IN2014DN10637A - - Google Patents

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Publication number
IN2014DN10637A
IN2014DN10637A IN10637DEN2014A IN2014DN10637A IN 2014DN10637 A IN2014DN10637 A IN 2014DN10637A IN 10637DEN2014 A IN10637DEN2014 A IN 10637DEN2014A IN 2014DN10637 A IN2014DN10637 A IN 2014DN10637A
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IN
India
Prior art keywords
homoserine
hydroxybutyrate
oxo
dihydroxybutyrate
ohb
Prior art date
Application number
Inventor
Thomas Walther
Hélène CORDIER
Clémentine Dressaire
Jean Marie Francois
Robert Huet
Original Assignee
Adisseo France Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Adisseo France Sas filed Critical Adisseo France Sas
Publication of IN2014DN10637A publication Critical patent/IN2014DN10637A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01028—D-Lactate dehydrogenase (1.1.1.28)
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01037—Malate dehydrogenase (1.1.1.37)
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01082—Malate dehydrogenase (NADP+) (1.1.1.82)
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01272—(R)-2-Hydroxyacid dehydrogenase (1.1.1.272)
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01299—Malate dehydrogenase (NAD(P)+)(1.1.1.299)
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    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
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    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01001—Aspartate transaminase (2.6.1.1), i.e. aspartate-aminotransferase
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    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01042—Branched-chain-amino-acid transaminase (2.6.1.42)
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    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01057—Aromatic-amino-acid transaminase (2.6.1.57)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention concerns a method for the preparation of 2,4- dihydroxybutyric acid from homoserine comprising a first step of conversion of the primary amino group of homoserine to a carbonyl group to obtain 2-oxo-4- hydroxybutyrate and a second step of reduction of the obtained 2-oxo-4- hydroxybutyrate (OHB) to 2,4-dihydroxybutyrate
IN10637DEN2014 2012-07-11 2013-07-10 IN2014DN10637A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261670405P 2012-07-11 2012-07-11
PCT/EP2013/064619 WO2014009435A1 (en) 2012-07-11 2013-07-10 Method for the preparation of 2,4-dihydroxybutyrate

Publications (1)

Publication Number Publication Date
IN2014DN10637A true IN2014DN10637A (en) 2015-09-11

Family

ID=48748274

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10637DEN2014 IN2014DN10637A (en) 2012-07-11 2013-07-10

Country Status (11)

Country Link
US (2) US10570422B2 (en)
EP (1) EP2872640B1 (en)
JP (1) JP6293746B2 (en)
KR (1) KR102093172B1 (en)
CN (1) CN104471069B (en)
AR (1) AR091726A1 (en)
BR (1) BR112015000534B1 (en)
ES (1) ES2800341T3 (en)
IN (1) IN2014DN10637A (en)
RU (1) RU2645260C2 (en)
WO (1) WO2014009435A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015155790A2 (en) * 2014-04-11 2015-10-15 String Bio Private Limited Production of lactic acid from organic waste or biogas or methane using recombinant methanotrophic bacteria
US20170152531A1 (en) * 2014-06-16 2017-06-01 North America S.A.R.L. Process for producing glutarate and glutaric acid methyl ester
EP3201326B1 (en) * 2014-10-03 2020-03-04 Metabolic Explorer Mutant glutamate dehydrogenase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate
WO2016162712A1 (en) 2015-04-07 2016-10-13 Metabolic Explorer Modified microorganism for the optimized production of 2,4-dihydroxyburyrate
US10858675B2 (en) 2015-04-07 2020-12-08 Metabolic Explorer Modified microorganism for the optimized production of 2,4-dihydroxybutyrate with enhanced 2,4-dihydroxybutyrate efflux
MX2017015668A (en) 2015-06-04 2018-08-15 Basf Se Recombinant microorganism for improved production of fine chemicals.
MY189932A (en) * 2015-06-12 2022-03-22 Basf Se Recombinant microorganism for improved production of alanine
JP6806716B2 (en) 2015-06-25 2021-01-06 ダイナミック フード イングリディエンツ コーポレーションＤｙｎａｍｉｃ Ｆｏｏｄ Ｉｎｇｒｅｄｉｅｎｔｓ Ｃｏｒｐ． Method for producing 2,4-dihydroxybutyric acid
KR102149044B1 (en) * 2017-07-12 2020-08-28 울산과학기술원 Method of producing 2-hydroxy gamma butyrolactone or 2,4-dihydroxybutanoic acid
EP3470512A1 (en) 2017-10-10 2019-04-17 Metabolic Explorer Mutant phosphoserine aminotransferase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate
CN108866017B (en) * 2018-08-24 2020-07-03 浙江华睿生物技术有限公司 Method for preparing β -hydroxy- β -methylbutyric acid by enzyme method
AU2020262490A1 (en) * 2019-04-25 2021-11-25 Zymochem, Inc. Production of chemicals from renewable sources
CN110577961B (en) * 2019-09-23 2021-05-04 安徽师范大学 Construction method of heat-stable malic acid dehydrogenase gene, encoded protein and application thereof
DE102021101004B3 (en) 2021-01-19 2022-03-10 Technische Universität Dresden, Körperschaft des öffentlichen Rechts Process for the production of 2,4-dihydroxybutyrate or L-threonine using a microbial pathway
CN113106029A (en) * 2021-04-20 2021-07-13 南京工业大学 Saccharomyces cerevisiae engineering bacterium for over-expressing ARO8 gene and construction method and application thereof
WO2023230399A1 (en) * 2022-05-23 2023-11-30 The Regents Of The University Of California Novel carbon fixation pathway
CN115948482B (en) * 2023-02-07 2024-02-09 中国科学院天津工业生物技术研究所 Construction method and application of 2, 4-dihydroxybutyric acid biosynthesis pathway
EP4431609A1 (en) 2023-03-14 2024-09-18 Adisseo France S.A.S. Method for improving 2, 4 dihydroxybutyric acid production and yield

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Also Published As

Publication number Publication date
EP2872640A1 (en) 2015-05-20
RU2014153354A (en) 2016-08-27
EP2872640B1 (en) 2020-03-25
WO2014009435A1 (en) 2014-01-16
US10570422B2 (en) 2020-02-25
KR20150035726A (en) 2015-04-07
US20150147793A1 (en) 2015-05-28
ES2800341T3 (en) 2020-12-29
US11505811B2 (en) 2022-11-22
BR112015000534A2 (en) 2017-12-19
BR112015000534A8 (en) 2023-01-03
BR112015000534B1 (en) 2023-02-28
KR102093172B1 (en) 2020-03-25
RU2645260C2 (en) 2018-02-19
AR091726A1 (en) 2015-02-25
US20200131542A1 (en) 2020-04-30
JP6293746B2 (en) 2018-03-14
JP2015524253A (en) 2015-08-24
CN104471069B (en) 2018-06-01
CN104471069A (en) 2015-03-25

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