IN2014DN00221A - - Google Patents
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- Publication number
- IN2014DN00221A IN2014DN00221A IN221DEN2014A IN2014DN00221A IN 2014DN00221 A IN2014DN00221 A IN 2014DN00221A IN 221DEN2014 A IN221DEN2014 A IN 221DEN2014A IN 2014DN00221 A IN2014DN00221 A IN 2014DN00221A
- Authority
- IN
- India
- Prior art keywords
- target polynucleotide
- strands
- double stranded
- polynucleotide
- stranded target
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Electrochemistry (AREA)
- General Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161511436P | 2011-07-25 | 2011-07-25 | |
PCT/GB2012/051786 WO2013014451A1 (en) | 2011-07-25 | 2012-07-25 | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014DN00221A true IN2014DN00221A (da) | 2015-06-05 |
Family
ID=46763140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN221DEN2014 IN2014DN00221A (da) | 2011-07-25 | 2012-07-25 |
Country Status (10)
Country | Link |
---|---|
US (7) | US9957560B2 (da) |
EP (1) | EP2737084B1 (da) |
JP (1) | JP6298404B2 (da) |
KR (1) | KR20140050067A (da) |
CN (1) | CN103827320B (da) |
AU (1) | AU2012288629B2 (da) |
BR (1) | BR112014001699A2 (da) |
CA (1) | CA2843136C (da) |
IN (1) | IN2014DN00221A (da) |
WO (1) | WO2013014451A1 (da) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010034018A2 (en) | 2008-09-22 | 2010-03-25 | University Of Washington | Msp nanopores and related methods |
KR101797773B1 (ko) | 2009-01-30 | 2017-11-15 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 막횡단 시퀀싱에서 핵산 구축물용 어댑터 |
CA2837306C (en) | 2011-05-27 | 2020-03-10 | Oxford Nanopore Technologies Limited | Determining the presence, absence or characteristics of an analyte coupled to a membrane |
AU2012288629B2 (en) * | 2011-07-25 | 2017-02-02 | Oxford Nanopore Technologies Limited | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
WO2013041878A1 (en) | 2011-09-23 | 2013-03-28 | Oxford Nanopore Technologies Limited | Analysis of a polymer comprising polymer units |
JP6226869B2 (ja) | 2011-10-21 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素法 |
CN104126018B (zh) | 2011-12-29 | 2021-09-14 | 牛津纳米孔技术公司 | 酶方法 |
US9617591B2 (en) | 2011-12-29 | 2017-04-11 | Oxford Nanopore Technologies Ltd. | Method for characterising a polynucleotide by using a XPD helicase |
US9238836B2 (en) | 2012-03-30 | 2016-01-19 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing modified nucleic acids |
EP2815235B1 (en) | 2012-02-15 | 2020-04-15 | Oxford Nanopore Technologies Limited | Aptamer method |
CN108949944A (zh) | 2012-02-16 | 2018-12-07 | 吉尼亚科技公司 | 产生用于纳米孔传感器的双层的方法 |
EP3736339B1 (en) | 2012-02-16 | 2022-07-27 | Oxford Nanopore Technologies plc | Analysis of measurements of a polymer |
AU2013246702B2 (en) | 2012-04-10 | 2017-06-15 | Oxford Nanopore Technologies Limited | Mutant lysenin pores |
WO2013185137A1 (en) | 2012-06-08 | 2013-12-12 | Pacific Biosciences Of California, Inc. | Modified base detection with nanopore sequencing |
US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
BR112015001054A8 (pt) | 2012-07-19 | 2022-08-02 | Oxford Nanopore Tech Ltd | Helicase monomérica que é membro da superfamília 1 ou superfamília 2, helicase hel308 isolada, método para caracterizar um polinucleotídeo alvo, e, sensor para a caracterização de um polinucleotídeo alvo |
BR112015001052B8 (pt) | 2012-07-19 | 2022-12-27 | Oxford Nanopore Tech Ltd | Métodos para distinguir um polinucleotídeo alvo,sensor para distinguir um polinucleotídeo alvo, e, uso de um construto |
EP2895618B1 (en) * | 2012-09-14 | 2017-07-26 | Oxford Nanopore Technologies Limited | Sample preparation method |
US9995728B2 (en) | 2012-11-06 | 2018-06-12 | Oxford Nanopore Technologies Ltd. | Quadruplex method |
EP2917732B1 (en) * | 2012-11-09 | 2016-09-07 | Stratos Genomics Inc. | Concentrating a target molecule for sensing by a nanopore |
GB201222928D0 (en) | 2012-12-19 | 2013-01-30 | Oxford Nanopore Tech Ltd | Analysis of a polynucleotide |
US9725763B2 (en) | 2013-02-20 | 2017-08-08 | Eve Biomedical, Inc. | Methods and compositions for nanostructure-based nucleic acid sequencing |
GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
EP2964779B1 (en) * | 2013-03-08 | 2018-08-29 | Oxford Nanopore Technologies Limited | Use of spacer elements in a nucleic acid to control movement of a helicase |
GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
CN117947149A (zh) | 2013-10-18 | 2024-04-30 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
CN111534504B (zh) * | 2014-01-22 | 2024-06-21 | 牛津纳米孔科技公开有限公司 | 将一个或多个多核苷酸结合蛋白连接到靶多核苷酸的方法 |
GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
SG10202111841TA (en) | 2014-02-19 | 2021-12-30 | Univ Washington | Nanopore-based analysis of protein characteristics |
GB201403096D0 (en) * | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
US10337060B2 (en) | 2014-04-04 | 2019-07-02 | Oxford Nanopore Technologies Ltd. | Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid |
GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
US10167503B2 (en) | 2014-05-02 | 2019-01-01 | Oxford Nanopore Technologies Ltd. | Mutant pores |
EP3831956A1 (en) | 2014-07-14 | 2021-06-09 | Oxford University Innovation Limited | Measurement of analytes with membrane channel molecules, and bilayer arrays |
CN114605507A (zh) | 2014-09-01 | 2022-06-10 | 弗拉芒区生物技术研究所 | 突变csgg孔 |
WO2016053891A1 (en) * | 2014-09-29 | 2016-04-07 | The Regents Of The University Of California | Nanopore sequencing of polynucleotides with multiple passes |
WO2016055778A1 (en) | 2014-10-07 | 2016-04-14 | Oxford Nanopore Technologies Limited | Mutant pores |
GB201418159D0 (en) * | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
CN115851894A (zh) | 2014-10-16 | 2023-03-28 | 牛津楠路珀尔科技股份有限公司 | 聚合物的分析 |
US10480026B2 (en) | 2014-10-17 | 2019-11-19 | Oxford Nanopore Technologies Ltd. | Method for nanopore RNA characterisation |
GB201418469D0 (en) * | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Method |
CN107002130B (zh) | 2014-11-11 | 2022-02-01 | 深圳华大基因研究院 | 多程测序 |
AU2016215453A1 (en) * | 2015-02-02 | 2017-08-10 | Two Pore Guys, Inc. | Nanopore detection of target polynucleotides from sample background |
GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
CN107208162B (zh) | 2015-02-26 | 2020-12-29 | 株式会社日立高新技术 | 核酸分子的构建方法 |
WO2016166232A1 (en) | 2015-04-14 | 2016-10-20 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
IL285795B (en) * | 2015-08-12 | 2022-07-01 | Univ Hong Kong Chinese | Sequencing a single molecule of DNA. plasma |
US10280411B2 (en) | 2015-10-27 | 2019-05-07 | Pacific Biosciences of California, In.c | Methods, systems, and reagents for direct RNA sequencing |
US20190078145A1 (en) | 2015-12-08 | 2019-03-14 | Quantapore, Inc. | Method of translocating nucleic acids through nanopores |
CA3011830A1 (en) | 2015-12-08 | 2017-06-15 | Katholieke Universiteit Leuven Ku Leuven Research & Development | Modified nanopores, compositions comprising the same, and uses thereof |
JP6776366B2 (ja) | 2016-03-02 | 2020-10-28 | オックスフォード ナノポール テクノロジーズ リミテッド | 変異体ポア |
US10961573B2 (en) | 2016-03-28 | 2021-03-30 | Boreal Genomics, Inc. | Linked duplex target capture |
CA3212147A1 (en) | 2016-04-06 | 2017-10-12 | Oxford Nanopore Technologies Plc | Mutant pore |
GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
GB201609221D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
EP3464612A4 (en) * | 2016-05-31 | 2019-11-27 | Quantapore Inc. | BICOLOR SEQUENCING BY NANOPORES |
JP6695450B2 (ja) | 2016-06-27 | 2020-05-20 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 二重層形成のための浸透性不均衡法 |
US10577653B2 (en) * | 2016-06-27 | 2020-03-03 | Roche Sequencing Solutions, Inc. | Counteracting osmotic imbalance in a sequencing cell |
GB201612458D0 (en) * | 2016-07-14 | 2016-08-31 | Howorka Stefan And Pugh Genevieve | Membrane spanning DNA nanopores for molecular transport |
CA3031812A1 (en) | 2016-08-19 | 2018-02-22 | Quantapore, Inc. | Optically-based nanopore sequencing using quenching agents |
GB201617886D0 (en) * | 2016-10-21 | 2016-12-07 | Oxford Nanopore Technologies Limited | Method |
GB201620450D0 (en) * | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
US11268137B2 (en) | 2016-12-09 | 2022-03-08 | Boreal Genomics, Inc. | Linked ligation |
