IN2015DN02771A - - Google Patents
Download PDFInfo
- Publication number
- IN2015DN02771A IN2015DN02771A IN2771DEN2015A IN2015DN02771A IN 2015DN02771 A IN2015DN02771 A IN 2015DN02771A IN 2771DEN2015 A IN2771DEN2015 A IN 2771DEN2015A IN 2015DN02771 A IN2015DN02771 A IN 2015DN02771A
- Authority
- IN
- India
- Prior art keywords
- nucleic acid
- poi
- host cell
- leader
- secretion
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12190361 | 2012-10-29 | ||
| PCT/EP2013/072572 WO2014067926A1 (en) | 2012-10-29 | 2013-10-29 | Expression sequences |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN02771A true IN2015DN02771A (enrdf_load_stackoverflow) | 2015-09-04 |
Family
ID=47115533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2771DEN2015 IN2015DN02771A (enrdf_load_stackoverflow) | 2012-10-29 | 2013-10-29 |
Country Status (16)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013341049B2 (en) * | 2012-10-29 | 2017-07-20 | Lonza Ltd | Expression sequences |
| CN104312933B (zh) * | 2014-10-17 | 2017-03-29 | 江南大学 | 一种优化信号肽提高胰蛋白酶胞外分泌表达的方法 |
| TW201718859A (zh) * | 2015-08-05 | 2017-06-01 | 隆查有限公司 | 啟動子變體 |
| US11377677B2 (en) | 2016-03-02 | 2022-07-05 | Lonza Ltd | Fermentation process |
| JP7063486B2 (ja) * | 2017-03-10 | 2022-05-09 | ボルト スレッズ インコーポレイテッド | 高分泌収量の組み換えタンパク質を産生するための組成物及び方法 |
| WO2018219995A1 (en) | 2017-05-31 | 2018-12-06 | Universität Für Bodenkultur Wien | Yeast expressing a synthetic calvin cycle |
| CA3089682A1 (en) | 2018-02-12 | 2019-08-15 | Lonza Ltd | Host cell for producing a protein of interest |
| WO2020106600A1 (en) | 2018-11-19 | 2020-05-28 | Basf Se | Leader sequence for yeast |
| DK3874047T4 (da) | 2019-01-11 | 2025-02-03 | Lonza Ag | Karbonkilde-reguleret proteinproduktion i en rekombinant værtscelle |
| WO2020200414A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Protein production in mut-methylotrophic yeast |
| WO2020200415A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Mut- methylotrophic yeast |
| HUE064229T2 (hu) | 2019-04-01 | 2024-02-28 | Univ Wien Bodenkultur | Mut-metilotróf élesztõ |
| CN110760003A (zh) * | 2019-09-10 | 2020-02-07 | 广东药科大学 | 一种抗her3单链抗体的制备方法 |
| EP4127185B1 (en) | 2020-04-01 | 2025-06-04 | Lonza Ltd. | Helper factors for expressing proteins in yeast |
| JP2023543604A (ja) | 2020-09-30 | 2023-10-17 | ロンザ リミテッド | 翻訳因子を過剰発現する宿主細胞 |
| US20240400974A1 (en) | 2020-12-29 | 2024-12-05 | Bisy Gmbh | Novel yeast strains |
| CN117794941A (zh) * | 2021-07-30 | 2024-03-29 | 赫莱纳公司 | 用于蛋白质合成和分泌的方法和组合物 |
| EP4175968B1 (en) * | 2021-07-30 | 2024-07-03 | Helaina, Inc. | Methods and compositions for protein synthesis and secretion |
| WO2024133538A1 (en) | 2022-12-20 | 2024-06-27 | Lonza Ltd | Host cells with pat1 knockout for increased specific protein productivity |
| WO2024141641A2 (en) * | 2022-12-30 | 2024-07-04 | Biotalys NV | Secretion signals |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984001153A1 (en) | 1982-09-15 | 1984-03-29 | Collaborative Res Inc | Production of interferon in yeast by use of invertase promoter |
| US5010182A (en) | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
| CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
| ATE220721T1 (de) | 1990-01-16 | 2002-08-15 | Ct Ingenieria Genetica Biotech | Verfahren zur expression heterologischer gene in der hefe pichia pastoris, expressionsvektoren und transformierte mikroorganismen |
| US5268273A (en) | 1990-12-14 | 1993-12-07 | Phillips Petroleum Company | Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same |
| DK82893D0 (da) | 1993-07-08 | 1993-07-08 | Novo Nordisk As | Peptid |
| CN101679992A (zh) | 2007-04-20 | 2010-03-24 | 波利门科学生物免疫研究有限公司 | 酵母菌表达系统 |
| US7741075B2 (en) | 2008-06-06 | 2010-06-22 | Board Of Regents Of The University Of Nebraska | Pichia pastoris PIR1 secretion signal peptide for recombinant protein expression and Pichia pastoris PIR1 and PIR2 anchor domain peptides for recombinant surface display |
| WO2010135678A1 (en) | 2009-05-22 | 2010-11-25 | Research Corporation Technologies, Inc. | Nucleic acids of pichia pastoris and use thereof for recombinant production of proteins |
