DE60029302D1 - Diagnose von Leberfibrose mit Hilfe von Serummarkeralgorithmen - Google Patents

Diagnose von Leberfibrose mit Hilfe von Serummarkeralgorithmen

Info

Publication number
DE60029302D1
DE60029302D1 DE60029302T DE60029302T DE60029302D1 DE 60029302 D1 DE60029302 D1 DE 60029302D1 DE 60029302 T DE60029302 T DE 60029302T DE 60029302 T DE60029302 T DE 60029302T DE 60029302 D1 DE60029302 D1 DE 60029302D1
Authority
DE
Germany
Prior art keywords
diagnosis
liver fibrosis
serum marker
algorithms
marker algorithms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60029302T
Other languages
English (en)
Other versions
DE60029302T2 (de
Inventor
Michael Dr Voelker
Michael Dr Becka
Werner Dr Kroll
Andreas Dr Knorr
Sylvia Dr Unger
Mathias Dr Gehrmann
Guido Dr Hennig
Elmar-Reinhold Burchardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE60029302D1 publication Critical patent/DE60029302D1/de
Publication of DE60029302T2 publication Critical patent/DE60029302T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE60029302T 2000-04-28 2000-04-28 Diagnose von Leberfibrose mit Hilfe von Serummarkeralgorithmen Expired - Lifetime DE60029302T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00109063A EP1150123B1 (de) 2000-04-28 2000-04-28 Diagnose von Leberfibrose mit Hilfe von Serummarkeralgorithmen

Publications (2)

Publication Number Publication Date
DE60029302D1 true DE60029302D1 (de) 2006-08-24
DE60029302T2 DE60029302T2 (de) 2007-08-09

Family

ID=8168573

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60029302T Expired - Lifetime DE60029302T2 (de) 2000-04-28 2000-04-28 Diagnose von Leberfibrose mit Hilfe von Serummarkeralgorithmen

Country Status (4)

Country Link
EP (1) EP1150123B1 (de)
JP (1) JP4712271B2 (de)
DE (1) DE60029302T2 (de)
IT (1) ITMI20010813A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7668661B2 (en) 2000-04-28 2010-02-23 Siemens Healthcare Diagnostics Inc. Liver disease-related methods and systems
US6986995B2 (en) 2002-02-28 2006-01-17 Prometheus Laboratories, Inc. Methods of diagnosing liver fibrosis
US7670764B2 (en) 2003-10-24 2010-03-02 Prometheus Laboratories Inc. Methods of diagnosing tissue fibrosis
ATE354097T1 (de) * 2004-08-12 2007-03-15 Hoffmann La Roche Verfahren zur diagnose von leberfibrose.
ES2303925T3 (es) * 2004-08-12 2008-09-01 F. Hoffmann-La Roche Ag Metodo para diagnosticar la fibrosis hepatica.
SG134283A1 (en) * 2006-01-24 2007-08-29 Ind Tech Res Inst Biomarkers for liver fibrotic injury
WO2010085879A1 (en) * 2009-01-28 2010-08-05 Industrial Technology Research Institute Urine and serum biomarkers associated with diabetic nephropathy
US8961925B2 (en) 2011-05-31 2015-02-24 The Regents Of The University Of Colorado, A Body Corporate Method for assessment of hepatic function and portal blood flow
AU2013341378B2 (en) 2012-11-12 2018-02-01 The Regents Of The University Of Colorado, A Body Corporate Disease Severity Index for assessment of chronic liver disease and method for diagnosis of three distinct subtypes of Primary Sclerosing Cholangitis
CN103399158A (zh) * 2013-08-02 2013-11-20 上海市同济医院 一种检测肝纤维化程度的液相蛋白芯片试剂盒
CA3009445C (en) * 2016-02-03 2024-03-19 Nordic Bioscience A/S Combined biomarker measurement of fibrosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2968538B2 (ja) * 1989-06-23 1999-10-25 富士薬品工業 株式会社 ヒトラミニンのモノクローナル抗体、その製法および利用
JP3327758B2 (ja) * 1995-12-11 2002-09-24 株式会社いかがく 肝線維化のスクリーニング方法及び診断用キット
JPH11171898A (ja) * 1997-10-03 1999-06-29 Tosoh Corp Ｉｖ型コラーゲン高分子画分、その製法、その測定法及び肝疾患の判定方法
US6060255A (en) * 1997-10-03 2000-05-09 Tosoh Corporation Type IV collagen high molecular form and production and diagnostic use thereof

Also Published As

Publication number Publication date
ITMI20010813A1 (it) 2002-10-13
ITMI20010813A0 (it) 2001-04-13
JP2003532899A (ja) 2003-11-05
EP1150123B1 (de) 2006-07-12
DE60029302T2 (de) 2007-08-09
EP1150123A1 (de) 2001-10-31
JP4712271B2 (ja) 2011-06-29

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