AU2018218531B2 (en) | 2017-02-10 | 2021-01-28 | Oxford Nanopore Technologies Limited | Modified nanopores, compositions comprising the same, and uses thereof |
GB201707140D0 (en) * | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
EP3642607A4 (en) * | 2017-06-21 | 2021-04-14 | Nooma Bio, Inc. | DOUBLE PORE DETECTION AND CONTROL DEVICE |
JP7282697B2 (ja) | 2017-06-30 | 2023-05-29 | ブイアイビー ブイゼットダブリュ | 新規タンパク質細孔 |
EP3731959A4 (en) | 2017-12-29 | 2021-10-13 | Clear Labs Inc. | AUTOMATED PRIMING AND LIBRARY LOADER |
EP3768853A4 (en) * | 2018-03-23 | 2021-04-28 | Board Of Regents The University Of Texas System | EFFICIENT SEQUENCING OF DSDNA WITH EXTREMELY LOW ERROR RATE |
GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
WO2020002621A2 (en) | 2018-06-29 | 2020-01-02 | F. Hoffmann-La Roche Ag | Detection of microsatellite instability |
GB201814369D0 (en) | 2018-09-04 | 2018-10-17 | Oxford Nanopore Tech Ltd | Method for determining a polymersequence |
EP3650558A1 (en) * | 2018-11-07 | 2020-05-13 | Siemens Healthcare GmbH | Liquid sample workflow for nanopore sequencing |
WO2020106630A1 (en) * | 2018-11-19 | 2020-05-28 | The Regents Of The University Of California | Methods for detecting and sequencing a target nucleic acid |
GB201819378D0 (en) | 2018-11-28 | 2019-01-09 | Oxford Nanopore Tech Ltd | Analysis of nanopore signal using a machine-learning technique |
US11473136B2 (en) * | 2019-01-03 | 2022-10-18 | Ncan Genomics, Inc. | Linked target capture |
US11860123B2 (en) | 2019-04-16 | 2024-01-02 | The Board Of Trustees Of The University Of Illinois | Classification of epigenetic biomarkers and/or DNA conformational superstructures via use of atomically thin nanopores |
GB201917060D0 (en) * | 2019-11-22 | 2020-01-08 | Oxford Nanopore Tech Ltd | Method |
EP4114966A1 (en) | 2020-03-03 | 2023-01-11 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing double stranded nucleic acids |
US20230295712A1 (en) | 2020-06-18 | 2023-09-21 | Oxford Nanopore Technologies Plc | A method of selectively characterising a polynucleotide using a detector |
KR20230083269A (ko) | 2020-07-30 | 2023-06-09 | 캠브리지 에피제네틱스 리미티드 | 핵산 분석을 위한 조성물 및 방법 |
US11248265B1 (en) | 2020-11-19 | 2022-02-15 | Clear Labs, Inc | Systems and processes for distinguishing pathogenic and non-pathogenic sequences from specimens |
CN115029424A (zh) * | 2021-03-03 | 2022-09-09 | 郑州思昆生物工程有限公司 | 一种固定化模板多核苷酸配对末端测序方法 |
CN113462764B (zh) * | 2021-09-01 | 2021-12-17 | 北京齐碳科技有限公司 | 用于表征双链靶多核苷酸的类发夹衔接子、构建体和方法 |
CN114134142B (zh) * | 2021-11-23 | 2024-05-28 | 成都齐碳科技有限公司 | 衔接体、复合物、单链分子、试剂盒、方法和应用 |
CN114262735A (zh) * | 2021-12-15 | 2022-04-01 | 成都齐碳科技有限公司 | 用于表征多核苷酸的衔接体及其用途 |
CN114457145B (zh) * | 2022-01-29 | 2023-08-11 | 成都齐碳科技有限公司 | 用于表征靶多核苷酸测序的接头、构建体、方法和应用 |
WO2024091124A1 (en) * | 2022-10-28 | 2024-05-02 | Rijksuniversiteit Groningen | Nanopore-based analysis of proteins |
WO2024124567A1 (zh) * | 2022-12-16 | 2024-06-20 | 深圳华大生命科学研究院 | 纳米孔测序方法和试剂盒 |
WO2024138572A1 (zh) * | 2022-12-29 | 2024-07-04 | 深圳华大生命科学研究院 | 测序接头、测序接头复合物、靶核酸序列多次纳米孔测序的方法 |
Family Cites Families (178)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE56026B1 (en) | 1982-10-19 | 1991-03-27 | Cetus Corp | Cysteine-depleted muteins of biologically active proteins |
GB8924338D0 (en) | 1989-10-28 | 1989-12-13 | Atomic Energy Authority Uk | Electrodes |
US5215899A (en) | 1989-11-09 | 1993-06-01 | Miles Inc. | Nucleic acid amplification employing ligatable hairpin probe and transcription |
US5424413A (en) | 1992-01-22 | 1995-06-13 | Gen-Probe Incorporated | Branched nucleic acid probes |
FR2703693B1 (fr) | 1993-04-06 | 1995-07-13 | Pasteur Institut | Procédé rapide de détermination d'une séquence d'ADN et application au séquençage et au diagnostic. |
US5777078A (en) | 1993-04-28 | 1998-07-07 | Worcester Foundation For Experimental Biology | Triggered pore-forming agents |
WO1994025616A1 (en) | 1993-04-28 | 1994-11-10 | Worcester Foundation For Experimental Biology | Cell-targeted lytic pore-forming agents |
DE4320201A1 (de) | 1993-06-18 | 1995-01-12 | Asta Medica Ag | Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation |
