IT1270183B - 1-b-metil-2-tiol carbapen derivati - Google Patents
1-b-metil-2-tiol carbapen derivatiInfo
- Publication number
- IT1270183B IT1270183B ITMI941191A ITMI941191A IT1270183B IT 1270183 B IT1270183 B IT 1270183B IT MI941191 A ITMI941191 A IT MI941191A IT MI941191 A ITMI941191 A IT MI941191A IT 1270183 B IT1270183 B IT 1270183B
- Authority
- IT
- Italy
- Prior art keywords
- carbapen
- tiol
- methyl
- derivatives
- gram
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
La presente invenzione si riferisce a nuovi 1-?-metil-2-tiol carbapen derivati rappresentati dalla seguente formula generale (I) e relativo metodo di produzione. (FORMULA I) Il sopra menzionato composto è molto stabile nei confronti dell'enzima DHP-1 per la schermatura efficace dell'anello carbapenico strutturale ed è molto efficace sia contro i microrganismi gram - positivi che gram - negativi, specialmente ha un rimarchevole effetto su Pseudomonas aeruginosa noto come germe infettivo avente una forte resistenza.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR930010878 | 1993-06-15 | ||
US08/155,477 US5463046A (en) | 1993-06-15 | 1993-11-19 | 1-β-methyl-2-thiolic carbapenem derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941191A0 ITMI941191A0 (it) | 1994-06-08 |
ITMI941191A1 ITMI941191A1 (it) | 1995-12-08 |
IT1270183B true IT1270183B (it) | 1997-04-29 |
Family
ID=26629717
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941191A IT1270183B (it) | 1993-06-15 | 1994-06-08 | 1-b-metil-2-tiol carbapen derivati |
Country Status (13)
Country | Link |
---|---|
US (1) | US5463046A (it) |
JP (1) | JP2531489B2 (it) |
KR (1) | KR950000700A (it) |
CN (1) | CN1100100A (it) |
AU (1) | AU4912393A (it) |
BR (1) | BR9400695A (it) |
CA (1) | CA2102003A1 (it) |
DE (1) | DE4335984A1 (it) |
ES (1) | ES2070790B1 (it) |
FR (1) | FR2706460A1 (it) |
GB (1) | GB2279073A (it) |
IT (1) | IT1270183B (it) |
NL (1) | NL9301877A (it) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2099817A1 (en) * | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Antibiotic compounds |
KR100386993B1 (ko) * | 1995-12-21 | 2003-12-18 | 상꾜 가부시키가이샤 | 1-메틸카르바페넴유도체 |
KR100309703B1 (ko) * | 1999-01-18 | 2001-10-29 | 박호군 | 이중고리 티올 유도체, 이를 치환기로 갖는 1-β-메틸-카바페넴 유도체, 및 그들의 제조방법 |
CN101260108B (zh) * | 2007-03-11 | 2010-06-02 | 山东轩竹医药科技有限公司 | 巯基吡咯烷酮碳青霉烯类衍生物 |
US10695322B2 (en) | 2016-01-29 | 2020-06-30 | The Johns Hopkins University | Inhibitors of bacterial growth |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
JPS60233076A (ja) * | 1984-05-03 | 1985-11-19 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
EP0243686B1 (en) * | 1986-03-27 | 1992-07-15 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production |
EP0272455B1 (en) * | 1986-11-24 | 1993-02-10 | Fujisawa Pharmaceutical Co., Ltd. | 3-Pyrrolidinylthio-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid compounds |
EP0337637B1 (en) * | 1988-04-01 | 1994-11-30 | Sankyo Company Limited | 2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics |
CA2022382A1 (en) * | 1989-08-02 | 1991-02-03 | Susumu Nakagawa | Piperidylthiocarbapenem derivatives |
US5227376A (en) * | 1990-02-14 | 1993-07-13 | Sumitomo Pharmaceuticals Co., Ltd. | β-lactam compounds and their production |
CA2036163C (en) * | 1990-02-14 | 2001-06-19 | Makoto Sunagawa | Novel beta-lactam compounds and their production |
IE910606A1 (en) * | 1990-02-23 | 1991-08-28 | Sankyo Co | Carbapenem derivatives having antibiotic activity, their¹preparation and their use |
AU644008B2 (en) * | 1990-08-10 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production and use |
GB9107341D0 (en) * | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
CA2070305A1 (en) * | 1991-06-04 | 1992-12-05 | Isao Kawamoto | 1-methylcarbapenem derivatives, their preparation and their use as antibiotics |
-
1993
- 1993-10-19 AU AU49123/93A patent/AU4912393A/en not_active Abandoned
- 1993-10-21 DE DE4335984A patent/DE4335984A1/de not_active Withdrawn
- 1993-10-29 CA CA002102003A patent/CA2102003A1/en not_active Abandoned
- 1993-11-01 NL NL9301877A patent/NL9301877A/nl not_active Application Discontinuation
- 1993-11-05 JP JP5277191A patent/JP2531489B2/ja not_active Expired - Fee Related
- 1993-11-19 US US08/155,477 patent/US5463046A/en not_active Expired - Lifetime
- 1993-12-16 FR FR9315186A patent/FR2706460A1/fr active Pending
- 1993-12-20 ES ES09302627A patent/ES2070790B1/es not_active Expired - Lifetime
-
1994
- 1994-01-28 CN CN94101093A patent/CN1100100A/zh active Pending
- 1994-02-25 BR BR9400695A patent/BR9400695A/pt not_active Application Discontinuation
- 1994-05-20 KR KR1019940011046A patent/KR950000700A/ko not_active Application Discontinuation
- 1994-06-08 IT ITMI941191A patent/IT1270183B/it active IP Right Grant
- 1994-06-14 GB GB9411844A patent/GB2279073A/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ES2070790A1 (es) | 1995-06-01 |
ITMI941191A0 (it) | 1994-06-08 |
GB2279073A (en) | 1994-12-21 |
JP2531489B2 (ja) | 1996-09-04 |
KR950000700A (ko) | 1995-01-03 |
CA2102003A1 (en) | 1994-12-16 |
DE4335984A1 (de) | 1994-12-22 |
ES2070790B1 (es) | 1996-03-16 |
GB9411844D0 (en) | 1994-08-03 |
NL9301877A (nl) | 1995-01-02 |
CN1100100A (zh) | 1995-03-15 |
US5463046A (en) | 1995-10-31 |
FR2706460A1 (fr) | 1994-12-23 |
BR9400695A (pt) | 1995-01-10 |
AU4912393A (en) | 1994-12-22 |
ITMI941191A1 (it) | 1995-12-08 |
JPH06345766A (ja) | 1994-12-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |