IN2014MN02393A - - Google Patents

Info

Publication number
IN2014MN02393A
IN2014MN02393A IN2393MUN2014A IN2014MN02393A IN 2014MN02393 A IN2014MN02393 A IN 2014MN02393A IN 2393MUN2014 A IN2393MUN2014 A IN 2393MUN2014A IN 2014MN02393 A IN2014MN02393 A IN 2014MN02393A
Authority
IN
India
Prior art keywords
derivatives
intreating
diseases
modulation
processes
Prior art date
Application number
Other languages
English (en)
Inventor
Gerard M P Giblin
David T Macpherson
David R Witty
Steven J Stanway
Original Assignee
Convergence Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Convergence Pharmaceuticals filed Critical Convergence Pharmaceuticals
Publication of IN2014MN02393A publication Critical patent/IN2014MN02393A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IN2393MUN2014 2012-05-22 2013-05-22 IN2014MN02393A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261650325P 2012-05-22 2012-05-22
GB201209015A GB201209015D0 (en) 2012-05-22 2012-05-22 Novel compounds
US201361773710P 2013-03-06 2013-03-06
PCT/GB2013/051335 WO2013175205A1 (fr) 2012-05-22 2013-05-22 Nouveaux composés

Publications (1)

Publication Number Publication Date
IN2014MN02393A true IN2014MN02393A (fr) 2015-08-21

Family

ID=46546493

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2393MUN2014 IN2014MN02393A (fr) 2012-05-22 2013-05-22

Country Status (28)

Country Link
US (7) US9309254B2 (fr)
EP (3) EP2861594B1 (fr)
JP (3) JP6169687B2 (fr)
KR (2) KR20200113027A (fr)
CN (2) CN107344942B (fr)
AU (3) AU2013265001B2 (fr)
BR (1) BR112014029280B1 (fr)
CA (1) CA2873956C (fr)
CY (2) CY1118274T1 (fr)
DK (2) DK3106464T3 (fr)
EA (1) EA025579B1 (fr)
ES (3) ES2602308T3 (fr)
GB (1) GB201209015D0 (fr)
HK (1) HK1209423A1 (fr)
HR (2) HRP20161349T1 (fr)
HU (2) HUE031664T2 (fr)
IL (4) IL235805A (fr)
IN (1) IN2014MN02393A (fr)
LT (2) LT2861602T (fr)
MX (1) MX355303B (fr)
PL (2) PL2861602T3 (fr)
PT (2) PT2861602T (fr)
RS (2) RS60368B1 (fr)
SG (2) SG10201703527WA (fr)
SI (2) SI2861602T1 (fr)
SM (1) SMT201600421B (fr)
WO (2) WO2013175206A1 (fr)
ZA (1) ZA201408253B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
US20200255438A1 (en) * 2017-09-28 2020-08-13 Biogen Inc. Novel salts
JP2020536898A (ja) 2017-10-10 2020-12-17 バイオジェン インコーポレイテッド スピロ誘導体を調製するためのプロセス
WO2022133097A1 (fr) * 2020-12-17 2022-06-23 Biogen Ma Inc. Synthèse de composés qui modulent des canaux sodiques sensibles à la tension en fonction de l'utilisation

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05000370A (es) * 2002-07-05 2005-04-19 Targacept Inc Compuestos n-aril diazaespiraciclicos y metodos de preparacion y usos de los mismos.
TW200728258A (en) * 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
ATE472529T1 (de) 2005-10-10 2010-07-15 Glaxo Group Ltd Prolinamidderivate als natriumkanalmodulatoren
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
GB0520578D0 (en) * 2005-10-10 2005-11-16 Glaxo Group Ltd Novel compounds
US8143306B2 (en) 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
WO2007047474A2 (fr) * 2005-10-12 2007-04-26 Vertex Pharmaceuticals Incorporated Derives de biphenyle utilises comme modulateurs des canaux ioniques sensibles au voltage
WO2007084314A2 (fr) * 2006-01-12 2007-07-26 Incyte Corporation MODULATEURS de la 11-ß HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1, LEURS COMPOSITIONS PHARMACEUTIQUES ET LEURS PROCEDES D'UTILISATION
CA2666143A1 (fr) 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Derives de spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one et composes connexes utilisables pour traiter des maladies dont la mediation est assuree par les canaux sodiques, comme la douleur
MX2009003874A (es) * 2006-10-12 2009-04-22 Xenon Pharmaceuticals Inc Derivados de espiro-oxindol triciclicos y sus usos como agentes terapeuticos.
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
WO2008090114A1 (fr) 2007-01-24 2008-07-31 Glaxo Group Limited Compositions pharmaceutiques contenant du 2-méthoxy-5- (5-trifluorométhyl-tétrazol-i-yl-benzyl) - (2s-phényl-pipéridin-3s-yl-)
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) * 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
AR077252A1 (es) * 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
WO2011029762A1 (fr) 2009-09-14 2011-03-17 Convergence Pharmaceuticals Limited Procédé de préparation de dérivés alpha-carboxamides
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
KR20140139000A (ko) * 2012-03-21 2014-12-04 인터디지탈 패튼 홀딩스, 인크 무선 네트워크에서 다른 이동국에 의한 이동국 세션의 스폰서링
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
GB201209670D0 (en) 2012-05-31 2012-07-18 Convergence Pharmaceuticals Novel compounds

