ITMI20131906A1 - Composizioni solide orali a lento rilascio - Google Patents

Composizioni solide orali a lento rilascio

Info

Publication number
ITMI20131906A1
ITMI20131906A1 IT001906A ITMI20131906A ITMI20131906A1 IT MI20131906 A1 ITMI20131906 A1 IT MI20131906A1 IT 001906 A IT001906 A IT 001906A IT MI20131906 A ITMI20131906 A IT MI20131906A IT MI20131906 A1 ITMI20131906 A1 IT MI20131906A1
Authority
IT
Italy
Prior art keywords
pharmaceutically acceptable
same
composition
salt
tablet
Prior art date
Application number
IT001906A
Other languages
English (en)
Italian (it)
Inventor
Marco Berna
Daniele Giovannone
Niccolo' Miraglia
Original Assignee
Gnosis Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gnosis Spa filed Critical Gnosis Spa
Priority to IT001906A priority Critical patent/ITMI20131906A1/it
Priority to AU2014349782A priority patent/AU2014349782B2/en
Priority to BR112016011142-7A priority patent/BR112016011142B1/pt
Priority to EA201691034A priority patent/EA039558B1/ru
Priority to LTEPPCT/IB2014/065852T priority patent/LT3071191T/lt
Priority to CN201480062634.8A priority patent/CN105764493B/zh
Priority to MX2016006442A priority patent/MX367664B/es
Priority to EP14812619.6A priority patent/EP3071191B1/en
Priority to UAA201605352A priority patent/UA119856C2/uk
Priority to GEAP201414177A priority patent/GEP20186884B/en
Priority to NZ719000A priority patent/NZ719000A/en
Priority to PL14812619T priority patent/PL3071191T3/pl
Priority to HRP20220271TT priority patent/HRP20220271T1/hr
Priority to US15/037,149 priority patent/US10702482B2/en
Priority to RS20220156A priority patent/RS62916B1/sr
Priority to CA2929426A priority patent/CA2929426C/en
Priority to PT148126196T priority patent/PT3071191T/pt
Priority to HUE14812619A priority patent/HUE058086T2/hu
Priority to JP2016532105A priority patent/JP6401270B2/ja
Priority to ES14812619T priority patent/ES2908924T3/es
Priority to KR1020167011680A priority patent/KR102224087B1/ko
Priority to PCT/IB2014/065852 priority patent/WO2015071806A1/en
Priority to DK14812619.6T priority patent/DK3071191T3/da
Priority to GEAP201814177A priority patent/GEAP201814177A/en
Publication of ITMI20131906A1 publication Critical patent/ITMI20131906A1/it
Priority to PH12016500693A priority patent/PH12016500693A1/en
Priority to IL245167A priority patent/IL245167B/en
Priority to ZA2016/02659A priority patent/ZA201602659B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/288—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Psychiatry (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT001906A 2013-11-18 2013-11-18 Composizioni solide orali a lento rilascio ITMI20131906A1 (it)

Priority Applications (27)

