IT1204421B - 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono - Google Patents

2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono

Info

Publication number
IT1204421B
IT1204421B IT20965/86A IT2096586A IT1204421B IT 1204421 B IT1204421 B IT 1204421B IT 20965/86 A IT20965/86 A IT 20965/86A IT 2096586 A IT2096586 A IT 2096586A IT 1204421 B IT1204421 B IT 1204421B
Authority
IT
Italy
Prior art keywords
aminoalkyltio
dihydropyridine
methyl
preparation
pharmaceutical compositions
Prior art date
Application number
IT20965/86A
Other languages
English (en)
Italian (it)
Other versions
IT8620965A0 (it
Inventor
Carmelo A Gandolfi
Marco Frigerio
Silvano Spinelli
Odoardo Tofanetti
Sergio Tognella
Original Assignee
Boehringer Biochemia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Biochemia Srl filed Critical Boehringer Biochemia Srl
Publication of IT8620965A0 publication Critical patent/IT8620965A0/it
Priority to IT20965/86A priority Critical patent/IT1204421B/it
Priority to PCT/EP1986/000445 priority patent/WO1987000836A1/en
Priority to KR1019870700295A priority patent/KR930011486B1/ko
Priority to HU864090A priority patent/HU199796B/hu
Priority to EP86904813A priority patent/EP0233228A1/en
Priority to AU62245/86A priority patent/AU593278B2/en
Priority to IL79572A priority patent/IL79572A0/xx
Priority to IE862066A priority patent/IE862066L/xx
Priority to PT83143A priority patent/PT83143B/pt
Priority to CN198686106242A priority patent/CN86106242A/zh
Priority to ES8600871A priority patent/ES2009136A6/es
Priority to DK175487A priority patent/DK175487A/da
Priority to NO871445A priority patent/NO173544C/no
Priority to FI871492A priority patent/FI92194C/fi
Priority to AU76969/87A priority patent/AU603595B2/en
Priority to EP87109116A priority patent/EP0254064B1/en
Priority to DE8787904520T priority patent/DE3781411T2/de
Priority to EP87904520A priority patent/EP0312541B1/en
Priority to KR1019880700205A priority patent/KR950002154B1/ko
Priority to HU873824A priority patent/HU201305B/hu
Priority to PCT/EP1987/000335 priority patent/WO1988000187A1/en
Priority to CA000540555A priority patent/CA1322753C/en
Priority to AT87904520T priority patent/ATE79869T1/de
Priority to JP62504184A priority patent/JPH0832686B2/ja
Priority to ES198787109116T priority patent/ES2037029T3/es
Priority to NZ220868A priority patent/NZ220868A/xx
Priority to PH35467A priority patent/PH23208A/en
Priority to ZA874636A priority patent/ZA874636B/xx
Priority to PL1987266481A priority patent/PL156170B1/pl
Priority to MX713487A priority patent/MX7134A/es
Priority to DK099588A priority patent/DK164051C/da
Priority to NO880865A priority patent/NO175365C/no
Priority to FI885930A priority patent/FI91149C/fi
Priority to SU884613190A priority patent/RU1816282C/ru
Application granted granted Critical
Publication of IT1204421B publication Critical patent/IT1204421B/it
Priority to US07/333,080 priority patent/US4999362A/en
Priority to US07/413,896 priority patent/US5021436A/en
Priority to US07/638,131 priority patent/US5047414A/en
Priority to GR920401276T priority patent/GR3004954T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IT20965/86A 1985-08-06 1986-06-27 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono IT1204421B (it)

Priority Applications (38)

