ITMI20002358A0 - Derivati di tieno [2,3-c]isochinolin-3-one come inibitori della poli(adp-ribosio)polimerasi - Google Patents

Derivati di tieno [2,3-c]isochinolin-3-one come inibitori della poli(adp-ribosio)polimerasi

Info

Publication number
ITMI20002358A0
ITMI20002358A0 IT2000MI002358A ITMI20002358A ITMI20002358A0 IT MI20002358 A0 ITMI20002358 A0 IT MI20002358A0 IT 2000MI002358 A IT2000MI002358 A IT 2000MI002358A IT MI20002358 A ITMI20002358 A IT MI20002358A IT MI20002358 A0 ITMI20002358 A0 IT MI20002358A0
Authority
IT
Italy
Prior art keywords
isoquinolin
thieno
adp
ribose
poly
Prior art date
Application number
IT2000MI002358A
Other languages
English (en)
Inventor
Roberto Pellicciari
Flavio Moroni
Original Assignee
Roberto Pellicciari
Flavio Moroni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roberto Pellicciari, Flavio Moroni filed Critical Roberto Pellicciari
Priority to IT002358A priority Critical patent/ITMI20002358A1/it
Publication of ITMI20002358A0 publication Critical patent/ITMI20002358A0/it
Priority to US10/415,601 priority patent/US6989388B2/en
Priority to AU2002212575A priority patent/AU2002212575A1/en
Priority to EP01980788A priority patent/EP1332147A1/en
Priority to JP2002539357A priority patent/JP4417622B2/ja
Priority to PCT/IB2001/002030 priority patent/WO2002036599A1/en
Priority to DE60140086T priority patent/DE60140086D1/de
Priority to AT04076527T priority patent/ATE444298T1/de
Priority to ES04076527T priority patent/ES2332588T3/es
Priority to EP04076527A priority patent/EP1464646B1/en
Publication of ITMI20002358A1 publication Critical patent/ITMI20002358A1/it
Priority to US11/264,468 priority patent/US7825129B2/en
Priority to US12/938,163 priority patent/US20110237617A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT002358A 2000-10-31 2000-10-31 Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi ITMI20002358A1 (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT002358A ITMI20002358A1 (it) 2000-10-31 2000-10-31 Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi
EP04076527A EP1464646B1 (en) 2000-10-31 2001-10-30 Thieno(2,3-C) Isoquinolines for use as inhibitors of Parp
JP2002539357A JP4417622B2 (ja) 2000-10-31 2001-10-30 Ｐａｒｐの阻害剤として用いるためのチエノ［２，３−ｃ］イソキノリン
AU2002212575A AU2002212575A1 (en) 2000-10-31 2001-10-30 Thieno(2,3-c)isoquinolines for use as inhibitors of parp
EP01980788A EP1332147A1 (en) 2000-10-31 2001-10-30 Thieno[2,3-c isoquinolines for use as inhibitors of parp
US10/415,601 US6989388B2 (en) 2000-10-31 2001-10-30 Thieno[2,3-c]iosquinolines for use as inhibitors of PARP
PCT/IB2001/002030 WO2002036599A1 (en) 2000-10-31 2001-10-30 Thieno[2,3-c]isoquinolines for use as inhibitors of parp
DE60140086T DE60140086D1 (de) 2000-10-31 2001-10-30 Thieno(2,3-c)isoquinolinen zur Verwendung als Parp-Inhibitoren
AT04076527T ATE444298T1 (de) 2000-10-31 2001-10-30 Thieno(2,3-c)isoquinolinen zur verwendung als parp-inhibitoren
ES04076527T ES2332588T3 (es) 2000-10-31 2001-10-30 Tieno(2,3-c)isoquinolinas para usar como inhibidores de parp.
US11/264,468 US7825129B2 (en) 2000-10-31 2005-11-01 Thieno[2,3-c] isoquinolines for use as inhibitors of PARP
US12/938,163 US20110237617A1 (en) 2000-10-31 2010-11-02 Thieno[2,3-c] isoquinolines for use as inhibitors of parp

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002358A ITMI20002358A1 (it) 2000-10-31 2000-10-31 Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi

Publications (2)

Publication Number Publication Date
ITMI20002358A0 true ITMI20002358A0 (it) 2000-10-31
ITMI20002358A1 ITMI20002358A1 (it) 2002-05-01

Family

ID=11446071

Family Applications (1)

Application Number Title Priority Date Filing Date
IT002358A ITMI20002358A1 (it) 2000-10-31 2000-10-31 Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi

Country Status (9)

