IN2014CN00414A - - Google Patents
Info
- Publication number
- IN2014CN00414A IN2014CN00414A IN414CHN2014A IN2014CN00414A IN 2014CN00414 A IN2014CN00414 A IN 2014CN00414A IN 414CHN2014 A IN414CHN2014 A IN 414CHN2014A IN 2014CN00414 A IN2014CN00414 A IN 2014CN00414A
- Authority
- IN
- India
- Prior art keywords
- amino acid
- acid sequences
- polypeptides
- proteins
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161500464P | 2011-06-23 | 2011-06-23 | |
| PCT/EP2012/061304 WO2012175400A1 (fr) | 2011-06-23 | 2012-06-14 | Protéines se liant à la sérumalbumine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN00414A true IN2014CN00414A (fr) | 2015-04-03 |
Family
ID=46298413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN414CHN2014 IN2014CN00414A (fr) | 2011-06-23 | 2012-06-14 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9573992B2 (fr) |
| EP (3) | EP3466972A1 (fr) |
| JP (3) | JP6324887B2 (fr) |
| CN (2) | CN106046168A (fr) |
| AU (1) | AU2012271974B2 (fr) |
| CA (1) | CA2839779C (fr) |
| CY (1) | CY1122691T1 (fr) |
| DK (1) | DK2723771T3 (fr) |
| ES (1) | ES2759936T3 (fr) |
| HR (2) | HRP20170535T4 (fr) |
| HU (1) | HUE047238T2 (fr) |
| IN (1) | IN2014CN00414A (fr) |
| LT (1) | LT2723771T (fr) |
| PL (1) | PL2723771T3 (fr) |
| PT (1) | PT2723771T (fr) |
| SI (1) | SI2723771T1 (fr) |
| WO (1) | WO2012175400A1 (fr) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2621953B1 (fr) | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Matières biologiques associées à c-met |
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| IL293155A (en) | 2011-06-23 | 2022-07-01 | Ablynx Nv | Techniques for predicting, detecting, and reducing A-specific protein interference in assays involving single immunoglobulin variable domains |
| LT2723771T (lt) * | 2011-06-23 | 2019-12-10 | Ablynx Nv | Serumo albuminą surišantys baltymai |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
| WO2013045707A2 (fr) * | 2011-09-30 | 2013-04-04 | Ablynx Nv | Substances biologiques liées à c-met |
| WO2014087010A1 (fr) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | Polypeptides améliorés dirigés contre ige |
| SG10201805288QA (en) | 2014-05-16 | 2018-07-30 | Ablynx Nv | Improved immunoglobulin variable domains |
| EP3143403B1 (fr) | 2014-05-16 | 2021-10-27 | Ablynx N.V. | Méthodes pour détecter et/ou mesurer des anticorps anti-médicaments, en particulier des anticorps anti-médicaments dus au traitement |
| NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
| PL3233910T3 (pl) | 2014-12-19 | 2020-06-01 | Ablynx N.V. | Dimery nanociał połączone cysteiną |
| WO2016120843A1 (fr) | 2015-01-29 | 2016-08-04 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa | Molécules d'anticorps et systèmes d'administration peptidiques destinés à être utilisés dans la maladie d'alzheimer et autres troubles apparentés |
| EP3297672B1 (fr) | 2015-05-21 | 2021-09-01 | Harpoon Therapeutics, Inc. | Protéines trispécifiques de liaison et méthodes d'utilisation |
| NO2768984T3 (fr) | 2015-11-12 | 2018-06-09 | ||
| AU2016351710B2 (en) | 2015-11-13 | 2023-08-03 | Ablynx Nv | Improved serum albumin-binding immunoglobulin variable domains |
