IT1292437B1 - Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti - Google Patents

Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti

Info

Publication number
IT1292437B1
IT1292437B1 IT97MI001544A ITMI971544A IT1292437B1 IT 1292437 B1 IT1292437 B1 IT 1292437B1 IT 97MI001544 A IT97MI001544 A IT 97MI001544A IT MI971544 A ITMI971544 A IT MI971544A IT 1292437 B1 IT1292437 B1 IT 1292437B1
Authority
IT
Italy
Prior art keywords
synthesis
tetrazol
ortho
substituted benzenes
process useful
Prior art date
Application number
IT97MI001544A
Other languages
English (en)
Italian (it)
Inventor
Marco Villa
Pietro Allegrini
Katiuscia Arrighi
Maurizio Paiocchi
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of ITMI971544A0 publication Critical patent/ITMI971544A0/it
Priority to IT97MI001544A priority Critical patent/IT1292437B1/it
Priority to EP98936398A priority patent/EP0994881B1/en
Priority to ES98936398T priority patent/ES2182349T3/es
Priority to HU0004227A priority patent/HU226471B1/hu
Priority to AT98936398T priority patent/ATE224395T1/de
Priority to US09/445,470 priority patent/US6271375B1/en
Priority to CA002294609A priority patent/CA2294609C/en
Priority to IL13324998A priority patent/IL133249A/xx
Priority to CZ19994774A priority patent/CZ293277B6/cs
Priority to JP50630899A priority patent/JP4128633B2/ja
Priority to DE69808093T priority patent/DE69808093T2/de
Priority to PCT/EP1998/003969 priority patent/WO1999001459A1/en
Publication of ITMI971544A1 publication Critical patent/ITMI971544A1/it
Application granted granted Critical
Publication of IT1292437B1 publication Critical patent/IT1292437B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT97MI001544A 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti IT1292437B1 (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT97MI001544A IT1292437B1 (it) 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
CA002294609A CA2294609C (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes
CZ19994774A CZ293277B6 (cs) 1997-06-30 1998-06-29 Způsob přímé ortho-metalace
HU0004227A HU226471B1 (en) 1997-06-30 1998-06-29 Direct ortho-metalation process for the synthesis of 5-(2-substituted-phenyl)-tetrazol derivatives
AT98936398T ATE224395T1 (de) 1997-06-30 1998-06-29 Verfahren zur herstellung von 2-substituierten 1- (tetrazol-5-yl)benzenverbindungen durch ortho- metallierung
US09/445,470 US6271375B1 (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes
EP98936398A EP0994881B1 (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes
IL13324998A IL133249A (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1- (tetrazol-5-yl) benzenes
ES98936398T ES2182349T3 (es) 1997-06-30 1998-06-29 Procedimiento de orto-metalizacion para la sintesis de 1-(tetrazol-5-il)bencenos sustituidos en la posicion 2.
JP50630899A JP4128633B2 (ja) 1997-06-30 1998-06-29 ２−置換−１−（テトラゾール−５−イル）ベンゼン合成のためのオルトメタル化方法
DE69808093T DE69808093T2 (de) 1997-06-30 1998-06-29 Verfahren zur herstellung von 2-substituierten 1-(tetrazol-5-yl)benzenverbindungen durch ortho-metallierung
PCT/EP1998/003969 WO1999001459A1 (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001544A IT1292437B1 (it) 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti

Publications (3)

Publication Number Publication Date
ITMI971544A0 ITMI971544A0 (enEXAMPLES) 1997-06-30
ITMI971544A1 ITMI971544A1 (it) 1998-12-30
IT1292437B1 true IT1292437B1 (it) 1999-02-08

Family

ID=11377464

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI001544A IT1292437B1 (it) 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti

Country Status (12)