Country Link
US (3) US6989388B2 (it)
EP (2) EP1464646B1 (it)
JP (1) JP4417622B2 (it)
AT (1) ATE444298T1 (it)
AU (1) AU2002212575A1 (it)
DE (1) DE60140086D1 (it)
ES (1) ES2332588T3 (it)
IT (1) ITMI20002358A1 (it)
WO (1) WO2002036599A1 (it)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20002358A1 (it) * 2000-10-31 2002-05-01 Flavio Moroni Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi
US6956035B2 (en) * 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
MXPA06005686A (es) 2003-11-20 2006-08-17 Janssen Pharmaceutica Nv 2-quinolinonas y 2-quinoxalinonas 7-fenilaquilo sustituidas como inhibidores de la poli(adp-ribosa)polimerasa.
ES2670349T3 (es) * 2003-11-20 2018-05-30 Janssen Pharmaceutica Nv 2-Quinolinonas y 2-quinoxalinonas sustituidas con 6-alquenilo y 6-fenilalquilo como inhibidores de poli(ADP-ribosa) polimerasa
EP1687277B1 (en) * 2003-11-20 2018-04-04 Janssen Pharmaceutica NV 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
US7803795B2 (en) 2004-06-30 2010-09-28 Janssen Pharmaceutica N.V. Phthalazine derivatives as parp inhibitors
CN1980913B (zh) 2004-06-30 2011-12-14 詹森药业有限公司 作为parp抑制剂的喹唑啉二酮衍生物
UA86237C2 (uk) 2004-06-30 2009-04-10 Янссен Фармацевтика Н.В. Похідні заміщеного 2-алкілхіназолінону як інгібітори parp
CA2615374A1 (en) * 2005-07-18 2007-01-25 Ernest Kun Kun Treatment of cancer
US20080262062A1 (en) * 2006-11-20 2008-10-23 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20070292883A1 (en) * 2006-06-12 2007-12-20 Ossovskaya Valeria S Method of treating diseases with PARP inhibitors
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
GB0615809D0 (en) * 2006-08-09 2006-09-20 Istituto Di Ricerche D Biolog Therapeutic compounds
AU2007292306A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
JP2010502730A (ja) * 2006-09-05 2010-01-28 バイパー サイエンシズ，インコーポレイティド 癌の治療法
GB0701273D0 (en) * 2007-01-24 2007-02-28 Angeletti P Ist Richerche Bio New compounds
EP2750098A3 (en) * 2007-02-16 2014-08-06 BodyMedia, Inc. Systems and methods for understanding and applying the physiological and contextual life patterns of an individual or set of individuals
EP2134691B1 (en) 2007-03-08 2012-01-25 Janssen Pharmaceutica, N.V. Quinolinone derivatives as parp and tank inhibitors
US9486449B2 (en) 2007-10-09 2016-11-08 Malka COHEN-ARMON Cancer therapy
EP2207548B1 (en) * 2007-10-09 2013-05-22 Malka Cohen-Armon Breast cancer therapy
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
KR20100102607A (ko) * 2007-11-12 2010-09-24 바이파 사이언스 인코포레이티드 Ｐａｒｐ 억제제를 단독으로 사용하거나 항종양제와 병용하여 자궁암 및 난소암을 치료하는 방법
CN103169973A (zh) * 2007-11-12 2013-06-26 彼帕科学公司 使用4-碘-3-硝基苯甲酰胺化合物与抗肿瘤剂组合治疗乳腺癌
CN101888777A (zh) * 2007-12-07 2010-11-17 彼帕科学公司 用拓扑异构酶抑制剂和parp抑制剂的组合治疗癌症
WO2009100159A2 (en) * 2008-02-04 2009-08-13 Bipar Sciences, Inc. Methods of diagnosing and treating parp-mediated diseases
AU2009228945B2 (en) 2008-03-27 2013-05-02 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
CN101981013B (zh) 2008-03-27 2013-05-29 詹森药业有限公司 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮
SA109300394B1 (ar) * 2008-06-19 2013-01-22 ويث ثيازوليل- وأوكسازوليل- أيزوكوينولينونات وطرق لاستخدامها
JP5632368B2 (ja) * 2008-06-19 2014-11-26 ワイス・エルエルシー チエニル−およびフラニル−イソキノリノン、ならびにそれらの使用方法
WO2011058367A2 (en) 2009-11-13 2011-05-19 Astrazeneca Ab Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor
CN103130723B (zh) 2011-11-30 2015-01-14 成都地奥制药集团有限公司 一种多聚(adp-核糖)聚合酶抑制剂
US10201521B2 (en) 2012-01-20 2019-02-12 Del Mar Pharmaceuticals (Bc) Ltd. Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem and cancer stem cells including glioblastoma multiforme and medulloblastoma
JP2016519684A (ja) 2013-04-08 2016-07-07 デニス エム ブラウン 準最適に投与された薬物療法の有効性を改善するための及び／又は副作用を低減するための方法および組成物
WO2015013579A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
CN106659765B (zh) 2014-04-04 2021-08-13 德玛医药 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途
CA2993270C (en) 2015-07-23 2019-07-16 Institut Curie Use of a combination of dbait molecule and parp inhibitors to treat cancer
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
US10874641B2 (en) 2016-07-28 2020-12-29 Mitobridge, Inc. Methods of treating acute kidney injury
CN110300600A (zh) 2016-11-02 2019-10-01 伊缪诺金公司 利用抗体-药物缀合物和parp抑制剂的组合治疗
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
WO2018197461A1 (en) 2017-04-28 2018-11-01 Akribes Biomedical Gmbh A parp inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing
EP3765613A1 (en) 2018-03-13 2021-01-20 Onxeo A dbait molecule against acquired resistance in the treatment of cancer
US20230017948A1 (en) 2019-11-25 2023-01-19 The Research Foundation For The State University Of New York Combination therapy using fabp5 inhibitors with taxanes for treatment of cancer
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1054655B (it) * 1975-08-27 1981-11-30 Lepetit Spa Derivati condensati del l isochinolina
US4263304A (en) * 1978-06-05 1981-04-21 Sumitomo Chemical Company, Limited 7 H-indolo[2,3-c]isoquinolines
US6358975B1 (en) * 1997-08-15 2002-03-19 Johns Hopkins University Method of using selective parp inhibitors to prevent or treat neurotoxicity
US6514983B1 (en) * 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
WO1999059975A1 (en) * 1998-05-15 1999-11-25 Guilford Pharmaceuticals Inc. Fused tricyclic compounds which inhibit parp activity
ITMI20002358A1 (it) * 2000-10-31 2002-05-01 Flavio Moroni Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi

Also Published As

Publication number Publication date
AU2002212575A1 (en) 2002-05-15
US20060094746A1 (en) 2006-05-04
EP1464646B1 (en) 2009-09-30
WO2002036599A1 (en) 2002-05-10
JP2004520273A (ja) 2004-07-08
US6989388B2 (en) 2006-01-24
US7825129B2 (en) 2010-11-02
ES2332588T3 (es) 2010-02-09
DE60140086D1 (de) 2009-11-12
EP1332147A1 (en) 2003-08-06
JP4417622B2 (ja) 2010-02-17
ITMI20002358A1 (it) 2002-05-01
US20040082789A1 (en) 2004-04-29
US20110237617A1 (en) 2011-09-29
EP1464646A1 (en) 2004-10-06
ATE444298T1 (de) 2009-10-15

Similar Documents

Publication Publication Date Title
ITMI20002358A0 (it) Derivati di tieno [2,3-c]isochinolin-3-one come inibitori della poli(adp-ribosio)polimerasi
MA25876A1 (fr) Inhibiteurs tricycliques de poly (adp-ribose) polymerases
DE60214428D1 (de) 1, 4-dihydro-1, 4-diphenylpyridin-derivate
AU2002214505A1 (en) New use of 4, 5, 6, 7-tetrahydroimidazo-(4,5-c)pyridine derivatives
DK1416935T3 (da) 4-Amino-6-phenyl-pyrrolo[2,3-d]pyrimidinderivater
ATE372988T1 (de) Pyrimidin-derivate
ATE256127T1 (de) Betacarbolinderivate als phosphodiesterase- inhibitoren
MA26060A1 (fr) Nouveaux derives de pyrazolopyridine
AU2002333524A1 (en) Furo-and thienopyrimidine derivatives as angiogenesis inhibitors
IS6443A (is) Pýridó[2,3-d]pýrimidín-2,7-díamín kínasa latar
AU6117801A (en) Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors
MXPA03004262A (es) Derivados de (dihidro)isoquinolina como inhibidores de fosfodiesterasa.
NO20023770L (no) Indol-3-ylderivater
DE50107988D1 (de) Substituierte 1,2,3,4-tetrahydrochinolin-2-carbonsäurederivate
DE60133430D1 (de) Hohle Zahnstange
ATE271080T1 (de) Hochfliessfähige propylenblockcopolymerisate
AR028607A1 (es) Derivados de 1,4-diazepan-2,5-diona
NO20042980L (no) 3,4-dihydro-1H-isokinolin-2-yl-derivater
HK1063311A1 (en) Pyrimidine derivatives useful as selective cox-2 inhibitors
IT1313592B1 (it) Derivati di 1h-pirido 3,4-b indol-1-one.
ATE258935T1 (de) Furo(3,2-b)pyridine als 5-ht1f agonisten
DK1259515T3 (da) Thienopyridinderivater og deres anvendelse som antiinflammatoriske midler
AU2001283336A1 (en) Selective urokinase inhibitors
GB0129215D0 (en) Trioxane derivatives
NO20035523D0 (no) (Pyrido/tieno)-[f]-oksazepin-5-on-derivater