IN2014KN02366A - - Google Patents

Info

Publication number
IN2014KN02366A
IN2014KN02366A IN2366KON2014A IN2014KN02366A IN 2014KN02366 A IN2014KN02366 A IN 2014KN02366A IN 2366KON2014 A IN2366KON2014 A IN 2366KON2014A IN 2014KN02366 A IN2014KN02366 A IN 2014KN02366A
Authority
IN
India
Application number
Other languages
English (en)
Inventor
Shunlin Ren
Original Assignee
Virgina Commonwealth University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virgina Commonwealth University filed Critical Virgina Commonwealth University
Publication of IN2014KN02366A publication Critical patent/IN2014KN02366A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IN2366KON2014 2012-04-12 2014-10-27 IN2014KN02366A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261623203P 2012-04-12 2012-04-12
US201261623414P 2012-04-12 2012-04-12
PCT/US2013/031861 WO2013154752A1 (en) 2012-04-12 2013-03-15 A NOVEL CHOLESTEROL METABOLITE, 5-CHOLESTEN, 3β-25-DIOL, DISULFATE (25HCDS) FOR THERAPY OF METABOLIC DISORDERS, HYPERLIPIDEMIA, DIABETES, FATTY LIVER DISEASES AND ATHEROSCLEROSIS

Publications (1)

Publication Number Publication Date
IN2014KN02366A true IN2014KN02366A (ja) 2015-05-01

Family

ID=49328028

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2366KON2014 IN2014KN02366A (ja) 2012-04-12 2014-10-27

Country Status (21)

Country Link
US (6) US20150072962A1 (ja)
EP (2) EP3239163A1 (ja)
JP (4) JP6125610B2 (ja)
KR (1) KR102180485B1 (ja)
CN (2) CN104220450B (ja)
AU (2) AU2013246435B2 (ja)
BR (1) BR112014025081B1 (ja)
CA (1) CA2867694C (ja)
DK (1) DK2836502T3 (ja)
EA (1) EA026683B1 (ja)
ES (1) ES2641841T3 (ja)
HK (1) HK1202294A1 (ja)
HU (1) HUE035073T2 (ja)
IL (1) IL234892B (ja)
IN (1) IN2014KN02366A (ja)
MX (1) MX357046B (ja)
PL (1) PL2836502T3 (ja)
PT (1) PT2836502T (ja)
SI (1) SI2836502T1 (ja)
WO (1) WO2013154752A1 (ja)
ZA (1) ZA201406981B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
EP3239163A1 (en) * 2012-04-12 2017-11-01 Virginia Commonwealth University A novel cholesterol metabolite, 5-cholesten-3,25-diol, disulfate (25hcds) for therapy of metabolic disorders, hyperlipidemia, diabetes, fatty liver diseases and atherosclerosis
US10272097B2 (en) * 2013-12-24 2019-04-30 Virginia Commonwealth University Uses of oxygenated cholesterol sulfates (OCS)
TWI547280B (zh) * 2014-04-24 2016-09-01 長弘生物科技股份有限公司 穩定醫藥組合物
EP3166613A4 (en) 2014-07-09 2018-02-21 Duke University Compositions and methods for the repair of myelin
EA034524B1 (ru) * 2014-10-10 2020-02-17 Вирджиния Коммонвелт Юниверсити Сульфаты окисленного холестерина для лечения пониженной лептиновой активности
WO2016103722A1 (en) * 2014-12-24 2016-06-30 Kyoto University Vitamin d3 derivatives and pharmaceutical use thereof
AU2017306140A1 (en) * 2016-08-02 2019-02-21 Durect Corporation Use of oxygenated cholesterol sulfates (OCS) to treat inflammatory skin disease and skin lesions
WO2018026837A1 (en) * 2016-08-02 2018-02-08 Durect Corporation Compositions comprising oxygenated cholesterol sulfate and at least one of polyalkylene glycol, carboxymethyl cellulose and polyoxylglyceride
SI3494125T1 (sl) 2016-08-02 2022-10-28 Virginia Commonwealth University Sestavki, ki vsebujejo 5-holesten-3, 25-diol, 3-sulfat(25HC3S) ali njegovo farmacevtsko sprejemljivo sol in vsaj en cikličen oligosaharid
US11458146B2 (en) 2017-01-13 2022-10-04 Duke University Compositions and methods for the treatment of myelin related and inflammation related diseases or disorders
KR101892577B1 (ko) 2017-04-21 2018-08-28 부산대학교 산학협력단 레블라스타틴 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 죽상동맥경화증 예방 또는 치료용 조성물
CN107286160A (zh) * 2017-06-05 2017-10-24 毛佳婧 一种抗肝炎药物的哌啶并吡啶并吡唑‑锌配合物的制备方法
WO2019043700A1 (en) * 2017-08-31 2019-03-07 Ariel Scientific Innovations Ltd S. SPINOSUM EXTRACT FOR THE TREATMENT OF HEPATIC STEATOSIS
EP4037650A4 (en) * 2019-09-30 2023-10-18 Durect Corporation TREATMENT OF ALCOHOLIC HEPATITIS
CN112294827B (zh) * 2020-11-12 2021-12-24 四川大学华西医院 5-胆甾烯 -3β-醇硫酸酯盐的用途
KR20230061860A (ko) 2021-10-29 2023-05-09 부산대학교 산학협력단 크산틴 유도체를 유효성분으로 포함하는 죽상동맥경화증 예방 또는 치료용 약학적 조성물
WO2024008614A1 (en) * 2022-07-08 2024-01-11 Société des Produits Nestlé S.A. Use of 25-hydroxycholesterol for diabetic treatment and/or prevention

