MX9206890A - Procedimiento para la preparacion de medicamentos de dihidrocloruro de melarsomia - Google Patents

Procedimiento para la preparacion de medicamentos de dihidrocloruro de melarsomia

Info

Publication number
MX9206890A
MX9206890A MX9206890A MX9206890A MX9206890A MX 9206890 A MX9206890 A MX 9206890A MX 9206890 A MX9206890 A MX 9206890A MX 9206890 A MX9206890 A MX 9206890A MX 9206890 A MX9206890 A MX 9206890A
Authority
MX
Mexico
Prior art keywords
preparation
dihydrochloride
procedure
converted
hydrochloride
Prior art date
Application number
MX9206890A
Other languages
English (en)
Inventor
Floc H Robert
Jean-Pierre Etchegaray
Gerard Wolf
Patrick Lubert
Jackie Anne-Marie Mazar Regine
Original Assignee
Rhone Merieux
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Merieux filed Critical Rhone Merieux
Publication of MX9206890A publication Critical patent/MX9206890A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/80—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/74—Aromatic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se relaciona a un medicamento que comprende a título de principio activo una preparación de dihidrocloruro de melarsomina que tiene una pureza comprendida entre el 98,5 y el 100. El procedimiento para obtener esta preparación se enuncia esencialmente como sigue: - etapa 1, se convierte triclorotriazina (TCT) en dianoclorotriazina (DTC) en medio amoniacal; - etapa 2, se convierte la DTC en hidrocloruro de melarsenácido (CMA) en presencia de ácido arsanílico; - etapa 3, se reduce el CMA a melarsenóxido dihidratado; y - etapa 4, se convierte el melarsenóxido dihidratado en dihidrocloruro de melarsomina en presencia de hidrocloruro de melarsomina en presencia de hidrocloruro cisteamina. En cada etapa se obtiene una preparación purificada del producto intermedio correspondiente o final en la etapa 4.
MX9206890A 1991-12-02 1992-11-30 Procedimiento para la preparacion de medicamentos de dihidrocloruro de melarsomia MX9206890A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR919114904A FR2684382B1 (fr) 1991-12-02 1991-12-02 Medicaments et preparations pures de dichlorhydrate de melarsomine, leur procede d'obtention et produits intermediaires obtenus.

Publications (1)

Publication Number Publication Date
MX9206890A true MX9206890A (es) 1993-08-01

Family

ID=9419573

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9206890A MX9206890A (es) 1991-12-02 1992-11-30 Procedimiento para la preparacion de medicamentos de dihidrocloruro de melarsomia

Country Status (15)

Country Link
US (3) US5459263A (es)
JP (1) JP3578277B2 (es)
AU (1) AU667329B2 (es)
BR (1) BR9204643A (es)
CA (1) CA2083766C (es)
ES (1) ES2039311B1 (es)
FR (1) FR2684382B1 (es)
GR (1) GR920100526A (es)
IT (1) IT1256117B (es)
MA (1) MA22723A1 (es)
MX (1) MX9206890A (es)
MY (1) MY111175A (es)
PH (1) PH31115A (es)
PT (1) PT101105B (es)
TW (1) TW358099B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2684382B1 (fr) * 1991-12-02 1994-10-21 Rhone Merieux Medicaments et preparations pures de dichlorhydrate de melarsomine, leur procede d'obtention et produits intermediaires obtenus.
US6191123B1 (en) * 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
AUPQ296799A0 (en) * 1999-09-20 1999-10-14 Unisearch Limited A cell-membrane impermeable trivalent organoarsenical derivative and use thereof
EP1563099B1 (en) * 2002-11-07 2009-07-22 Newsouth Innovations Pty Limited Induction of the mitochondrial permeability transition
US6686344B1 (en) 2003-01-30 2004-02-03 Paker Hughes Institute Organic-arsonic compounds
US8268883B2 (en) 2006-11-01 2012-09-18 Newsouth Innovations Pty Limited Organo-arsenoxide compounds and use thereof
US8324895B2 (en) * 2009-01-23 2012-12-04 Baker Hughes Incorporated MWD/LWD NMR imaging with long echo trains
US8373412B2 (en) * 2009-01-23 2013-02-12 Baker Hughes Incorporated NMR-LWD imaging tool
CN102558235B (zh) * 2011-04-08 2015-01-07 浙江工商大学 一种通过三甲氧苄氨嘧啶重氮化制备阿散酸制剂的方法
CN102558234B (zh) * 2011-04-08 2015-01-07 浙江工商大学 一种通过对氨基苯胂酸重氮化制备阿散酸制剂的方法
US20140051840A1 (en) * 2012-08-17 2014-02-20 The Curators Of The University Of Missouri Arsenic complexes for potential diagnostic applications
US9593052B2 (en) 2012-08-17 2017-03-14 The Curators Of The University Of Missouri Arsenic complexes for potential diagnostic applications

