IN2014MN01876A - - Google Patents

Download PDF

Info

Publication number
IN2014MN01876A
IN2014MN01876A IN1876MUN2014A IN2014MN01876A IN 2014MN01876 A IN2014MN01876 A IN 2014MN01876A IN 1876MUN2014 A IN1876MUN2014 A IN 1876MUN2014A IN 2014MN01876 A IN2014MN01876 A IN 2014MN01876A
Authority
IN
India
Prior art keywords
baff
bispecific antibodies
sle
pss
psoriasis
Prior art date
Application number
Other languages
English (en)
Inventor
Barrett Allan
Robert Jan Benschop
Jirong Lu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IN2014MN01876A publication Critical patent/IN2014MN01876A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624Disulfide-stabilized antibody (dsFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
IN1876MUN2014 2012-04-20 2013-04-16 IN2014MN01876A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261636302P 2012-04-20 2012-04-20
US201361768747P 2013-02-25 2013-02-25
PCT/US2013/036677 WO2013158577A1 (en) 2012-04-20 2013-04-16 Anti-baff-anti-il-17 bispecific antibodies

Publications (1)

Publication Number Publication Date
IN2014MN01876A true IN2014MN01876A (ja) 2015-07-03

Family

ID=48539373

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1876MUN2014 IN2014MN01876A (ja) 2012-04-20 2013-04-16

Country Status (40)

Country Link
US (2) US9359448B2 (ja)
EP (2) EP2838920B1 (ja)
JP (1) JP6216772B2 (ja)
KR (1) KR101673735B1 (ja)
CN (1) CN104220455B (ja)
AP (1) AP2014008002A0 (ja)
AR (1) AR090626A1 (ja)
AU (1) AU2013249546B2 (ja)
BR (1) BR112014025649A2 (ja)
CA (1) CA2869148C (ja)
CL (1) CL2014002616A1 (ja)
CO (1) CO7160039A2 (ja)
CR (1) CR20140466A (ja)
CY (1) CY1118824T1 (ja)
DK (1) DK2838920T3 (ja)
DO (1) DOP2014000234A (ja)
EA (1) EA029185B1 (ja)
EC (1) ECSP14023405A (ja)
ES (2) ES2621917T3 (ja)
GT (1) GT201400217A (ja)
HK (1) HK1201862A1 (ja)
HR (1) HRP20170468T1 (ja)
HU (1) HUE032153T2 (ja)
IL (1) IL234965B (ja)
IN (1) IN2014MN01876A (ja)
LT (1) LT2838920T (ja)
ME (1) ME02596B (ja)
MX (1) MX367460B (ja)
MY (1) MY173282A (ja)
NZ (1) NZ630865A (ja)
PE (1) PE20142147A1 (ja)
PH (1) PH12014502333A1 (ja)
PL (1) PL2838920T3 (ja)
PT (1) PT2838920T (ja)
RS (1) RS55729B1 (ja)
SG (1) SG11201406726PA (ja)
SI (1) SI2838920T1 (ja)
TW (1) TWI585103B (ja)
WO (1) WO2013158577A1 (ja)
ZA (1) ZA201407272B (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2012149227A (ru) 2010-05-20 2014-06-27 Аблинкс Нв Биологические материалы, относящиеся к her3
UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
AR090626A1 (es) * 2012-04-20 2014-11-26 Lilly Co Eli Anticuerpos anti-baff-anti-il-17 biespecificos
TW201444867A (zh) * 2013-03-08 2014-12-01 Lilly Co Eli 抗tnf-抗il-17雙特異性抗體
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
JOP20140087B1 (ar) 2013-03-13 2021-08-17 Amgen Inc بروتينات مخصصة ل baff و b7rp1 وإستخداماتها
CA2929846C (en) * 2013-11-19 2020-09-15 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized b-cell activating factor gene
WO2016039801A1 (en) 2014-01-31 2016-03-17 Boehringer Ingelheim International Gmbh Novel anti-baff antibodies
AR102417A1 (es) 2014-11-05 2017-03-01 Lilly Co Eli Anticuerpos biespecíficos anti-tnf- / anti-il-23
TW202144411A (zh) * 2015-07-23 2021-12-01 德商包林格因蓋爾漢國際股份有限公司 靶向il-23a與b細胞活化因子(baff)之化合物及其用途
CN105061596B (zh) * 2015-08-05 2019-01-29 江苏诺迈博生物医药科技有限公司 人b淋巴细胞刺激因子的单克隆抗体及其应用
US20200385478A1 (en) * 2018-01-05 2020-12-10 Biograph 55, Inc. Compositions and methods for cancer immunotherapy
CN117529506A (zh) * 2021-06-11 2024-02-06 海南先声药业有限公司 抗人il-17抗体和taci的双功能融合蛋白分子

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009917A1 (en) 1993-10-07 1995-04-13 The Regents Of The University Of California Genetically engineered bispecific tetravalent antibodies
AR035119A1 (es) * 2001-08-16 2004-04-14 Lilly Co Eli Anticuerpos humanos antagonistas anti-htnfsf13b
RU2515108C2 (ru) * 2005-08-19 2014-05-10 Эббви Инк Иммуноглобулин с двойными вариабельными доменами и его применения
KR101158959B1 (ko) 2005-12-13 2012-07-09 일라이 릴리 앤드 캄파니 항-il-17 항체
US20110293629A1 (en) * 2010-05-14 2011-12-01 Bastid Jeremy Methods of Treating and/or Preventing Cell Proliferation Disorders with IL-17 Antagonists
AR090626A1 (es) * 2012-04-20 2014-11-26 Lilly Co Eli Anticuerpos anti-baff-anti-il-17 biespecificos