Application Number Priority Date Filing Date Title
IT20965/86A IT1204421B (it) 1986-06-27 1986-06-27 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono
PCT/EP1986/000445 WO1987000836A1 (en) 1985-08-06 1986-07-29 Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines
KR1019870700295A KR930011486B1 (ko) 1985-08-06 1986-07-29 제약상 유효한 2-티오메틸-치환-1,4-디히드로피리딘
HU864090A HU199796B (en) 1985-08-06 1986-07-29 Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds
EP86904813A EP0233228A1 (en) 1985-08-06 1986-07-29 Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines
AU62245/86A AU593278B2 (en) 1985-08-06 1986-07-29 Pharmaceutically active 2-thiomethyl-substituted-1,4- dihydropyridines
IL79572A IL79572A0 (en) 1985-08-06 1986-07-30 2-thiomethyl-substituted-1,4-dihydropyridines,method for their preparation and pharmaceutical compositions containing them
IE862066A IE862066L (en) 1985-08-06 1986-08-01 2-thiomethyl-substituted-1,4-dihydropyridines, method for¹their preparation and pharmaceutical compositions containing¹them
PT83143A PT83143B (pt) 1985-08-06 1986-08-05 Processo para a preparacao de 1,4-dihidro-piridinas 2-substituidas com tiometilo e de composicoes farmaceuticas que as contem
CN198686106242A CN86106242A (zh) 1985-08-06 1986-08-05 2-硫代甲基-取代-1，4-二氢吡啶，其制造方法和含有这些化合物的药物组合物
ES8600871A ES2009136A6 (es) 1985-08-06 1986-08-05 Un compuesto
DK175487A DK175487A (da) 1985-08-06 1987-04-06 Farmaceutisk aktive 2-thiomethyl-substitueret-1,4-dihydro-pyridiner
NO871445A NO173544C (no) 1985-08-06 1987-04-06 Analogifremgangsmaate ved fremstilling av terapeutisk aktive 2- tiometyl-substituerte 1,4-dihydropyridiner
FI871492A FI92194C (fi) 1985-08-06 1987-04-06 Menetelmä lääkeaineina käyttökelpoisten 2-tiometyyli-substituoitujen 1,4-dihydropyridiinien valmistamiseksi
KR1019880700205A KR950002154B1 (ko) 1986-06-27 1987-06-25 2-(아미노알킬티오)메틸-1,4-디히드로피리딘의 제조방법
EP87109116A EP0254064B1 (en) 1986-06-27 1987-06-25 2-(aminoalkylthio)methyl-1,4-dihydropyridine, a method for the preparation thereof and pharmaceutical compositions containing them
DE8787904520T DE3781411T2 (de) 1986-06-27 1987-06-25 2-(aminoalkylthio)methyl-1,4-dihydropyridine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
EP87904520A EP0312541B1 (en) 1986-06-27 1987-06-25 2-(aminoalkylthio)methyl-1,4-dihydropyridine, a method for the preparation thereof and pharmaceutical compositions containing them
AU76969/87A AU603595B2 (en) 1986-06-27 1987-06-25 2-(aminoalkylthio)methyl-1,4-dihydropyridine, a method for the preparation thereof and pharmaceutical compositions containing them
HU873824A HU201305B (en) 1986-06-27 1987-06-25 Process for production of derivatives of 2-(amin-alkyl-tio)-methil-1,4-dihydropiridin and medical compositions containing them
PCT/EP1987/000335 WO1988000187A1 (en) 1986-06-27 1987-06-25 2-(aminoalkylthio)methyl-1,4-dihydropyridine, a method for the preparation thereof and pharmaceutical compositions containing them
CA000540555A CA1322753C (en) 1986-06-27 1987-06-25 2-(aminoalkylthio)methyl-1,4-dihydropyridine, a method for the preparation thereof and pharmaceutical compositions containing them
AT87904520T ATE79869T1 (de) 1986-06-27 1987-06-25 2-(aminoalkylthio)methyl-1,4-dihydropyridine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
JP62504184A JPH0832686B2 (ja) 1986-06-27 1987-06-25 ２―（アミノアルキルチオ）メチル―１，４―ジヒドロピリジン、その製造方法およびそれらを含有する医薬組成物
ES198787109116T ES2037029T3 (es) 1986-06-27 1987-06-25 2-(aminoalquiltio)metil-1,4-dihidropiridinas, un metodo para su preparacion y composiciones farmaceuticas que las contienen.
ZA874636A ZA874636B (en) 1986-06-27 1987-06-26 2-(aminoalkylthio)methyl-1,4-dihydropyridine,a method for the preparation thereof and pharmaceutical compositions containing them
PH35467A PH23208A (en) 1986-06-27 1987-06-26 2(aminoalkylthio)methyl-1,4 dihydropyridine
NZ220868A NZ220868A (en) 1986-06-27 1987-06-26 2-(aminoalkylthio)methyl-1,4-dihydropyridine derivatives and pharmaceutical compositions
PL1987266481A PL156170B1 (pl) 1986-06-27 1987-06-27 Sposób wytwarzania pochodnych 2-/aminoalkilotio/metylol,4-dihydropirydyny PL PL PL
MX713487A MX7134A (es) 1986-06-27 1987-06-29 Procedimiento para la preparacion de 2-(aminoalquiltio) metil-1,4-dihidropiridinas producto obtenidoy composiciones farmaceuticas que las incluyen
DK099588A DK164051C (da) 1986-06-27 1988-02-25 2-(aminoalkylthio)methyl-1,4-dihydropyridin-forbindelser samt farmaceutisk middel indeholdende en saadan forbindelse
NO880865A NO175365C (no) 1986-06-27 1988-02-26 Analogifremgangsmåte ved fremstilling av terapeutisk aktive 2-(aminoalkyltio)metyl-1,4-dihydropyridinderivater
FI885930A FI91149C (fi) 1986-06-27 1988-12-21 Menetelmä lääkeaineena käyttökelpoisten 2-(aminoalkyylitio)metyyli-1,4-dihydropyridiinien valmistamiseksi
SU884613190A RU1816282C (ru) 1986-06-27 1988-12-26 Способ получени производных 2-аминоалкилтиометил-1,4-дигидропиридина или их энантиомеров
US07/333,080 US4999362A (en) 1985-08-06 1989-04-04 2-thiomethyl-substituted-1,4-dihydropyridines, method for their preparation and pharmaceutical compositions containing them
US07/413,896 US5021436A (en) 1985-08-06 1989-09-28 2-thiomethyl-substituted-1,4-dihydropyridines, and pharmaceutical compositions containing same and antihypertensive properties
US07/638,131 US5047414A (en) 1986-06-27 1990-12-21 2-(aminoalkylthio)methyl-1,4-dihydropyridine, a method for the preparation thereof and pharmaceutical compositions containing them
GR920401276T GR3004954T3 (en, 2012) 1986-06-27 1992-06-18

