ITPD920121A1 - Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn) - Google Patents

Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)

Info

Publication number
ITPD920121A1
ITPD920121A1 IT000121A ITPD920121A ITPD920121A1 IT PD920121 A1 ITPD920121 A1 IT PD920121A1 IT 000121 A IT000121 A IT 000121A IT PD920121 A ITPD920121 A IT PD920121A IT PD920121 A1 ITPD920121 A1 IT PD920121A1
Authority
IT
Italy
Prior art keywords
ipn
polymer
hyaluronic acid
pct
synthetic chemical
Prior art date
Application number
IT000121A
Other languages
English (en)
Inventor
Lanfranco Callegaro
Paolo Giusti
Original Assignee
Mini Ricerca Scient Tecnolog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mini Ricerca Scient Tecnolog filed Critical Mini Ricerca Scient Tecnolog
Priority to ITPD920121A priority Critical patent/IT1260154B/it
Publication of ITPD920121A0 publication Critical patent/ITPD920121A0/it
Priority to PCT/EP1993/001727 priority patent/WO1994001468A1/en
Priority to US08/367,137 priority patent/US5644049A/en
Priority to EP93915792A priority patent/EP0648229B1/en
Priority to DE69318407T priority patent/DE69318407T2/de
Priority to AT93915792T priority patent/ATE165839T1/de
Priority to JP50293394A priority patent/JP3698720B2/ja
Publication of ITPD920121A1 publication Critical patent/ITPD920121A1/it
Application granted granted Critical
Publication of IT1260154B publication Critical patent/IT1260154B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/26Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/041Mixtures of macromolecular compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00Compositions of unspecified macromolecular compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/02Homopolymers or copolymers of acids; Metal or ammonium salts thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24Homopolymers or copolymers of amides or imides
    • C08L33/26Homopolymers or copolymers of acrylamide or methacrylamide
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/04Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
    • C08L39/06Homopolymers or copolymers of N-vinyl-pyrrolidones
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/04Polyurethanes
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00Polymer mixtures characterised by other features
    • C08L2205/04Polymer mixtures characterised by other features containing interpenetrating networks
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
ITPD920121A 1992-07-03 1992-07-03 Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn) IT1260154B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITPD920121A IT1260154B (it) 1992-07-03 1992-07-03 Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
PCT/EP1993/001727 WO1994001468A1 (en) 1992-07-03 1993-07-05 Hyaluronic acid and derivatives thereof in interpenetrating polymer networks (ipn)
US08/367,137 US5644049A (en) 1992-07-03 1993-07-05 Biomaterial comprising hyaluronic acid and derivatives thereof in interpenetrating polymer networks (IPN)
EP93915792A EP0648229B1 (en) 1992-07-03 1993-07-05 Hyaluronic acid and derivatives thereof in interpenetrating polymer networks (ipn)
DE69318407T DE69318407T2 (de) 1992-07-03 1993-07-05 Hyaluronsaeure und deren derivate in sich gegenseitig durchdringenden polymernetzwerken
AT93915792T ATE165839T1 (de) 1992-07-03 1993-07-05 Hyaluronsaeure und deren derivate in sich gegenseitig durchdringenden polymernetzwerken
JP50293394A JP3698720B2 (ja) 1992-07-03 1993-07-05 相互貫入ポリマー網(ipn)におけるヒアルロン酸およびその誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITPD920121A IT1260154B (it) 1992-07-03 1992-07-03 Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)

Publications (3)

Publication Number Publication Date
ITPD920121A0 ITPD920121A0 (it) 1992-07-03
ITPD920121A1 true ITPD920121A1 (it) 1994-01-03
IT1260154B IT1260154B (it) 1996-03-28

Family

ID=11390000

Family Applications (1)

Application Number Title Priority Date Filing Date
ITPD920121A IT1260154B (it) 1992-07-03 1992-07-03 Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)

Country Status (7)

