IN2014DN10637A - - Google Patents

Download PDF

Info

Publication number
IN2014DN10637A
IN2014DN10637A IN10637DEN2014A IN2014DN10637A IN 2014DN10637 A IN2014DN10637 A IN 2014DN10637A IN 10637DEN2014 A IN10637DEN2014 A IN 10637DEN2014A IN 2014DN10637 A IN2014DN10637 A IN 2014DN10637A
Authority
IN
India
Prior art keywords
homoserine
hydroxybutyrate
oxo
dihydroxybutyrate
ohb
Prior art date
Application number
Other languages
English (en)
Inventor
Thomas Walther
Hélène CORDIER
Clémentine Dressaire
Jean Marie Francois
Robert Huet
Original Assignee
Adisseo France Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adisseo France Sas filed Critical Adisseo France Sas
Publication of IN2014DN10637A publication Critical patent/IN2014DN10637A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01028—D-Lactate dehydrogenase (1.1.1.28)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01037—Malate dehydrogenase (1.1.1.37)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01082—Malate dehydrogenase (NADP+) (1.1.1.82)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01272—(R)-2-Hydroxyacid dehydrogenase (1.1.1.272)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01299—Malate dehydrogenase (NAD(P)+)(1.1.1.299)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01001—Aspartate transaminase (2.6.1.1), i.e. aspartate-aminotransferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01042—Branched-chain-amino-acid transaminase (2.6.1.42)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01057—Aromatic-amino-acid transaminase (2.6.1.57)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
IN10637DEN2014 2012-07-11 2013-07-10 IN2014DN10637A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261670405P 2012-07-11 2012-07-11
PCT/EP2013/064619 WO2014009435A1 (en) 2012-07-11 2013-07-10 Method for the preparation of 2,4-dihydroxybutyrate

Publications (1)

Publication Number Publication Date
IN2014DN10637A true IN2014DN10637A (de) 2015-09-11

Family

ID=48748274

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10637DEN2014 IN2014DN10637A (de) 2012-07-11 2013-07-10

Country Status (11)