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE437342A (es) * 1938-12-23 1900-01-01
NL60802C (es) * 1940-12-10
CH242529A (de) * 1940-12-10 1946-05-15 Friedheim Ernst Albert Hermann Verfahren zur Darstellung von m-(2,4-Diamino-1,3,5-triazinyl-(6))-amino-phenylarsinoxyd.
US2422724A (en) * 1944-01-20 1947-06-24 Ernst A H Friedheim Substituted 1,3,5-triazinyl-(6)-aminophenyl-arsenic compounds
US2400547A (en) * 1944-01-20 1946-05-21 Ernst A H Friedheim Substituted 1, 3, 5-triazinyl-(6)-aminophenyl-arsenic compounds
US2390091A (en) * 1944-06-03 1945-11-27 Ernst A H Friedheim Substituted 1,3,5-triazinyl-(6)-aminophenyl-arsenic compounds
CH245837A (de) * 1946-11-16 1946-11-30 Dr Friedheim Ernst A H Verfahren zur Darstellung von p-2,4-Diamino-1,3,5-triazinyl-(6)-amino-phenyl-arsenoxyd.
CH254164A (de) * 1946-11-16 1948-04-15 Dr Friedheim Ernst A H Verfahren zur Darstellung von p-(2,4-Diamino-1,3,5-triazinyl-(6)-aminophenyl-arsenoxyd.
US2659723A (en) * 1947-01-28 1953-11-17 Ernst A H Friedheim Triazine organometallic compounds and process for preparing same
US2593434A (en) * 1947-02-19 1952-04-22 Ernst A H Friedheim Propylene glycol solution of arsenic medicaments
US3482171A (en) * 1966-07-15 1969-12-02 Itt Bidirectional electronic phase shifter
US3856971A (en) * 1971-07-20 1974-12-24 E Friedheim Method of combating filariasis in dogs
BE786573A (fr) * 1971-07-20 1973-01-22 Hoechst Ag Medicament a base de composes arsenicaux organiques et de derives du benzimidazole
GB2024008B (en) * 1978-06-28 1983-02-16 Merck & Co Inc Compositions for treating trypanosomiasis infections
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
US4514390A (en) * 1982-04-12 1985-04-30 The Rockefeller University Melaminylthioarsenites
FR2572730B1 (fr) * 1984-11-02 1987-12-11 Centre Nat Rech Scient Nouveaux derives de l'arsenic, leur preparation et leur application, notamment comme medicaments antiparasitaires
FR2640269B1 (fr) * 1988-12-13 1991-03-15 Maes Ludo Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant
FR2684382B1 (fr) * 1991-12-02 1994-10-21 Rhone Merieux Medicaments et preparations pures de dichlorhydrate de melarsomine, leur procede d'obtention et produits intermediaires obtenus.

Also Published As

Publication number Publication date
ITMI922692A1 (it) 1994-05-25
FR2684382A1 (fr) 1993-06-04
MA22723A1 (fr) 1993-07-01
JPH0624960A (ja) 1994-02-01
MY111175A (en) 1999-09-30
GR920100526A (el) 1993-08-31
CA2083766C (en) 2002-09-10
BR9204643A (pt) 1993-06-08
PT101105B (pt) 1999-10-29
ITMI922692A0 (it) 1992-11-25
PT101105A (pt) 1994-03-31
ES2039311A1 (es) 1993-09-16
AU2972092A (en) 1993-06-03
JP3578277B2 (ja) 2004-10-20
US5635499A (en) 1997-06-03
AU667329B2 (en) 1996-03-21
CA2083766A1 (en) 1993-06-03
US5459263A (en) 1995-10-17
US5770733A (en) 1998-06-23
IT1256117B (it) 1995-11-28
ES2039311B1 (es) 1997-08-16
PH31115A (en) 1998-02-23
FR2684382B1 (fr) 1994-10-21
TW358099B (en) 1999-05-11

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