Country Link
US (1) US5644049A (it)
EP (1) EP0648229B1 (it)
JP (1) JP3698720B2 (it)
AT (1) ATE165839T1 (it)
DE (1) DE69318407T2 (it)
IT (1) IT1260154B (it)
WO (1) WO1994001468A1 (it)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3629685C2 (de) * 1986-09-01 2000-08-10 Daimler Chrysler Ag Photoempfänger
US6610669B1 (en) 1987-09-18 2003-08-26 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1263144B (it) * 1993-02-04 1996-08-01 Lanfranco Callegaro Composizioni farmaceutiche comprendenti materiale spugnoso costituito da derivati esterei dell'acido ialuronico in associazione con altre sostanze farmacologicamente attive
IT1263316B (it) * 1993-02-12 1996-08-05 Fidia Advanced Biopolymers Srl Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico
IT1268954B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
US6294202B1 (en) * 1994-10-06 2001-09-25 Genzyme Corporation Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers
IT1281886B1 (it) * 1995-05-22 1998-03-03 Fidia Advanced Biopolymers Srl Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro
PL186859B1 (pl) * 1995-08-29 2004-03-31 Fidia Advanced Biopolymers Biomateriał do zapobiegania zrostom tkanek po zabiegu chirurgicznym i zastosowanie biomateriału
US6638508B2 (en) 1995-12-21 2003-10-28 Yeda Research And Development Co., Ltd. Modified avidin-type molecules as targeting agents for the liver and cells of the reticuloendothelial system
US5939047A (en) * 1996-04-16 1999-08-17 Jernberg; Gary R. Local delivery of chemotherapeutic agents for treatment of periodontal disease
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
AU4648697A (en) * 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
ES2189166T3 (es) * 1997-04-04 2003-07-01 Fidia Advanced Biopolymers Srl Compuestos del acido hialuronico n-sulfatado, sus derivados y proceso para su preparacion.
US6071982A (en) * 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
US6099952A (en) * 1998-02-18 2000-08-08 Xomed Surgical Products, Inc. Medical sponge having mucopolysaccharide coating
CN1185352C (zh) 1998-04-30 2005-01-19 吗鲁哈株式会社 在其结构中具有葡糖醛酸衍生物和葡糖胺衍生物的化合物、其制备方法及其用途
ITFI980104A1 (it) * 1998-05-04 1999-11-04 Hibiscus S R L Composizioni stabilizzate contenenti acido ialuronico,loro preparazione ed uso
US6824793B1 (en) * 1998-06-01 2004-11-30 Chiron Corporation Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants
ITPD980169A1 (it) * 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
DE1095076T1 (de) * 1998-07-08 2002-04-04 Sunsoft Corp., Albuquerque Ineinandergreifendes polymernetzwerk aus hydrophilen hydrogelen für kontaktlinsen
GB9902412D0 (en) * 1999-02-03 1999-03-24 Fermentech Med Ltd Process
GB9902652D0 (en) * 1999-02-05 1999-03-31 Fermentech Med Ltd Process
US7005513B1 (en) 1999-04-02 2006-02-28 Netech, Inc. Functionalized glycosaminoglycan polymer and medical instruments and drugs by using the same
ATE386075T1 (de) * 1999-04-12 2008-03-15 Cornell Res Foundation Inc Hydrogel-formendes system mit hydrophoben und hydrophilen komponenten
US6716445B2 (en) * 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
US6576226B1 (en) 2000-11-17 2003-06-10 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6726898B2 (en) 2000-11-17 2004-04-27 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6673919B2 (en) * 2001-03-30 2004-01-06 Chisso Cororation Chemically modified hyaluronic acid or salts thereof, and a process for producing thereof
EP1249247B1 (en) * 2001-03-30 2007-02-28 Chisso Corporation Pharmaceutical preparation for the treatment of gynecological diseases