US5561043A (en) | 1994-01-31 | 1996-10-01 | Trustees Of Boston University | Self-assembling multimeric nucleic acid constructs |
US7569341B2 (en) | 1994-01-31 | 2009-08-04 | Trustees Of Boston University | Nucleic acid directed immobilization arrays and methods of assembly |
US5795782A (en) | 1995-03-17 | 1998-08-18 | President & Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US6362002B1 (en) | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US6395887B1 (en) | 1995-08-01 | 2002-05-28 | Yale University | Analysis of gene expression by display of 3'-end fragments of CDNAS |
US5866336A (en) | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
AU8586298A (en) | 1997-07-25 | 1999-02-16 | University Of Massachusetts | Designed protein pores as components for biosensors |
US6087099A (en) | 1997-09-08 | 2000-07-11 | Myriad Genetics, Inc. | Method for sequencing both strands of a double stranded DNA in a single sequencing reaction |
US6127166A (en) | 1997-11-03 | 2000-10-03 | Bayley; Hagan | Molluscan ligament polypeptides and genes encoding them |
JPH11137260A (ja) | 1997-11-06 | 1999-05-25 | Soyaku Gijutsu Kenkyusho:Kk | 抗インフルエンザウイルス環状ダンベル型rna−dnaキメラ化合物及び抗インフルエンザウイルス剤 |
US6123819A (en) | 1997-11-12 | 2000-09-26 | Protiveris, Inc. | Nanoelectrode arrays |
DE19826758C1 (de) | 1998-06-15 | 1999-10-21 | Soft Gene Gmbh | Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte |
US6743605B1 (en) | 1998-06-24 | 2004-06-01 | Enzo Life Sciences, Inc. | Linear amplification of specific nucleic acid sequences |
US6787308B2 (en) * | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
US6235502B1 (en) | 1998-09-18 | 2001-05-22 | Molecular Staging Inc. | Methods for selectively isolating DNA using rolling circle amplification |
US6267872B1 (en) | 1998-11-06 | 2001-07-31 | The Regents Of The University Of California | Miniature support for thin films containing single channels or nanopores and methods for using same |
US6426231B1 (en) | 1998-11-18 | 2002-07-30 | The Texas A&M University System | Analyte sensing mediated by adapter/carrier molecules |
US6465193B2 (en) | 1998-12-11 | 2002-10-15 | The Regents Of The University Of California | Targeted molecular bar codes and methods for using the same |
NO986133D0 (no) | 1998-12-23 | 1998-12-23 | Preben Lexow | FremgangsmÕte for DNA-sekvensering |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
EP2383776B1 (en) * | 1999-06-22 | 2015-02-25 | President and Fellows of Harvard College | Solid state nanopore device for evaluating biopolymers |
EP1196434A2 (en) | 1999-06-29 | 2002-04-17 | University Health Network | Peptide conjugates for the stabilization of membrane proteins and interactions with biological membranes |
AU6638000A (en) | 1999-08-13 | 2001-03-13 | Yale University | Binary encoded sequence tags |
US6682649B1 (en) | 1999-10-01 | 2004-01-27 | Sophion Bioscience A/S | Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels |
CA2360342A1 (en) | 1999-12-02 | 2001-06-07 | Molecular Staging Inc. | Generation of single-strand circular dna from linear self-annealing segments |
EP1255772A2 (en) | 2000-02-11 | 2002-11-13 | The Texas A & M University System | Biosensor compositions and methods of use |
AU5091201A (en) | 2000-03-21 | 2001-10-03 | Curagen Corp | Vegf-modulated genes and methods employing them |
AU4778101A (en) | 2000-03-22 | 2001-10-03 | Curagen Corp | Novel polypeptides, and nucleic acids encoding the same |
US6596488B2 (en) | 2000-03-30 | 2003-07-22 | City Of Hope | Tumor suppressor gene |
US6387624B1 (en) | 2000-04-14 | 2002-05-14 | Incyte Pharmaceuticals, Inc. | Construction of uni-directionally cloned cDNA libraries from messenger RNA for improved 3′ end DNA sequencing |
US7001792B2 (en) | 2000-04-24 | 2006-02-21 | Eagle Research & Development, Llc | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
US20020132350A1 (en) | 2000-09-14 | 2002-09-19 | Pioneer Hi-Bred International, Inc. | Targeted genetic manipulation using Mu bacteriophage cleaved donor complex |
WO2002042496A2 (en) | 2000-11-27 | 2002-05-30 | The Regents Of The University Of California | Methods and devices for characterizing duplex nucleic acid molecules |
