PT3539965T - Processo melhorado para a preparação de (3r,4r)-(1-benzil-4-metilpiperidin-3-il)-metilamina - Google Patents
Processo melhorado para a preparação de (3r,4r)-(1-benzil-4-metilpiperidin-3-il)-metilaminaInfo
- Publication number
- PT3539965T PT3539965T PT191509728T PT19150972T PT3539965T PT 3539965 T PT3539965 T PT 3539965T PT 191509728 T PT191509728 T PT 191509728T PT 19150972 T PT19150972 T PT 19150972T PT 3539965 T PT3539965 T PT 3539965T
- Authority
- PT
- Portugal
- Prior art keywords
- methylpiperidin
- methylamine
- benzyl
- preparation
- improved process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/98—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3843MU2013 IN2013MU03843A (pt) | 2013-12-09 | 2014-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3539965T true PT3539965T (pt) | 2021-04-07 |
Family
ID=53370688
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT191509728T PT3539965T (pt) | 2013-12-09 | 2014-12-02 | Processo melhorado para a preparação de (3r,4r)-(1-benzil-4-metilpiperidin-3-il)-metilamina |
| PT14869304T PT2994454T (pt) | 2013-12-09 | 2014-12-02 | Um processo melhorado para a preparacao de (3r,4r)-(1-benzil-4- metilpiperidin-3-il)-metilamina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT14869304T PT2994454T (pt) | 2013-12-09 | 2014-12-02 | Um processo melhorado para a preparacao de (3r,4r)-(1-benzil-4- metilpiperidin-3-il)-metilamina |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9951012B2 (pt) |
| EP (2) | EP3539965B1 (pt) |
| JP (1) | JP6368794B2 (pt) |
| BR (1) | BR112015025543B1 (pt) |
| ES (2) | ES2720066T3 (pt) |
| HU (2) | HUE053975T2 (pt) |
| IN (1) | IN2013MU03843A (pt) |
| MX (1) | MX362290B (pt) |
| PL (2) | PL2994454T3 (pt) |
| PT (2) | PT3539965T (pt) |
| SI (2) | SI2994454T1 (pt) |
| TR (1) | TR201904767T4 (pt) |
| WO (1) | WO2015087201A1 (pt) |
| ZA (1) | ZA201506551B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE053975T2 (hu) * | 2013-12-09 | 2021-08-30 | Unichem Lab Ltd | Továbbfejlesztett eljárás (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin elõállítására |
| CN108349977B (zh) | 2015-01-20 | 2021-05-25 | 无锡福祈制药有限公司 | Jak抑制剂 |
| ES2734048T3 (es) | 2015-04-29 | 2019-12-04 | Wuxi Fortune Pharmaceutical Co Ltd | Inhibidores de Janus cinasas (JAK) |
| EA036063B1 (ru) | 2015-05-29 | 2020-09-22 | Уси Форчун Фармасьютикал Ко., Лтд | Ингибитор янус-киназы |
| CN105237463B (zh) * | 2015-10-09 | 2017-10-10 | 刘卫国 | 一种(3r,4r)‑(1‑苄基‑4‑甲基哌啶‑3‑基)甲胺‑l‑二对甲苯甲酰酒石酸盐的制备方法 |
| CN105884781B (zh) * | 2016-04-18 | 2018-04-20 | 山东罗欣药业集团股份有限公司 | 一种枸橼酸托法替布的制备方法 |
| EP3301087A1 (en) * | 2016-09-30 | 2018-04-04 | DPx Fine Chemicals Austria GmbH & Co KG | Process for preparing chiral amines |
| CN107056681B (zh) * | 2017-03-30 | 2019-10-01 | 广州白云山光华制药股份有限公司 | 一种托法替布中间体的制备方法 |
| CN110668995A (zh) * | 2018-07-03 | 2020-01-10 | 江苏海悦康医药科技有限公司 | 一种枸橼酸托法替布中间体及枸橼酸托法替布的制备方法 |
| CN114685515A (zh) * | 2022-03-15 | 2022-07-01 | 上海蓝乐鸟实业有限公司 | 一种托法替尼的制备方法 |
| CN115872923B (zh) * | 2022-12-29 | 2023-04-28 | 成都泰和伟业生物科技有限公司 | 一种化合物及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06145144A (ja) | 1992-11-04 | 1994-05-24 | Ihara Chem Ind Co Ltd | 新規な３−アミノピリジン誘導体第４級アンモニウム塩及びこれを有効成分とする抗癌剤 |
| JP4671079B2 (ja) * | 1999-07-05 | 2011-04-13 | 日本農薬株式会社 | フタラミド誘導体、その中間体及び農園芸用殺虫剤並びにその使用方法 |
| ATE292634T1 (de) * | 1999-10-20 | 2005-04-15 | Tanabe Seiyaku Co | Inhibitoren der alpha-l beta-2 vermittelten zelladhäsion |
| KR100477818B1 (ko) | 1999-12-10 | 2005-03-22 | 화이자 프로덕츠 인코포레이티드 | 피롤로[2,3-ｄ] 피리미딘 화합물 |
| CN100408579C (zh) | 2001-02-24 | 2008-08-06 | 贝林格尔英格海姆法玛两合公司 | 黄嘌呤衍生物,其制法及其作为药物组合物的用途 |
| US7301023B2 (en) | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
| GT200200234A (es) * | 2001-12-06 | 2003-06-27 | Compuestos cristalinos novedosos | |
