IT1252944B - Polilattide purificato e relativo metodo di produzione - Google Patents
Polilattide purificato e relativo metodo di produzioneInfo
- Publication number
- IT1252944B IT1252944B ITRM910553A ITRM910553A IT1252944B IT 1252944 B IT1252944 B IT 1252944B IT RM910553 A ITRM910553 A IT RM910553A IT RM910553 A ITRM910553 A IT RM910553A IT 1252944 B IT1252944 B IT 1252944B
- Authority
- IT
- Italy
- Prior art keywords
- polylactide
- production method
- related production
- purified
- purified polylactide
- Prior art date
Links
- 229920000747 poly(lactic acid) Polymers 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000004040 coloring Methods 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 abstract 1
- 108010016076 Octreotide Proteins 0.000 abstract 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 abstract 1
- 229960002802 bromocriptine Drugs 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 abstract 1
- 229960002700 octreotide Drugs 0.000 abstract 1
- 239000012088 reference solution Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/88—Post-polymerisation treatment
- C08G63/90—Purification; Drying
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909016882A GB9016882D0 (en) | 1990-08-01 | 1990-08-01 | Improvements in or relating to organic compounds |
| GB909016840A GB9016840D0 (en) | 1990-08-01 | 1990-08-01 | Improvements in or relating to organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM910553A0 ITRM910553A0 (it) | 1991-07-23 |
| ITRM910553A1 ITRM910553A1 (it) | 1993-01-23 |
| IT1252944B true IT1252944B (it) | 1995-07-05 |
Family
ID=26297417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM910553A IT1252944B (it) | 1990-08-01 | 1991-07-23 | Polilattide purificato e relativo metodo di produzione |
Country Status (27)
| Country | Link |
|---|---|
| EP (2) | EP0816413B1 (en:Method) |
| JP (1) | JP3137368B2 (en:Method) |
| KR (1) | KR100255904B1 (en:Method) |
| AT (1) | AT402503B (en:Method) |
| AU (1) | AU650277B2 (en:Method) |
| CA (1) | CA2048200C (en:Method) |
| CH (1) | CH683772A5 (en:Method) |
| CY (1) | CY1986A (en:Method) |
| DE (1) | DE4124468B4 (en:Method) |
| DK (2) | DK0469520T3 (en:Method) |
| ES (2) | ES2243966T3 (en:Method) |
| FI (2) | FI108040B (en:Method) |
| FR (1) | FR2665453B1 (en:Method) |
| GB (1) | GB2246573B (en:Method) |
| GR (1) | GR3026322T3 (en:Method) |
| HK (1) | HK11797A (en:Method) |
| HU (1) | HUT59837A (en:Method) |
| IE (1) | IE66185B1 (en:Method) |
| IL (1) | IL99007A (en:Method) |
| IT (1) | IT1252944B (en:Method) |
| LU (1) | LU87985A1 (en:Method) |
| MY (1) | MY108621A (en:Method) |
| NO (1) | NO912960D0 (en:Method) |
| NZ (1) | NZ239184A (en:Method) |
| PH (1) | PH31047A (en:Method) |
| PT (1) | PT98491B (en:Method) |
| TW (2) | TW282477B (en:Method) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5560929A (en) * | 1986-08-18 | 1996-10-01 | The Dow Chemical Company | Structured copolymers and their use as absorbents, gels and carriers of metal ions |
| US5527524A (en) * | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
| US5225521A (en) * | 1991-12-31 | 1993-07-06 | E. I. Du Pont De Nemours And Company | Star-shaped hydroxyacid polymers |
| US6200558B1 (en) | 1993-09-14 | 2001-03-13 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5405919A (en) * | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
| US5525357A (en) * | 1992-08-24 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| JPH06116381A (ja) * | 1992-10-09 | 1994-04-26 | Mitsui Toatsu Chem Inc | ポリヒドロキシカルボン酸の精製方法 |
| DE4412317A1 (de) * | 1993-04-21 | 1994-10-27 | Basf Ag | Polylactid mit verbreiterter Molmassenverteilung |