US6939536B2 (en) * 2001-04-16 2005-09-06 Wsp Chemicals & Technology, Llc Cosmetic compositions containing water-soluble polymer complexes
US7615593B2 (en) * 2001-04-23 2009-11-10 Wisconsin Alumni Research Foundation Bifunctional-modified hydrogels
US6899897B2 (en) 2001-06-18 2005-05-31 Jaleva, Inc. Gum resin as a carrier for topical application of pharmacologically active agents
US8524884B2 (en) 2001-10-30 2013-09-03 Colorado State University Research Foundation Outer layer material having entanglement of hydrophobic polymer hostblended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest
US7662954B2 (en) * 2001-10-30 2010-02-16 Colorado State University Research Foundation Outer layer having entanglement of hydrophobic polymer host and hydrophilic polymer guest
AU2002351164A1 (en) * 2001-11-26 2003-06-10 Molecular Reflections, Inc. Microscale immobilization of molecules using a hydrogel and methods of use thereof
AU2002309026A1 (en) * 2002-05-01 2003-11-17 Hokkaido Technology Licensing Office Co., Ltd. Gel having multiple network structure and method for preparation thereof
US20040185022A1 (en) * 2003-02-19 2004-09-23 Steven Rubin Regimen for acne treatment
EP1610838A1 (en) * 2003-04-04 2006-01-04 Bayco Tech Limited Vascular stent
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
CA2538793C (en) * 2003-09-19 2011-01-11 Colorado State University Research Foundation (Csurf) Hyaluronan (ha) esterification via acylation technique for moldable devices
US9554984B2 (en) * 2003-11-03 2017-01-31 Jaleva Pharmaceuticals, Llc Oral care compositions for topical application
GB0329907D0 (en) * 2003-12-23 2004-01-28 Innomed Ltd Compositions
CA2567532C (en) * 2004-05-20 2013-10-01 Mentor Corporation Methods for making injectable polymer hydrogels
US7651702B2 (en) * 2004-05-20 2010-01-26 Mentor Corporation Crosslinking hyaluronan and chitosanic polymers
WO2006013612A1 (ja) * 2004-06-18 2006-02-09 Hokkaido Technology Licensing Office Co., Ltd. 人工半月板
WO2006033698A2 (en) * 2004-07-12 2006-03-30 Isto Technologies, Inc. Tissue matrix system
US8512730B2 (en) 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
US20090088846A1 (en) 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
US7857849B2 (en) * 2004-10-05 2010-12-28 The Board Of Trustees Of The Leland Stanford Junior Iniversity Artificial corneal implant
US7857447B2 (en) * 2004-10-05 2010-12-28 The Board Of Trustees Of The Leland Stanford Junior University Interpenetrating polymer network hydrogel contact lenses
US7909867B2 (en) * 2004-10-05 2011-03-22 The Board Of Trustees Of The Leland Stanford Junior University Interpenetrating polymer network hydrogel corneal prosthesis
ITPD20050056A1 (it) * 2005-03-02 2006-09-03 Fidia Farmaceutici Derivati ammidici del'acido ialuronico in osteoartrosi
JP2009507110A (ja) * 2005-09-09 2009-02-19 オタワ ヘルス リサーチ インスティテュート 相互侵入ネットワーク、およびそれに関連する方法および組成物
EP1947934A4 (en) * 2005-11-07 2012-04-25 Jaleva Llc FILM-FORMING RESINS AS CARRIERS FOR LOCAL APPLICATION OF PHARMACOLOGICALLY ACTIVE AGENTS
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
US8444968B2 (en) 2005-12-07 2013-05-21 Isto Technologies, Inc. Cartilage repair methods
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7993675B2 (en) 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
EP2500015A1 (en) * 2006-12-05 2012-09-19 Landec Corporation Delivery of drugs
US8088095B2 (en) * 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
EP3498299A1 (en) 2007-11-16 2019-06-19 Aclaris Therapeutics, Inc. Compositions and methods for treating purpura
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
FR2924615B1 (fr) * 2007-12-07 2010-01-22 Vivacy Lab Hydrogel cohesif biodegradable.
