ITMI20010813A0 - Valutazione di fibrosi del fegato con algoritmi basati su marcatori del siero - Google Patents

Valutazione di fibrosi del fegato con algoritmi basati su marcatori del siero

Info

Publication number
ITMI20010813A0
ITMI20010813A0 IT2001MI000813A ITMI20010813A ITMI20010813A0 IT MI20010813 A0 ITMI20010813 A0 IT MI20010813A0 IT 2001MI000813 A IT2001MI000813 A IT 2001MI000813A IT MI20010813 A ITMI20010813 A IT MI20010813A IT MI20010813 A0 ITMI20010813 A0 IT MI20010813A0
Authority
IT
Italy
Prior art keywords
assessment
liver fibrosis
algorithms based
serum markers
markers
Prior art date
Application number
IT2001MI000813A
Other languages
English (en)
Inventor
Michael Volker
Michael Becka
Werner Kroll
Andreas Knorr
Sylvia Unger
Mathias Gehrmann
Guido Hennig
Guido Burchardt
Michael J Arthur
Alastair D Burt
Massimo Pinzani
Detlef Schuppan
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ITMI20010813A0 publication Critical patent/ITMI20010813A0/it
Priority to JP2001583196A priority Critical patent/JP4712271B2/ja
Priority to EP01945050A priority patent/EP1283989B1/en
Priority to US10/258,689 priority patent/US7141380B2/en
Priority to AT01945050T priority patent/ATE366939T1/de
Priority to ES01945050T priority patent/ES2288962T3/es
Priority to PCT/EP2001/004696 priority patent/WO2001086304A2/en
Priority to AU67380/01A priority patent/AU6738001A/en
Priority to DE60129314T priority patent/DE60129314T2/de
Publication of ITMI20010813A1 publication Critical patent/ITMI20010813A1/it

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IT2001MI000813A 2000-04-28 2001-04-13 Valutazione di fibrosi del fegato con algoritmi basati su marcatori del siero ITMI20010813A1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2001583196A JP4712271B2 (ja) 2000-04-28 2001-04-26 血清マーカーアルゴリズムを用いる肝線維症スコアリングの評価
EP01945050A EP1283989B1 (en) 2000-04-28 2001-04-26 Diagnosis of liver fibrosis with serum marker algorithms
US10/258,689 US7141380B2 (en) 2000-04-28 2001-04-26 Assessment of liver fibrosis scoring with serum marker algorithms
AT01945050T ATE366939T1 (de) 2000-04-28 2001-04-26 Diagnose von leberfibrose mit hilfe von serummarkeralgorithmen
ES01945050T ES2288962T3 (es) 2000-04-28 2001-04-26 Diagnostico de fibrosis hepatica con algoritmos de marcadores sericos.
PCT/EP2001/004696 WO2001086304A2 (en) 2000-04-28 2001-04-26 Diagnostic of liver fibrosis with serum marker algorithms
AU67380/01A AU6738001A (en) 2000-04-28 2001-04-26 Assessment of liver fibrosis scoring with serum marker algorithms
DE60129314T DE60129314T2 (de) 2000-04-28 2001-04-26 Diagnose von leberfibrose mit hilfe von serummarkeralgorithmen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00109063A EP1150123B1 (en) 2000-04-28 2000-04-28 Diagnosis of liver fibrosis with serum marker algorithms

Publications (2)

Publication Number Publication Date
ITMI20010813A0 true ITMI20010813A0 (it) 2001-04-13
ITMI20010813A1 ITMI20010813A1 (it) 2002-10-13

Family

ID=8168573

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2001MI000813A ITMI20010813A1 (it) 2000-04-28 2001-04-13 Valutazione di fibrosi del fegato con algoritmi basati su marcatori del siero

Country Status (4)

Country Link
EP (1) EP1150123B1 (it)
JP (1) JP4712271B2 (it)
DE (1) DE60029302T2 (it)
IT (1) ITMI20010813A1 (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7668661B2 (en) * 2000-04-28 2010-02-23 Siemens Healthcare Diagnostics Inc. Liver disease-related methods and systems
US6986995B2 (en) 2002-02-28 2006-01-17 Prometheus Laboratories, Inc. Methods of diagnosing liver fibrosis
US7670764B2 (en) 2003-10-24 2010-03-02 Prometheus Laboratories Inc. Methods of diagnosing tissue fibrosis
ATE354097T1 (de) * 2004-08-12 2007-03-15 Hoffmann La Roche Verfahren zur diagnose von leberfibrose.
ES2303925T3 (es) * 2004-08-12 2008-09-01 F. Hoffmann-La Roche Ag Metodo para diagnosticar la fibrosis hepatica.
SG134283A1 (en) * 2006-01-24 2007-08-29 Ind Tech Res Inst Biomarkers for liver fibrotic injury
JP5689426B2 (ja) * 2009-01-28 2015-03-25 インダストリアル テクノロジー リサーチ インスティテュートＩｎｄｕｓｔｒｉａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ 糖尿病性ネフロパシーに関連する尿および血清のバイオマーカー
US8961925B2 (en) 2011-05-31 2015-02-24 The Regents Of The University Of Colorado, A Body Corporate Method for assessment of hepatic function and portal blood flow
JP6378194B2 (ja) 2012-11-12 2018-08-22 ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド，ア ボディ コーポレイト 慢性肝疾患の評価のための疾患重症度指数および原発性硬化性胆管炎の３つの異なるサブタイプの診断方法
CN103399158A (zh) * 2013-08-02 2013-11-20 上海市同济医院 一种检测肝纤维化程度的液相蛋白芯片试剂盒
EP3411716A1 (en) * 2016-02-03 2018-12-12 Nordic Bioscience A/S Combined biomarker measurement of fibrosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2968538B2 (ja) * 1989-06-23 1999-10-25 富士薬品工業 株式会社 ヒトラミニンのモノクローナル抗体、その製法および利用
JP3327758B2 (ja) * 1995-12-11 2002-09-24 株式会社いかがく 肝線維化のスクリーニング方法及び診断用キット
JPH11171898A (ja) * 1997-10-03 1999-06-29 Tosoh Corp Ｉｖ型コラーゲン高分子画分、その製法、その測定法及び肝疾患の判定方法
US6060255A (en) * 1997-10-03 2000-05-09 Tosoh Corporation Type IV collagen high molecular form and production and diagnostic use thereof

Also Published As

Publication number Publication date
JP4712271B2 (ja) 2011-06-29
EP1150123B1 (en) 2006-07-12
JP2003532899A (ja) 2003-11-05
DE60029302D1 (de) 2006-08-24
ITMI20010813A1 (it) 2002-10-13
DE60029302T2 (de) 2007-08-09
EP1150123A1 (en) 2001-10-31

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