IT1256117B - Medicamenti e preparazioni pure di dicloridrato di melarsomina, processo per il loro ottenimento e prodotti intermedi ottenuti - Google Patents

Medicamenti e preparazioni pure di dicloridrato di melarsomina, processo per il loro ottenimento e prodotti intermedi ottenuti

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Publication number
IT1256117B
IT1256117B ITMI922692A ITMI922692A IT1256117B IT 1256117 B IT1256117 B IT 1256117B IT MI922692 A ITMI922692 A IT MI922692A IT MI922692 A ITMI922692 A IT MI922692A IT 1256117 B IT1256117 B IT 1256117B
Authority
IT
Italy
Prior art keywords
stage
obtaining
melarsomine
preparations
pure
Prior art date
Application number
ITMI922692A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITMI922692A0 publication Critical patent/ITMI922692A0/it
Publication of ITMI922692A1 publication Critical patent/ITMI922692A1/it
Application granted granted Critical
Publication of IT1256117B publication Critical patent/IT1256117B/it

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/80—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/74—Aromatic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Medicamenti a base di preparazioni pure di dicloridrato di melarsomina, processo per il loro ottenimento, preparazioni pure di dicloridrato di melarsomina e di intermedi ottenuti in tale procedimento.Il medicamento comprende come principio attivo una preparazione di dicloridrato di melarsomina con una purezza compresa tra il 98,5 e il 100%. Il procedimento per l'ottenimento di tale preparazione recita sostanzialmente:- stadio 1, si converte triclorotriazina (TCT) in diamminoclorotriazina (DTC) in ambiente ammoniacale;- stadio 2, si converte la DTC in cloridrato dell'acido melarsenico (CMA) in presenza di acido arsanilico;- stadio 3, si riduce il CMA a melarsenossido diidrato; e - stadio 4, si converte il melarsenossido diidrato in dicloridrato di melarsomina in presenza di cloridrato di cisteamina. Ad ogni stadio, si ottiene una preparazione purificata del prodotto intermedio corrispondente, o finale allo stadio 4.
ITMI922692A 1991-12-02 1992-11-25 Medicamenti e preparazioni pure di dicloridrato di melarsomina, processo per il loro ottenimento e prodotti intermedi ottenuti IT1256117B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR919114904A FR2684382B1 (fr) 1991-12-02 1991-12-02 Medicaments et preparations pures de dichlorhydrate de melarsomine, leur procede d'obtention et produits intermediaires obtenus.

Publications (3)

Publication Number Publication Date
ITMI922692A0 ITMI922692A0 (it) 1992-11-25
ITMI922692A1 ITMI922692A1 (it) 1994-05-25
IT1256117B true IT1256117B (it) 1995-11-28

Family

ID=9419573

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI922692A IT1256117B (it) 1991-12-02 1992-11-25 Medicamenti e preparazioni pure di dicloridrato di melarsomina, processo per il loro ottenimento e prodotti intermedi ottenuti

Country Status (15)

Country Link
US (3) US5459263A (it)
JP (1) JP3578277B2 (it)
AU (1) AU667329B2 (it)
BR (1) BR9204643A (it)
CA (1) CA2083766C (it)
ES (1) ES2039311B1 (it)
FR (1) FR2684382B1 (it)
GR (1) GR920100526A (it)
IT (1) IT1256117B (it)
MA (1) MA22723A1 (it)
MX (1) MX9206890A (it)
MY (1) MY111175A (it)
PH (1) PH31115A (it)
PT (1) PT101105B (it)
TW (1) TW358099B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2684382B1 (fr) * 1991-12-02 1994-10-21 Rhone Merieux Medicaments et preparations pures de dichlorhydrate de melarsomine, leur procede d'obtention et produits intermediaires obtenus.
US6191123B1 (en) * 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
AUPQ296799A0 (en) * 1999-09-20 1999-10-14 Unisearch Limited A cell-membrane impermeable trivalent organoarsenical derivative and use thereof
US20060166208A1 (en) 2002-11-07 2006-07-27 Hogg Philip J Induction of the mitochondrial permeability transition
US6686344B1 (en) 2003-01-30 2004-02-03 Paker Hughes Institute Organic-arsonic compounds
AU2007314076B2 (en) 2006-11-01 2012-07-19 Newsouth Innovations Pty Limited Organo-arsenoxide compounds and use thereof
US8373412B2 (en) * 2009-01-23 2013-02-12 Baker Hughes Incorporated NMR-LWD imaging tool
US8324895B2 (en) * 2009-01-23 2012-12-04 Baker Hughes Incorporated MWD/LWD NMR imaging with long echo trains
CN102558234B (zh) * 2011-04-08 2015-01-07 浙江工商大学 一种通过对氨基苯胂酸重氮化制备阿散酸制剂的方法
CN102558235B (zh) * 2011-04-08 2015-01-07 浙江工商大学 一种通过三甲氧苄氨嘧啶重氮化制备阿散酸制剂的方法
US20140051840A1 (en) * 2012-08-17 2014-02-20 The Curators Of The University Of Missouri Arsenic complexes for potential diagnostic applications
US9593052B2 (en) 2012-08-17 2017-03-14 The Curators Of The University Of Missouri Arsenic complexes for potential diagnostic applications

