IN2014MN02106A - - Google Patents
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- Publication number
- IN2014MN02106A IN2014MN02106A IN2106MUN2014A IN2014MN02106A IN 2014MN02106 A IN2014MN02106 A IN 2014MN02106A IN 2106MUN2014 A IN2106MUN2014 A IN 2106MUN2014A IN 2014MN02106 A IN2014MN02106 A IN 2014MN02106A
- Authority
- IN
- India
- Prior art keywords
- compound
- formula
- disclosed
- preparation
- pharmaceutically acceptable
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229930195695 Halichondrin Natural products 0.000 abstract 1
- UFNVPOGXISZXJD-XJPMSQCNSA-N eribulin Chemical compound C([C@H]1CC[C@@H]2O[C@@H]3[C@H]4O[C@H]5C[C@](O[C@H]4[C@H]2O1)(O[C@@H]53)CC[C@@H]1O[C@H](C(C1)=C)CC1)C(=O)C[C@@H]2[C@@H](OC)[C@@H](C[C@H](O)CN)O[C@H]2C[C@@H]2C(=C)[C@H](C)C[C@H]1O2 UFNVPOGXISZXJD-XJPMSQCNSA-N 0.000 abstract 1
- 229960003649 eribulin Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261618004P | 2012-03-30 | 2012-03-30 | |
| US201261647127P | 2012-05-15 | 2012-05-15 | |
| PCT/CA2013/050254 WO2013142999A1 (en) | 2012-03-30 | 2013-03-28 | Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN02106A true IN2014MN02106A (cs) | 2015-09-11 |
Family
ID=49258019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2106MUN2014 IN2014MN02106A (cs) | 2012-03-30 | 2013-03-28 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9278979B2 (cs) |
| EP (1) | EP2831082B1 (cs) |
| JP (1) | JP6531911B2 (cs) |
| CN (1) | CN104334562A (cs) |
| AU (1) | AU2013239290B2 (cs) |
| CA (1) | CA2868627C (cs) |
| IN (1) | IN2014MN02106A (cs) |
| WO (1) | WO2013142999A1 (cs) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE45324E1 (en) | 2004-06-03 | 2015-01-06 | Eisai R&D Management Co., Ltd. | Intermediates for the preparation of analogs of halichondrin B |
| SG10201811715YA (en) | 2007-10-03 | 2019-02-27 | Eisai R&D Man Co Ltd | Intermediates and methods for the synthesis of halichondrin b analogs |
| BR112012018232B8 (pt) | 2010-01-26 | 2023-01-10 | Eisai R&D Man Co Ltd | Compostos derivados de furo [3,2-b] pirano úteis na síntese de análogos de halicondrina b e métodos de sintetização de er-80402 e de eribulina |
| CA2857385A1 (en) | 2011-11-30 | 2013-06-06 | Alphora Research Inc. | Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene |
| JP2015501818A (ja) | 2011-12-16 | 2015-01-19 | アルフォラ リサーチ インコーポレイテッドＡｌｐｈｏｒａ Ｒｅｓｅａｒｃｈ Ｉｎｃ． | ３−（（２ｓ，５ｓ）−４−メチレン−５−（３−オキソプロピル）テトラヒドロフラン−２−イル）プロパノール誘導体およびそれらの有用な中間体を調製する方法 |
| IN2014MN01521A (cs) | 2011-12-29 | 2015-05-01 | Alphora Res Inc | |
| US9850254B2 (en) * | 2013-07-03 | 2017-12-26 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO2-(p-tolyl) groups |
| CN103483352A (zh) * | 2013-10-18 | 2014-01-01 | 李友香 | 抗肿瘤的药用原料药 |
| BR112016009452B1 (pt) * | 2013-11-04 | 2022-06-07 | Eisai R&D Management Co., Ltd | Métodos de preparar intermediários na síntese de eribulina, métodos de preparar eribulina e mesilato de eribulina, e compostos intermediários |
| CN105916861B (zh) | 2013-12-06 | 2018-12-14 | 卫材R&D管理有限公司 | 可用于合成软海绵素b类似物的方法 |
| TW201617326A (zh) | 2014-03-06 | 2016-05-16 | Ａｌｐｈｏｒａ研發股份有限公司 | （ｓ）－１－（（２ｒ，３ｒ，４ｓ，５ｓ）－５－烯丙－３－甲氧－４－（對甲苯磺醯甲基）四氫呋喃－２－基）－３－氨基丙－２－醇之結晶衍生物 |
| WO2016003975A1 (en) | 2014-06-30 | 2016-01-07 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| CN105713031B (zh) * | 2014-12-05 | 2021-05-07 | 正大天晴药业集团股份有限公司 | 一种用于制备艾日布林的中间体及其制备方法 |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| US10308661B2 (en) * | 2015-05-07 | 2019-06-04 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides |
| MX377663B (es) | 2016-02-12 | 2025-03-11 | Eisai R&D Man Co Ltd | Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados. |
| MX2018010562A (es) | 2016-03-02 | 2019-02-20 | Eisai R&D Man Co Ltd | Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso. |
| BR112018074287A2 (pt) * | 2016-05-26 | 2019-06-18 | Dr Reddys Laboratories Ltd | processo para preparação de eribulina e intermediários da mesma |