WO2009152374A2 (en) 2008-06-12 2009-12-17 Medtronic Xomed, Inc. Method for treating chronic wounds
US8334342B2 (en) 2008-06-18 2012-12-18 Basf Se Glyoxal and methylglyoxal as additive for polymer blends
US8883915B2 (en) 2008-07-07 2014-11-11 Biomimedica, Inc. Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
WO2010017282A1 (en) 2008-08-05 2010-02-11 Biomimedica, Inc. Polyurethane-grafted hydrogels
EP2324064B1 (en) 2008-09-02 2017-11-08 Tautona Group LP Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
WO2010038231A1 (en) 2008-10-02 2010-04-08 L.R.R.& D. Ltd. Interface layer wound dressing
US20100086576A1 (en) * 2008-10-06 2010-04-08 Myntti Matthew F Antimicrobial composition and methods of making and using same
JP5724108B2 (ja) 2009-04-22 2015-05-27 メドスキン ソリューションズ ドクター ズベラック アーゲーMedSkin Solutions Dr.Suwelack AG 凍結乾燥組成物
KR101091575B1 (ko) 2009-04-29 2011-12-13 한남대학교 산학협력단 생체적합성 폴리비닐알콜계 하이드로겔의 제조방법
US8273725B2 (en) 2009-09-10 2012-09-25 Genzyme Corporation Stable hyaluronan/steroid formulation
US20110171310A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
WO2011109130A1 (en) * 2010-03-01 2011-09-09 Tautona Group Lp Threads of hyaluronic acid and methods of use thereof
AU2010348090B2 (en) 2010-03-12 2015-09-03 Allergan Industrie Sas A fluid composition comprising a hyaluronan polymer and mannitol for improving skin condition
EP4062950A1 (en) 2010-03-22 2022-09-28 Allergan, Inc. Syringe comprising dermal filler for soft tissue augmentation
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US11484627B2 (en) 2010-10-20 2022-11-01 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11058796B2 (en) 2010-10-20 2021-07-13 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10525169B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11207109B2 (en) 2010-10-20 2021-12-28 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
WO2015095745A1 (en) 2010-10-20 2015-06-25 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
EP2629780A4 (en) 2010-10-20 2014-10-01 206 Ortho Inc IMPLANTABLE POLYMER FOR BONE AND VASCULAR LESIONS
US11291483B2 (en) 2010-10-20 2022-04-05 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
EP2663342B1 (en) * 2011-01-13 2020-03-25 Allergan, Inc. Stable hydrogel compositions including phenylephrine
WO2012154953A2 (en) 2011-05-10 2012-11-15 Microbial Defense Systems, Llc Antimicrobial solid and methods of making and using same
JP6009550B2 (ja) 2011-06-03 2016-10-19 アラーガン、インコーポレイテッドAllergan,Incorporated 抗酸化物質を含む皮膚充填剤組成物
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
JP2013067709A (ja) * 2011-09-21 2013-04-18 Gunze Ltd ヒアルロン酸修飾物
KR20140115294A (ko) 2011-10-03 2014-09-30 바이오미메디카, 인코포레이티드 순응성 재료들을 또 다른 표면으로 앵커링하기 위한 중합체성 접착제
US20140371210A1 (en) 2011-10-13 2014-12-18 Jaleva Pharmaceuticals, Llc Methods and compositions for rapid transbuccal delivery of active agents
WO2013071216A1 (en) * 2011-11-11 2013-05-16 Miba Medical Inc. Injectable filler
CA2856512A1 (en) 2011-11-21 2013-05-30 Biomimedica, Inc. Systems, devices, and methods for anchoring orthopaedic implants to bone
WO2013103956A1 (en) * 2012-01-05 2013-07-11 President And Fellows Of Harvard College Interpenetrating networks with covalent and ionic crosslinks
EP2819620A4 (en) 2012-02-29 2015-11-04 206 Ortho Inc METHOD AND APPARATUS FOR TREATING BONE FRACTURES, INCLUDING THE USE OF COMPOSITE IMPLANTS
ES2443544B1 (es) * 2012-07-19 2014-11-26 Universidad Politécnica De Valencia Material compuesto de ácido hialurónico y al menos un polímero acrílico para aplicaciones biomédicas
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
