IS5360A - Greining á kjarnsýruröð - Google Patents

Greining á kjarnsýruröð

Info

Publication number
IS5360A
IS5360A IS5360A IS5360A IS5360A IS 5360 A IS5360 A IS 5360A IS 5360 A IS5360 A IS 5360A IS 5360 A IS5360 A IS 5360A IS 5360 A IS5360 A IS 5360A
Authority
IS
Iceland
Prior art keywords
analysis
nucleic acid
acid sequence
nucleotide
blocking
Prior art date
Application number
IS5360A
Other languages
English (en)
Inventor
Henry Densham Daniel
Original Assignee
Medical Biosystems Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26311958&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS5360(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9715942.0A external-priority patent/GB9715942D0/en
Priority claimed from GBGB9727103.5A external-priority patent/GB9727103D0/en
Application filed by Medical Biosystems Ltd. filed Critical Medical Biosystems Ltd.
Publication of IS5360A publication Critical patent/IS5360A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IS5360A 1997-07-28 2000-01-25 Greining á kjarnsýruröð IS5360A (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9715942.0A GB9715942D0 (is) 1997-07-28 1997-07-28
GBGB9727103.5A GB9727103D0 (is) 1997-12-22 1997-12-22
PCT/GB1998/002214 WO1999005315A2 (en) 1997-07-28 1998-07-24 Nucleic acid sequence analysis

Publications (1)

Publication Number Publication Date
IS5360A true IS5360A (is) 2000-01-25

Family

ID=26311958

Family Applications (1)

Application Number Title Priority Date Filing Date
IS5360A IS5360A (is) 1997-07-28 2000-01-25 Greining á kjarnsýruröð

Country Status (19)