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL54891C (it) * 1938-12-23 1900-01-01
CH242529A (de) * 1940-12-10 1946-05-15 Friedheim Ernst Albert Hermann Verfahren zur Darstellung von m-(2,4-Diamino-1,3,5-triazinyl-(6))-amino-phenylarsinoxyd.
NL60802C (it) * 1940-12-10
US2422724A (en) * 1944-01-20 1947-06-24 Ernst A H Friedheim Substituted 1,3,5-triazinyl-(6)-aminophenyl-arsenic compounds
US2400547A (en) * 1944-01-20 1946-05-21 Ernst A H Friedheim Substituted 1, 3, 5-triazinyl-(6)-aminophenyl-arsenic compounds
US2390091A (en) * 1944-06-03 1945-11-27 Ernst A H Friedheim Substituted 1,3,5-triazinyl-(6)-aminophenyl-arsenic compounds
CH245837A (de) * 1946-11-16 1946-11-30 Dr Friedheim Ernst A H Verfahren zur Darstellung von p-2,4-Diamino-1,3,5-triazinyl-(6)-amino-phenyl-arsenoxyd.
CH254164A (de) * 1946-11-16 1948-04-15 Dr Friedheim Ernst A H Verfahren zur Darstellung von p-(2,4-Diamino-1,3,5-triazinyl-(6)-aminophenyl-arsenoxyd.
US2659723A (en) * 1947-01-28 1953-11-17 Ernst A H Friedheim Triazine organometallic compounds and process for preparing same
US2593434A (en) * 1947-02-19 1952-04-22 Ernst A H Friedheim Propylene glycol solution of arsenic medicaments
US3482171A (en) * 1966-07-15 1969-12-02 Itt Bidirectional electronic phase shifter
US3856971A (en) * 1971-07-20 1974-12-24 E Friedheim Method of combating filariasis in dogs
BE786573A (fr) * 1971-07-20 1973-01-22 Hoechst Ag Medicament a base de composes arsenicaux organiques et de derives du benzimidazole
GB2024008B (en) * 1978-06-28 1983-02-16 Merck & Co Inc Compositions for treating trypanosomiasis infections
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
US4514390A (en) * 1982-04-12 1985-04-30 The Rockefeller University Melaminylthioarsenites
FR2572730B1 (fr) * 1984-11-02 1987-12-11 Centre Nat Rech Scient Nouveaux derives de l'arsenic, leur preparation et leur application, notamment comme medicaments antiparasitaires
FR2640269B1 (fr) * 1988-12-13 1991-03-15 Maes Ludo Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant
FR2684382B1 (fr) * 1991-12-02 1994-10-21 Rhone Merieux Medicaments et preparations pures de dichlorhydrate de melarsomine, leur procede d'obtention et produits intermediaires obtenus.

Also Published As

Publication number Publication date
TW358099B (en) 1999-05-11
FR2684382B1 (fr) 1994-10-21
PT101105B (pt) 1999-10-29
BR9204643A (pt) 1993-06-08
AU667329B2 (en) 1996-03-21
PH31115A (en) 1998-02-23
CA2083766C (en) 2002-09-10
MY111175A (en) 1999-09-30
US5635499A (en) 1997-06-03
ITMI922692A0 (it) 1992-11-25
MX9206890A (es) 1993-08-01
US5459263A (en) 1995-10-17
FR2684382A1 (fr) 1993-06-04
CA2083766A1 (en) 1993-06-03
MA22723A1 (fr) 1993-07-01
PT101105A (pt) 1994-03-31
US5770733A (en) 1998-06-23
ES2039311A1 (es) 1993-09-16
ITMI922692A1 (it) 1994-05-25
JPH0624960A (ja) 1994-02-01
ES2039311B1 (es) 1997-08-16
AU2972092A (en) 1993-06-03
GR920100526A (el) 1993-08-31
JP3578277B2 (ja) 2004-10-20

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