| US5359026A (en) * | 1993-07-30 | 1994-10-25 | Cargill, Incorporated | Poly(lactide) copolymer and process for manufacture thereof |
| US5496923A (en) * | 1993-09-20 | 1996-03-05 | Mitsui Toatsu Chemicals, Inc. | Purification process of aliphatic polyester |
| NZ276088A (en) | 1993-11-19 | 1999-07-29 | Janssen Pharmaceutica Nv | [(1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-6,7,8,9-tetrahydro-4h- pyrido[1,2-a]-pyrimidin-4-one derivatives (ie risperidone) |
| IL128774A (en) * | 1994-03-07 | 2001-05-20 | Dow Chemical Co | Composition comprising a dendritic poymer in complex with at least one unit of biological response modifier and a process for the preparation thereof |
| AU5862199A (en) | 1998-09-11 | 2000-04-03 | Michael Raschke | Biologically active implants |
| US6362308B1 (en) * | 2000-08-10 | 2002-03-26 | Alkermes Controlled Therapeutics Inc. Ii | Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content |
| WO2003006525A1 (en) * | 2001-07-10 | 2003-01-23 | Kureha Chemical Industry Company, Limited | Polyhydroxycarboxylic acid and its production process |
| AU2002358831B2 (en) | 2001-10-10 | 2007-09-06 | Pierre Fabre Medicament | Prolonged release biodegradable microspheres and method for preparing same |
| FR2830448B1 (fr) * | 2001-10-10 | 2004-03-19 | Pf Medicament | Microspheres biodegradables a liberation prolongee et leur procede de preparation |
| GB0226993D0 (en) * | 2002-11-19 | 2002-12-24 | Novartis Ag | Organic compounds |
| AU2013204972B2 (en) * | 2002-11-19 | 2016-04-21 | Novartis Ag | Pharmaceutical composition comprising octreotide microparticles |
| US20040097419A1 (en) * | 2002-11-19 | 2004-05-20 | Holger Petersen | Organic compounds |
| ES2383303T3 (es) | 2005-11-10 | 2012-06-20 | Chemi S.P.A. | Formulaciones de inhibidores de la liberación prolongada de la hormona del crecimiento análogos de la somatostatina |
| CN101193531B (zh) | 2006-11-29 | 2010-12-01 | 富准精密工业(深圳)有限公司 | 散热装置 |
| WO2009091150A2 (en) * | 2007-12-31 | 2009-07-23 | Samyang Corporation | Highly pure amphiphilic copolymer comprising hydrophobic block from alpha-hydroxy acid and process for the preparation thereof |
| CA2756388C (en) * | 2009-03-23 | 2015-10-27 | Micell Technologies, Inc. | Biodegradable polymers with low acidic impurity |
| JP5594996B2 (ja) | 2009-09-14 | 2014-09-24 | 三菱重工業株式会社 | 航空機の操縦システム |
| US8722845B2 (en) | 2010-06-21 | 2014-05-13 | Lg Chem, Ltd. | Polylactide resin having excellent heat resistance and preparation method thereof |
| EP2455414A1 (de) * | 2010-11-17 | 2012-05-23 | Evonik Röhm GmbH | Verfahren zur Herstellung von hochmolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren hochmolekularen resorbierbaren Polyester und deren Verwendung |
| EP2455415A1 (de) * | 2010-11-17 | 2012-05-23 | Evonik Röhm GmbH | Verfahren zur Herstellung von niedermolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren niedermolekularen resorbierbaren Polyester und deren Verwendung |
| CN105820332B (zh) * | 2015-01-09 | 2018-06-29 | 北京化工大学 | 一种星形聚氨基酸和星形聚氨基酸载药纳米胶束及制备方法 |
| EP3408305B1 (en) | 2016-01-29 | 2024-03-06 | Tolmar Inc. | Purification and decolorization of polymers |
| CA3073842A1 (en) * | 2017-08-31 | 2019-03-07 | Evonik Corporation | Improved resorbable polymer purification process |
| GR1009392B (el) * | 2017-09-19 | 2018-10-25 | Φαρματεν Αβεε | Φαρμακευτικο σκευασμα που περιλαμβανει ενα πεπτιδικο φαρμακο και μεθοδος για την παρασκευη αυτου |
| GB2568526A (en) * | 2017-11-20 | 2019-05-22 | Rebio Tech Oy | Composition |
