IS2092B - 8-azabísýkló(3,2,1)okt-2-en og oktanafleiður sem kólínergir bindlar á nikótín ach viðtakanum - Google Patents
8-azabísýkló(3,2,1)okt-2-en og oktanafleiður sem kólínergir bindlar á nikótín ach viðtakanumInfo
- Publication number
- IS2092B IS2092B IS5243A IS5243A IS2092B IS 2092 B IS2092 B IS 2092B IS 5243 A IS5243 A IS 5243A IS 5243 A IS5243 A IS 5243A IS 2092 B IS2092 B IS 2092B
- Authority
- IS
- Iceland
- Prior art keywords
- thienyl
- azabicyclo
- oct
- ene
- benzofuryl
- Prior art date
Links
- SURHOQQBDZIWSO-UHFFFAOYSA-N 8-azabicyclo[3.2.1]oct-3-ene Chemical compound N1C2CCC1C=CC2 SURHOQQBDZIWSO-UHFFFAOYSA-N 0.000 title abstract 2
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 title 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 title 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical class CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 title 1
- -1 2-(3-methoxymethyl) Chemical group 0.000 abstract 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000016160 smooth muscle contraction Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 201000009032 substance abuse Diseases 0.000 abstract 1
- 231100000736 substance abuse Toxicity 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Pregnancy & Childbirth (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK62797 | 1997-05-30 | ||
| DK150297 | 1997-12-19 | ||
| DK40898 | 1998-03-24 | ||
| DK53498 | 1998-04-16 | ||
| PCT/DK1998/000225 WO1998054181A1 (en) | 1997-05-30 | 1998-05-29 | 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IS5243A IS5243A (is) | 1999-11-10 |
| IS2092B true IS2092B (is) | 2006-04-12 |
Family
ID=27439314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS5243A IS2092B (is) | 1997-05-30 | 1999-11-10 | 8-azabísýkló(3,2,1)okt-2-en og oktanafleiður sem kólínergir bindlar á nikótín ach viðtakanum |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6645977B1 (enExample) |
| EP (1) | EP0984965B1 (enExample) |
| JP (1) | JP4447663B2 (enExample) |
| KR (1) | KR100589872B1 (enExample) |
| CN (1) | CN1157392C (enExample) |
| AT (1) | ATE267199T1 (enExample) |
| AU (1) | AU745964B2 (enExample) |
| BR (1) | BR9809697A (enExample) |
| CA (1) | CA2289574C (enExample) |
| CZ (1) | CZ298824B6 (enExample) |
| DE (1) | DE69823994T2 (enExample) |
| DK (1) | DK0984965T3 (enExample) |
| EE (1) | EE04057B1 (enExample) |
| HU (1) | HUP0002713A3 (enExample) |
| IL (2) | IL132437A0 (enExample) |
| IS (1) | IS2092B (enExample) |
| NO (1) | NO325513B1 (enExample) |
| NZ (1) | NZ500642A (enExample) |
| RU (1) | RU2186780C2 (enExample) |
| SK (1) | SK284994B6 (enExample) |
| TR (1) | TR199902942T2 (enExample) |
| WO (1) | WO1998054181A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5790598A (en) * | 1996-12-02 | 1998-06-29 | Georgetown University | Tropane derivatives and method for their synthesis |
| JP2002518331A (ja) | 1998-06-19 | 2002-06-25 | イーライ・リリー・アンド・カンパニー | セロトニン再取り込みの阻害 |
| US6218383B1 (en) * | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| EP1382605A3 (en) * | 1998-11-27 | 2004-09-15 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene derivatives and their use as nAChR ligands |
| US6432975B1 (en) * | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
| DE60007841T2 (de) | 1999-01-28 | 2004-07-08 | Neurosearch A/S | Neue azabicyclo derivate und ihre verwendung |
| DE60006213T2 (de) * | 1999-01-29 | 2004-07-29 | Abbott Laboratories, Abbott Park | Diazabicyloderivate als nikotin-acetylcholin-rezeptorliganden |
| US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| CA2365258A1 (en) * | 1999-05-04 | 2000-11-09 | Neurosearch A/S | Heteroaryl diazabicycloalkanes, their preparation and use |