Country Link
US (4) US7008766B1 (is)
EP (4) EP2267164B1 (is)
JP (1) JP2001511358A (is)
KR (1) KR100664331B1 (is)
CN (1) CN1152140C (is)
AT (1) ATE225858T1 (is)
AU (1) AU735898B2 (is)
BR (1) BR9812270A (is)
CA (1) CA2294962C (is)
DE (1) DE69808661T3 (is)
DK (1) DK1017848T3 (is)
ES (1) ES2183394T5 (is)
HK (1) HK1031130A1 (is)
IL (1) IL133411A (is)
IS (1) IS5360A (is)
NZ (1) NZ502557A (is)
PT (1) PT1017848E (is)
RU (1) RU2198221C2 (is)
WO (1) WO1999005315A2 (is)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9620209D0 (en) * 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
WO1998035012A2 (en) * 1997-02-12 1998-08-13 Chan Eugene Y Methods and products for analyzing polymers
ATE225858T1 (de) * 1997-07-28 2002-10-15 Medical Biosystems Ltd Sequenzanalyse von nukleinsäuren
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
WO2002061126A2 (en) * 2001-01-30 2002-08-08 Solexa Ltd. The preparation of polynucleotide arrays
AU772281B2 (en) 1998-12-14 2004-04-22 Li-Cor Inc. A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis
AU2005201777B2 (en) * 1999-03-10 2007-08-02 Asm Scientific, Inc. A Method for Direct Nucleic Acid Sequencing
EP1159453B1 (en) * 1999-03-10 2008-05-28 ASM Scientific, Inc. A method for direct nucleic acid sequencing
GB9907812D0 (en) * 1999-04-06 1999-06-02 Medical Biosystems Ltd Sequencing
GB9907813D0 (en) * 1999-04-06 1999-06-02 Medical Biosystems Ltd Synthesis
WO2000061594A2 (de) * 1999-04-08 2000-10-19 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Nucleosid-derivate mit photolabilen schutzgruppen
EP1681356B1 (en) * 1999-05-19 2011-10-19 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6927065B2 (en) 1999-08-13 2005-08-09 U.S. Genomics, Inc. Methods and apparatus for characterization of single polymers
WO2001016375A2 (en) * 1999-08-30 2001-03-08 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services High speed parallel molecular nucleic acid sequencing
US6982146B1 (en) 1999-08-30 2006-01-03 The United States Of America As Represented By The Department Of Health And Human Services High speed parallel molecular nucleic acid sequencing
GB9923644D0 (en) * 1999-10-06 1999-12-08 Medical Biosystems Ltd DNA sequencing
US6908736B1 (en) 1999-10-06 2005-06-21 Medical Biosystems, Ltd. DNA sequencing method
WO2001046464A1 (en) * 1999-12-21 2001-06-28 Vbc-Genomics Bioscience Research Gmbh Branched compound for use in nucleic acid detection and analysis reactions
GB0002389D0 (en) * 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
GB0016473D0 (en) * 2000-07-05 2000-08-23 Amersham Pharm Biotech Uk Ltd Sequencing method
AU2001282881B2 (en) 2000-07-07 2007-06-14 Visigen Biotechnologies, Inc. Real-time sequence determination
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
ATE356222T1 (de) 2000-10-06 2007-03-15 Univ Columbia Massives parallelverfahren zur dekodierung von dna und rna
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
GB0112238D0 (en) * 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
US7118907B2 (en) 2001-06-06 2006-10-10 Li-Cor, Inc. Single molecule detection systems and methods
US6613523B2 (en) 2001-06-29 2003-09-02 Agilent Technologies, Inc. Method of DNA sequencing using cleavable tags
US7668697B2 (en) * 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US6852492B2 (en) * 2001-09-24 2005-02-08 Intel Corporation Nucleic acid sequencing by raman monitoring of uptake of precursors during molecular replication
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
SI3363809T1 (sl) 2002-08-23 2020-08-31 Illumina Cambridge Limited Modificirani nukleotidi za polinukleotidno sekvenciranje
JP2004347621A (ja) * 2003-04-24 2004-12-09 Dainippon Printing Co Ltd 透過型スクリーン
BRPI0412555A (pt) * 2003-07-15 2006-09-19 Daniel Henry Densham medições de uma reação de amplificação de polinucleotìdeo
GB0316553D0 (en) * 2003-07-15 2003-08-20 Densham Daniel Method
GB0317343D0 (en) 2003-07-24 2003-08-27 Medical Biosystems Ltd Polynucleotide sequencing
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
JP2007518107A (ja) 2004-01-13 2007-07-05 ユー．エス． ジェノミクス， インコーポレイテッド ポリマーを使用する溶液中の分析物の検出および定量化
US7595160B2 (en) 2004-01-13 2009-09-29 U.S. Genomics, Inc. Analyte detection using barcoded polymers
US7981604B2 (en) 2004-02-19 2011-07-19 California Institute Of Technology Methods and kits for analyzing polynucleotide sequences
AR048685A1 (es) 2004-04-09 2006-05-17 Monsanto Technology Llc Metodos para el control de infestaciones de insectos en plantas.
GB0413082D0 (en) * 2004-06-11 2004-07-14 Medical Biosystems Ltd Method
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
EP3415641B1 (en) 2004-09-17 2023-11-01 Pacific Biosciences Of California, Inc. Method for analysis of molecules
US7274458B2 (en) * 2005-03-07 2007-09-25 3M Innovative Properties Company Thermoplastic film having metallic nanoparticle coating
