IN2014DN10637A - - Google Patents
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- Publication number
- IN2014DN10637A IN2014DN10637A IN10637DEN2014A IN2014DN10637A IN 2014DN10637 A IN2014DN10637 A IN 2014DN10637A IN 10637DEN2014 A IN10637DEN2014 A IN 10637DEN2014A IN 2014DN10637 A IN2014DN10637 A IN 2014DN10637A
- Authority
- IN
- India
- Prior art keywords
- homoserine
- hydroxybutyrate
- oxo
- dihydroxybutyrate
- ohb
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01028—D-Lactate dehydrogenase (1.1.1.28)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01037—Malate dehydrogenase (1.1.1.37)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01082—Malate dehydrogenase (NADP+) (1.1.1.82)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01272—(R)-2-Hydroxyacid dehydrogenase (1.1.1.272)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01299—Malate dehydrogenase (NAD(P)+)(1.1.1.299)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01001—Aspartate transaminase (2.6.1.1), i.e. aspartate-aminotransferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01042—Branched-chain-amino-acid transaminase (2.6.1.42)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01057—Aromatic-amino-acid transaminase (2.6.1.57)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261670405P | 2012-07-11 | 2012-07-11 | |
| PCT/EP2013/064619 WO2014009435A1 (en) | 2012-07-11 | 2013-07-10 | Method for the preparation of 2,4-dihydroxybutyrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN10637A true IN2014DN10637A (de) | 2015-09-11 |
Family
ID=48748274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN10637DEN2014 IN2014DN10637A (de) | 2012-07-11 | 2013-07-10 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10570422B2 (de) |
| EP (1) | EP2872640B1 (de) |
| JP (1) | JP6293746B2 (de) |
| KR (1) | KR102093172B1 (de) |
| CN (1) | CN104471069B (de) |
| AR (1) | AR091726A1 (de) |
| BR (1) | BR112015000534B1 (de) |
| ES (1) | ES2800341T3 (de) |
| IN (1) | IN2014DN10637A (de) |
| RU (1) | RU2645260C2 (de) |
| WO (1) | WO2014009435A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015155790A2 (en) * | 2014-04-11 | 2015-10-15 | String Bio Private Limited | Production of lactic acid from organic waste or biogas or methane using recombinant methanotrophic bacteria |
| US20170152531A1 (en) * | 2014-06-16 | 2017-06-01 | North America S.A.R.L. | Process for producing glutarate and glutaric acid methyl ester |
| EP3201326B1 (de) * | 2014-10-03 | 2020-03-04 | Metabolic Explorer | Mutante glutamatdehydrogenase zur umwandlung von homoserin in 4-hydroxy-2-ketobutyrat |
| WO2016162712A1 (en) | 2015-04-07 | 2016-10-13 | Metabolic Explorer | Modified microorganism for the optimized production of 2,4-dihydroxyburyrate |
| US10858675B2 (en) | 2015-04-07 | 2020-12-08 | Metabolic Explorer | Modified microorganism for the optimized production of 2,4-dihydroxybutyrate with enhanced 2,4-dihydroxybutyrate efflux |
| MX2017015668A (es) | 2015-06-04 | 2018-08-15 | Basf Se | Microorganismos recombinante para la produccion mejorada de quimicos finos. |
| MY189932A (en) * | 2015-06-12 | 2022-03-22 | Basf Se | Recombinant microorganism for improved production of alanine |
| JP6806716B2 (ja) | 2015-06-25 | 2021-01-06 | ダイナミック フード イングリディエンツ コーポレーションＤｙｎａｍｉｃ Ｆｏｏｄ Ｉｎｇｒｅｄｉｅｎｔｓ Ｃｏｒｐ． | ２，４−ジヒドロキシ酪酸の製造方法 |
| KR102149044B1 (ko) * | 2017-07-12 | 2020-08-28 | 울산과학기술원 | 2-히드록시 감마 부티로락톤 또는 2,4-디히드록시-부티레이트 의 제조 방법 |
| EP3470512A1 (de) | 2017-10-10 | 2019-04-17 | Metabolic Explorer | Mutierte phosphoserin-aminotransferase für die konversion von homoserin zu 4-hydroxy-2-ketobutyrat |
| CN108866017B (zh) * | 2018-08-24 | 2020-07-03 | 浙江华睿生物技术有限公司 | 一种酶法制备β-羟基-β-甲基丁酸的方法 |
| AU2020262490A1 (en) * | 2019-04-25 | 2021-11-25 | Zymochem, Inc. | Production of chemicals from renewable sources |
| CN110577961B (zh) * | 2019-09-23 | 2021-05-04 | 安徽师范大学 | 一种热稳定性苹果酸脱氢酶基因的构建方法、编码蛋白及其应用 |
| DE102021101004B3 (de) | 2021-01-19 | 2022-03-10 | Technische Universität Dresden, Körperschaft des öffentlichen Rechts | Verfahren zur Herstellung von 2,4-Dihydroxybutyrat oder L-Threonin unter Nutzung eines mikrobiellen Stoffwechselweges |
| CN113106029A (zh) * | 2021-04-20 | 2021-07-13 | 南京工业大学 | 一种过表达aro8基因的酿酒酵母工程菌及其构建方法与应用 |