Country Link
US (1) US6271375B1 (enEXAMPLES)
EP (1) EP0994881B1 (enEXAMPLES)
JP (1) JP4128633B2 (enEXAMPLES)
AT (1) ATE224395T1 (enEXAMPLES)
CA (1) CA2294609C (enEXAMPLES)
CZ (1) CZ293277B6 (enEXAMPLES)
DE (1) DE69808093T2 (enEXAMPLES)
ES (1) ES2182349T3 (enEXAMPLES)
HU (1) HU226471B1 (enEXAMPLES)
IL (1) IL133249A (enEXAMPLES)
IT (1) IT1292437B1 (enEXAMPLES)
WO (1) WO1999001459A1 (enEXAMPLES)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU774799B2 (en) * 1999-04-28 2004-07-08 Takeda Pharmaceutical Company Limited Preventives / remedies / progression inhibitors for simplex retinopathy or preproliferating retinopathy
CA2769703A1 (en) 2002-07-26 2004-02-19 Amo Groningen B.V. Method and device for manipulation of an intraocular lens
SI1509517T1 (sl) * 2003-01-16 2008-10-31 Teva Pharma Nova sinteza irbesartana
US20040242661A1 (en) * 2003-03-17 2004-12-02 Igor Rukhman Polymorphs of valsartan
EP1950204A1 (en) 2003-03-17 2008-07-30 Teva Pharmaceutical Industries Ltd. Amorphous form of valsartan
US7199144B2 (en) * 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
EP1618097A1 (en) * 2003-04-21 2006-01-25 Teva Pharmaceutical Industries Ltd Process for the preparation of valsartan
WO2004094391A2 (en) * 2003-04-21 2004-11-04 Teva Pharmaceutical Industries Ltd. Process for the preparation of valsartan and intermediates thereof
PL1660463T3 (pl) * 2003-08-08 2008-05-30 Dipharma Francis Srl Sposób wytwarzania pochodnych fenylotetrazolu
WO2005049587A1 (en) * 2003-11-21 2005-06-02 Ranbaxy Laboratories Limited Process for preparation of biphenyl tetrazole
JP4880591B2 (ja) 2004-06-04 2012-02-22 テバ ファーマシューティカル インダストリーズ リミティド イルベサルタンを含む医薬組成物
KR20070100717A (ko) 2004-12-22 2007-10-11 이난티아, 에스. 엘. 앤지오텐신 ⅱ 수용기 길항제의 제조를 위한 중간화합물
ES2308591T3 (es) * 2004-12-22 2008-12-01 Algry Quimica, S.L Intermedios para la preparacion de antagonistas de los receptores de la angiotensina ii.
EP1812411A2 (en) * 2005-07-05 2007-08-01 Teva Pharmaceutical Industries Ltd. Process for preparing valsartan
US20090304797A1 (en) * 2006-06-23 2009-12-10 Tarur Venkatasubramanian Radha Process for the Preparation of Micronized Valsartan
US7943794B2 (en) * 2008-02-13 2011-05-17 Ranbaxy Laboratories Limited Processes for the preparation of intermediates of valsartan
EP2260018A2 (en) * 2008-04-07 2010-12-15 Hetero Research Foundation Process for preparation of valsartan intermediate
WO2012056294A1 (en) 2010-10-29 2012-05-03 Jubilant Life Sciences Ltd. An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yi)[1,1'-biphenyl]-4-yi]methyl]-l-valine
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
CN114845713B (zh) 2019-12-02 2025-07-08 哈曼菲诺化学有限公司 制备高纯度缬沙坦的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039814A (en) 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
US5149699A (en) 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
TW226375B (enEXAMPLES) * 1991-10-24 1994-07-11 American Home Prod
US5256654A (en) 1991-10-24 1993-10-26 American Home Products Corporation Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
EP0550313A1 (fr) 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
FR2696746B1 (fr) 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
US5760220A (en) 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
DE69628175D1 (de) * 1995-06-07 2003-06-18 Wyeth Corp Verfahren zur herstellung von biphenylderivaten

Also Published As

Publication number Publication date
EP0994881B1 (en) 2002-09-18
HUP0004227A2 (hu) 2001-06-28
JP2002510314A (ja) 2002-04-02
ES2182349T3 (es) 2003-03-01
ITMI971544A0 (enEXAMPLES) 1997-06-30
JP4128633B2 (ja) 2008-07-30
WO1999001459A1 (en) 1999-01-14
HU226471B1 (en) 2008-12-29
CA2294609A1 (en) 1999-01-14
CA2294609C (en) 2008-08-19
ITMI971544A1 (it) 1998-12-30
DE69808093D1 (de) 2002-10-24
HUP0004227A3 (en) 2003-03-28
IL133249A (en) 2003-12-10
CZ293277B6 (cs) 2004-03-17
ATE224395T1 (de) 2002-10-15
CZ477499A3 (cs) 2000-07-12
US6271375B1 (en) 2001-08-07
DE69808093T2 (de) 2003-06-05
IL133249A0 (en) 2001-04-30
EP0994881A1 (en) 2000-04-26

Similar Documents

Publication Publication Date Title
IT1292437B1 (it) Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
ES2088839T1 (es) Compuestos inhibidores de la proteasa retroviral.
CY1111759T1 (el) Ενδιαμεσες ενωσεις για την παρασκευη συγκεκριμενων τριαζολοπυριμιδινων ως ρ2τ ανταγωνιστων
SE0000540D0 (sv) New compounds
BG106340A (en) Substituted oxoazaheterocyclyl compounds
BR0214268A (pt) Aperfeiçoamentos em relação a abrilhantadores ópticos
PT1312609E (pt) Compostos de acido e ester boronico, sinteses e utilizacoes
SE0100903D0 (sv) Compounds
IS6614A (is) Ný tríasólpýrimídínefnasambönd
TR200800474T2 (tr) Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
YU25497A (sh) Postupak za dobijanje sildenafila
DE69812634D1 (de) Metalloproteinase-inhibitoren
IT1293778B1 (it) 1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
ATE411287T1 (de) Neue metallproteinaseinhibitoren
EA200000094A1 (ru) Способ получения замещенного пергидроизоиндола
NZ331875A (en) Asymmetric synthesis of R-alpha-propyl-piperonyl amine and its analogs
NO20016151L (no) Fremstilling av substituerte piperidin-4-oner
SG143062A1 (en) Synthesis of temozolomide and analogs
DE60041001D1 (de) Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
CY1107481T1 (el) Εναντιοεκλεκτικη αλκυλιωση τρικυκλικων ενωσεων
DK1206452T3 (da) Fremgangsmåde til fremstilling af benzoperhydro-isoindolforbindelser
DE69703115D1 (de) Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.
ES2137999T3 (es) Procedimiento para sintetizar intermedios utiles de compuestos de imidazol sustituidos.
IT1303074B1 (it) Catalizzatore per la fluorurazione di composti organici alogenati
MXPA04003085A (es) Proceso estereoespecifico para sintesis de derivados de 2-il cromano.

Legal Events

Date Code Title Description
0001 Granted