US20020197618A1 (en) | 2001-01-20 | 2002-12-26 | Sampson Jeffrey R. | Synthesis and amplification of unstructured nucleic acids for rapid sequencing |
US20030087232A1 (en) | 2001-01-25 | 2003-05-08 | Fred Christians | Methods for screening polypeptides |
US7807408B2 (en) | 2001-03-19 | 2010-10-05 | President & Fellows Of Harvard College | Directed evolution of proteins |
US6863833B1 (en) | 2001-06-29 | 2005-03-08 | The Board Of Trustees Of The Leland Stanford Junior University | Microfabricated apertures for supporting bilayer lipid membranes |
EP1585954B1 (en) | 2001-07-03 | 2014-03-26 | The Regents of The University of California | Mammalian sweet and amino acid heterodimeric taste receptors |
US6852492B2 (en) | 2001-09-24 | 2005-02-08 | Intel Corporation | Nucleic acid sequencing by raman monitoring of uptake of precursors during molecular replication |
EP2186897B1 (en) | 2002-03-15 | 2016-02-17 | Nuevolution A/S | An improved method for synthesising templated molecules |
EP1504114B1 (en) | 2002-05-10 | 2017-07-12 | The Texas A & M University System | Stochastic sensing through covalent interactions |
US7452699B2 (en) | 2003-01-15 | 2008-11-18 | Dana-Farber Cancer Institute, Inc. | Amplification of DNA in a hairpin structure, and applications |
WO2004072294A2 (en) | 2003-02-12 | 2004-08-26 | Genizon Svenska Ab | Methods and means for nucleic acid sequencing |
WO2004092331A2 (en) | 2003-04-08 | 2004-10-28 | Li-Cor, Inc. | Composition and method for nucleic acid sequencing |
US7163658B2 (en) | 2003-04-23 | 2007-01-16 | Rouvain Bension | Rapid sequencing of polymers |
US7344882B2 (en) | 2003-05-12 | 2008-03-18 | Bristol-Myers Squibb Company | Polynucleotides encoding variants of the TRP channel family member, LTRPC3 |
WO2005056750A2 (en) | 2003-12-11 | 2005-06-23 | Quark Biotech, Inc. | Inversion-duplication of nucleic acids and libraries prepared thereby |
US7238485B2 (en) | 2004-03-23 | 2007-07-03 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
GB2413796B (en) | 2004-03-25 | 2006-03-29 | Global Genomics Ab | Methods and means for nucleic acid sequencing |
US20050227239A1 (en) * | 2004-04-08 | 2005-10-13 | Joyce Timothy H | Microarray based affinity purification and analysis device coupled with solid state nanopore electrodes |
US7618778B2 (en) * | 2004-06-02 | 2009-11-17 | Kaufman Joseph C | Producing, cataloging and classifying sequence tags |
WO2005124888A1 (en) | 2004-06-08 | 2005-12-29 | President And Fellows Of Harvard College | Suspended carbon nanotube field effect transistor |
US7700281B2 (en) | 2004-06-30 | 2010-04-20 | Usb Corporation | Hot start nucleic acid amplification |
CN101103357B (zh) | 2004-08-13 | 2012-10-03 | 哈佛学院院长等 | 超高处理量光学-纳米孔dna读出平台 |
US20060086626A1 (en) * | 2004-10-22 | 2006-04-27 | Joyce Timothy H | Nanostructure resonant tunneling with a gate voltage source |
WO2007084103A2 (en) | 2004-12-21 | 2007-07-26 | The Texas A & M University System | High temperature ion channels and pores |
US7890268B2 (en) | 2004-12-28 | 2011-02-15 | Roche Molecular Systems, Inc. | De-novo sequencing of nucleic acids |
GB0505971D0 (en) | 2005-03-23 | 2005-04-27 | Isis Innovation | Delivery of molecules to a lipid bilayer |
US7507575B2 (en) | 2005-04-01 | 2009-03-24 | 3M Innovative Properties Company | Multiplex fluorescence detection device having removable optical modules |
WO2007145612A1 (en) | 2005-06-06 | 2007-12-21 | 454 Life Sciences Corporation | Paired end sequencing |
US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
DK1924704T3 (da) | 2005-08-02 | 2011-09-05 | Rubicon Genomics Inc | Sammensætninger og fremgangsmåder til bearbejdning og mangfoldiggørelse af DNA, herunder ved anvendelse af flere enzymer i en enkelt reaktion |
WO2007024997A2 (en) | 2005-08-22 | 2007-03-01 | Fermalogic, Inc. | Methods of increasing production of secondary metabolites |
GB0523282D0 (en) | 2005-11-15 | 2005-12-21 | Isis Innovation | Methods using pores |
WO2007075987A2 (en) | 2005-12-22 | 2007-07-05 | Pacific Biosciences Of California, Inc. | Active surface coupled polymerases |
US7932029B1 (en) | 2006-01-04 | 2011-04-26 | Si Lok | Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities |
EP1994179A2 (en) * | 2006-02-18 | 2008-11-26 | Michael Strathmann | Massively multiplexed sequencing |
US8673567B2 (en) * | 2006-03-08 | 2014-03-18 | Atila Biosystems, Inc. | Method and kit for nucleic acid sequence detection |
DK2002017T3 (da) | 2006-04-04 | 2015-09-07 | Keygene Nv | Højkapacitet-detektering af molekylære markører baseret på restriktionsfragmenter |
CN101495656B (zh) | 2006-06-07 | 2017-02-08 | 纽约哥伦比亚大学理事会 | 采用带修饰的核苷酸通过纳米通道进行dna序列测定 |
JP4876766B2 (ja) | 2006-08-10 | 2012-02-15 | トヨタ自動車株式会社 | 燃料電池 |
EP2059606A4 (en) | 2006-09-06 | 2010-04-07 | Phasebio Pharmaceuticals Inc | PEPTIDE FUSION THERAPEUTIC COMPOSITIONS |
WO2008045575A2 (en) | 2006-10-13 | 2008-04-17 | J. Craig Venter Institute, Inc. | Sequencing method |
AU2007309504B2 (en) | 2006-10-23 | 2012-09-13 | Pacific Biosciences Of California, Inc. | Polymerase enzymes and reagents for enhanced nucleic acid sequencing |
GB2445016B (en) | 2006-12-19 | 2012-03-07 | Microsaic Systems Plc | Microengineered ionisation device |
WO2008102120A1 (en) | 2007-02-20 | 2008-08-28 | Oxford Nanopore Technologies Limited | Lipid bilayer sensor system |
CN101680873B (zh) * | 2007-04-04 | 2015-11-25 | 加利福尼亚大学董事会 | 使用纳米孔的组合物、设备、系统和方法 |
EP3540436B1 (en) | 2007-09-12 | 2023-11-01 | President And Fellows Of Harvard College | High-resolution molecular sensor |
GB2453377A (en) | 2007-10-05 | 2009-04-08 | Isis Innovation | Transmembrane protein pores and molecular adapters therefore. |
KR101414713B1 (ko) | 2007-10-11 | 2014-07-03 | 삼성전자주식회사 | 리가제 및 엔도뉴클레아제의 존재하에서 롤링서클 증폭에의하여 표적 핵산을 증폭하는 방법 |
CN100554946C (zh) * | 2007-12-18 | 2009-10-28 | 中国农业大学 | 一种双链核酸精确定量的方法 |
GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
EP2232233B1 (en) | 2007-12-31 | 2014-03-12 | Fujirebio Inc. | Clusters of microresonators for cavity mode optical sensing |
WO2009092035A2 (en) * | 2008-01-17 | 2009-07-23 | Sequenom, Inc. | Methods and compositions for the analysis of biological molecules |
US8231969B2 (en) | 2008-03-26 | 2012-07-31 | University Of Utah Research Foundation | Asymmetrically functionalized nanoparticles |
US8628940B2 (en) | 2008-09-24 | 2014-01-14 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
EP2274449B1 (en) | 2008-03-28 | 2015-12-23 | Pacific Biosciences of California, Inc. | Methods for nucleic acid sequencing |
US8236499B2 (en) | 2008-03-28 | 2012-08-07 | Pacific Biosciences Of California, Inc. | Methods and compositions for nucleic acid sample preparation |
US8143030B2 (en) | 2008-09-24 | 2012-03-27 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
WO2009132315A1 (en) * | 2008-04-24 | 2009-10-29 | Life Technologies Corporation | Method of sequencing and mapping target nucleic acids |
JP2012500620A (ja) | 2008-04-24 | 2012-01-12 | ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク | Dna分子組織化のための幾何学的パターンおよび脂質二重層、ならびにその使用 |
US20110229877A1 (en) | 2008-07-07 | 2011-09-22 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
AU2009269792A1 (en) | 2008-07-07 | 2010-01-14 | Oxford Nanopore Technologies Limited | Base-detecting pore |
US20100092960A1 (en) | 2008-07-25 | 2010-04-15 | Pacific Biosciences Of California, Inc. | Helicase-assisted sequencing with molecular beacons |
WO2010030683A1 (en) * | 2008-09-09 | 2010-03-18 | Rosetta Inpharmatics Llc | Methods of generating gene specific libraries |
WO2010034018A2 (en) | 2008-09-22 | 2010-03-25 | University Of Washington | Msp nanopores and related methods |
US8383369B2 (en) | 2008-09-24 | 2013-02-26 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
US9080211B2 (en) | 2008-10-24 | 2015-07-14 | Epicentre Technologies Corporation | Transposon end compositions and methods for modifying nucleic acids |
ES2743029T3 (es) | 2008-10-24 | 2020-02-18 | Epicentre Tech Corporation | Composiciones de extremo del transposón y métodos para modificar ácidos nucleicos |
US8486630B2 (en) * | 2008-11-07 | 2013-07-16 | Industrial Technology Research Institute | Methods for accurate sequence data and modified base position determination |
GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