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020028876A (ko) * 1999-04-30 2002-04-17 추후제출 스테로이드 유도체
WO2006047022A1 (en) * 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
EP1983972A4 (en) 2006-02-13 2012-01-25 Wellstat Therapeutics Corp COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
US8003795B2 (en) 2007-06-22 2011-08-23 Cvi Pharmaceuticals Limited Compounds and compositions for reducing lipid levels
WO2011077245A2 (en) * 2009-12-23 2011-06-30 Fondazione Centro San Raffaele Del Monte Tabor Compositions
EP3239163A1 (en) * 2012-04-12 2017-11-01 Virginia Commonwealth University A novel cholesterol metabolite, 5-cholesten-3,25-diol, disulfate (25hcds) for therapy of metabolic disorders, hyperlipidemia, diabetes, fatty liver diseases and atherosclerosis

Also Published As

Publication number Publication date
AU2017268646B2 (en) 2019-07-11
WO2013154752A1 (en) 2013-10-17
US20180127457A1 (en) 2018-05-10
US20200157140A1 (en) 2020-05-21
HK1202294A1 (en) 2015-09-25
MX2014012324A (es) 2015-05-11
EA026683B1 (ru) 2017-05-31
JP2021138713A (ja) 2021-09-16
US20190135856A1 (en) 2019-05-09
AU2013246435A1 (en) 2014-10-16
CN104220450A (zh) 2014-12-17
JP2019089777A (ja) 2019-06-13
US20150072962A1 (en) 2015-03-12
AU2013246435B2 (en) 2017-10-05
CN104220450B (zh) 2016-07-06
CA2867694C (en) 2021-08-31
EP2836502B1 (en) 2017-08-02
PL2836502T3 (pl) 2018-01-31
BR112014025081A2 (pt) 2018-05-08
HUE035073T2 (en) 2018-05-02
MX357046B (es) 2018-06-22
CN106083976B (zh) 2018-02-09
CN106083976A (zh) 2016-11-09
CA2867694A1 (en) 2013-10-17
DK2836502T3 (en) 2017-10-23
EP2836502A1 (en) 2015-02-18
JP6125610B2 (ja) 2017-05-10
KR20150013520A (ko) 2015-02-05
AU2017268646A1 (en) 2017-12-21
IL234892B (en) 2019-02-28
US20210238219A1 (en) 2021-08-05
EP2836502A4 (en) 2015-08-19
PT2836502T (pt) 2017-10-27
US20160355544A1 (en) 2016-12-08
ES2641841T3 (es) 2017-11-14
ZA201406981B (en) 2016-05-25
EA201491859A1 (ru) 2015-02-27
JP2017160213A (ja) 2017-09-14
BR112014025081B1 (pt) 2020-12-08
SI2836502T1 (sl) 2017-11-30
KR102180485B1 (ko) 2020-11-18
EP3239163A1 (en) 2017-11-01
JP2015512937A (ja) 2015-04-30

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