| SG11201811671XA (en) | 2016-06-30 | 2019-01-30 | Eisai R&D Man Co Ltd | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| BR112019010494A2 (pt) | 2016-11-23 | 2019-09-17 | Dr Reddys Laboratories Ltd | processo para a preparação de eribulina e intermediários do mesmo |
| CN108658956B (zh) * | 2017-03-28 | 2021-02-02 | 上海时莱生物技术有限公司 | 艾日布林中间体及其制备方法 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| KR102634732B1 (ko) | 2017-04-05 | 2024-02-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 마크로시클릭 화합물 및 그의 용도 |
| CN108948064B (zh) * | 2017-05-17 | 2021-02-02 | 上海时莱生物技术有限公司 | 一种艾日布林中间体及其制备方法 |
| WO2018217894A1 (en) * | 2017-05-24 | 2018-11-29 | Eisai R&D Management Co., Ltd. | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
| IL307273B2 (en) * | 2017-07-06 | 2025-03-01 | Harvard College | Synthesis of halichondrins |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| CN111566113B (zh) | 2017-11-15 | 2024-01-09 | 哈佛大学的校长及成员们 | 大环化合物及其用途 |
| IL275729B2 (en) * | 2018-01-03 | 2023-09-01 | Eisai R&D Man Co Ltd | Prins reaction and compounds useful in the synthesis of helicondrin macrolides and their analogs |
| IL279168B (en) * | 2020-12-02 | 2022-04-01 | Finetech Pharmaceutical Ltd | A process for the preparation of eribulin |
| CN114213429B (zh) * | 2021-12-22 | 2023-06-20 | 苏州正济药业有限公司 | 一种甲磺酸艾立布林杂质的制备方法 |
| WO2024153123A1 (zh) * | 2023-01-17 | 2024-07-25 | 成都百利多特生物药业有限责任公司 | 一种艾日布林类药物的偶联物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| NZ271332A (en) | 1993-07-09 | 2001-03-30 | Theramex | Vitamin D analogues and pharmaceutical use |
| JP4454151B2 (ja) * | 1998-06-17 | 2010-04-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 大環状類似体及びそれらの使用並びに調製方法 |
| US7001982B2 (en) | 2003-03-31 | 2006-02-21 | Council Of Scientific And Industrial Research | Non-natural C-linked carbo-β-peptides with robust secondary structures |
| USRE45324E1 (en) | 2004-06-03 | 2015-01-06 | Eisai R&D Management Co., Ltd. | Intermediates for the preparation of analogs of halichondrin B |
| US20060045846A1 (en) * | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
| US8598373B2 (en) * | 2008-04-04 | 2013-12-03 | Eisai R&D Management Co., Ltd. | Halichondrin B analogs |
| CA2857385A1 (en) | 2011-11-30 | 2013-06-06 | Alphora Research Inc. | Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene |
| JP2015501818A (ja) | 2011-12-16 | 2015-01-19 | アルフォラ リサーチ インコーポレイテッドＡｌｐｈｏｒａ Ｒｅｓｅａｒｃｈ Ｉｎｃ． | ３−（（２ｓ，５ｓ）−４−メチレン−５−（３−オキソプロピル）テトラヒドロフラン−２−イル）プロパノール誘導体およびそれらの有用な中間体を調製する方法 |
| IN2014MN01521A (cs) | 2011-12-29 | 2015-05-01 | Alphora Res Inc | |
| TW201514159A (zh) | 2013-05-15 | 2015-04-16 | Alphora Res Inc | ３-（（２ｓ，５ｓ）-４-亞甲基-５-（３-氧代丙基）四氫呋喃-２-基）丙醇衍生物、其製備及對其有用的中間體 |
-
2013
- 2013-03-28 CA CA2868627A patent/CA2868627C/en active Active
- 2013-03-28 US US14/389,439 patent/US9278979B2/en not_active Expired - Fee Related
- 2013-03-28 WO PCT/CA2013/050254 patent/WO2013142999A1/en active Application Filing
- 2013-03-28 CN CN201380028907.2A patent/CN104334562A/zh active Pending
- 2013-03-28 AU AU2013239290A patent/AU2013239290B2/en not_active Ceased
- 2013-03-28 JP JP2015502027A patent/JP6531911B2/ja not_active Expired - Fee Related
- 2013-03-28 EP EP13769493.1A patent/EP2831082B1/en not_active Not-in-force
- 2013-03-28 IN IN2106MUN2014 patent/IN2014MN02106A/en unknown
-
2016
- 2016-02-04 US US15/015,161 patent/US9695187B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20150065733A1 (en) | 2015-03-05 |
| CN104334562A (zh) | 2015-02-04 |
| US20160152631A1 (en) | 2016-06-02 |
| AU2013239290A1 (en) | 2014-10-30 |
| EP2831082A4 (en) | 2016-01-06 |
| AU2013239290B2 (en) | 2017-08-03 |
| WO2013142999A1 (en) | 2013-10-03 |
| EP2831082B1 (en) | 2019-02-20 |
| JP6531911B2 (ja) | 2019-06-19 |
| CA2868627A1 (en) | 2013-10-03 |
| JP2015512897A (ja) | 2015-04-30 |
| CA2868627C (en) | 2021-02-16 |
| US9278979B2 (en) | 2016-03-08 |
| EP2831082A1 (en) | 2015-02-04 |
| US9695187B2 (en) | 2017-07-04 |
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