JP6084833B2 (ja) * 2012-12-07 2017-02-22 大日精化工業株式会社 ヒアルロン酸フィルムの製造方法、及び、ヒアルロン酸フィルム
CN103131054B (zh) * 2013-03-12 2015-05-13 武汉大学 一种高强度水凝胶
US9744260B2 (en) * 2013-04-12 2017-08-29 Phi Nguyen Timing controlled in-situ cross-linking of halyuronic acid during injection
JP2016525379A (ja) 2013-05-23 2016-08-25 206 オーソ,インコーポレーテッド 複合材インプラントの提供および使用を含む、骨折を治療するための、ならびに/または、骨を補強および/もしくは増強するための方法および装置
US9512279B2 (en) * 2013-12-18 2016-12-06 Universite Cegy-Pontoise Interpenetrating polymer network
BR112016026141A2 (pt) 2014-05-09 2018-08-07 Interojo Inc. lentes de contato de hidrogel com superfície molhada, e método de fabricação das mesmas.
ES2761558T3 (es) 2014-09-30 2020-05-20 Allergan Ind Sas Composiciones de hidrogel estables que incluyen aditivos
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
CN104910569B (zh) * 2015-06-03 2017-03-01 西安交通大学 一种可生物还原的透明质酸/聚(Nε‑丙烯酰基‑L‑赖氨酸)双网络水凝胶及其制备方法
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
JP7137213B2 (ja) 2016-03-22 2022-09-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 生体適合性接着剤およびその使用の方法
FR3062854B1 (fr) 2017-02-10 2019-04-12 Polymerexpert Sa Solution viscoelastique aqueuse et son utilisation dans un dispositif d'injection
US11246994B2 (en) 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
CN109575321B (zh) * 2018-12-07 2022-03-18 南京理工大学 一种电响应型互穿聚合物水凝胶及其制备方法
CN110249853B (zh) * 2019-07-22 2021-06-29 中铁四川生态城投资有限公司 一种沉水植物种植袋
CN111443007B (zh) * 2020-04-13 2022-08-05 厦门眼科中心有限公司 一种基于水凝胶复合膜流速测定透明质酸酶浓度的检测方法
US11801143B2 (en) 2021-07-01 2023-10-31 Hyalex Orthopaedics, Inc. Multi-layered biomimetic osteochondral implants and methods of using thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO169637C (no) * 1983-10-11 1992-07-22 Fidia Spa Fremgangsmaate for fremstilling av terapeutisk aktive hyaluronsyre-fraksjoner
US4500676A (en) 1983-12-15 1985-02-19 Biomatrix, Inc. Hyaluronate modified polymeric articles
CA1238043A (en) * 1983-12-15 1988-06-14 Endre A. Balazs Water insoluble preparations of hyaluronic acid and processes therefor
US4487865A (en) 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
JPS6145765A (ja) 1984-08-07 1986-03-05 宇部興産株式会社 血管補綴物及びその製造方法
US5409904A (en) * 1984-11-13 1995-04-25 Alcon Laboratories, Inc. Hyaluronic acid compositions and methods
US4582865A (en) * 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US4731078A (en) * 1985-08-21 1988-03-15 Kingston Technologies Limited Partnership Intraocular lens
JPS62129698A (ja) * 1985-11-28 1987-06-11 Kansai Electric Power Co Inc:The 復水器における防食・防汚管理装置
US4747953A (en) * 1986-02-21 1988-05-31 Allied Corporation Composite membranes based on interpenetrating polymer networks
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
IT1248666B (it) * 1990-05-30 1995-01-26 Fidia Spa Gel in forma di film autosupportanti altamente idrati, processo per laloro preparazione e impiego nella terapia di lesioni e/o patologie cutanee
US5143724A (en) * 1990-07-09 1992-09-01 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5191016A (en) * 1990-07-19 1993-03-02 Manssur Yalpani Functionalized poly(hydroxyalkanoates) and method of manufacturing same
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
IT1251151B (it) * 1991-08-05 1995-05-04 Fidia Spa Materiale spugnoso essenzialmente costituito da acido ialuronico,o suoi derivati
AU636544B1 (en) * 1991-11-27 1993-04-29 Lignyte Co., Ltd. Water insoluble biocompatible hyaluronic acid polyion complex and method of making the same
IT1254704B (it) * 1991-12-18 1995-10-09 Mini Ricerca Scient Tecnolog Tessuto non tessuto essenzialmente costituito da derivati dell'acido ialuronico