| WO2023230399A1 (en) * | 2022-05-23 | 2023-11-30 | The Regents Of The University Of California | Novel carbon fixation pathway |
| CN115948482B (zh) * | 2023-02-07 | 2024-02-09 | 中国科学院天津工业生物技术研究所 | 一种2，4-二羟基丁酸生物合成途径的构建方法及应用 |
| EP4431609A1 (de) | 2023-03-14 | 2024-09-18 | Adisseo France S.A.S. | Verfahren zur verbesserung der herstellung und ausbeute von 2,4-dihydroxybuttersäure |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3631829A1 (de) * | 1986-09-19 | 1988-07-28 | Hoechst Ag | Klonierung und verwendung des transaminase gens-tyrb |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| EP0814166A3 (de) | 1989-08-09 | 1998-05-13 | DeKalb Genetics Corporation | Methoden und Zusammensetzungen für die Herstellung von stabil-transformierten, fruchtbaren monokotyledonen Pflanzen und Zellen dafür |
| US5693781A (en) | 1991-06-03 | 1997-12-02 | Mitsubishi Chemical Corporation | Promoter DNA fragment from coryneform bacteria |
| WO1994004673A1 (en) | 1992-08-19 | 1994-03-03 | Alko Group Ltd. | Fungal promoters active in the presence of glucose |
| GB9413710D0 (en) * | 1994-07-07 | 1994-08-24 | Genzyme Ltd | Chiral synthesis |
| FR2734842B1 (fr) | 1995-06-02 | 1998-02-27 | Rhone Poulenc Agrochimie | Sequence adn d'un gene de l'hydroxy-phenyl pyruvate dioxygenase et obtention de plantes contenant un gene de l'hydroxy-phenyl pyruvate dioxygenase, tolerantes a certains herbicides |
| FR2736926B1 (fr) | 1995-07-19 | 1997-08-22 | Rhone Poulenc Agrochimie | 5-enol pyruvylshikimate-3-phosphate synthase mutee, gene codant pour cette proteine et plantes transformees contenant ce gene |
| FR2780416B1 (fr) | 1998-06-10 | 2002-12-20 | Rhone Poulenc Nutrition Animal | Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede |
| CA2372983A1 (en) | 1999-05-06 | 2000-11-16 | Aventis Animal Nutrition S.A. | Recombinant penicillium funiculosum for homologous and heterologous protein production |
| JP3687497B2 (ja) * | 2000-06-28 | 2005-08-24 | ダイソー株式会社 | 微生物培養法による光学活性１，２−ジオール類の製造法 |
| BRPI0717005A2 (pt) | 2006-08-24 | 2013-10-08 | Evonik Degussa Gmbh | Processo para preparar ácidos d,l-2-hidróxi-4-alquiltiobutíricos |
| WO2010022763A1 (en) * | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
| KR101827230B1 (ko) * | 2008-12-31 | 2018-02-07 | 메타볼릭 익스플로러 | 디올의 제조 방법 |
| WO2012001003A1 (en) * | 2010-07-02 | 2012-01-05 | Metabolic Explorer | Method for the preparation of hydroxy acids |
| TWI500768B (zh) * | 2010-07-05 | 2015-09-21 | Metabolic Explorer Sa | 由蔗糖製備１，３－丙二醇之方法 |
| CN103270155B (zh) | 2010-10-28 | 2016-02-10 | 安迪苏法国联合股份有限公司 | 2,4-二羟基丁酸的生产方法 |
| JP6342385B2 (ja) * | 2012-04-26 | 2018-06-13 | アディッソ・フランス・エス．エー．エス．Ａｄｉｓｓｅｏ Ｆｒａｎｃｅ Ｓ．Ａ．Ｓ． | ２，４−ジヒドロキシ酪酸を生成する方法 |
-
2013
- 2013-07-10 ES ES13734811T patent/ES2800341T3/es active Active
- 2013-07-10 BR BR112015000534-9A patent/BR112015000534B1/pt active IP Right Grant
- 2013-07-10 US US14/414,331 patent/US10570422B2/en active Active
- 2013-07-10 KR KR1020147036006A patent/KR102093172B1/ko active IP Right Grant
- 2013-07-10 EP EP13734811.6A patent/EP2872640B1/de active Active
- 2013-07-10 JP JP2015520978A patent/JP6293746B2/ja active Active
- 2013-07-10 CN CN201380036661.3A patent/CN104471069B/zh active Active
- 2013-07-10 WO PCT/EP2013/064619 patent/WO2014009435A1/en active Application Filing
- 2013-07-10 IN IN10637DEN2014 patent/IN2014DN10637A/en unknown
- 2013-07-10 RU RU2014153354A patent/RU2645260C2/ru active
- 2013-07-11 AR ARP130102456 patent/AR091726A1/es active IP Right Grant
-
2020
- 2020-01-13 US US16/740,598 patent/US11505811B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2872640A1 (de) | 2015-05-20 |
| RU2014153354A (ru) | 2016-08-27 |
| EP2872640B1 (de) | 2020-03-25 |
| WO2014009435A1 (en) | 2014-01-16 |
| US10570422B2 (en) | 2020-02-25 |
| KR20150035726A (ko) | 2015-04-07 |
| US20150147793A1 (en) | 2015-05-28 |
| ES2800341T3 (es) | 2020-12-29 |
| US11505811B2 (en) | 2022-11-22 |
| BR112015000534A2 (pt) | 2017-12-19 |
| BR112015000534A8 (pt) | 2023-01-03 |
| BR112015000534B1 (pt) | 2023-02-28 |
| KR102093172B1 (ko) | 2020-03-25 |
| RU2645260C2 (ru) | 2018-02-19 |
| AR091726A1 (es) | 2015-02-25 |
| US20200131542A1 (en) | 2020-04-30 |
| JP6293746B2 (ja) | 2018-03-14 |
| JP2015524253A (ja) | 2015-08-24 |
| CN104471069B (zh) | 2018-06-01 |
| CN104471069A (zh) | 2015-03-25 |
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