-咪唑并吡啶和三唑基嘌呤类的衍生物及其作为药物的应用 |
EP02760555A EP1412354B1 (en) | 2001-07-31 | 2002-07-25 | DERIVATIVES OF TRIAZOLYL-IMIDAZOPYRIDINE AND OF THE TRIAZOLYLPURINES USEFUL AS LIGANDS OF THE ADENOSINE A 2a? RECEPTOR AND THEIR USE AS MEDICAMENTS |
HK05100306A HK1068334A1 (en) | 2001-07-31 | 2005-01-13 | Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligands of the adenosine a2a receptor and their use as medicaments |
US11/797,566 US7528252B2 (en) | 2001-07-31 | 2007-05-04 | Derivatives of triazoly-imidazopyridine useful as ligands of the adenosine A2a receptor and their use as medicaments |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001RM000465A ITRM20010465A1 (it) | 2001-07-31 | 2001-07-31 | Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam |
Publications (2)
Publication Number | Publication Date |
---|---|
ITRM20010465A0 true ITRM20010465A0 (it) | 2001-07-31 |
ITRM20010465A1 ITRM20010465A1 (it) | 2003-01-31 |
Family
ID=11455703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2001RM000465A ITRM20010465A1 (it) | 2001-07-31 | 2001-07-31 | Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam |
Country Status (19)
Country | Link |
---|---|
US (2) | US7230102B2 (it) |
EP (1) | EP1412354B1 (it) |
JP (1) | JP4366186B2 (it) |
KR (1) | KR100884818B1 (it) |
CN (1) | CN1271070C (it) |
AT (1) | ATE325796T1 (it) |
AU (1) | AU2002326146B2 (it) |
BR (1) | BR0211550A (it) |
CA (1) | CA2451279C (it) |
DE (1) | DE60211343T2 (it) |
DK (1) | DK1412354T3 (it) |
ES (1) | ES2263810T3 (it) |
HK (1) | HK1068334A1 (it) |
HU (1) | HU228985B1 (it) |
IT (1) | ITRM20010465A1 (it) |
MX (1) | MXPA04000886A (it) |
PL (1) | PL217269B1 (it) |
PT (1) | PT1412354E (it) |
WO (1) | WO2003011864A1 (it) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6770651B2 (en) * | 2001-06-29 | 2004-08-03 | Venkata Palle | A2B adenosine receptor antagonists |
ITRM20010465A1 (it) * | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam |
AU2002357295A1 (en) * | 2001-12-18 | 2003-06-30 | Cv Therapeutics, Inc. | A2a adenosine receptor antagonists |
BRPI0509258A8 (pt) | 2004-03-26 | 2019-01-22 | Astrazeneca Ab | composto de 8-oxoadenina 9-substituída |
CA2646891A1 (en) * | 2006-03-23 | 2007-09-27 | Novartis Ag | Immunopotentiating compounds |
JP2009542645A (ja) | 2006-07-05 | 2009-12-03 | アストラゼネカ・アクチエボラーグ | Tlr7のモジュレーターとして作用する8−オキソアデニン誘導体 |
TW200831105A (en) | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
ATE530549T1 (de) | 2007-03-19 | 2011-11-15 | Astrazeneca Ab | 9-substituierte 8-oxoadeninverbindungen als modulatoren des toll-like-receptor (tlr7) |
EP2132209B8 (en) | 2007-03-19 | 2014-04-16 | AstraZeneca AB | 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7 ) modulators |
PE20081887A1 (es) * | 2007-03-20 | 2009-01-16 | Dainippon Sumitomo Pharma Co | Nuevo compuesto de adenina |
KR101313804B1 (ko) * | 2007-03-20 | 2013-10-01 | 쿠리스 인코퍼레이션 | Hsp90 억제제로서의 융합된 아미노 피리딘 |
JPWO2008114819A1 (ja) | 2007-03-20 | 2010-07-08 | 大日本住友製薬株式会社 | 新規アデニン化合物 |
JP5400763B2 (ja) * | 2007-05-08 | 2014-01-29 | アストラゼネカ・アクチエボラーグ | 免疫調節特性を有するイミダゾキノリン類 |
PE20091156A1 (es) | 2007-12-17 | 2009-09-03 | Astrazeneca Ab | Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo |
WO2009091031A1 (ja) * | 2008-01-17 | 2009-07-23 | Dainippon Sumitomo Pharma Co., Ltd. | アデニン化合物の製造方法 |
KR20100125245A (ko) | 2008-01-17 | 2010-11-30 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 아데닌 화합물의 제조 방법 |
TWI473614B (zh) | 2008-05-29 | 2015-02-21 | Kyowa Hakko Kirin Co Ltd | Anti-analgesic inhibitors |
AU2009266889B2 (en) | 2008-07-03 | 2013-05-02 | Glaxosmithkline Llc | Benzimidazoles and related analogs as sirtuin modulators |
KR20110040856A (ko) * | 2008-07-23 | 2011-04-20 | 교와 핫꼬 기린 가부시키가이샤 | 편두통 치료제 |
WO2010106145A1 (en) | 2009-03-20 | 2010-09-23 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Oxidated derivatives of triazolypurines useful as ligands of the adenosine a2a receptor and their use as medicaments |
WO2012064340A1 (en) * | 2009-11-13 | 2012-05-18 | Academia Sinica | Dual-action compounds targeting adenosine a2a receptor and adenosine transporter for prevention and treatment of neurodegenerative diseases |