CA2746632C (en) * | 2008-12-11 | 2020-06-30 | Pacific Biosciences Of California, Inc. | Characterization of modified nucleic acids |
KR20110125226A (ko) | 2009-01-30 | 2011-11-18 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 혼성화 링커 |
KR101797773B1 (ko) * | 2009-01-30 | 2017-11-15 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 막횡단 시퀀싱에서 핵산 구축물용 어댑터 |
EP2396430B1 (en) | 2009-02-16 | 2013-05-01 | Epicentre Technologies Corporation | Template-independent ligation of single-stranded dna |
RU2011138951A (ru) | 2009-02-23 | 2013-03-27 | Сайтомкс Терапьютикс, Инк. | Пропротеины и способы их применения |
FR2943656A1 (fr) | 2009-03-25 | 2010-10-01 | Air Liquide | Procede et installation de production d'hydrogene mettant en oeuvre un compresseur thermocinetique |
GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
US8986928B2 (en) | 2009-04-10 | 2015-03-24 | Pacific Biosciences Of California, Inc. | Nanopore sequencing devices and methods |
JP5781502B2 (ja) | 2009-04-20 | 2015-09-24 | オックスフォード ナノポール テクノロジーズ リミテッド | 脂質二重層センサアレイ |
KR101814056B1 (ko) | 2009-12-01 | 2018-01-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 생화학적 분석 기구 |
US20120010085A1 (en) * | 2010-01-19 | 2012-01-12 | Rava Richard P | Methods for determining fraction of fetal nucleic acids in maternal samples |
FR2955773B1 (fr) | 2010-02-01 | 2017-05-26 | Commissariat A L'energie Atomique | Complexe moleculaire de ciblage des antigenes vers les cellules presentatrices d'antigene et ses applications pour la vaccination |
KR20110100963A (ko) * | 2010-03-05 | 2011-09-15 | 삼성전자주식회사 | 미세 유동 장치 및 이를 이용한 표적 핵산의 염기 서열 결정 방법 |
ES2626411T3 (es) | 2010-03-10 | 2017-07-25 | Ibis Biosciences, Inc. | Producción de ácido nucleico circular monocatenario |
US8652779B2 (en) | 2010-04-09 | 2014-02-18 | Pacific Biosciences Of California, Inc. | Nanopore sequencing using charge blockade labels |
US20120244525A1 (en) | 2010-07-19 | 2012-09-27 | New England Biolabs, Inc. | Oligonucleotide Adapters: Compositions and Methods of Use |
US20140051068A1 (en) | 2010-09-07 | 2014-02-20 | The Regents Of The University Of California | Control of dna movement in a nanopore at one nucleotide precision by a processive enzyme |
EP2635679B1 (en) | 2010-11-05 | 2017-04-19 | Illumina, Inc. | Linking sequence reads using paired code tags |
US10443096B2 (en) | 2010-12-17 | 2019-10-15 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by synthesis using modified nucleotides and nanopore detection |
US20130291392A1 (en) | 2011-01-18 | 2013-11-07 | R.K. Swamy | Multipurpose instrument for triangle solutions, measurements and geometrical applications called triometer |
US9402808B2 (en) | 2011-01-19 | 2016-08-02 | Panacea Biotec Limited | Liquid oral composition of lanthanum salts |
US9238671B2 (en) | 2011-01-28 | 2016-01-19 | Illumina, Inc. | Oligonucleotide replacement for di-tagged and directional libraries |
US20120196279A1 (en) | 2011-02-02 | 2012-08-02 | Pacific Biosciences Of California, Inc. | Methods and compositions for nucleic acid sample preparation |
CA2826374C (en) | 2011-02-11 | 2024-01-23 | Oxford Nanopore Technologies Limited | Mutant pores |
CA2837306C (en) | 2011-05-27 | 2020-03-10 | Oxford Nanopore Technologies Limited | Determining the presence, absence or characteristics of an analyte coupled to a membrane |
US20130017978A1 (en) | 2011-07-11 | 2013-01-17 | Finnzymes Oy | Methods and transposon nucleic acids for generating a dna library |
US9145623B2 (en) | 2011-07-20 | 2015-09-29 | Thermo Fisher Scientific Oy | Transposon nucleic acids comprising a calibration sequence for DNA sequencing |
AU2012288629B2 (en) | 2011-07-25 | 2017-02-02 | Oxford Nanopore Technologies Limited | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
WO2013041878A1 (en) | 2011-09-23 | 2013-03-28 | Oxford Nanopore Technologies Limited | Analysis of a polymer comprising polymer units |
US20140308661A1 (en) | 2011-09-25 | 2014-10-16 | Theranos, Inc. | Systems and methods for multi-analysis |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
JP6226869B2 (ja) | 2011-10-21 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素法 |
CN104126018B (zh) | 2011-12-29 | 2021-09-14 | 牛津纳米孔技术公司 | 酶方法 |