Country Link
US (2) US10570422B2 (de)
EP (1) EP2872640B1 (de)
JP (1) JP6293746B2 (de)
KR (1) KR102093172B1 (de)
CN (1) CN104471069B (de)
AR (1) AR091726A1 (de)
BR (1) BR112015000534B1 (de)
ES (1) ES2800341T3 (de)
IN (1) IN2014DN10637A (de)
RU (1) RU2645260C2 (de)
WO (1) WO2014009435A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015155790A2 (en) * 2014-04-11 2015-10-15 String Bio Private Limited Production of lactic acid from organic waste or biogas or methane using recombinant methanotrophic bacteria
BR112016029471A2 (pt) * 2014-06-16 2017-10-24 Invista Tech Sarl método para biosintetizar éster de metil glutarato em um hospedeiro recombinante, método para preparar glutarato, célula hospedeira recombinante, hospedeiro recombinante, produto bioderivado, produto de base biológica ou produto derivado de fermentação e método para aumentar a atividade de um polipeptídeo tendo atividade carboxilato reductase sobre um ácido dicarboxílico c4-c8 substituído ou não-substituído
WO2016050959A2 (en) * 2014-10-03 2016-04-07 Metabolic Explorer Mutant glutamate dehydrogenase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate
EP3280794B1 (de) * 2015-04-07 2020-05-27 Metabolic Explorer Modifizierter mikroorganismus zur optimierten herstellung von 2,4-dihydroxybutyrat mit verlängertem 2,4-dihydroxybutyrat-ausfluss
BR112017021255A2 (pt) * 2015-04-07 2018-06-26 Metabolic Explorer Sa microrganismo modificado para a produção otimizada de 2,4-di-hidroxibutirato
RU2017146342A (ru) 2015-06-04 2019-07-10 Басф Се Рекомбинантный микроорганизм для улучшенного получения химических продуктов тонкого органического синтеза
JP2018516587A (ja) * 2015-06-12 2018-06-28 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ アラニンの生産改善のための組換え微生物
JP6806716B2 (ja) 2015-06-25 2021-01-06 ダイナミック フード イングリディエンツ コーポレーションＤｙｎａｍｉｃ Ｆｏｏｄ Ｉｎｇｒｅｄｉｅｎｔｓ Ｃｏｒｐ． ２，４−ジヒドロキシ酪酸の製造方法
KR102149044B1 (ko) * 2017-07-12 2020-08-28 울산과학기술원 2-히드록시 감마 부티로락톤 또는 2,4-디히드록시-부티레이트 의 제조 방법
EP3470512A1 (de) 2017-10-10 2019-04-17 Metabolic Explorer Mutierte phosphoserin-aminotransferase für die konversion von homoserin zu 4-hydroxy-2-ketobutyrat
CN108866017B (zh) * 2018-08-24 2020-07-03 浙江华睿生物技术有限公司 一种酶法制备β-羟基-β-甲基丁酸的方法
WO2020220001A1 (en) * 2019-04-25 2020-10-29 Zymochem, Inc. Production of chemicals from renewable sources
CN110577961B (zh) * 2019-09-23 2021-05-04 安徽师范大学 一种热稳定性苹果酸脱氢酶基因的构建方法、编码蛋白及其应用
DE102021101004B3 (de) 2021-01-19 2022-03-10 Technische Universität Dresden, Körperschaft des öffentlichen Rechts Verfahren zur Herstellung von 2,4-Dihydroxybutyrat oder L-Threonin unter Nutzung eines mikrobiellen Stoffwechselweges
CN113106029A (zh) * 2021-04-20 2021-07-13 南京工业大学 一种过表达aro8基因的酿酒酵母工程菌及其构建方法与应用
WO2023230399A1 (en) * 2022-05-23 2023-11-30 The Regents Of The University Of California Novel carbon fixation pathway
CN115948482B (zh) * 2023-02-07 2024-02-09 中国科学院天津工业生物技术研究所 一种2，4-二羟基丁酸生物合成途径的构建方法及应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631829A1 (de) * 1986-09-19 1988-07-28 Hoechst Ag Klonierung und verwendung des transaminase gens-tyrb
US7705215B1 (en) 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
WO1991002071A2 (en) 1989-08-09 1991-02-21 Dekalb Plant Genetics Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5693781A (en) 1991-06-03 1997-12-02 Mitsubishi Chemical Corporation Promoter DNA fragment from coryneform bacteria
AU4712193A (en) 1992-08-19 1994-03-15 Alko Group Limited Fungal promoters active in the presence of glucose
GB9413710D0 (en) * 1994-07-07 1994-08-24 Genzyme Ltd Chiral synthesis
FR2734842B1 (fr) 1995-06-02 1998-02-27 Rhone Poulenc Agrochimie Sequence adn d'un gene de l'hydroxy-phenyl pyruvate dioxygenase et obtention de plantes contenant un gene de l'hydroxy-phenyl pyruvate dioxygenase, tolerantes a certains herbicides
FR2736926B1 (fr) 1995-07-19 1997-08-22 Rhone Poulenc Agrochimie 5-enol pyruvylshikimate-3-phosphate synthase mutee, gene codant pour cette proteine et plantes transformees contenant ce gene
FR2780416B1 (fr) 1998-06-10 2002-12-20 Rhone Poulenc Nutrition Animal Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede
WO2000068401A1 (en) 1999-05-06 2000-11-16 Aventis Animal Nutrition S.A. Recombinant penicillium funiculosum for homologous and heterologous protein production
JP3687497B2 (ja) * 2000-06-28 2005-08-24 ダイソー株式会社 微生物培養法による光学活性１，２−ジオール類の製造法
CN101506153A (zh) 2006-08-24 2009-08-12 赢创德固赛有限责任公司 制备d，l-2-羟基-4-烷基硫代丁酸的方法
WO2010022763A1 (en) * 2008-08-25 2010-03-04 Metabolic Explorer Method for the preparation of 2-hydroxy-isobutyrate
JP5774493B2 (ja) * 2008-12-31 2015-09-09 メタボリック エクスプローラー ジオールの生産方法
WO2012001003A1 (en) * 2010-07-02 2012-01-05 Metabolic Explorer Method for the preparation of hydroxy acids
TWI500768B (zh) * 2010-07-05 2015-09-21 Metabolic Explorer Sa 由蔗糖製備１，３－丙二醇之方法
CN105505892B (zh) * 2010-10-28 2019-03-26 安迪苏法国联合股份有限公司 2,4-二羟基丁酸的生产方法
MY175391A (en) * 2012-04-26 2020-06-23 Adisseo France Sas Method of production of 2,4-dihydroxybutyric acid