| US6890935B2 (en) | 1999-11-01 | 2005-05-10 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| MY137020A (en) * | 2000-04-27 | 2008-12-31 | Abbott Lab | Diazabicyclic central nervous system active agents |
| CN1185233C (zh) * | 2000-07-04 | 2005-01-19 | 神经研究公司 | 芳基和杂芳基－二氮杂双环烷烃,其制备和用途 |
| DE60122015T2 (de) * | 2000-10-13 | 2006-11-23 | Neurosearch A/S | Behandlung affektiver störungen durch kombinierte wirkung eines nikotinischen rezeptoragonisten und einer monoaminergischen substanz |
| US6911543B2 (en) * | 2001-10-02 | 2005-06-28 | Pfizer Inc. | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| JP2005523288A (ja) | 2002-02-19 | 2005-08-04 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 疾病治療用の縮合した二環式−ｎ−架橋−複素環式芳香族カルボキサミド |
| CA2480378A1 (en) * | 2002-05-07 | 2003-11-20 | Neurosearch A/S | Novel azacyclic ethynyl derivatives |
| GB2398636A (en) * | 2003-02-21 | 2004-08-25 | Ipsen Ltd | Method for determining the quantity of pre-synaptic neuromuscular blocking substance contained in a sample |
| EP1601664B1 (en) * | 2003-02-28 | 2008-04-30 | Schering Corporation | Biaryltetrahydroisoquinoline piperidines as selective mch receptor antagonists for the treatment of obesity and related disorders |
| AU2004220327B2 (en) | 2003-03-12 | 2010-06-24 | Pfizer Products Inc. | Pyridyloxymethyl and benzisoxazole azabicyclic derivatives |
| CA2580329C (en) | 2004-09-13 | 2015-01-06 | Chrono Therapeutics Inc. | Biosynchronous transdermal drug delivery |
| US20060173037A1 (en) * | 2005-01-10 | 2006-08-03 | Nathalie Schlienger | Aminophenyl derivatives as selective androgen receptor modulators |
| ATE495178T1 (de) | 2005-02-16 | 2011-01-15 | Neurosearch As | Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin- acetylcholin-rezeptoren |
| DE102005007859A1 (de) * | 2005-02-21 | 2006-08-24 | Lts Lohmann Therapie-Systeme Ag | Vefahren für eine medikamentöse Kombinations-Behandlung, sowie hierfür geeignete Arzneimittel-Kombinationen |
| WO2006108790A1 (en) * | 2005-04-08 | 2006-10-19 | Neurosearch A/S | (+) - and (-) -8-alkyl-3-(trifluoralkylsulfonyloxy)-8-azabicycl (3.2.1.)oct-2-ene |
| FR2889701B1 (fr) | 2005-08-12 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique. |
| EP1963323B1 (en) | 2005-12-06 | 2010-07-14 | Neurosearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
| US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
| AU2007213670A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US7700596B2 (en) | 2006-02-10 | 2010-04-20 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP1987031A1 (en) | 2006-02-10 | 2008-11-05 | NeuroSearch A/S | 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| US20090247570A1 (en) * | 2006-06-12 | 2009-10-01 | Pfizer Inc | Pharmaceuticals |
| EP1977746B8 (en) | 2007-04-02 | 2014-09-24 | Parkinson's Institute | Methods and compositions for reduction of side effects of therapeutic treatments |
| TWI415850B (zh) * | 2007-07-20 | 2013-11-21 | Theravance Inc | 製備ｍｕ類鴉片受體拮抗劑之中間物的方法 |
| SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| US8697722B2 (en) * | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
| WO2010014257A2 (en) * | 2008-08-01 | 2010-02-04 | Purdue Pharma L.P. | Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof |
| JP2012509354A (ja) * | 2008-11-18 | 2012-04-19 | ノイロサーチ アクティーゼルスカブ | ８−アザビシクロ［３．２．１］オクタ−２−エン誘導体及びモノアミン神経伝達物質再取込阻害剤としてのそれらの使用 |
| SI2889033T1 (en) | 2008-11-19 | 2018-08-31 | Forum Pharmaceuticals Inc. | Treatment of negative symptoms of schizophrenia with (R) -7-chloro-N- (chonylidin-3-yl) benzo (B) thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| WO2010132423A1 (en) * | 2009-05-11 | 2010-11-18 | Envivo Pharmaceuticals, Inc. | Treatment of cognitive disorders with certain alpha-7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors |
| EP2523562B1 (en) * | 2010-01-11 | 2019-01-02 | Astraea Therapeutics, LLC | Nicotinic acetylcholine receptor modulators |
| CN103221411B (zh) | 2010-05-17 | 2016-05-11 | 富瑞姆制药公司 | (R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺盐酸盐单水合物的晶型 |
| AU2013259871A1 (en) | 2012-05-08 | 2014-11-20 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
| WO2014011768A1 (en) * | 2012-07-10 | 2014-01-16 | Adispell, Inc. | Anti-anxiety treatment |
| CA2974324A1 (en) | 2015-01-28 | 2016-08-04 | Zita S. Netzel | Drug delivery methods and systems |
| US9724340B2 (en) | 2015-07-31 | 2017-08-08 | Attenua, Inc. | Antitussive compositions and methods |
| EP3565617A1 (en) | 2017-01-06 | 2019-11-13 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| CA3119992A1 (en) | 2018-11-16 | 2020-05-22 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
| KR102272452B1 (ko) | 2020-12-11 | 2021-07-05 | (주)예광솔라 | 스파이럴 파일 공법 및 이에 적용되는 스파이럴 파일 |
| KR200497569Y1 (ko) | 2021-02-18 | 2023-12-21 | 주식회사 알파인랩 | 지주 기초용 스크루 파일 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133073A (en) * | 1959-12-10 | 1964-05-12 | Sterling Drug Inc | 3-aryl-1, 5-iminocycloalkanes and preparation thereof |
| US3657257A (en) * | 1970-08-31 | 1972-04-18 | Robins Co Inc A H | 3-aryl-8-carbamoyl nortropanes |
| CA1244028A (en) | 1983-04-14 | 1988-11-01 | Hans Maag | Pyrimidine derivatives |
| GB9019973D0 (en) | 1990-09-12 | 1990-10-24 | Wyeth John & Brother Ltd | Azabicyclic derivatives |
| US5045546A (en) | 1990-10-26 | 1991-09-03 | Hoechst-Roussel Pharmaceuticals Inc. | 8-azabicyclo[3.2.1]octylalkylthiazolidines |
| FI111367B (fi) | 1991-02-04 | 2003-07-15 | Aventis Pharma Inc | Menetelmä terapeuttisesti käyttökelpoisten N-(aryylioksialkyyli)heteroaryyli-8-atsabisyklo[3.2.1]oktaanijohdannaisten valmistamiseksi ja menetelmässä käytetyt välituotteet |
| EP0588917B1 (en) * | 1991-05-29 | 2000-11-08 | Abbott Laboratories | Isoxazole and isothiazole compounds that enhance cognitive function |
| US5731317A (en) * | 1995-03-10 | 1998-03-24 | Merck & Co., Inc. | Bridged piperidines promote release of growth hormone |
| GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
| AU7083596A (en) * | 1995-09-22 | 1997-04-09 | Novo Nordisk A/S | Novel substituted azacyclic or azabicyclic compounds |
| KR100274829B1 (ko) * | 1995-10-13 | 2000-12-15 | 페더 벨링 | 8-아자바이사이클로[3,2,1]-옥트-2-엔 유도체의 제조방법 및 용도 |
| GB9706222D0 (en) * | 1997-03-26 | 1997-05-14 | Zeneca Ltd | Bicyclic amine derivatives |
| EP0955301A3 (en) * | 1998-04-27 | 2001-04-18 | Pfizer Products Inc. | 7-aza-bicyclo[2.2.1]-heptane derivatives, their preparation and use according to their affinity for neuronal nicotinic acetylcholine receptors |
| JP2002518331A (ja) * | 1998-06-19 | 2002-06-25 | イーライ・リリー・アンド・カンパニー | セロトニン再取り込みの阻害 |
-
1998
- 1998-05-29 HU HU0002713A patent/HUP0002713A3/hu unknown
- 1998-05-29 CA CA002289574A patent/CA2289574C/en not_active Expired - Fee Related
- 1998-05-29 AU AU74261/98A patent/AU745964B2/en not_active Ceased
- 1998-05-29 KR KR1019997011137A patent/KR100589872B1/ko not_active Expired - Fee Related
- 1998-05-29 TR TR1999/02942T patent/TR199902942T2/xx unknown
- 1998-05-29 CZ CZ0414799A patent/CZ298824B6/cs not_active IP Right Cessation
- 1998-05-29 SK SK1626-99A patent/SK284994B6/sk not_active IP Right Cessation
- 1998-05-29 EE EEP199900529A patent/EE04057B1/xx not_active IP Right Cessation
- 1998-05-29 EP EP98921378A patent/EP0984965B1/en not_active Expired - Lifetime