Also Published As

Publication number Publication date
JP3698720B2 (ja) 2005-09-21
US5644049A (en) 1997-07-01
EP0648229B1 (en) 1998-05-06
EP0648229A1 (en) 1995-04-19
DE69318407D1 (de) 1998-06-10
JPH08504841A (ja) 1996-05-28
ATE165839T1 (de) 1998-05-15
DE69318407T2 (de) 1999-01-07
IT1260154B (it) 1996-03-28
WO1994001468A1 (en) 1994-01-20
ITPD920121A0 (it) 1992-07-03

Similar Documents

Publication Publication Date Title
ITPD920121A1 (it) Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
Corkhill et al. Synthetic hydrogels VI. Hydrogel composites as wound dressings and implant materials
US5395305A (en) Multilayer wound covering materials comprising a supporting layer and a moisture permeation controlling layer and method for their manufacture
US6099952A (en) Medical sponge having mucopolysaccharide coating
BG98863U (bg) Нетъкан материал,съдържащ производни на хиалуронова киселина
SE9101853D0 (sv) Improved tissue ashesive
DE69630990D1 (de) Biovertragliche Klebmasse
JPH02211145A (ja) 手当用品
AU745199B2 (en) Sulphated hyaluronic acid and sulphated derivatives thereof covalently bound to polyurethanes, and the process for their preparation
DE69621104D1 (de) Verwendung einer ein Polymersystem enthaltenden Zubereitung
AU5647996A (en) Artificial skin containing as support biocompatible materials based on hyaluronic acid derivatives
ES2022689B3 (es) Nuevos biomateriales a base de mezclas de colageno, quitosano y glicosamino glicanos, su procedimiento de preparacion asi como sus aplicaciones en medicina humana.
JP2008504912A (ja) 非接着性ヒドロゲル
DE69738164D1 (de) Als vorrichtung zum schliessen von wunden wirksame monomerzusammensetzung
DK1233796T3 (da) Biokompatible medicinske artikler og fremgangsmåde til deres fremstilling
CN102947376A (zh) 用于制备亲水性涂层的涂料配制品
NO993219L (no) Termoplastisk sammensetning
Jayasree et al. Development of artificial skin (Template) and influence of different types of sterilization procedures on wound healing pattern in rabbits and guinea pigs
ATE106721T1 (de) Verfahren zur umhüllung von wirkstoffen mittels ph-empfindlichen polymeren.
JP2852954B2 (ja) 人工皮膚及びその製造方法
JPS6164256A (ja) 創傷被覆保護材
CN211068233U (zh) 一种成纤维细胞生长因子自粘性人工硬膜修补片
JP3823367B2 (ja) 創傷被覆材
CN1079909A (zh) 烧伤生物敷料的配方及加工工艺
Herman et al. Congenital aplasia cutis: nonsurgical treatment with a synthetic skin substitute

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990614