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20965/86A IT1204421B (it) 1986-06-27 1986-06-27 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono

Publications (2)

Publication Number Publication Date
IT8620965A0 IT8620965A0 (it) 1986-06-27
IT1204421B true IT1204421B (it) 1989-03-01

Family

ID=11174716

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20965/86A IT1204421B (it) 1985-08-06 1986-06-27 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono

Country Status (19)

Country Link
US (1) US5047414A (en, 2012)
EP (2) EP0254064B1 (en, 2012)
JP (1) JPH0832686B2 (en, 2012)
KR (1) KR950002154B1 (en, 2012)
AU (1) AU603595B2 (en, 2012)
CA (1) CA1322753C (en, 2012)
DK (1) DK164051C (en, 2012)
ES (1) ES2037029T3 (en, 2012)
FI (1) FI91149C (en, 2012)
GR (1) GR3004954T3 (en, 2012)
HU (1) HU201305B (en, 2012)
IT (1) IT1204421B (en, 2012)
MX (1) MX7134A (en, 2012)
NZ (1) NZ220868A (en, 2012)
PH (1) PH23208A (en, 2012)
PL (1) PL156170B1 (en, 2012)
RU (1) RU1816282C (en, 2012)
WO (1) WO1988000187A1 (en, 2012)
ZA (1) ZA874636B (en, 2012)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213555B (it) * 1986-12-11 1989-12-20 Boehringer Biochemia Srl 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
IL68604A0 (en) * 1982-05-21 1983-09-30 Haessle Ab Processes for preparing therapeutically active dihydropyridines and intermediates for the processes
PH19166A (en) * 1982-09-04 1986-01-16 Pfizer Dihydropyridined,pharmaceutical compositions and method of use
US4572908A (en) * 1982-12-21 1986-02-25 Pfizer Inc. Dihydropyridines
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
GR851819B (en, 2012) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
HU199796B (en) * 1985-08-06 1990-03-28 Boehringer Biochemia Srl Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds

Also Published As

Publication number Publication date
EP0254064A1 (en) 1988-01-27
FI91149C (fi) 1994-05-25
IT8620965A0 (it) 1986-06-27
GR3004954T3 (en, 2012) 1993-04-28
PL266481A1 (en) 1988-09-01
WO1988000187A1 (en) 1988-01-14
KR950002154B1 (ko) 1995-03-14
EP0254064B1 (en) 1992-06-17
HUT49572A (en) 1989-10-30
US5047414A (en) 1991-09-10
AU603595B2 (en) 1990-11-22
FI885930L (fi) 1988-12-21
PH23208A (en) 1989-06-06
ES2037029T3 (es) 1993-06-16
DK99588D0 (da) 1988-02-25
PL156170B1 (pl) 1992-02-28
AU7696987A (en) 1988-01-29
DK164051C (da) 1992-09-28
NZ220868A (en) 1989-10-27
DK99588A (da) 1988-02-25
JPH0832686B2 (ja) 1996-03-29
FI91149B (fi) 1994-02-15
DK164051B (da) 1992-05-04
RU1816282C (ru) 1993-05-15
CA1322753C (en) 1993-10-05
EP0312541B1 (en) 1992-08-26
ZA874636B (en) 1988-03-30
KR880701228A (ko) 1988-07-26
MX7134A (es) 1993-10-01
JPH01503065A (ja) 1989-10-19
EP0312541A1 (en) 1989-04-26
HU201305B (en) 1990-10-28

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