| PE20181532A1 (es) | 2015-11-18 | 2018-09-26 | Merck Sharp & Dohme | Enlazadores de pd1 y/o lag3 |
| US11332519B2 (en) * | 2015-11-18 | 2022-05-17 | Ablynx N.V. | Serum albumin binders |
| JP6768800B2 (ja) | 2015-11-18 | 2020-10-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｃｔｌａ４結合性物質 |
| CA3003777A1 (fr) | 2015-11-18 | 2017-05-26 | Merck Sharp & Dohme Corp. | Liants pd1/ctla4 |
| CA3006398A1 (fr) * | 2015-11-27 | 2017-06-01 | Ablynx Nv | Polypeptides inhibant le ligand cd40l |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| MX2018014228A (es) | 2016-05-20 | 2019-08-12 | Harpoon Therapeutics Inc | Proteina de union de albumina sérica de dominio unico. |
| BR112018076569A2 (pt) | 2016-06-23 | 2019-04-02 | Ablynx Nv | ensaios farmacocinéticos melhorados para domínios variáveis simples de imunoglobulina |
| MX2019005696A (es) | 2016-11-16 | 2019-08-14 | Ablynx Nv | Polipeptidos de reclutamiento de celulas t capaces de unir cd123 y tcr alfa/beta. |
| US11414480B2 (en) * | 2016-12-07 | 2022-08-16 | Ablynx N.V. | Serum albumin binding immunoglobulin single variable domains |
| CN107674122A (zh) * | 2016-12-28 | 2018-02-09 | 天津天锐生物科技有限公司 | 一种识别人血清白蛋白的单域抗体 |
| SG11201906264YA (en) | 2017-01-17 | 2019-08-27 | Ablynx Nv | Improved serum albumin binders |
| KR20230165374A (ko) * | 2017-01-17 | 2023-12-05 | 아블린쓰 엔.브이. | 개선된 혈청 알부민 결합제 |
| US11535668B2 (en) | 2017-02-28 | 2022-12-27 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| CN110546506B (zh) | 2017-03-31 | 2023-04-04 | 埃博灵克斯股份有限公司 | 改进的免疫原性测定法 |
| US10543271B2 (en) | 2017-05-12 | 2020-01-28 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
| MX2020003915A (es) | 2017-10-13 | 2020-10-08 | Harpoon Therapeutics Inc | Proteinas trispecificas y metodos de uso. |
| CA3078799A1 (fr) | 2017-10-13 | 2019-04-18 | Harpoon Therapeutics, Inc. | Proteines de liaison a l'antigene de maturation de cellules b |
| WO2019162521A1 (fr) * | 2018-02-26 | 2019-08-29 | Ablynx Nv | Séquences nucléotidiques améliorées codant des lieurs peptidiques |
| JP7425049B2 (ja) | 2018-09-25 | 2024-01-30 | ハープーン セラピューティクス，インク． | Ｄｌｌ３結合タンパク質および使用方法 |
| CN110964107B (zh) * | 2018-09-30 | 2022-08-09 | 苏州康宁杰瑞生物科技有限公司 | Met结合分子、其组合和用途 |
| CN111138536B (zh) * | 2018-11-06 | 2021-07-09 | 瑞阳(苏州)生物科技有限公司 | 抗人血清白蛋白单域抗体的制备及其应用 |
| CN111138537B (zh) * | 2018-11-06 | 2021-07-09 | 瑞阳(苏州)生物科技有限公司 | 一种抗人血清白蛋白抗体片段、制备方法和应用 |
| BR112022010231A2 (pt) | 2019-12-06 | 2022-09-06 | Ablynx Nv | Polipeptídeos compreendendo domínios variáveis únicos de imunoglobulina direcionados a tnfalfa e ox40l |
| CA3163877A1 (fr) | 2019-12-06 | 2021-06-10 | Ablynx Nv | Polypeptides comprenant des domaines variables uniques d'immunoglobuline ciblant tnf.alpha. et il-23 |
| JP2023504914A (ja) | 2019-12-09 | 2023-02-07 | アブリンクス・エヌ・フェー | Ｉｌ－１３およびｔｓｌｐを標的化する免疫グロブリン単一可変ドメインを含むポリペプチド |
| CN110988361B (zh) * | 2019-12-13 | 2020-09-18 | 山东民康生物科技有限公司 | 人血清白蛋白去除试剂盒 |
| AU2021224851A1 (en) | 2020-02-21 | 2022-09-15 | Harpoon Therapeutics, Inc. | FLT3 binding proteins and methods of use |
| IL296767A (en) | 2020-03-30 | 2022-11-01 | Ablynx Nv | A method for the production and purification of single variable multivalent immunoglobulin sites |
| JP2023544124A (ja) | 2020-09-25 | 2023-10-20 | アブリンクス エン．ヴェー． | Ｉｌ－１３およびｏｘ４０ｌを標的化する免疫グロブリン単一可変ドメインを含むポリペプチド |
