IT1232170B - Emulsione multipla, in particolare di emoglobina, e procedimento per la sua preparazione - Google Patents

Emulsione multipla, in particolare di emoglobina, e procedimento per la sua preparazione

Info

Publication number
IT1232170B
IT1232170B IT8948297A IT4829789A IT1232170B IT 1232170 B IT1232170 B IT 1232170B IT 8948297 A IT8948297 A IT 8948297A IT 4829789 A IT4829789 A IT 4829789A IT 1232170 B IT1232170 B IT 1232170B
Authority
IT
Italy
Prior art keywords
hemoglobin
procedure
preparation
multiple emulsion
emulsion
Prior art date
Application number
IT8948297A
Other languages
English (en)
Other versions
IT8948297A0 (it
Inventor
Richard L Beissinger
Darsh T Wasan
Lakshman R Sehgal
Arthur L Rosen
Original Assignee
Illinois Technology Inst
Northfield Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illinois Technology Inst, Northfield Lab filed Critical Illinois Technology Inst
Publication of IT8948297A0 publication Critical patent/IT8948297A0/it
Application granted granted Critical
Publication of IT1232170B publication Critical patent/IT1232170B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/922—Colloid systems having specified particle size, range, or distribution, e.g. bimodal particle distribution
    • Y10S516/923—Emulsion

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT8948297A 1988-08-19 1989-08-21 Emulsione multipla, in particolare di emoglobina, e procedimento per la sua preparazione IT1232170B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/234,386 US5061688A (en) 1988-08-19 1988-08-19 Hemoglobin multiple emulsion

Publications (2)

Publication Number Publication Date
IT8948297A0 IT8948297A0 (it) 1989-08-21
IT1232170B true IT1232170B (it) 1992-01-25

Family

ID=22881174

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8948297A IT1232170B (it) 1988-08-19 1989-08-21 Emulsione multipla, in particolare di emoglobina, e procedimento per la sua preparazione

Country Status (12)

Country Link
US (3) US5061688A (it)
JP (1) JPH02160724A (it)
AU (1) AU614173B2 (it)
CA (1) CA1330937C (it)
CH (1) CH679206A5 (it)
DE (1) DE3927298C2 (it)
ES (1) ES2015777A6 (it)
FR (1) FR2635458B1 (it)
GB (1) GB2221912B (it)
IT (1) IT1232170B (it)
NL (1) NL194665C (it)
SE (1) SE504671C2 (it)