- 1998-05-29 BR BR9809697-4A patent/BR9809697A/pt not_active Application Discontinuation
- 1998-05-29 DK DK98921378T patent/DK0984965T3/da active
- 1998-05-29 IL IL13243798A patent/IL132437A0/xx active IP Right Grant
- 1998-05-29 RU RU99128075/04A patent/RU2186780C2/ru not_active IP Right Cessation
- 1998-05-29 AT AT98921378T patent/ATE267199T1/de not_active IP Right Cessation
- 1998-05-29 JP JP50013099A patent/JP4447663B2/ja not_active Expired - Fee Related
- 1998-05-29 CN CNB988054132A patent/CN1157392C/zh not_active Expired - Fee Related
- 1998-05-29 DE DE69823994T patent/DE69823994T2/de not_active Expired - Lifetime
- 1998-05-29 NZ NZ500642A patent/NZ500642A/en unknown
- 1998-05-29 WO PCT/DK1998/000225 patent/WO1998054181A1/en not_active Ceased
-
1999
- 1999-10-17 IL IL132437A patent/IL132437A/en not_active IP Right Cessation
- 1999-11-10 IS IS5243A patent/IS2092B/is unknown
- 1999-11-29 US US09/450,637 patent/US6645977B1/en not_active Expired - Fee Related
- 1999-11-29 NO NO19995850A patent/NO325513B1/no not_active IP Right Cessation
-
2003
- 2003-07-17 US US10/620,559 patent/US6964972B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IS2092B (is) | 8-azabísýkló(3,2,1)okt-2-en og oktanafleiður sem kólínergir bindlar á nikótín ach viðtakanum | |
| US8624040B2 (en) | Substituted hydroxamic acids and uses thereof | |
| TWI357903B (en) | Diazabicyclic central nervous system active agents | |
| RU99128075A (ru) | Производные 8-азабицикло(3,2,1)окт-2-ена и-октана в качестве холинергических лигандов на ацх-рецепторах | |
| KR100614900B1 (ko) | 질병의 치료를 위한 아자비시클릭-치환된 융합-헤테로아릴화합물 | |
| US7135484B2 (en) | Azabicyclic compounds are central nervous system active agents | |
| US20090264411A1 (en) | Fused thiophene derivatives as mek inhibitors | |
| AU774337B2 (en) | Condensed indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands | |
| AU2003248592A1 (en) | Biaryl diazabicycloalkane amides as nicotinic acetylcholine agonists | |
| HU211575A9 (en) | 2-methyl-thieno-benzodiazepine | |
| PT853083E (pt) | Composto de piridilfurano e piridiltiofeno e sua utilizacao farmaceutica | |
| WO2005023819A1 (en) | Thienopyrroles as antiviral agents | |
| AU2007269646A1 (en) | Fused heterocyclic inhibitors of D-amino acid oxidase | |
| US7041695B2 (en) | N-sulfonylheterocyclopyrrolyl-alkylamine compounds as 5-hydroxytryptamine-6 ligands | |
| IL83066A (en) | N-(3-substituted phenyl)-3-(3-pyridyl)-1h,3h-pyrrolo(1,2-c)thiazole-7-carboxamide derivatives,preparation thereof and pharmaceutical compositions containing them | |
| JP2003524633A (ja) | キノリンおよびナフチリジンカルボン酸抗菌剤 | |
| DK0534343T3 (da) | Substituerede pyridinylamino-1H-indoler, 1H-indazoler, 2H-indazoler, benzo[b]thiophener og 1,2-benzoisothiazoler, fremgangs | |
| WO2005056562A1 (en) | Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxylic acid amide compounds as ikk inhibitors | |
| US20090325933A1 (en) | Pyrimidinone Derivatives and Their Use as a Drug | |
| Suresh et al. | α-Oxoketene Dithioacetals Mediated Benzoannelation of Aromatic Heterocycles: an Efficient Regiocontrolled Synthesis of Highly Substituted and Polycyclic Benzo [b] thiophenes | |
| MXPA05003972A (es) | Abridor de canal de k activado por calcio de alta conductancia. | |
| WO2010045008A1 (en) | AMIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS | |
| Singh et al. | A Novel Radical Cyclization Approach to Thieno‐Fused Heterocycles | |
| Press | Biologically active thiophene derivatives revisited: 1983–1988 | |
| Attanasi et al. | Synthesis of biphenylyltetrazole derivatives of 1-aminopyrroles as angiotensin II antagonists |