Application Number Priority Date Filing Date Title
IT001906A ITMI20131906A1 (it) 2013-11-18 2013-11-18 Composizioni solide orali a lento rilascio
KR1020167011680A KR102224087B1 (ko) 2013-11-18 2014-11-06 지효성 고체 경구용 조성물
US15/037,149 US10702482B2 (en) 2013-11-18 2014-11-06 Slow-release solid oral compositions
EA201691034A EA039558B1 (ru) 2013-11-18 2014-11-06 Композиции в форме таблетки с замедленным высвобождением для перорального введения
LTEPPCT/IB2014/065852T LT3071191T (lt) 2013-11-18 2014-11-06 Lėto atpalaidavimo kietos geriamosios kompozicijos
CN201480062634.8A CN105764493B (zh) 2013-11-18 2014-11-06 缓释的固体口服组合物
MX2016006442A MX367664B (es) 2013-11-18 2014-11-06 Composiciones sólidas orales de liberación lenta.
EP14812619.6A EP3071191B1 (en) 2013-11-18 2014-11-06 Slow-release solid oral compositions
UAA201605352A UA119856C2 (uk) 2013-11-18 2014-11-06 Тверді пероральні композиції з повільним вивільненням
GEAP201414177A GEP20186884B (en) 2013-11-18 2014-11-06 Slow-release solid oral compositions
NZ719000A NZ719000A (en) 2013-11-18 2014-11-06 Slow-release solid oral compositions
PL14812619T PL3071191T3 (pl) 2013-11-18 2014-11-06 Stałe kompozycje doustne o powolnym uwalnianiu
CA2929426A CA2929426C (en) 2013-11-18 2014-11-06 Slow-release solid oral compositions
AU2014349782A AU2014349782B2 (en) 2013-11-18 2014-11-06 Slow-release solid oral compositions
RS20220156A RS62916B1 (sr) 2013-11-18 2014-11-06 Čvrste oralne kompozicije sa sporim oslobađanjem
HRP20220271TT HRP20220271T1 (hr) 2013-11-18 2014-11-06 Čvrsti oralni pripravci sa sporim otpuštanjem
PT148126196T PT3071191T (pt) 2013-11-18 2014-11-06 Composições sólidas orais de libertação lenta
HUE14812619A HUE058086T2 (hu) 2013-11-18 2014-11-06 Lassú hatóanyagleadású szilárd készítmények
JP2016532105A JP6401270B2 (ja) 2013-11-18 2014-11-06 徐放性固体経口組成物
ES14812619T ES2908924T3 (es) 2013-11-18 2014-11-06 Composiciones orales sólidas de liberación lenta
BR112016011142-7A BR112016011142B1 (pt) 2013-11-18 2014-11-06 Composições orais sólidas de liberação lenta
PCT/IB2014/065852 WO2015071806A1 (en) 2013-11-18 2014-11-06 Slow-release solid oral compositions
DK14812619.6T DK3071191T3 (da) 2013-11-18 2014-11-06 Faste orale sammensætninger med langsom frigivelse
GEAP201814177A GEAP201814177A (en) 2013-11-18 2014-11-06 Slow-release solid oral compositions
PH12016500693A PH12016500693A1 (en) 2013-11-18 2016-04-14 Slow-release solid oral compositions
IL245167A IL245167B (en) 2013-11-18 2016-04-17 Slow-release solid oral compositions
ZA2016/02659A ZA201602659B (en) 2013-11-18 2016-04-19 Slow-release solid oral compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001906A ITMI20131906A1 (it) 2013-11-18 2013-11-18 Composizioni solide orali a lento rilascio

Publications (1)

Publication Number Publication Date
ITMI20131906A1 true ITMI20131906A1 (it) 2015-05-19

Family

ID=49780196

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001906A ITMI20131906A1 (it) 2013-11-18 2013-11-18 Composizioni solide orali a lento rilascio

Country Status (26)

Country Link
US (1) US10702482B2 (https=)
EP (1) EP3071191B1 (https=)
JP (1) JP6401270B2 (https=)
KR (1) KR102224087B1 (https=)
CN (1) CN105764493B (https=)
AU (1) AU2014349782B2 (https=)
BR (1) BR112016011142B1 (https=)
CA (1) CA2929426C (https=)
DK (1) DK3071191T3 (https=)
EA (1) EA039558B1 (https=)
ES (1) ES2908924T3 (https=)
GE (2) GEP20186884B (https=)
HR (1) HRP20220271T1 (https=)
HU (1) HUE058086T2 (https=)
IL (1) IL245167B (https=)
IT (1) ITMI20131906A1 (https=)
LT (1) LT3071191T (https=)
MX (1) MX367664B (https=)
NZ (1) NZ719000A (https=)
PH (1) PH12016500693A1 (https=)
PL (1) PL3071191T3 (https=)
PT (1) PT3071191T (https=)
RS (1) RS62916B1 (https=)
UA (1) UA119856C2 (https=)
WO (1) WO2015071806A1 (https=)
ZA (1) ZA201602659B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201700074957A1 (it) * 2017-07-04 2019-01-04 Gnosis Spa Sale di (ss)-adenosil metionina con inositolo esafosfato e procedimento per ottenerlo
CN109939077B (zh) * 2017-12-04 2022-07-22 深圳奥萨制药有限公司 一种含有5-甲基四氢叶酸的控释制剂
CN111990674B (zh) * 2020-01-14 2021-07-02 青岛圣邦健康食品有限公司 肠溶包衣材料及其制备方法和肠溶制品
IT202000006127A1 (it) * 2020-03-23 2021-09-23 Fmc S R L Formulazione farmaceutica, dietetica e/o alimentare a base ademetionina e processo di realizzazione di detta formulazione
IT202300007692A1 (it) * 2023-04-19 2024-10-19 Vifra S R L Formulazione farmaceutica, dietetica e/o alimentare a base ademetionina e processo di realizzazione di detta formulazione