US7666494B2 (en) 2005-05-04 2010-02-23 3M Innovative Properties Company Microporous article having metallic nanoparticle coating
CN101218497B (zh) * 2005-07-07 2012-04-25 索尼株式会社 利用瞬逝光的物质信息获取方法和物质信息测量装置、以及碱基序列确定方法和装置
WO2007011331A2 (en) 2005-07-14 2007-01-25 3M Innovative Properties Company Water-soluble polymeric substrate having metallic nanoparticle coating
US7805081B2 (en) * 2005-08-11 2010-09-28 Pacific Biosciences Of California, Inc. Methods and systems for monitoring multiple optical signals from a single source
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
EP2431473B1 (en) 2005-09-16 2016-11-09 Monsanto Technology LLC Methods for genetic control of insect infestations in plants and compositions thereof
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
US7763423B2 (en) 2005-09-30 2010-07-27 Pacific Biosciences Of California, Inc. Substrates having low density reactive groups for monitoring enzyme activity
US7998717B2 (en) * 2005-12-02 2011-08-16 Pacific Biosciences Of California, Inc. Mitigation of photodamage in analytical reactions
DE602006016984D1 (de) 2005-12-12 2010-10-28 Us Gov Health & Human Serv Sonde zum sequenzieren von nukleinsäure und verwendungsverfahren
US8703734B2 (en) 2005-12-12 2014-04-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nanoprobes for detection or modification of molecules
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7692783B2 (en) * 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) * 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US7563574B2 (en) 2006-03-31 2009-07-21 Pacific Biosciences Of California, Inc. Methods, systems and compositions for monitoring enzyme activity and applications thereof
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
EP4220138A1 (en) 2006-09-01 2023-08-02 Pacific Biosciences of California, Inc. Substrates, systems and methods for analyzing materials
US20080076123A1 (en) * 2006-09-27 2008-03-27 Helicos Biosciences Corporation Polymerase variants for DNA sequencing
US20080080059A1 (en) * 2006-09-28 2008-04-03 Pacific Biosciences Of California, Inc. Modular optical components and systems incorporating same
EP2071927A2 (en) 2006-09-28 2009-06-24 Illumina, Inc. Compositions and methods for nucleotide sequencing
US7883869B2 (en) 2006-12-01 2011-02-08 The Trustees Of Columbia University In The City Of New York Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
US8551704B2 (en) 2007-02-16 2013-10-08 Pacific Biosciences Of California, Inc. Controllable strand scission of mini circle DNA
US20100167413A1 (en) * 2007-05-10 2010-07-01 Paul Lundquist Methods and systems for analyzing fluorescent materials with reduced autofluorescence
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
DE102007022915A1 (de) * 2007-05-14 2008-11-20 Stiftung Caesar Center Of Advanced European Studies And Research Polymerisationssensor
US7901889B2 (en) 2007-07-26 2011-03-08 Pacific Biosciences Of California, Inc. Molecular redundant sequencing
EP2203566A4 (en) 2007-09-28 2011-02-09 Pacific Biosciences California ERROR-FREE DNA AMPLIFICATION FOR CLONAL SEQUENCING
US7960116B2 (en) 2007-09-28 2011-06-14 Pacific Biosciences Of California, Inc. Nucleic acid sequencing methods and systems
US9115163B2 (en) 2007-10-19 2015-08-25 The Trustees Of Columbia University In The City Of New York DNA sequence with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators
US20110014611A1 (en) 2007-10-19 2011-01-20 Jingyue Ju Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequences by synthesis
AU2009204461A1 (en) 2008-01-10 2009-07-16 Pacific Biosciences Of California, Inc. Methods and systems for analysis of fluorescent reactions with modulated excitation
EP2255014A4 (en) 2008-02-12 2011-05-18 Pacific Biosciences California COMPOSITIONS AND METHODS FOR USE IN ANALYTICAL REACTIONS
US8143030B2 (en) 2008-09-24 2012-03-27 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
US8236499B2 (en) 2008-03-28 2012-08-07 Pacific Biosciences Of California, Inc. Methods and compositions for nucleic acid sample preparation
US8628940B2 (en) 2008-09-24 2014-01-14 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
EP2274449B1 (en) 2008-03-28 2015-12-23 Pacific Biosciences of California, Inc. Methods for nucleic acid sequencing
US8198023B2 (en) 2008-08-05 2012-06-12 Pacific Biosciences Of California, Inc. Prevention and alleviation of steric hindrance during single molecule nucleic acid synthesis by a polymerase
WO2010027497A2 (en) 2008-09-05 2010-03-11 Pacific Biosciences Of California, Inc Preparations, compositions, and methods for nucleic acid sequencing
CA2737505C (en) 2008-09-16 2017-08-29 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8481264B2 (en) 2008-09-19 2013-07-09 Pacific Biosciences Of California, Inc. Immobilized nucleic acid complexes for sequence analysis
