IN2013MU03843A - - Google Patents
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- Publication number
- IN2013MU03843A IN2013MU03843A IN3843MU2013A IN2013MU03843A IN 2013MU03843 A IN2013MU03843 A IN 2013MU03843A IN 3843MU2013 A IN3843MU2013 A IN 3843MU2013A IN 2013MU03843 A IN2013MU03843 A IN 2013MU03843A
- Authority
- IN
- India
- Prior art keywords
- benzyl
- methylpiperidin
- methylamine
- methanol
- pyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/98—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14869304.7A EP2994454B1 (en) | 2013-12-09 | 2014-12-02 | An improved process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| ES19150972T ES2865058T3 (es) | 2013-12-09 | 2014-12-02 | Un proceso mejorado para la preparación de (3R,4R)-(1-bencil-4-metilpiperidin-3-il)-metilamina |
| PT191509728T PT3539965T (pt) | 2013-12-09 | 2014-12-02 | Processo melhorado para a preparação de (3r,4r)-(1-benzil-4-metilpiperidin-3-il)-metilamina |
| PL14869304T PL2994454T3 (pl) | 2013-12-09 | 2014-12-02 | Ulepszony sposób wytwarzania (3R,4R)-(1-benzylo-4-metylopiperydyn-3-ylo)metyloaminy |
| PL19150972T PL3539965T3 (pl) | 2013-12-09 | 2014-12-02 | Ulepszony sposób wytwarzania (3r,4r)-(1-benzylo-4-mety-lopiperydyn-3-ylo)metyloaminy |
| SI201431159T SI2994454T1 (sl) | 2013-12-09 | 2014-12-02 | Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metil piperidin-3-il)-metil amina |
| PT14869304T PT2994454T (pt) | 2013-12-09 | 2014-12-02 | Um processo melhorado para a preparacao de (3r,4r)-(1-benzil-4- metilpiperidin-3-il)-metilamina |
| ES14869304T ES2720066T3 (es) | 2013-12-09 | 2014-12-02 | Mejora del proceso de preparación de (3R,4R)-(1-bencil-4-metilpiperidín-3-il)-metilamina |
| SI201431805T SI3539965T1 (sl) | 2013-12-09 | 2014-12-02 | Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamina |
| BR112015025543-4A BR112015025543B1 (pt) | 2013-12-09 | 2014-12-02 | processo para a preparação de (3r,4r)-(1-benzil-4- metilpiperidina-3-il)-metilamina e compostos intermediários |
| HUE19150972A HUE053975T2 (hu) | 2013-12-09 | 2014-12-02 | Továbbfejlesztett eljárás (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin elõállítására |
| JP2016557204A JP6368794B2 (ja) | 2013-12-09 | 2014-12-02 | （３ｒ，４ｒ）−（１−ベンジル−４−メチルピペリジン−３−イル）−メチルアミンの改良された調製方法 |
| US14/891,028 US9951012B2 (en) | 2013-12-09 | 2014-12-02 | Process for the preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| HUE14869304A HUE042911T2 (hu) | 2013-12-09 | 2014-12-02 | Javított eljárás a (3R,4R)-(1-benzil-4-metil-piperidin-3-il)-metilamin elõállítására |
| EP19150972.8A EP3539965B1 (en) | 2013-12-09 | 2014-12-02 | An improved process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| TR2019/04767T TR201904767T4 (tr) | 2013-12-09 | 2014-12-02 | (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin hazırlanması için geliştirilmiş bir işlem. |
| MX2015015432A MX362290B (es) | 2013-12-09 | 2014-12-02 | Un proceso mejorado para la preparacion de (3r,4r)-(1-bencilo-4-me tilpiperidina-3-il)-metilamina. |
| PCT/IB2014/066510 WO2015087201A1 (en) | 2013-12-09 | 2014-12-02 | An improved process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| IN3843MU2013 IN2013MU03843A (lv) | 2013-12-09 | 2014-12-02 | |
| ZA2015/06551A ZA201506551B (en) | 2013-12-09 | 2015-09-04 | An improved process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| US15/590,408 US20170240510A1 (en) | 2013-12-09 | 2017-05-09 | Process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| US15/786,195 US20180037551A1 (en) | 2013-12-09 | 2017-10-17 | Process for the Preparation of (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE |
| US15/868,331 US10829450B2 (en) | 2013-12-09 | 2018-01-11 | Process for the preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3843MU2013 IN2013MU03843A (lv) | 2013-12-09 | 2014-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2013MU03843A true IN2013MU03843A (lv) | 2015-08-14 |
Family
ID=53370688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3843MU2013 IN2013MU03843A (lv) | 2013-12-09 | 2014-12-02 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9951012B2 (lv) |
| EP (2) | EP2994454B1 (lv) |
| JP (1) | JP6368794B2 (lv) |
| BR (1) | BR112015025543B1 (lv) |
| ES (2) | ES2865058T3 (lv) |
| HU (2) | HUE053975T2 (lv) |
| IN (1) | IN2013MU03843A (lv) |
| MX (1) | MX362290B (lv) |
| PL (2) | PL2994454T3 (lv) |
| PT (2) | PT2994454T (lv) |
| SI (2) | SI2994454T1 (lv) |
| TR (1) | TR201904767T4 (lv) |
| WO (1) | WO2015087201A1 (lv) |
| ZA (1) | ZA201506551B (lv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE053975T2 (hu) * | 2013-12-09 | 2021-08-30 | Unichem Lab Ltd | Továbbfejlesztett eljárás (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin elõállítására |
| HUE064003T2 (hu) | 2015-01-20 | 2024-02-28 | Wuxi Fortune Pharmaceutical Co Ltd | JAK-gátló |
| ES2734048T3 (es) | 2015-04-29 | 2019-12-04 | Wuxi Fortune Pharmaceutical Co Ltd | Inhibidores de Janus cinasas (JAK) |
| MX2017013797A (es) | 2015-05-29 | 2018-03-21 | Wuxi Fortune Pharmaceutical Co Ltd | Inhibidor de janus quinasa. |
| CN105237463B (zh) * | 2015-10-09 | 2017-10-10 | 刘卫国 | 一种(3r,4r)‑(1‑苄基‑4‑甲基哌啶‑3‑基)甲胺‑l‑二对甲苯甲酰酒石酸盐的制备方法 |
| CN105884781B (zh) * | 2016-04-18 | 2018-04-20 | 山东罗欣药业集团股份有限公司 | 一种枸橼酸托法替布的制备方法 |
| EP3301087A1 (en) * | 2016-09-30 | 2018-04-04 | DPx Fine Chemicals Austria GmbH & Co KG | Process for preparing chiral amines |
| CN107056681B (zh) * | 2017-03-30 | 2019-10-01 | 广州白云山光华制药股份有限公司 | 一种托法替布中间体的制备方法 |
| CN110668995A (zh) * | 2018-07-03 | 2020-01-10 | 江苏海悦康医药科技有限公司 | 一种枸橼酸托法替布中间体及枸橼酸托法替布的制备方法 |
| CN114685515A (zh) * | 2022-03-15 | 2022-07-01 | 上海蓝乐鸟实业有限公司 | 一种托法替尼的制备方法 |
| CN115872923B (zh) * | 2022-12-29 | 2023-04-28 | 成都泰和伟业生物科技有限公司 | 一种化合物及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06145144A (ja) | 1992-11-04 | 1994-05-24 | Ihara Chem Ind Co Ltd | 新規な３−アミノピリジン誘導体第４級アンモニウム塩及びこれを有効成分とする抗癌剤 |
| JP4671079B2 (ja) * | 1999-07-05 | 2011-04-13 | 日本農薬株式会社 | フタラミド誘導体、その中間体及び農園芸用殺虫剤並びにその使用方法 |
| ATE292634T1 (de) * | 1999-10-20 | 2005-04-15 | Tanabe Seiyaku Co | Inhibitoren der alpha-l beta-2 vermittelten zelladhäsion |
| PT1235830E (pt) | 1999-12-10 | 2004-04-30 | Pfizer Prod Inc | Compostos de pirrolo¬2,3-d|pirimidina como inibidores das proteina cinases |
| RS50955B (sr) | 2001-02-24 | 2010-08-31 | Boehringer Ingelheim Pharma Gmbh. & Co.Kg. | Derivati ksantina, njihovo dobijanje i njihova primena kao lekova |
| US7301023B2 (en) | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
| GT200200234A (es) * | 2001-12-06 | 2003-06-27 | Compuestos cristalinos novedosos | |
| CA2589773A1 (en) * | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Pyridine carboxamide derivatives for use as anticancer agents |
| PL1913000T3 (pl) * | 2005-07-29 | 2012-05-31 | Pfizer Prod Inc | Pochodne pirolo[2,3-d]pirymidyny, ich związki pośrednie i synteza |
| WO2008029237A2 (en) * | 2006-09-05 | 2008-03-13 | Pfizer Products Inc. | Combination therapies for rheumatoid arthritis |