Also Published As

Publication number Publication date
CA2869148C (en) 2017-06-20
BR112014025649A2 (pt) 2017-07-04
PH12014502333B1 (en) 2014-12-22
ES2621917T3 (es) 2017-07-05
AU2013249546A1 (en) 2014-09-25
LT2838920T (lt) 2017-05-25
SG11201406726PA (en) 2014-11-27
JP6216772B2 (ja) 2017-10-18
EP2838920B1 (en) 2017-02-01
ES2789474T3 (es) 2020-10-26
MX367460B (es) 2019-08-22
MY173282A (en) 2020-01-10
KR20140135830A (ko) 2014-11-26
WO2013158577A1 (en) 2013-10-24
PH12014502333A1 (en) 2014-12-22
KR101673735B1 (ko) 2016-11-07
AR090626A1 (es) 2014-11-26
JP2015514423A (ja) 2015-05-21
US9708402B2 (en) 2017-07-18
EA201491622A1 (ru) 2015-01-30
EP2838920A1 (en) 2015-02-25
HRP20170468T1 (hr) 2017-06-02
RS55729B1 (sr) 2017-07-31
GT201400217A (es) 2015-06-02
DOP2014000234A (es) 2014-11-30
TW201402607A (zh) 2014-01-16
EP3192809A1 (en) 2017-07-19
TWI585103B (zh) 2017-06-01
SI2838920T1 (sl) 2017-03-31
CR20140466A (es) 2014-11-13
EA029185B1 (ru) 2018-02-28
NZ630865A (en) 2016-02-26
US20160251430A1 (en) 2016-09-01
US20130280256A1 (en) 2013-10-24
CN104220455A (zh) 2014-12-17
AU2013249546B2 (en) 2017-10-26
CA2869148A1 (en) 2013-10-24
DK2838920T3 (en) 2017-04-18
CY1118824T1 (el) 2018-01-10
PL2838920T3 (pl) 2017-07-31
IL234965B (en) 2018-04-30
PE20142147A1 (es) 2014-12-13
PT2838920T (pt) 2017-05-03
CO7160039A2 (es) 2015-01-15
US9359448B2 (en) 2016-06-07
MX2014012692A (es) 2015-01-22
HUE032153T2 (en) 2017-09-28
EP3192809B1 (en) 2020-04-15
HK1201862A1 (en) 2015-09-11
CL2014002616A1 (es) 2015-01-30
AP2014008002A0 (en) 2014-10-31
ME02596B (me) 2017-06-20
ZA201407272B (en) 2016-11-30
ECSP14023405A (es) 2015-09-30
CN104220455B (zh) 2017-04-26

Similar Documents

Publication Publication Date Title
IN2014MN01876A (ja)
MX2015011957A (es) Anticuerpos biespecificos anti-tnf-anti-il-17.
AU2018253639A1 (en) Compositions and methods for antibodies targeting EPO
NZ711355A (en) Anti-lag-3 binding proteins
SG10201906328RA (en) Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
EP4071176A3 (en) Agonistic tnf receptor binding agents
CL2008001673A1 (es) Dominio variable simple de la inmunoglobulina del receptor tipo 1 de la anti-interleucina 1 (il-1r1); acido nucleico que lo codifica; vector y celula huesped; metodo de produccion; antagonista de il-1r1 que lo comprende; composicion que comprende al antagonista; y uso del antagonista para tratar una condicion inflamatoria.
UA117575C2 (uk) Антитіло, яке специфічно зв'язується з il-17a та його застосування
PH12015501994A1 (en) Antibodies that bind il-23
CL2007002835A1 (es) Anticuerpo monoclonal especifico para el receptor cxcr4; acido nucleico que lo codifica; vector y celula que lo comprenden; metodo de produccion; inmunoconjugado y composicion que lo comprende; y su uso para tratar cancer, trastornos inflamatorios y
EP4036240A3 (en) Transduction buffer
NZ708033A (en) Anti-blood dendritic cell antigen 2 antibodies and uses thereof
EA201391298A1 (ru) Неводные концентрированные суспензионные композиции с пониженной вязкостью на основе антител
PH12014501410A1 (en) Compositions and methods for antibodies targeting factor p
MX353476B (es) Anticuerpos anti-cxcl13 y metodos para usarlos.
CL2008000820A1 (es) Anticuerpo aislado o fragmentos funcionales con capacidad para neutralizar cepas hiv; acido nucleico que lo codifica; vector y celula huesped que comprenden dicho acido nucleico; metodo para producir un anticuerpo; uso del anticuerpo para el tratamie
MX2013013832A (es) Proteínas de unión receptoras fc.
MX2016006101A (es) Agente ligante de la il-17a y usos del mismo.
MY158481A (en) Compositions and methods for treating inflammatory disorders
MX371412B (es) ANTICUERPOS BIESPECÍFICOS QUE SE UNEN ESPECÍFICAMENTE A LOXL2 Y ccl.2, COMPOSICIONES DE LOS MISMOS, Y SU USO EN EL TRATAMIENTO DE ESCLERODERMIA.
EA201491471A1 (ru) Состав, содержащий антитело против ил-17
TN2014000413A1 (en) Anti-baff-anti-il-17 bispecific antibodies
WO2014113431A3 (en) Methods and compositions for targeting immunoglobulins
TH1401006266A (th) แอนติ-baff-แอนติ-il-17ไบสเปซิฟิกแอนติบอดี
UA113080C2 (xx) Біспецифічне антитіло, яке специфічно зв'язується з il17 та baff