US8921046B2 (en) 2008-09-19 2014-12-30 Pacific Biosciences Of California, Inc. Nucleic acid sequence analysis
US8383369B2 (en) 2008-09-24 2013-02-26 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
WO2010059206A2 (en) 2008-11-19 2010-05-27 Pacific Biosciences Of California, Inc. Modular nucleotide compositions and uses therefor
WO2010059235A2 (en) 2008-11-20 2010-05-27 Pacific Biosciences Of California, Inc. Algorithms for sequence determination
US8993230B2 (en) 2008-12-04 2015-03-31 Pacific Biosciences of Californ, Inc. Asynchronous sequencing of biological polymers
US9175338B2 (en) 2008-12-11 2015-11-03 Pacific Biosciences Of California, Inc. Methods for identifying nucleic acid modifications
CA2746632C (en) 2008-12-11 2020-06-30 Pacific Biosciences Of California, Inc. Characterization of modified nucleic acids
US20230148447A9 (en) 2008-12-11 2023-05-11 Pacific Biosciences Of California, Inc. Classification of nucleic acid templates
EP2425023B1 (en) 2009-04-27 2015-12-23 Pacific Biosciences of California, Inc. Real-time sequencing methods and systems
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
US8518643B2 (en) 2010-02-04 2013-08-27 Pacific Biosciences Of California, Inc. Method to improve single molecule analyses
EP2537053B1 (en) 2010-02-19 2016-11-02 Pacific Biosciences of California, Inc. An analytical device comprising an optode array chip
WO2011116120A2 (en) * 2010-03-16 2011-09-22 Life Technologies Corporation Method and apparatus for addressable flow cells in single molecule sequencing
US8318094B1 (en) 2010-06-18 2012-11-27 Pacific Biosciences Of California, Inc. Substrate analysis systems
US8834847B2 (en) 2010-08-12 2014-09-16 Pacific Biosciences Of California, Inc. Photodamage mitigation compounds and systems
US8465922B2 (en) 2010-08-26 2013-06-18 Pacific Biosciences Of California, Inc. Methods and systems for monitoring reactions
EP2689028B1 (en) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
EP2694686B2 (en) 2011-04-06 2023-07-19 The University of Chicago COMPOSITION AND METHODS RELATED TO MODIFICATION OF 5-METHYLCYTOSINE (5mC)
WO2013019759A1 (en) * 2011-07-30 2013-02-07 The Regents Of The University Of California Enzymatic preparation of 10 base to 50 kb double-strand dna reagent for sequencing with a nanopore-polymerase sequencing device
WO2013056241A2 (en) 2011-10-14 2013-04-18 Pacific Biosciences Of California, Inc. Real-time redox sequencing
US9267917B2 (en) 2011-11-04 2016-02-23 Pacific Biosciences Of California, Inc. Nanopores in zero mode waveguides
US9238836B2 (en) 2012-03-30 2016-01-19 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing modified nucleic acids
US9175348B2 (en) 2012-04-24 2015-11-03 Pacific Biosciences Of California, Inc. Identification of 5-methyl-C in nucleic acid templates
DK2970356T3 (en) 2013-03-15 2018-08-27 Illumina Cambridge Ltd Modified nucleosides or nucleotides
US9416414B2 (en) 2013-10-24 2016-08-16 Pacific Biosciences Of California, Inc. Delaying real-time sequencing
US10302972B2 (en) 2015-01-23 2019-05-28 Pacific Biosciences Of California, Inc. Waveguide transmission
CN114691585B (zh) 2015-05-07 2023-10-13 加利福尼亚太平洋生物科学股份有限公司 多处理器流水线架构
US10077470B2 (en) 2015-07-21 2018-09-18 Omniome, Inc. Nucleic acid sequencing methods and systems
US10731211B2 (en) 2015-11-18 2020-08-04 Pacific Biosciences Of California, Inc. Methods and compositions for loading of polymerase complexes
WO2017190018A1 (en) 2016-04-29 2017-11-02 Omniome, Inc. Sequencing method employing ternary complex destabilization to identify cognate nucleotides
AU2017313718B2 (en) 2016-08-15 2023-09-14 Pacific Biosciences Of California, Inc. Method and system for sequencing nucleic acids
WO2018034780A1 (en) 2016-08-15 2018-02-22 Omniome, Inc. Sequencing method for rapid identification and processing of cognate nucleotide pairs
CA3048415C (en) 2016-12-30 2023-02-28 Omniome, Inc. Method and system employing distinguishable polymerases for detecting ternary complexes and identifying cognate nucleotides
EP3571319A1 (en) 2017-01-20 2019-11-27 Omniome, Inc. Process for cognate nucleotide detection in a nucleic acid sequencing workflow
US9932631B1 (en) 2017-09-11 2018-04-03 Omniome, Inc. Genotyping by polymerase binding
WO2018136117A1 (en) 2017-01-20 2018-07-26 Omniome, Inc. Allele-specific capture of nucleic acids
US9951385B1 (en) 2017-04-25 2018-04-24 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
EP3697932A1 (en) 2017-10-19 2020-08-26 Omniome, Inc. Simultaneous background reduction and complex stabilization in binding assay workflows
US11078534B2 (en) * 2017-11-27 2021-08-03 Roche Molecular Systems, Inc. Photocleavable nucleotide reagents with high stability
MX2020014061A (es) 2018-12-21 2021-05-27 Illumina Inc Sistemas de deteccion.
WO2022101400A1 (en) * 2020-11-16 2022-05-19 Illumina, Inc. Incorporation and imaging mixes