| KR20110050654A (ko) * | 2008-08-01 | 2011-05-16 | 바이오크리스트 파마수티컬즈, 인코퍼레이티드 | Ｊａｋ3 억제제로서의 피페리딘 유도체 |
| US20120034250A1 (en) | 2009-04-14 | 2012-02-09 | Astellas Pharma Inc. | Condensed pyrrolopyridine derivative |
| CA2759026C (en) | 2009-04-20 | 2019-01-15 | Auspex Pharmaceuticals, Inc. | Piperidine inhibitors of janus kinase 3 |
| AU2010276215A1 (en) * | 2009-07-21 | 2012-02-16 | Auckland Uniservices Limited | Heteroaryl benzamides, compositions and methods of use |
| ES2512727T3 (es) * | 2009-09-29 | 2014-10-24 | Glaxo Group Limited | Nuevos compuestos |
| HUE053975T2 (hu) * | 2013-12-09 | 2021-08-30 | Unichem Lab Ltd | Továbbfejlesztett eljárás (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin elõállítására |
-
2014
- 2014-12-02 HU HUE19150972A patent/HUE053975T2/hu unknown
- 2014-12-02 PT PT14869304T patent/PT2994454T/pt unknown
- 2014-12-02 EP EP14869304.7A patent/EP2994454B1/en active Active
- 2014-12-02 JP JP2016557204A patent/JP6368794B2/ja not_active Expired - Fee Related
- 2014-12-02 IN IN3843MU2013 patent/IN2013MU03843A/en unknown
- 2014-12-02 PL PL14869304T patent/PL2994454T3/pl unknown
- 2014-12-02 WO PCT/IB2014/066510 patent/WO2015087201A1/en active Application Filing
- 2014-12-02 HU HUE14869304A patent/HUE042911T2/hu unknown
- 2014-12-02 US US14/891,028 patent/US9951012B2/en active Active
- 2014-12-02 MX MX2015015432A patent/MX362290B/es active IP Right Grant
- 2014-12-02 SI SI201431159T patent/SI2994454T1/sl unknown
- 2014-12-02 TR TR2019/04767T patent/TR201904767T4/tr unknown
- 2014-12-02 PL PL19150972T patent/PL3539965T3/pl unknown
- 2014-12-02 PT PT191509728T patent/PT3539965T/pt unknown
- 2014-12-02 EP EP19150972.8A patent/EP3539965B1/en active Active
- 2014-12-02 BR BR112015025543-4A patent/BR112015025543B1/pt not_active IP Right Cessation
- 2014-12-02 SI SI201431805T patent/SI3539965T1/sl unknown
- 2014-12-02 ES ES19150972T patent/ES2865058T3/es active Active
- 2014-12-02 ES ES14869304T patent/ES2720066T3/es active Active
-
2015
- 2015-09-04 ZA ZA2015/06551A patent/ZA201506551B/en unknown
-
2017
- 2017-05-09 US US15/590,408 patent/US20170240510A1/en not_active Abandoned
- 2017-10-17 US US15/786,195 patent/US20180037551A1/en not_active Abandoned
-
2018
- 2018-01-11 US US15/868,331 patent/US10829450B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TR201904767T4 (tr) | 2019-05-21 |
| HUE042911T2 (hu) | 2019-07-29 |
| PL2994454T3 (pl) | 2019-09-30 |
| PT2994454T (pt) | 2019-04-02 |
| SI3539965T1 (sl) | 2021-07-30 |
| MX362290B (es) | 2019-01-10 |
| ZA201506551B (en) | 2017-02-22 |
| MX2015015432A (es) | 2016-03-15 |
| US20180037551A1 (en) | 2018-02-08 |
| ES2865058T3 (es) | 2021-10-14 |
| BR112015025543B1 (pt) | 2020-11-03 |
| EP3539965A1 (en) | 2019-09-18 |
| EP3539965B1 (en) | 2021-01-20 |
| US20170240510A1 (en) | 2017-08-24 |
| JP6368794B2 (ja) | 2018-08-01 |
| EP2994454B1 (en) | 2019-03-06 |
| WO2015087201A1 (en) | 2015-06-18 |
| PT3539965T (pt) | 2021-04-07 |
| ES2720066T3 (es) | 2019-07-17 |
| US20180134661A1 (en) | 2018-05-17 |
| HUE053975T2 (hu) | 2021-08-30 |
| BR112015025543A2 (pt) | 2017-07-18 |
| PL3539965T3 (pl) | 2021-07-05 |
| EP2994454A1 (en) | 2016-03-16 |
| US20160102057A1 (en) | 2016-04-14 |
| US9951012B2 (en) | 2018-04-24 |
| EP2994454A4 (en) | 2016-12-21 |
| SI2994454T1 (sl) | 2019-05-31 |
| JP2017503007A (ja) | 2017-01-26 |
| US10829450B2 (en) | 2020-11-10 |
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