US9617591B2 (en) | 2011-12-29 | 2017-04-11 | Oxford Nanopore Technologies Ltd. | Method for characterising a polynucleotide by using a XPD helicase |
NO2694769T3 (da) | 2012-03-06 | 2018-03-03 | ||
AU2013246702B2 (en) | 2012-04-10 | 2017-06-15 | Oxford Nanopore Technologies Limited | Mutant lysenin pores |
WO2013185137A1 (en) | 2012-06-08 | 2013-12-12 | Pacific Biosciences Of California, Inc. | Modified base detection with nanopore sequencing |
TWI655213B (zh) | 2012-07-13 | 2019-04-01 | 目立康股份有限公司 | 自我組織化肽衍生物的製造方法 |
BR112015001052B8 (pt) | 2012-07-19 | 2022-12-27 | Oxford Nanopore Tech Ltd | Métodos para distinguir um polinucleotídeo alvo,sensor para distinguir um polinucleotídeo alvo, e, uso de um construto |
US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
BR112015001054A8 (pt) | 2012-07-19 | 2022-08-02 | Oxford Nanopore Tech Ltd | Helicase monomérica que é membro da superfamília 1 ou superfamília 2, helicase hel308 isolada, método para caracterizar um polinucleotídeo alvo, e, sensor para a caracterização de um polinucleotídeo alvo |
EP2895618B1 (en) | 2012-09-14 | 2017-07-26 | Oxford Nanopore Technologies Limited | Sample preparation method |
AU2013336430B2 (en) | 2012-10-26 | 2018-02-15 | Oxford Nanopore Technologies Limited | Droplet interfaces |
GB201313121D0 (en) | 2013-07-23 | 2013-09-04 | Oxford Nanopore Tech Ltd | Array of volumes of polar medium |
EP2917732B1 (en) | 2012-11-09 | 2016-09-07 | Stratos Genomics Inc. | Concentrating a target molecule for sensing by a nanopore |
US9683230B2 (en) | 2013-01-09 | 2017-06-20 | Illumina Cambridge Limited | Sample preparation on a solid support |
US20140206842A1 (en) | 2013-01-22 | 2014-07-24 | Muhammed Majeed | Peptides Modified with Triterpenoids and Small Organic Molecules: Synthesis and use in Cosmeceutical |
GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
EP2964779B1 (en) | 2013-03-08 | 2018-08-29 | Oxford Nanopore Technologies Limited | Use of spacer elements in a nucleic acid to control movement of a helicase |
US10557133B2 (en) | 2013-03-13 | 2020-02-11 | Illumina, Inc. | Methods and compositions for nucleic acid sequencing |
US9708658B2 (en) | 2013-03-19 | 2017-07-18 | New England Biolabs, Inc. | Enrichment of target sequences |
CN105992634B (zh) | 2013-08-30 | 2019-06-14 | 华盛顿大学商业中心 | 选择性修饰聚合物亚单位以改进基于纳米孔的分析 |
GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
CN117947149A (zh) | 2013-10-18 | 2024-04-30 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
CN111534504B (zh) | 2014-01-22 | 2024-06-21 | 牛津纳米孔科技公开有限公司 | 将一个或多个多核苷酸结合蛋白连接到靶多核苷酸的方法 |
GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
WO2015148567A1 (en) | 2014-03-24 | 2015-10-01 | Bernick David L | Molecular adapter for capture and manipulation of transfer rna |
EP3715468A1 (en) | 2014-06-13 | 2020-09-30 | Illumina Cambridge Limited | Methods and compositions for preparing sequencing libraries |
US10017759B2 (en) | 2014-06-26 | 2018-07-10 | Illumina, Inc. | Library preparation of tagged nucleic acid |
WO2016003814A1 (en) | 2014-06-30 | 2016-01-07 | Illumina, Inc. | Methods and compositions using one-sided transposition |
WO2016022557A1 (en) | 2014-08-05 | 2016-02-11 | Twist Bioscience Corporation | Cell free cloning of nucleic acids |
WO2016028887A1 (en) | 2014-08-19 | 2016-02-25 | Pacific Biosciences Of California, Inc. | Compositions and methods for enrichment of nucleic acids |
GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
CN107208162B (zh) | 2015-02-26 | 2020-12-29 | 株式会社日立高新技术 | 核酸分子的构建方法 |
GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
CN107488656B (zh) | 2016-06-13 | 2020-07-17 | 陆欣华 | 一种核酸等温自扩增方法 |
GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
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EP2737084B1 (en) | 2017-10-18 |
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AU2012288629B2 (en) | 2017-02-02 |
US20160362739A1 (en) | 2016-12-15 |
US20220127669A1 (en) | 2022-04-28 |
AU2012288629A1 (en) | 2014-03-06 |
US20160281159A1 (en) | 2016-09-29 |
CN103827320A (zh) | 2014-05-28 |
KR20140050067A (ko) | 2014-04-28 |
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