| CN112142846B (zh) * | 2020-10-10 | 2022-07-08 | 西北大学 | Aox特异性抗体组合及其制备方法和用途 |
| EP4237438A1 (fr) | 2020-10-27 | 2023-09-06 | Beijing QL Biopharmaceutical Co., Ltd. | Protéines de fusion de gdf15 et leur utilisation |
| IL303783A (en) | 2020-12-18 | 2023-08-01 | Sanofi Sa | Polypeptides comprising single immunoglobulin variable sites targeting GLYPICAN-3 and the T-cell receptor |
| WO2022129572A1 (fr) | 2020-12-18 | 2022-06-23 | Ablynx Nv | Polypeptides comprenant des domaines variables uniques d'immunoglobuline ciblant il-6 et tnf-alpha |
| CA3203141A1 (fr) | 2020-12-18 | 2022-06-23 | Ablynx Nv | Polypeptides de recrutement de lymphocytes t bases sur la reactivite tcr alpha/beta |
| CA3224743A1 (fr) * | 2021-07-14 | 2023-01-19 | Beijing Ql Biopharmaceutical Co., Ltd. | Polypeptides de fusion pour troubles metaboliques |
| WO2023088295A1 (fr) * | 2021-11-17 | 2023-05-25 | 江苏先声药业有限公司 | Anticorps multi-spécifique et utilisation pharmaceutique associée |
| WO2023111266A1 (fr) | 2021-12-17 | 2023-06-22 | Ablynx Nv | POLYPEPTIDES COMPRENANT DES DOMAINES VARIABLES UNIQUES D'IMMUNOGLOBULINE CIBLANT TCRαβ, CD33 ET CD123 |
| CN118139892A (zh) * | 2022-01-14 | 2024-06-04 | 浙江道尔生物科技有限公司 | 一种三靶点抗肿瘤药物、其制备方法及其应用 |
| US20240109965A1 (en) | 2022-06-14 | 2024-04-04 | Ablynx N.V. | Immunoglobulin single variable domains targeting t cell receptor |
| WO2023242371A1 (fr) | 2022-06-15 | 2023-12-21 | argenx BV | Molécules de liaison hsa dépendantes du ph et procédés d'utilisation |
| US20240132624A1 (en) | 2022-07-27 | 2024-04-25 | Ablynx N.V. | Polypeptides binding to a specific epitope of the neonatal fc receptor |
| WO2024084203A1 (fr) | 2022-10-18 | 2024-04-25 | Isogenica Limited | Anticorps à domaine unique se liant à l'albumine |
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| US20110200525A1 (en) | 2008-10-09 | 2011-08-18 | Patz Jr Edward F | Vhh antibody fragments for use in the detection and treatment of cancer |
| AU2009314311B2 (en) | 2008-10-29 | 2013-01-10 | Ablynx N.V. | Methods for purification of single domain antigen binding molecules |
| EA021146B1 (ru) * | 2009-03-27 | 2015-04-30 | Глаксо Груп Лимитед | Продукты слияния и конъюгаты лекарственных средств |
| US9644022B2 (en) | 2009-11-30 | 2017-05-09 | Ablynx N.V. | Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
| SI2513147T1 (sl) | 2009-12-18 | 2016-11-30 | Sanofi | Nova protitelesa antagonisti in njihovi delci Fab proti GPVI in njihova uporaba |
| CA2788275A1 (fr) | 2010-03-03 | 2011-09-09 | Boehringer Ingelheim International Gmbh | Polypeptides de liaison beta-amyloides biparatopiques |
| EA201201273A1 (ru) | 2010-03-10 | 2013-02-28 | Генмаб А/С | Моноклональные антитела к с-мет |
| EP2621953B1 (fr) * | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Matières biologiques associées à c-met |
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| LT2723771T (lt) * | 2011-06-23 | 2019-12-10 | Ablynx Nv | Serumo albuminą surišantys baltymai |
| US20150344568A1 (en) | 2011-06-23 | 2015-12-03 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| IL293155A (en) | 2011-06-23 | 2022-07-01 | Ablynx Nv | Techniques for predicting, detecting, and reducing A-specific protein interference in assays involving single immunoglobulin variable domains |