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JP6378404B2 (ja) 2018-08-22
CN107344942A (zh) 2017-11-14
BR112014029280A2 (pt) 2017-06-27
AU2018201653A1 (en) 2018-03-29
JP2015517561A (ja) 2015-06-22
IL271330A (en) 2020-01-30
JP6169687B2 (ja) 2017-07-26
IL235805A0 (en) 2015-02-01
US9376445B2 (en) 2016-06-28
IL252033B (en) 2019-12-31
KR20150023401A (ko) 2015-03-05
AU2013265001B2 (en) 2016-12-01
US20150166551A1 (en) 2015-06-18
US20170304303A1 (en) 2017-10-26
US20150119404A1 (en) 2015-04-30
SG11201407755UA (en) 2014-12-30
EA201492169A1 (ru) 2015-04-30
US9737536B2 (en) 2017-08-22
EA025579B1 (ru) 2017-01-30
KR20200113027A (ko) 2020-10-05
EP2861602B1 (fr) 2016-08-10
CA2873956C (fr) 2021-03-23
PL3106464T3 (pl) 2020-11-16
AU2017201421B2 (en) 2017-12-07
BR112014029280B1 (pt) 2022-10-04
EP3106464B1 (fr) 2020-01-08
RS55415B1 (sr) 2017-04-28
SI2861602T1 (sl) 2017-03-31
WO2013175205A1 (fr) 2013-11-28
PL2861602T3 (pl) 2017-05-31
EP2861602A1 (fr) 2015-04-22
HRP20200580T1 (hr) 2020-10-02
DK2861602T3 (en) 2016-11-28
ES2782088T3 (es) 2020-09-10
SI3106464T1 (sl) 2020-12-31
CN107344942B (zh) 2020-09-25
HUE031664T2 (en) 2017-07-28
EP2861594B1 (fr) 2016-08-24
CY1118274T1 (el) 2017-06-28
US20200289508A1 (en) 2020-09-17
ZA201408253B (en) 2015-12-23
CY1123044T1 (el) 2021-10-29
LT2861602T (lt) 2016-11-10
CN104640867A (zh) 2015-05-20
SG10201703527WA (en) 2017-06-29
US10010551B2 (en) 2018-07-03
MX355303B (es) 2018-04-12
US10485801B2 (en) 2019-11-26
ES2602308T3 (es) 2017-02-20
HRP20161349T1 (hr) 2017-01-27
LT3106464T (lt) 2020-04-10
IL252033A0 (en) 2017-06-29
PT3106464T (pt) 2020-04-03
AU2018201653B2 (en) 2019-05-02
RS60368B1 (sr) 2020-07-31
IL271330B (en) 2021-02-28
DK3106464T3 (da) 2020-03-23
HUE049445T2 (hu) 2020-09-28
JP2015517562A (ja) 2015-06-22
KR102161101B1 (ko) 2020-10-20
GB201209015D0 (en) 2012-07-04
IL280595A (en) 2021-03-25
US20160263115A1 (en) 2016-09-15
AU2013265001A1 (en) 2014-12-18
EP3106464A1 (fr) 2016-12-21
CN104640867B (zh) 2017-07-21
HK1209423A1 (en) 2016-04-01
US20160184306A1 (en) 2016-06-30
WO2013175206A1 (fr) 2013-11-28
CA2873956A1 (fr) 2013-11-28
US20180360833A1 (en) 2018-12-20
ES2602193T3 (es) 2017-02-20
JP2017206534A (ja) 2017-11-24
EP2861594A1 (fr) 2015-04-22
US9309254B2 (en) 2016-04-12
SMT201600421B (it) 2017-01-10
AU2017201421A1 (en) 2017-03-23
PT2861602T (pt) 2016-11-14
MX2014014274A (es) 2015-06-17
IL235805A (en) 2017-05-29

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