Also Published As

Publication number Publication date
US11505811B2 (en) 2022-11-22
CN104471069A (zh) 2015-03-25
EP2872640B1 (de) 2020-03-25
RU2645260C2 (ru) 2018-02-19
BR112015000534B1 (pt) 2023-02-28
US10570422B2 (en) 2020-02-25
BR112015000534A8 (pt) 2023-01-03
KR20150035726A (ko) 2015-04-07
JP6293746B2 (ja) 2018-03-14
AR091726A1 (es) 2015-02-25
ES2800341T3 (es) 2020-12-29
US20200131542A1 (en) 2020-04-30
WO2014009435A1 (en) 2014-01-16
JP2015524253A (ja) 2015-08-24
BR112015000534A2 (pt) 2017-12-19
EP2872640A1 (de) 2015-05-20
KR102093172B1 (ko) 2020-03-25
US20150147793A1 (en) 2015-05-28
RU2014153354A (ru) 2016-08-27
CN104471069B (zh) 2018-06-01

Similar Documents

Publication Publication Date Title
IN2014DN10637A (de)
IN2015KN00262A (de)
UY33735A (es) Compuestos antivirales
MY163339A (en) A method of producing ingenol-3-angelate
EA033455B1 (ru) Кристаллические формы замещенных 5-фтор-1h-пиразолопиридинов, способы их получения, их применение для получения лекарственного средства, лекарственное средство и способ лечения на их основе
PL2329816T3 (pl) Przeciwrakowa substancja czynna z Antrodia camphorata, sposób jej wytwarzania i jej zastosowanie
MX348767B (es) Metodo para preparar mentona a partir de isopulegol.
WO2011131368A3 (en) A method of preparing an oral dosage form comprising fingolimod
WO2013121436A3 (en) A process for preparation of rivaroxaban and intermediates thereof
WO2012016683A3 (en) Oral dosage form of pregabalin
EP2803406A4 (de) Phosphidkatalysator zur umwandlung von synthesegas, herstellungsverfahren dafür und verwendung davon
IN2014DN07691A (de)
WO2014057498A3 (en) Process for the preparation of cobicistat intermediates
MX2014010433A (es) Nueva forma cristalina de sulfato de sitagliptina.
WO2014068586A3 (en) Solid oral compositions of tolvaptan
WO2011095571A3 (de) Verfahren zur herstellung von astaxanthin-dimethyldisuccinat
GEP20156234B (en) Agomelatine intermediates and preparation method thereof
MX2015013589A (es) Proceso e intermediario para la preparacion de pregabalina.
WO2014141294A3 (en) An improved process for the synthesis of melphalan and the hydrochloride salt
EA201590116A1 (ru) Способ получения замещенных триазолопиридинов
MX2012010443A (es) Proceso para la preparacion de 1-alquiltetrazoles 5-sustituidos.
WO2014064712A3 (en) An improved process for the preparation of fulvestrant
MX360870B (es) Catalizadores para la preparación de poliamida de moldeo, procedimiento para su preparación y su uso.
PH12014501327A1 (en) Processes for making magnolol analogs
AU2012248013B2 (en) Intermediate for synthesizing caspofungin and preparation method therefor