| CN112940234B (zh) * | 2021-01-28 | 2022-05-03 | 广东粤港澳大湾区黄埔材料研究院 | 一种高纯度聚乙丙交酯的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1467970A (en) * | 1975-05-02 | 1977-03-23 | Ici Ltd | Purification of polyethers |
| US4273920A (en) * | 1979-09-12 | 1981-06-16 | Eli Lilly And Company | Polymerization process and product |
| CH656884A5 (de) * | 1983-08-26 | 1986-07-31 | Sandoz Ag | Polyolester, deren herstellung und verwendung. |
| CA1256638A (en) * | 1984-07-06 | 1989-06-27 | Motoaki Tanaka | Polymer and its production |
| US4677231A (en) * | 1984-11-13 | 1987-06-30 | Asahi Kasei Kogyo Kabushiki Kaisha | Process for purification of polyether |
| JP2551756B2 (ja) * | 1985-05-07 | 1996-11-06 | 武田薬品工業株式会社 | ポリオキシカルボン酸エステルおよびその製造法 |
| JPH0610252B2 (ja) * | 1985-08-21 | 1994-02-09 | 和光純薬工業株式会社 | 重合体の製造法 |
| DE3641692A1 (de) * | 1986-12-06 | 1988-06-09 | Boehringer Ingelheim Kg | Katalysatorfreie resorbierbare homopolymere und copolymere |
| DE3708916A1 (de) * | 1987-03-19 | 1988-09-29 | Boehringer Ingelheim Kg | Verfahren zur reinigung resorbierbarer polyester |
| JP2714454B2 (ja) * | 1988-11-07 | 1998-02-16 | 三井東圧化学株式会社 | 生体吸収性ポリエステルの製造方法 |
| CA2040141C (en) * | 1990-04-13 | 2002-05-14 | Minoru Yamada | Biodegradable high-molecular polymers, production and use therof |
-
1991
- 1991-07-17 MY MYPI91001289A patent/MY108621A/en unknown
- 1991-07-22 HU HU912452A patent/HUT59837A/hu unknown
- 1991-07-23 IT ITRM910553A patent/IT1252944B/it active IP Right Grant
- 1991-07-24 DE DE4124468A patent/DE4124468B4/de not_active Expired - Fee Related
- 1991-07-29 ES ES97202586T patent/ES2243966T3/es not_active Expired - Lifetime
- 1991-07-29 CH CH2264/91A patent/CH683772A5/de not_active IP Right Cessation
- 1991-07-29 DK DK91112725T patent/DK0469520T3/da active
- 1991-07-29 EP EP97202586A patent/EP0816413B1/en not_active Expired - Lifetime
- 1991-07-29 DK DK97202586T patent/DK0816413T3/da active
- 1991-07-29 EP EP91112725A patent/EP0469520B1/en not_active Expired - Lifetime
- 1991-07-29 ES ES91112725T patent/ES2112259T3/es not_active Expired - Lifetime
- 1991-07-30 FI FI913641A patent/FI108040B/fi active
- 1991-07-30 AU AU81430/91A patent/AU650277B2/en not_active Ceased
- 1991-07-30 PH PH42864A patent/PH31047A/en unknown
- 1991-07-30 FR FR9109673A patent/FR2665453B1/fr not_active Expired - Fee Related
- 1991-07-30 AT AT0151591A patent/AT402503B/de not_active IP Right Cessation
- 1991-07-30 NO NO912960A patent/NO912960D0/no unknown
- 1991-07-30 PT PT98491A patent/PT98491B/pt not_active IP Right Cessation
- 1991-07-30 LU LU87985A patent/LU87985A1/fr unknown
- 1991-07-30 NZ NZ239184A patent/NZ239184A/en not_active IP Right Cessation
- 1991-07-30 IL IL9900791A patent/IL99007A/en not_active IP Right Cessation
- 1991-07-30 GB GB9116396A patent/GB2246573B/en not_active Expired - Fee Related
- 1991-07-31 KR KR1019910013171A patent/KR100255904B1/ko not_active Expired - Fee Related
- 1991-07-31 CA CA002048200A patent/CA2048200C/en not_active Expired - Lifetime
- 1991-07-31 JP JP03191781A patent/JP3137368B2/ja not_active Expired - Fee Related
- 1991-07-31 IE IE269791A patent/IE66185B1/en not_active IP Right Cessation
- 1991-08-02 TW TW082100731A patent/TW282477B/zh not_active IP Right Cessation
- 1991-08-02 TW TW080106046A patent/TW218025B/zh not_active IP Right Cessation
-
1997
- 1997-02-05 HK HK11797A patent/HK11797A/xx not_active IP Right Cessation
- 1997-09-05 CY CY198697A patent/CY1986A/en unknown
-
1998
- 1998-03-11 GR GR980400513T patent/GR3026322T3/el unknown
-
2001
- 2001-06-05 FI FI20011189A patent/FI111268B/fi active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970623 |