| EP2258855A1 (en) * | 2009-05-28 | 2010-12-08 | Universität für Bodenkultur Wien | Expression sequences |
| DE102009055015B4 (de) | 2009-12-18 | 2013-12-24 | Technische Universität Dresden | Hefe-Sekretionssystem auf Basis einer Signalsequenz aus der Hydrophobin 1-Gensequenz von Trichoderma reesei |
| EP2707382B1 (en) | 2011-05-09 | 2019-07-17 | Ablynx NV | Method for the production of immunoglobulin single variable domains |
| AU2013341049B2 (en) * | 2012-10-29 | 2017-07-20 | Lonza Ltd | Expression sequences |
-
2013
- 2013-10-29 AU AU2013341049A patent/AU2013341049B2/en not_active Ceased
- 2013-10-29 PL PL13785840T patent/PL2912053T3/pl unknown
- 2013-10-29 IN IN2771DEN2015 patent/IN2015DN02771A/en unknown
- 2013-10-29 ES ES16184950T patent/ES2789299T3/es active Active
- 2013-10-29 CN CN201380056279.9A patent/CN104837857B/zh active Active
- 2013-10-29 EP EP16184950.0A patent/EP3130598B1/en active Active
- 2013-10-29 US US14/435,581 patent/US10160988B2/en active Active
- 2013-10-29 BR BR112015008289A patent/BR112015008289A2/pt not_active Application Discontinuation
- 2013-10-29 CA CA3212565A patent/CA3212565A1/en active Pending
- 2013-10-29 WO PCT/EP2013/072572 patent/WO2014067926A1/en active Application Filing
- 2013-10-29 EP EP13785840.3A patent/EP2912053B1/en active Active
- 2013-10-29 HU HUE13785840A patent/HUE033282T2/en unknown
- 2013-10-29 CA CA2886460A patent/CA2886460C/en active Active
- 2013-10-29 ES ES13785840.3T patent/ES2610990T3/es active Active
- 2013-10-29 JP JP2015540103A patent/JP6556625B2/ja active Active
- 2013-10-29 SG SG11201502745XA patent/SG11201502745XA/en unknown
- 2013-10-29 KR KR1020157009776A patent/KR102079293B1/ko active Active
- 2013-10-29 DK DK13785840.3T patent/DK2912053T3/da active
-
2015
- 2015-04-21 IL IL238420A patent/IL238420B/en active IP Right Grant
-
2018
- 2018-01-02 US US15/860,186 patent/US11359223B2/en active Active
-
2019
- 2019-04-01 JP JP2019069948A patent/JP2019141063A/ja not_active Withdrawn
- 2019-05-16 IL IL266700A patent/IL266700B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2015DN02771A (enrdf_load_stackoverflow) | ||
| PH12019500694A1 (en) | Factor viii compositions and methods of making and using the same | |
| IN2014CN04586A (enrdf_load_stackoverflow) | ||
| EP4477734A3 (en) | Protease variants and polynucleotides encoding same | |
| IN2014CN02469A (enrdf_load_stackoverflow) | ||
| NZ712168A (en) | Synthetic brassica-derived chloroplast transit peptides | |
| MX337984B (es) | Variantes de alfa amilasa y polinucleotidos que codifican la misma. | |
| MX351565B (es) | Colageno 7 y metodos relacionados. | |
| EP4223772A3 (en) | Optimized factor viii gene | |
| IN2014CN00597A (enrdf_load_stackoverflow) | ||
| MX355356B (es) | Variantes de alfa-amilasa y polinucleotidos que codifican las mismas. | |
| MX2020003508A (es) | Un factor de secrecion de proteinas con alta eficacia secretora y un vector de expresion que lo comprende. | |
| MX2014004539A (es) | Variantes de alfa-amilasa y polinucleotidos que codifican las mismas. | |
| WO2013119302A3 (en) | Gh61 polypeptide variants and polynucleotides encoding same | |
| MX349517B (es) | Polipeptidos que tienen actividad de proteasa y polinucleotidos que codifican los mismos. | |
| IN2015DN03206A (enrdf_load_stackoverflow) | ||
| WO2013163590A3 (en) | Gh61 polypeptide variants and polynucleotides encoding same | |
| MX2015010078A (es) | Uso de polipeptidos con actividad proteasa en alimentos para animales. | |
| MX2016012840A (es) | Moléculas para transporte de antígeno modular mejoradas y sus usos. | |
| IN2014CN03187A (enrdf_load_stackoverflow) | ||
| MX2014003403A (es) | Polipeptidos que poseen actividad proteasa y polinucleotidos que los codifican. | |
| MX2014007446A (es) | Variantes de subtilasa y polinucleotidos que las codifican. | |
| MX2015012281A (es) | Proteinas de union a tnf mejoradas. | |
| MX2016007109A (es) | Proteina estructurante de hielo. | |
| MX2016006586A (es) | Identificacion de una citocina de linfocitos b novedosa. |