FR2635458B1 - Emulsion multiple de transport d'oxygene utile notamment comme succedane du sang et son procede de fabrication - Google Patents

Emulsion multiple de transport d'oxygene utile notamment comme succedane du sang et son procede de fabrication

Info

Publication number
FR2635458B1
FR2635458B1 FR898911078A FR8911078A FR2635458B1 FR 2635458 B1 FR2635458 B1 FR 2635458B1 FR 898911078 A FR898911078 A FR 898911078A FR 8911078 A FR8911078 A FR 8911078A FR 2635458 B1 FR2635458 B1 FR 2635458B1
Authority
FR
France
Prior art keywords
manufacturing
multiple emulsion
blood substitute
transporting oxygen
oxygen useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR898911078A
Other languages
English (en)
Other versions
FR2635458A1 (fr
Inventor
Richard L Beissinger
Darsh T Wasan
Lakshman R Sehgal
Arthur L Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ILLINOIS INSTITUTE TECHNOLOGY
NORTHFIELD LAB
Northfield Laboratories Inc
Illinois Institute of Technology
Original Assignee
ILLINOIS INSTITUTE TECHNOLOGY
NORTHFIELD LAB
Northfield Laboratories Inc
Illinois Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ILLINOIS INSTITUTE TECHNOLOGY, NORTHFIELD LAB, Northfield Laboratories Inc, Illinois Institute of Technology filed Critical ILLINOIS INSTITUTE TECHNOLOGY
Publication of FR2635458A1 publication Critical patent/FR2635458A1/fr
Application granted granted Critical
Publication of FR2635458B1 publication Critical patent/FR2635458B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/922—Colloid systems having specified particle size, range, or distribution, e.g. bimodal particle distribution
    • Y10S516/923—Emulsion

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR898911078A 1988-08-19 1989-08-21 Emulsion multiple de transport d'oxygene utile notamment comme succedane du sang et son procede de fabrication Expired - Fee Related FR2635458B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/234,386 US5061688A (en) 1988-08-19 1988-08-19 Hemoglobin multiple emulsion

Publications (2)

Publication Number Publication Date
FR2635458A1 FR2635458A1 (fr) 1990-02-23
FR2635458B1 true FR2635458B1 (fr) 1994-11-18

Family

ID=22881174

Family Applications (1)

Application Number Title Priority Date Filing Date
FR898911078A Expired - Fee Related FR2635458B1 (fr) 1988-08-19 1989-08-21 Emulsion multiple de transport d'oxygene utile notamment comme succedane du sang et son procede de fabrication

Country Status (12)

Country Link
US (3) US5061688A (fr)
JP (1) JPH02160724A (fr)
AU (1) AU614173B2 (fr)
CA (1) CA1330937C (fr)
CH (1) CH679206A5 (fr)
DE (1) DE3927298C2 (fr)
ES (1) ES2015777A6 (fr)
FR (1) FR2635458B1 (fr)
GB (1) GB2221912B (fr)
IT (1) IT1232170B (fr)
NL (1) NL194665C (fr)
SE (1) SE504671C2 (fr)

Families Citing this family (60)

