MX2020014061A - Sistemas de deteccion. - Google Patents

Sistemas de deteccion.

Info

Publication number
MX2020014061A
MX2020014061A MX2020014061A MX2020014061A MX2020014061A MX 2020014061 A MX2020014061 A MX 2020014061A MX 2020014061 A MX2020014061 A MX 2020014061A MX 2020014061 A MX2020014061 A MX 2020014061A MX 2020014061 A MX2020014061 A MX 2020014061A
Authority
MX
Mexico
Prior art keywords
electrically conductive
unbound
sensing system
conductive channel
charge configuration
Prior art date
Application number
MX2020014061A
Other languages
English (en)
Inventor
Boyan Boyanov
Jeffrey G Mandell
Sergio Peisajovich
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of MX2020014061A publication Critical patent/MX2020014061A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/12—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid, for detecting components in the fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/12—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid, for detecting components in the fluid
    • G01N27/125—Composition of the body, e.g. the composition of its sensitive layer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/12—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid, for detecting components in the fluid
    • G01N27/128—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/548—Carbohydrates, e.g. dextran
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/607—Detection means characterised by use of a special device being a sensor, e.g. electrode

Abstract

Un sistema de detección incluye un sensor de carga que incluye dos electrodos y un canal conductor de electricidad que conecta los dos electrodos. El sistema de detección también incluye una molécula cargada unida al canal conductor de electricidad. La molécula cargada incluye un sitio de reconocimiento para la unión reversible de un marcador de un nucleótido marcado; tiene una conformación favorecida no unida asociada a una configuración de carga no unida; y tiene una conformación favorecida asociada a una configuración de carga cuando el sitio de reconocimiento está unido al marcador. La configuración de carga es diferente de la configuración de carga no unida. El sistema de detección incluye adicionalmente una polimerasa unida al canal conductor de electricidad o a la molécula cargada.
MX2020014061A 2018-12-21 2019-12-03 Sistemas de deteccion. MX2020014061A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862783951P 2018-12-21 2018-12-21
PCT/US2019/064189 WO2020131352A1 (en) 2018-12-21 2019-12-03 Sensing systems

Publications (1)

Publication Number Publication Date
MX2020014061A true MX2020014061A (es) 2021-05-27

Family

ID=71097473

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020014061A MX2020014061A (es) 2018-12-21 2019-12-03 Sistemas de deteccion.

Country Status (14)

Country Link
US (1) US11782006B2 (es)
EP (1) EP3899542A4 (es)
JP (1) JP2022510063A (es)
KR (1) KR20210095796A (es)
CN (1) CN112689760A (es)
AU (1) AU2019403889A1 (es)
BR (1) BR112020026394A2 (es)
CA (1) CA3103296A1 (es)
IL (1) IL279519B1 (es)
MX (1) MX2020014061A (es)
PH (1) PH12020552296A1 (es)
SG (1) SG11202012396QA (es)
TW (1) TWI753333B (es)
WO (1) WO2020131352A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022297010A1 (en) * 2021-06-23 2024-01-18 Royal Melbourne Institute Of Technology Conductometric sensor for detecting a bioanalyte and a method for the detection thereof

Family Cites Families (20)

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KR100664331B1 (ko) 1997-07-28 2007-01-02 메디칼 바이오시스템스 리미티드 핵산 서열 분석
GB9803382D0 (en) 1998-02-19 1998-04-15 Secr Defence Detection system
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US8241573B2 (en) * 2006-03-31 2012-08-14 Illumina, Inc. Systems and devices for sequence by synthesis analysis
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WO2010093223A2 (ko) * 2009-02-16 2010-08-19 동국대학교산합협력단 압타머를 이용한 타겟물질의 검출 방법
US9353412B2 (en) * 2010-06-18 2016-05-31 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
WO2012045012A2 (en) * 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
EA022475B1 (ru) 2010-10-19 2016-01-29 Ооо "Центр Инновационных Технологий-Нано" Способ секвенирования днк
US9164053B2 (en) * 2011-09-26 2015-10-20 The Regents Of The University Of California Electronic device for monitoring single molecule dynamics
JP6095681B2 (ja) * 2011-11-23 2017-03-15 ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント 多用途かつ感度の高いバイオセンサー
WO2013082619A1 (en) * 2011-12-01 2013-06-06 Genapsys, Inc. Systems and methods for high efficiency electronic sequencing and detection
US9809852B2 (en) 2013-03-15 2017-11-07 Genapsys, Inc. Systems and methods for biological analysis
CN111187811B (zh) 2013-05-06 2024-03-08 加利福尼亚太平洋生物科学股份有限公司 实时电子测序
TW201502276A (zh) 2013-07-09 2015-01-16 Univ Nat Chiao Tung 單分子無標定核酸定序方法
US9683958B2 (en) * 2013-09-11 2017-06-20 Agilent Technologies, Inc. Nanofluidic device for charge analysis of straightened molecules
US20150316502A1 (en) 2013-12-03 2015-11-05 FemtoDx Debye length modulation
SG11201700348VA (en) * 2014-07-15 2017-02-27 Illumina Inc Biochemically activated electronic device
JP6692831B2 (ja) * 2015-05-12 2020-05-13 イラミーナ インコーポレーテッド 核酸をシーケンシングするための電界効果装置および方法
KR101758355B1 (ko) * 2016-01-28 2017-07-31 한국과학기술연구원 비침습적 이온 감응 소변 센서

Also Published As

Publication number Publication date
IL279519B1 (en) 2024-04-01
EP3899542A1 (en) 2021-10-27
US11782006B2 (en) 2023-10-10
PH12020552296A1 (en) 2021-12-13
CA3103296A1 (en) 2020-06-25
AU2019403889A1 (en) 2021-01-14
TWI753333B (zh) 2022-01-21
WO2020131352A1 (en) 2020-06-25
TW202032118A (zh) 2020-09-01
IL279519A (en) 2021-01-31
KR20210095796A (ko) 2021-08-03
BR112020026394A2 (pt) 2021-03-23
CN112689760A (zh) 2021-04-20
JP2022510063A (ja) 2022-01-26
US20200200693A1 (en) 2020-06-25
SG11202012396QA (en) 2021-01-28
EP3899542A4 (en) 2022-09-14

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