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2003043608A1 (en) * 2001-11-22 2003-05-30 Gnosis Srl Process for the preparation of tablets comprising s-adenosylmethionine
US20050181047A1 (en) * 2004-02-18 2005-08-18 Jaime Romero Compositions and methods for timed release of water-soluble nutritional supplements
WO2007113885A2 (en) * 2006-03-31 2007-10-11 Gnosis Spa Solid oral compositions based on s-adenosyl methionine and/or nadh and process for obtaining them

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IT1200589B (it) * 1985-02-14 1989-01-27 Gibipharma Spa Derivati naturali attivita farmagologica
EP1809255A4 (en) * 2004-11-05 2011-08-03 Fabre Kramer Holdings Inc HIGH DOSAGE FORMULATION OF GEPIRON WITH EXTENDED RELEASE
US20090088404A1 (en) 2007-01-31 2009-04-02 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
KR20070093972A (ko) * 2007-06-05 2007-09-19 파브르-크래머 홀딩스. 인크 게피론의 고용량 서방성 제제
US7947662B2 (en) * 2008-02-20 2011-05-24 Gnosis S.P.A. Folates, compositions and uses thereof
US8329208B2 (en) 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
US20110027342A1 (en) 2009-07-28 2011-02-03 Msi Methylation Sciences, Inc. S-adenosylmethionine formulations with enhanced bioavailability
IT1401146B1 (it) * 2010-07-27 2013-07-12 Gnosis Spa Composizione comprendente shellac e/o un suo sale e sodio amido glicolato

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003043608A1 (en) * 2001-11-22 2003-05-30 Gnosis Srl Process for the preparation of tablets comprising s-adenosylmethionine
US20050181047A1 (en) * 2004-02-18 2005-08-18 Jaime Romero Compositions and methods for timed release of water-soluble nutritional supplements
WO2007113885A2 (en) * 2006-03-31 2007-10-11 Gnosis Spa Solid oral compositions based on s-adenosyl methionine and/or nadh and process for obtaining them

Non-Patent Citations (2)

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Title
DOUG NELSON ET AL: "Effects of Magnesium Stearate on Tablet Properties", 23 July 2009 (2009-07-23), XP055117008, Retrieved from the Internet <URL:http://www.osd.rutgers.edu/gs/09papers/PharmaDC.pdf> [retrieved on 20140508] *
DUERIG T ET AL: "MECHANISTIC EVALUATION OF BINARY EFFECTS OF MAGNESIUM STEARATE AND TALC AS DISSOLUTION RETARDANTS AT 85% DRUG LOADING IN AN EXPERIMENTAL EXTENDED-RELEASE FORMULATION", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION, WASHINGTON, US, vol. 86, no. 10, 1 October 1997 (1997-10-01), pages 1092 - 1098, XP000699740, ISSN: 0022-3549, DOI: 10.1021/JS970052V *

Also Published As

Publication number Publication date
US20160287519A1 (en) 2016-10-06
PH12016500693B1 (en) 2016-05-30
WO2015071806A1 (en) 2015-05-21
ZA201602659B (en) 2017-08-30
MX2016006442A (es) 2016-12-09
IL245167B (en) 2020-04-30
EP3071191B1 (en) 2022-01-05
RS62916B1 (sr) 2022-03-31
EP3071191A1 (en) 2016-09-28
GEAP201814177A (en) 2018-03-26
GEP20186884B (en) 2018-07-25
UA119856C2 (uk) 2019-08-27
NZ719000A (en) 2017-06-30
KR20160086829A (ko) 2016-07-20
CA2929426A1 (en) 2015-05-21
CN105764493A (zh) 2016-07-13
MX367664B (es) 2019-08-30
EA039558B1 (ru) 2022-02-10
KR102224087B1 (ko) 2021-03-10
DK3071191T3 (da) 2022-03-07
IL245167A0 (en) 2016-06-30
LT3071191T (lt) 2022-04-25
PL3071191T3 (pl) 2022-04-04
AU2014349782B2 (en) 2019-04-04
PH12016500693A1 (en) 2016-05-30
BR112016011142B1 (pt) 2023-01-03
PT3071191T (pt) 2022-04-05
JP6401270B2 (ja) 2018-10-10
EA201691034A1 (ru) 2016-09-30
HUE058086T2 (hu) 2022-07-28
ES2908924T3 (es) 2022-05-04
US10702482B2 (en) 2020-07-07
JP2016539112A (ja) 2016-12-15
CA2929426C (en) 2021-08-31
BR112016011142A2 (https=) 2017-08-08
HRP20220271T1 (hr) 2022-05-13
CN105764493B (zh) 2020-02-21

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