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US5061688A (en) * 1988-08-19 1991-10-29 Illinois Institute Of Technology Hemoglobin multiple emulsion
US5256422A (en) * 1991-03-28 1993-10-26 Micro Vesicular Systems, Inc. Lipid vesicle containing water-in-oil emulsions
US5622649A (en) * 1991-06-27 1997-04-22 Emory University Multiple emulsions and methods of preparation
DE69225404T2 (de) * 1991-06-27 1998-12-17 Univ Emory Mehrkomponentemulsionen und verfahren zur deren herstellung
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US5670173A (en) * 1992-09-14 1997-09-23 Mcgill University Biodegradable polymer membrane containing hemoglobin for blood substitute
US6506340B1 (en) 1993-06-01 2003-01-14 Cobe Cardiovascular, Inc. Antifoaming device and method for extracorporeal blood processing
US5578564A (en) * 1993-07-23 1996-11-26 Somatogen, Inc. Nickel-free hemoglobin and methods for producing such hemoglobin
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
TW381022B (en) * 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
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US5589177A (en) * 1994-12-06 1996-12-31 Helene Curtis, Inc. Rinse-off water-in-oil-in-water compositions
US6436969B1 (en) * 1995-09-12 2002-08-20 Kansas University Medical Center Research Institute Inc. Dialysis solutions and methods
WO1997025978A1 (fr) * 1996-01-15 1997-07-24 BELOYARTSEV, Arkady Felixovich Procede de production d'emulsions perfluorocarbonees a des fins medicales
US5834519A (en) 1996-10-11 1998-11-10 Wayne State University Stabilized gas-supersaturated emulsions and suspensions
AU735799C (en) * 1997-02-28 2005-04-28 Regents Of The University Of California, The Methods and compositions for optimisation of oxygen transport by cell-free systems
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
WO1999043301A1 (fr) * 1998-02-24 1999-09-02 The Board Of Trustees Of The University Of Illinois Emulsions lipides pour le traitement de l'intoxication generale
EP1038573B1 (fr) * 1999-03-19 2005-12-14 Kao Corporation Procédé pour préparer une émulsion
US6500809B1 (en) 1999-11-12 2002-12-31 Neuron Therapeutics, Inc. Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith
US6777450B1 (en) * 2000-05-26 2004-08-17 Color Access, Inc. Water-thin emulsions with low emulsifier levels
DE10034970B4 (de) * 2000-07-19 2004-11-18 Sanguibiotech Gmbh Einen Sauerstoffträger, ausgewählt aus Hämoglobin oder Hämoglobin- und Myoglobin-enthaltende Zubereitung in Form einer Emulsion sowie deren Verwendung als kosmetisches Externum und zur natürlichen Regeneration der Haut bei Sauerstoff-Mangel
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US6995209B2 (en) * 2001-03-21 2006-02-07 Madash Llc Thermally reversible water in oil in water emulsions
CA2444590C (fr) 2001-04-18 2009-12-01 Robert L. Mcginnis Solutions d'hemoglobine stabilisees
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en) 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
DE10209860A1 (de) * 2002-03-06 2003-09-25 Hemofarm Konzern A D Hydrophobe Nanotropfen mit gebundenen Hämoglobinmolekülen in hydrophiler Phase enthaltene Emulsion als Blutersatzstoff
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
US20040072729A1 (en) * 2002-10-10 2004-04-15 Sunbio Inc. High oxygen affinity PEG-hemoglobin as treatment for brain stroke
US7803365B2 (en) * 2002-12-02 2010-09-28 Biovec, Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
US9388427B2 (en) * 2002-12-02 2016-07-12 Biovec, Llc In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors
EP1592437A4 (fr) * 2003-01-29 2007-12-26 Northfield Lab Solutions d'hemoglobine polymerisees comportant une quantite reduite de tetramere et procede de fabrication correspondant
CA2515916A1 (fr) * 2003-02-25 2004-09-10 Biovec B.V. Applications therapeutiques du gene de la thrombomoduline au moyen de vecteurs viraux et non viraux
US20050186183A1 (en) * 2003-12-08 2005-08-25 Deangelo Joseph Stabilized products, processes and devices for preparing same
US7087369B2 (en) * 2003-12-17 2006-08-08 The Regents Of The University Of California Cornea preservation medium
KR101327649B1 (ko) * 2005-03-31 2013-11-12 산토리 홀딩스 가부시키가이샤 리그난류 화합물 함유 수중 유적형 에멀션 및 그것을함유하는 조성물
CN1733298B (zh) * 2005-08-16 2011-08-24 华东理工大学 血红蛋白为基础的微囊型血液代用品及其制备方法
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US20070196810A1 (en) * 2006-01-24 2007-08-23 Northfield Laboratories Inc. Polymerized Hemoglobin Media and its Use in Isolation and Transplantation of Islet Cells
CN101511356A (zh) * 2006-10-04 2009-08-19 三得利株式会社 含有木脂素类化合物的o/w/o型乳液及含有该乳液的组合物
US8063020B2 (en) * 2007-12-22 2011-11-22 Simpkins Cuthbert O Resuscitation fluid
US20100196461A1 (en) * 2009-01-30 2010-08-05 Simpkins Cuthbert O Resuscitation fluid
US8906855B2 (en) 2007-12-22 2014-12-09 Vivacelle Bio, Inc. Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries
US8618056B2 (en) 2007-12-22 2013-12-31 Cuthbert O. Simpkins Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries
WO2010017459A1 (fr) 2008-08-07 2010-02-11 Bioactive Surgical, Inc> Revêtements de capture et d’immobilisation de cellules souches pour dispositifs et implants médicaux
US8851741B2 (en) * 2009-04-28 2014-10-07 Shmuel Ganmor Emulsifier with two shear stages
US8273857B2 (en) * 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
DE102011118500A1 (de) * 2011-11-15 2013-05-16 Planaturo GmbH & Co. KG Vegane Emulsion
US10252231B2 (en) 2014-10-31 2019-04-09 Massachusetts Institute Of Technology Compositions and methods for forming emulsions
US11119098B2 (en) 2014-10-31 2021-09-14 Massachusetts Institute Of Technology Systems including Janus droplets
EP3511020B1 (fr) 2014-12-02 2021-01-20 Novartis AG Fabrication de compositions contenant des tensioactifs

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Also Published As

Publication number Publication date
JPH02160724A (ja) 1990-06-20
SE8902773L (sv) 1990-02-20
SE8902773D0 (sv) 1989-08-18
US5061688A (en) 1991-10-29
ES2015777A6 (es) 1990-09-01
AU614173B2 (en) 1991-08-22
US5438041A (en) 1995-08-01
US5217648A (en) 1993-06-08
NL8902100A (nl) 1990-03-16
GB2221912B (en) 1992-09-23
DE3927298C2 (de) 2003-02-06
CH679206A5 (fr) 1992-01-15
DE3927298A1 (de) 1990-03-01
SE504671C2 (sv) 1997-03-24
NL194665C (nl) 2002-11-04
FR2635458A1 (fr) 1990-02-23
GB2221912A (en) 1990-02-21
NL194665B (nl) 2002-07-01
IT1232170B (it) 1992-01-25
AU4008689A (en) 1990-02-22
GB8918880D0 (en) 1989-09-27
IT8948297A0 (it) 1989-08-21
CA1330937C (fr) 1994-07-26

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