| AR054183A1 (es) * | 2004-12-22 | 2007-06-06 | Astrazeneca Ab | Derivados de piridincarboxamida y su uso como agentes anticancerigenos. procesos de obtencion y composiciones farmaceuticas. |
| AU2006273762A1 (en) * | 2005-07-29 | 2007-02-01 | Pfizer Products Inc. | Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis |
| WO2008029237A2 (en) * | 2006-09-05 | 2008-03-13 | Pfizer Products Inc. | Combination therapies for rheumatoid arthritis |
| NZ590922A (en) * | 2008-08-01 | 2012-09-28 | Biocryst Pharm Inc | Piperidine derivatives as jak3 inhibitors |
| TW201102389A (en) | 2009-04-14 | 2011-01-16 | Astellas Pharma Inc | Fused pyrroloprydine derivatives |
| EP2421867B1 (en) * | 2009-04-20 | 2015-09-02 | Auspex Pharmaceuticals, Llc | Piperidine inhibitors of janus kinase 3 |
| WO2011011514A1 (en) * | 2009-07-21 | 2011-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Heteroaryl benzamides, compositions and methods of use |
| SG179120A1 (en) * | 2009-09-29 | 2012-05-30 | Glaxo Group Ltd | Novel compounds |
| HUE053975T2 (hu) * | 2013-12-09 | 2021-08-30 | Unichem Lab Ltd | Továbbfejlesztett eljárás (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin elõállítására |
-
2014
- 2014-12-02 HU HUE19150972A patent/HUE053975T2/hu unknown
- 2014-12-02 TR TR2019/04767T patent/TR201904767T4/tr unknown
- 2014-12-02 PT PT191509728T patent/PT3539965T/pt unknown
- 2014-12-02 MX MX2015015432A patent/MX362290B/es active IP Right Grant
- 2014-12-02 PL PL14869304T patent/PL2994454T3/pl unknown
- 2014-12-02 HU HUE14869304A patent/HUE042911T2/hu unknown
- 2014-12-02 WO PCT/IB2014/066510 patent/WO2015087201A1/en active Application Filing
- 2014-12-02 IN IN3843MU2013 patent/IN2013MU03843A/en unknown
- 2014-12-02 SI SI201431159T patent/SI2994454T1/sl unknown
- 2014-12-02 US US14/891,028 patent/US9951012B2/en active Active
- 2014-12-02 PT PT14869304T patent/PT2994454T/pt unknown
- 2014-12-02 EP EP19150972.8A patent/EP3539965B1/en active Active
- 2014-12-02 ES ES14869304T patent/ES2720066T3/es active Active
- 2014-12-02 PL PL19150972T patent/PL3539965T3/pl unknown
- 2014-12-02 SI SI201431805T patent/SI3539965T1/sl unknown
- 2014-12-02 ES ES19150972T patent/ES2865058T3/es active Active
- 2014-12-02 BR BR112015025543-4A patent/BR112015025543B1/pt not_active IP Right Cessation
- 2014-12-02 EP EP14869304.7A patent/EP2994454B1/en active Active
- 2014-12-02 JP JP2016557204A patent/JP6368794B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-04 ZA ZA2015/06551A patent/ZA201506551B/en unknown
-
2017
- 2017-05-09 US US15/590,408 patent/US20170240510A1/en not_active Abandoned
- 2017-10-17 US US15/786,195 patent/US20180037551A1/en not_active Abandoned
-
2018
- 2018-01-11 US US15/868,331 patent/US10829450B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10829450B2 (en) | 2020-11-10 |
| US20180037551A1 (en) | 2018-02-08 |
| US20180134661A1 (en) | 2018-05-17 |
| MX362290B (es) | 2019-01-10 |
| HUE053975T2 (hu) | 2021-08-30 |
| ES2720066T3 (es) | 2019-07-17 |
| SI2994454T1 (sl) | 2019-05-31 |
| JP6368794B2 (ja) | 2018-08-01 |
| US20170240510A1 (en) | 2017-08-24 |
| EP3539965B1 (en) | 2021-01-20 |
| WO2015087201A1 (en) | 2015-06-18 |
| HUE042911T2 (hu) | 2019-07-29 |
| PL2994454T3 (pl) | 2019-09-30 |
| EP2994454B1 (en) | 2019-03-06 |
| SI3539965T1 (sl) | 2021-07-30 |
| EP3539965A1 (en) | 2019-09-18 |
| PT2994454T (pt) | 2019-04-02 |
| US20160102057A1 (en) | 2016-04-14 |
| EP2994454A4 (en) | 2016-12-21 |
| IN2013MU03843A (pt) | 2015-08-14 |
| EP2994454A1 (en) | 2016-03-16 |
| MX2015015432A (es) | 2016-03-15 |
| BR112015025543A2 (pt) | 2017-07-18 |
| PL3539965T3 (pl) | 2021-07-05 |
| ES2865058T3 (es) | 2021-10-14 |
| US9951012B2 (en) | 2018-04-24 |
| JP2017503007A (ja) | 2017-01-26 |
| TR201904767T4 (tr) | 2019-05-21 |
| BR112015025543B1 (pt) | 2020-11-03 |
| ZA201506551B (en) | 2017-02-22 |
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