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3728032A (en) * 1971-10-13 1973-04-17 H Noll Flow cell for spectroscopic analysis of density gradients
GB2102005B (en) * 1981-07-23 1984-11-21 Mta Koezponti Kemiai Kutato In Process for synthesis of polydeoxynucleotides
US5064754A (en) * 1984-12-14 1991-11-12 Mills Randell L Genomic sequencing method
US4863849A (en) * 1985-07-18 1989-09-05 New York Medical College Automatable process for sequencing nucleotide
US4971903A (en) † 1988-03-25 1990-11-20 Edward Hyman Pyrophosphate-based method and apparatus for sequencing nucleic acids
WO1990001069A1 (en) 1988-07-20 1990-02-08 Segev Diagnostics, Inc. Process for amplifying and detecting nucleic acid sequences
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
GB2225339A (en) * 1988-11-15 1990-05-30 Aligena Ag Separating electrically charged macromolecular compounds by forced-flow membrane electrophoresis
GB8910880D0 (en) 1989-05-11 1989-06-28 Amersham Int Plc Sequencing method
US5302509A (en) * 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
CA2044616A1 (en) * 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
EP1046421B8 (en) 1990-12-06 2006-01-11 Affymetrix, Inc. (a Delaware Corporation) Methods and reagents for very large scale immobilized polymer synthesis
DE4104076C2 (de) * 1991-02-11 1994-03-31 Bruker Analytische Messtechnik Vorrichtung zur kernresonanzspektrometrischen Messung von chemischen und/oder physikalischen Reaktionsabläufen
US6004744A (en) † 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
GB9119735D0 (en) * 1991-09-16 1991-10-30 Secr Defence Gene probe biosensor method
US5583026A (en) * 1994-08-31 1996-12-10 Cornell Research Foundation, Inc. Process for reconstituting the polymerase III* and other subassemblies of E. coli DNA polymerase III holoenzyme from peptide subunits
GB9208733D0 (en) * 1992-04-22 1992-06-10 Medical Res Council Dna sequencing method
SE9201984D0 (sv) 1992-06-29 1992-06-29 Pharmacia Biosensor Ab Improvement in optical assays
US5360714A (en) * 1992-08-28 1994-11-01 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
AU5449094A (en) * 1992-11-02 1994-05-24 Affymax Technologies N.V. Novel photoreactive protecting groups
EP0689610B1 (en) * 1993-03-19 2002-07-03 Sequenom, Inc. Dna sequencing by mass spectrometry via exonuclease degradation
WO1995006138A1 (en) * 1993-08-25 1995-03-02 The Regents Of The University Of California Microscopic method for detecting micromotions
US5485277A (en) * 1994-07-26 1996-01-16 Physical Optics Corporation Surface plasmon resonance sensor and methods for the utilization thereof
US5801042A (en) * 1994-08-18 1998-09-01 The Trustees Of Columbia University In The City Of New York Unique associated Kaposi's sarcoma virus sequences and uses thereof
US5635608A (en) * 1994-11-08 1997-06-03 Molecular Probes, Inc. α-carboxy caged compounds
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US5753439A (en) * 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
US6331692B1 (en) * 1996-10-12 2001-12-18 Volker Krause Diode laser, laser optics, device for laser treatment of a workpiece, process for a laser treatment of workpiece
US6331392B1 (en) 1997-03-05 2001-12-18 Anadys Pharmaceutical, Inc. Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids
US6159687A (en) * 1997-03-18 2000-12-12 Novo Nordisk A/S Methods for generating recombined polynucleotides
ATE225858T1 (de) * 1997-07-28 2002-10-15 Medical Biosystems Ltd Sequenzanalyse von nukleinsäuren
US6780591B2 (en) * 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) * 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
GB9907813D0 (en) * 1999-04-06 1999-06-02 Medical Biosystems Ltd Synthesis
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
GB9923644D0 (en) * 1999-10-06 1999-12-08 Medical Biosystems Ltd DNA sequencing
US6908736B1 (en) * 1999-10-06 2005-06-21 Medical Biosystems, Ltd. DNA sequencing method
GB0112238D0 (en) * 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
GB0317343D0 (en) * 2003-07-24 2003-08-27 Medical Biosystems Ltd Polynucleotide sequencing
GB0413082D0 (en) * 2004-06-11 2004-07-14 Medical Biosystems Ltd Method
US9752978B2 (en) * 2012-02-03 2017-09-05 Agilent Technologies, Inc. Micromachined flow cell with freestanding fluidic tube