| PE20141522A1 (es) | 2011-08-17 | 2014-11-17 | Glaxo Group Ltd | Proteinas y peptidos modificados |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
-
2012
- 2012-06-14 LT LT12727658T patent/LT2723771T/lt unknown
- 2012-06-14 CA CA2839779A patent/CA2839779C/fr active Active
- 2012-06-14 SI SI201231696T patent/SI2723771T1/sl unknown
- 2012-06-14 DK DK12727658T patent/DK2723771T3/da active
- 2012-06-14 CN CN201610392570.9A patent/CN106046168A/zh active Pending
- 2012-06-14 US US14/128,719 patent/US9573992B2/en active Active
- 2012-06-14 EP EP18205150.8A patent/EP3466972A1/fr active Pending
- 2012-06-14 JP JP2014516279A patent/JP6324887B2/ja active Active
- 2012-06-14 CN CN201280030647.8A patent/CN103619878B/zh active Active
- 2012-06-14 PT PT127276582T patent/PT2723771T/pt unknown
- 2012-06-14 EP EP12727658.2A patent/EP2723771B1/fr active Active
- 2012-06-14 HU HUE12727658A patent/HUE047238T2/hu unknown
- 2012-06-14 PL PL12727658T patent/PL2723771T3/pl unknown
- 2012-06-14 AU AU2012271974A patent/AU2012271974B2/en active Active
- 2012-06-14 EP EP23159592.7A patent/EP4218933A1/fr active Pending
- 2012-06-14 WO PCT/EP2012/061304 patent/WO2012175400A1/fr active Application Filing
- 2012-06-14 ES ES12727658T patent/ES2759936T3/es active Active
- 2012-06-14 IN IN414CHN2014 patent/IN2014CN00414A/en unknown
- 2012-06-25 HR HRP20170535TT patent/HRP20170535T4/hr unknown
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2017
- 2017-01-03 US US15/397,313 patent/US20170210789A1/en not_active Abandoned
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2018
- 2018-04-11 JP JP2018076201A patent/JP6843090B2/ja active Active
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2019
- 2019-11-29 HR HRP20192160TT patent/HRP20192160T1/hr unknown
- 2019-12-10 CY CY20191101299T patent/CY1122691T1/el unknown
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2021
- 2021-02-22 JP JP2021026177A patent/JP7304375B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20170535T4 (hr) | 2022-08-19 |
| JP2014520129A (ja) | 2014-08-21 |
| PL2723771T3 (pl) | 2020-04-30 |
| AU2012271974A1 (en) | 2013-12-12 |
| EP2723771B1 (fr) | 2019-09-11 |
| CN106046168A (zh) | 2016-10-26 |
| SI2723771T1 (sl) | 2019-12-31 |
| JP2021088585A (ja) | 2021-06-10 |
| HRP20170535T1 (hr) | 2017-06-16 |
| EP2723771A1 (fr) | 2014-04-30 |
| ES2759936T3 (es) | 2020-05-12 |
| US20140228546A1 (en) | 2014-08-14 |
| JP7304375B2 (ja) | 2023-07-06 |
| PT2723771T (pt) | 2019-12-11 |
| HUE047238T2 (hu) | 2020-04-28 |
| EP3466972A1 (fr) | 2019-04-10 |
| WO2012175400A1 (fr) | 2012-12-27 |
| CY1122691T1 (el) | 2021-03-12 |
| LT2723771T (lt) | 2019-12-10 |
| JP2018127478A (ja) | 2018-08-16 |
| AU2012271974B2 (en) | 2017-01-12 |
| US9573992B2 (en) | 2017-02-21 |
| CN103619878B (zh) | 2016-10-26 |
| CN103619878A (zh) | 2014-03-05 |
| HRP20192160T1 (hr) | 2020-02-21 |
| DK2723771T3 (da) | 2019-12-02 |
| CA2839779C (fr) | 2020-10-06 |
| US20170210789A1 (en) | 2017-07-27 |
| JP6324887B2 (ja) | 2018-05-16 |
| CA2839779A1 (fr) | 2012-12-27 |
| EP4218933A1 (fr) | 2023-08-02 |
| JP6843090B2 (ja) | 2021-03-17 |
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