JP2013512859A (ja) * | 2009-12-03 | 2013-04-18 | 大日本住友製薬株式会社 | トール様受容体(tlr)を介して作用するイミダゾキノリン |
EP2657236A4 (en) * | 2010-11-24 | 2014-02-26 | Yamasa Corp | NEW 2-ALKYNYL-N9-PROPARGYLADENINE AND ITS MEDICAL USE |
EP2651937B8 (en) | 2010-12-16 | 2016-07-13 | Sumitomo Dainippon Pharma Co., Ltd. | Imidazo[4,5-c]quinolin-1-yl derivative useful in therapy |
JP5978226B2 (ja) | 2010-12-17 | 2016-08-24 | 大日本住友製薬株式会社 | プリン誘導体 |
WO2014140365A1 (en) * | 2013-03-15 | 2014-09-18 | Syngenta Participations Ag | Microbicidally active imidazopyridine derivatives |
CN105622495A (zh) * | 2016-03-23 | 2016-06-01 | 叶芳 | 4-氯-3-硝基吡啶及其制备方法 |
GB2555264A (en) | 2016-04-15 | 2018-04-25 | Univ Oxford Innovation Ltd | Adenosine receptor modulators for the treatment of circadian rhythm disorders |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990009178A1 (en) * | 1989-01-31 | 1990-08-23 | Whitby Research, Inc. | N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists |
US5670501A (en) * | 1994-09-01 | 1997-09-23 | Discovery Therapeutics, Inc. | N-substituted 9-alkyladenines |
EP1054012B1 (en) | 1998-01-05 | 2003-06-11 | Eisai Co., Ltd. | Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes |
GB9915437D0 (en) * | 1999-07-01 | 1999-09-01 | Cerebrus Ltd | Chemical compounds III |
US6770651B2 (en) * | 2001-06-29 | 2004-08-03 | Venkata Palle | A2B adenosine receptor antagonists |
ITRM20010465A1 (it) | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam |
-
2001
- 2001-07-31 IT IT2001RM000465A patent/ITRM20010465A1/it unknown
-
2002
- 2002-07-25 CN CNB028138481A patent/CN1271070C/zh not_active Expired - Fee Related
- 2002-07-25 PL PL368409A patent/PL217269B1/pl unknown
- 2002-07-25 AT AT02760555T patent/ATE325796T1/de active
- 2002-07-25 US US10/484,491 patent/US7230102B2/en not_active Expired - Fee Related
- 2002-07-25 KR KR1020047000173A patent/KR100884818B1/ko not_active IP Right Cessation
- 2002-07-25 HU HU0401987A patent/HU228985B1/hu not_active IP Right Cessation
- 2002-07-25 DK DK02760555T patent/DK1412354T3/da active
- 2002-07-25 ES ES02760555T patent/ES2263810T3/es not_active Expired - Lifetime
- 2002-07-25 AU AU2002326146A patent/AU2002326146B2/en not_active Ceased
- 2002-07-25 PT PT02760555T patent/PT1412354E/pt unknown
- 2002-07-25 EP EP02760555A patent/EP1412354B1/en not_active Expired - Lifetime
- 2002-07-25 BR BR0211550-6A patent/BR0211550A/pt not_active IP Right Cessation
- 2002-07-25 DE DE60211343T patent/DE60211343T2/de not_active Expired - Lifetime
- 2002-07-25 CA CA2451279A patent/CA2451279C/en not_active Expired - Fee Related
- 2002-07-25 WO PCT/IT2002/000489 patent/WO2003011864A1/en active IP Right Grant
- 2002-07-25 MX MXPA04000886A patent/MXPA04000886A/es active IP Right Grant
- 2002-07-25 JP JP2003517056A patent/JP4366186B2/ja not_active Expired - Fee Related
-
2005
- 2005-01-13 HK HK05100306A patent/HK1068334A1/xx unknown
-
2007
- 2007-05-04 US US11/797,566 patent/US7528252B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT1412354E (pt) | 2006-09-29 |
HUP0401987A3 (en) | 2012-12-28 |
PL368409A1 (en) | 2005-03-21 |
PL217269B1 (pl) | 2014-06-30 |
WO2003011864A1 (en) | 2003-02-13 |
US7528252B2 (en) | 2009-05-05 |
ATE325796T1 (de) | 2006-06-15 |
DK1412354T3 (da) | 2006-09-18 |
US7230102B2 (en) | 2007-06-12 |
HUP0401987A2 (hu) | 2005-01-28 |
KR20040023641A (ko) | 2004-03-18 |
CA2451279C (en) | 2011-05-10 |
BR0211550A (pt) | 2004-07-13 |
JP4366186B2 (ja) | 2009-11-18 |
ES2263810T3 (es) | 2006-12-16 |
MXPA04000886A (es) | 2004-06-03 |
EP1412354A1 (en) | 2004-04-28 |
HU228985B1 (en) | 2013-07-29 |
ITRM20010465A1 (it) | 2003-01-31 |
AU2002326146B2 (en) | 2008-05-01 |
CN1525974A (zh) | 2004-09-01 |
US20070249638A1 (en) | 2007-10-25 |
EP1412354B1 (en) | 2006-05-10 |
JP2005500355A (ja) | 2005-01-06 |
DE60211343D1 (de) | 2006-06-14 |
KR100884818B1 (ko) | 2009-02-20 |
HK1068334A1 (en) | 2005-04-29 |
US20040204428A1 (en) | 2004-10-14 |
CA2451279A1 (en) | 2003-02-13 |
CN1271070C (zh) | 2006-08-23 |
DE60211343T2 (de) | 2007-05-10 |
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