Also Published As

Publication number Publication date
RU2198221C2 (ru) 2003-02-10
IL133411A0 (en) 2001-04-30
ES2183394T3 (es) 2003-03-16
CN1265158A (zh) 2000-08-30
EP1229133A3 (en) 2004-10-13
AU8455998A (en) 1999-02-16
EP2267164B1 (en) 2016-09-14
ATE225858T1 (de) 2002-10-15
EP1017848B2 (en) 2012-02-22
KR100664331B1 (ko) 2007-01-02
PT1017848E (pt) 2003-02-28
EP2267164A2 (en) 2010-12-29
US7008766B1 (en) 2006-03-07
DE69808661D1 (de) 2002-11-14
US20100316999A1 (en) 2010-12-16
CA2294962A1 (en) 1999-02-04
US20080014592A1 (en) 2008-01-17
KR20010022392A (ko) 2001-03-15
CN1152140C (zh) 2004-06-02
AU735898B2 (en) 2001-07-19
EP2267165B1 (en) 2016-11-30
WO1999005315A3 (en) 1999-04-22
EP2267164A3 (en) 2012-08-15
WO1999005315A2 (en) 1999-02-04
CA2294962C (en) 2012-09-18
EP1229133B1 (en) 2016-03-09
JP2001511358A (ja) 2001-08-14
EP1017848B1 (en) 2002-10-09
NZ502557A (en) 2002-02-01
HK1031130A1 (en) 2001-06-01
DE69808661T3 (de) 2012-05-03
EP1017848A2 (en) 2000-07-12
IL133411A (en) 2003-09-17
DE69808661T2 (de) 2003-07-31
BR9812270A (pt) 2000-07-18
DK1017848T3 (da) 2003-02-10
EP2267165A3 (en) 2012-10-10
EP1229133A2 (en) 2002-08-07
US20040241719A1 (en) 2004-12-02
EP2267165A2 (en) 2010-12-29
ES2183394T5 (es) 2012-05-03

Similar Documents

Publication Publication Date Title
IS5360A (is) Greining á kjarnsýruröð
ATE199100T1 (de) Kettenabbrechende nukleinsäure-sequenziermethode mit 2'-desoxyuridin-5'-triphosphat
ES2066760T3 (es) Nucleotidos de alquinilamino.
DE69824716D1 (de) Methode zur sequenzierung von nukleinsäuren
DK1159453T3 (da) Fremgangsmåde til direkte nukleinsyresekventering
ATE239090T1 (de) Methode zum generieren von einzelsträngigen dna molekülen
IS3495A7 (is) Aðferð til margföldunar byggingareininga kjarnasýrukeðja.
ES2143680T3 (es) Metodo para caracterizar dna genomico.
DE60040335D1 (de) Derivatisierte nukleinsäuren und deren verwendung
ATE174065T1 (de) Simultane sequenzierung von nukleinsäuren
ATE168136T1 (de) Nichtradioaktive dns-sequenzierung
DE69632643D1 (de) Verwendungen von nukleinsäuren die ein retrovirus aus schweinen entnommen sind
DK0920501T3 (da) Neuritin, et neurogen
ATE371740T1 (de) Phosphodiesterasen
DK1129191T3 (da) Fremgangsmåder til diagnosticering eller behandling af neurologiske sygdomme
NZ515315A (en) Blocked nucleotides, removable by monochromatic light, for use in nucleic acid sequence analysis
IS3445A7 (is) Aðferð til greiningar byggingareininga kjarnasýrukeðja
EE9600101A (et) Vahend ja meetod DNA nukleotiidide järjestuse määramiseks laserspektroskoopia abil
DE3782288D1 (de) Verfahren zum waermebehandeln von rasch abgeschreckten fe-6,5% si-baendern.
FI873674A (fi) --2-plasmin-inhibitorliknande protein kodande dna.
SE9403170D0 (sv) Process for nucleic acid hybridisation analysis