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US5256422A (en) * 1991-03-28 1993-10-26 Micro Vesicular Systems, Inc. Lipid vesicle containing water-in-oil emulsions
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US5670173A (en) * 1992-09-14 1997-09-23 Mcgill University Biodegradable polymer membrane containing hemoglobin for blood substitute
US6506340B1 (en) 1993-06-01 2003-01-14 Cobe Cardiovascular, Inc. Antifoaming device and method for extracorporeal blood processing
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US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
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US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
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DE69831248T2 (de) * 1997-02-28 2006-04-13 The Regents Of The University Of California, Oakland Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
WO1999043301A1 (en) * 1998-02-24 1999-09-02 The Board Of Trustees Of The University Of Illinois Lipid emulsions in the treatment of systemic poisoning
DE60024700T2 (de) * 1999-03-19 2006-09-28 Kao Corp. Verfahren zur Herstellung einer Emulsion
US6500809B1 (en) 1999-11-12 2002-12-31 Neuron Therapeutics, Inc. Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith
US6777450B1 (en) * 2000-05-26 2004-08-17 Color Access, Inc. Water-thin emulsions with low emulsifier levels
DE10034970B4 (de) * 2000-07-19 2004-11-18 Sanguibiotech Gmbh Einen Sauerstoffträger, ausgewählt aus Hämoglobin oder Hämoglobin- und Myoglobin-enthaltende Zubereitung in Form einer Emulsion sowie deren Verwendung als kosmetisches Externum und zur natürlichen Regeneration der Haut bei Sauerstoff-Mangel
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
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US20050164915A1 (en) 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
DE10209860A1 (de) * 2002-03-06 2003-09-25 Hemofarm Konzern A D Hydrophobe Nanotropfen mit gebundenen Hämoglobinmolekülen in hydrophiler Phase enthaltene Emulsion als Blutersatzstoff
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
US20040072729A1 (en) * 2002-10-10 2004-04-15 Sunbio Inc. High oxygen affinity PEG-hemoglobin as treatment for brain stroke
US9388427B2 (en) * 2002-12-02 2016-07-12 Biovec, Llc In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors
US7803365B2 (en) * 2002-12-02 2010-09-28 Biovec, Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
KR20050095636A (ko) * 2003-01-29 2005-09-29 노쓰필드 라보라토리스, 인코포레이티드 감소된 양의 테트라머를 지닌 중합된 헤모글로빈 용액 및이의 제조 방법
WO2004076635A2 (en) * 2003-02-25 2004-09-10 Biovec B.V. Therapeutic applications of thrombomodulin gene via viral and non-viral vectors
US20050186183A1 (en) * 2003-12-08 2005-08-25 Deangelo Joseph Stabilized products, processes and devices for preparing same
US7087369B2 (en) * 2003-12-17 2006-08-08 The Regents Of The University Of California Cornea preservation medium
CA2603347C (en) * 2005-03-31 2014-06-17 Suntory Limited Oil-in-water emulsions of lignans that exhibit improved absorption rate
CN1733298B (zh) * 2005-08-16 2011-08-24 华东理工大学 血红蛋白为基础的微囊型血液代用品及其制备方法
WO2008021577A2 (en) 2006-01-24 2008-02-21 The Board Of Trustees Of The University Of Illinois Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
EP2070532B1 (en) * 2006-10-04 2013-07-24 Suntory Holdings Limited O/w/o emulsion containing lignan compounds, and composition containing the same
US8618056B2 (en) 2007-12-22 2013-12-31 Cuthbert O. Simpkins Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries
US8063020B2 (en) * 2007-12-22 2011-11-22 Simpkins Cuthbert O Resuscitation fluid
US8906855B2 (en) 2007-12-22 2014-12-09 Vivacelle Bio, Inc. Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries
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CA2749698C (en) * 2009-01-30 2017-08-01 Cuthbert O. Simpkins Resuscitation fluid
WO2010125558A1 (en) * 2009-04-28 2010-11-04 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), The Volcani Center Emulsions, emulsifier, method of use and production process
US8273857B2 (en) * 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
DE102011118500A1 (de) * 2011-11-15 2013-05-16 Planaturo GmbH & Co. KG Vegane Emulsion
JP6914192B2 (ja) 2014-10-31 2021-08-04 マサチューセッツ インスティテュート オブ テクノロジー 乳剤形成のための組成および方法
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Also Published As

Publication number Publication date
FR2635458A1 (fr) 1990-02-23
CH679206A5 (it) 1992-01-15
GB2221912A (en) 1990-02-21
US5061688A (en) 1991-10-29
JPH02160724A (ja) 1990-06-20
SE8902773D0 (sv) 1989-08-18
US5438041A (en) 1995-08-01
DE3927298A1 (de) 1990-03-01
GB2221912B (en) 1992-09-23
CA1330937C (en) 1994-07-26
NL8902100A (nl) 1990-03-16
DE3927298C2 (de) 2003-02-06
AU614173B2 (en) 1991-08-22
NL194665C (nl) 2002-11-04
SE504671C2 (sv) 1997-03-24
US5217648A (en) 1993-06-08
SE8902773L (sv) 1990-02-20
IT8948297A0 (it) 1989-08-21
AU4008689A (en) 1990-02-22
ES2015777A6 (es) 1990-09-01
GB8918880D0 (en) 1989-09-27
FR2635458B1 (fr) 1994-11-18
NL194665B (nl) 2002-07-01

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Effective date: 19960729