IN2013MN02407A - - Google Patents

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Publication number
IN2013MN02407A
IN2013MN02407A IN2407MUN2013A IN2013MN02407A IN 2013MN02407 A IN2013MN02407 A IN 2013MN02407A IN 2407MUN2013 A IN2407MUN2013 A IN 2407MUN2013A IN 2013MN02407 A IN2013MN02407 A IN 2013MN02407A
Authority
IN
India
Prior art keywords
compound
formula
salt
paliperidone
iii
Prior art date
Application number
Other languages
English (en)
Inventor
Ravikumar Puppala
Srinivas Laxminarayan Pathi
Rajendra Narayanrao Kankan
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Priority to IN2407MUN2013 priority Critical patent/IN2013MN02407A/en
Publication of IN2013MN02407A publication Critical patent/IN2013MN02407A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IN2407MUN2013 2011-05-30 2012-05-30 IN2013MN02407A (enrdf_load_stackoverflow)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IN2407MUN2013 IN2013MN02407A (enrdf_load_stackoverflow) 2011-05-30 2012-05-30

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1592MU2011 2011-05-30
IN2407MUN2013 IN2013MN02407A (enrdf_load_stackoverflow) 2011-05-30 2012-05-30
PCT/GB2012/000480 WO2012164242A1 (en) 2011-05-30 2012-05-30 Process for the preparation of paliperidone

Publications (1)

Publication Number Publication Date
IN2013MN02407A true IN2013MN02407A (enrdf_load_stackoverflow) 2015-06-12

Family

ID=46201755

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2407MUN2013 IN2013MN02407A (enrdf_load_stackoverflow) 2011-05-30 2012-05-30

Country Status (9)

Country Link
US (1) US9062049B2 (enrdf_load_stackoverflow)
EP (1) EP2714687B1 (enrdf_load_stackoverflow)
JP (1) JP2014515392A (enrdf_load_stackoverflow)
KR (1) KR20140040766A (enrdf_load_stackoverflow)
AU (1) AU2012264476B2 (enrdf_load_stackoverflow)
CA (1) CA2837251A1 (enrdf_load_stackoverflow)
IN (1) IN2013MN02407A (enrdf_load_stackoverflow)
WO (1) WO2012164242A1 (enrdf_load_stackoverflow)
ZA (1) ZA201309713B (enrdf_load_stackoverflow)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2837251A1 (en) 2011-05-30 2012-12-06 Cipla Limited Process for the preparation of paliperidone
CN104292226B (zh) * 2013-07-16 2016-12-28 江苏恩华药业股份有限公司 帕利哌酮氨基酸类衍生物及其应用
CN105481856B (zh) * 2015-12-17 2017-07-28 合肥立方制药股份有限公司 一种帕利哌酮的制备方法
CN108250195A (zh) * 2016-12-29 2018-07-06 江苏豪森药业集团有限公司 帕利哌酮的新合成方法
CN115109056A (zh) * 2022-06-16 2022-09-27 常州市第四制药厂有限公司 一种帕利哌酮的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158952A (en) 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
JP2009512627A (ja) * 2006-08-14 2009-03-26 テバ ファーマシューティカル インダストリーズ リミティド ９−ヒドロキシリスペリドン（パリペリドン）の合成方法
WO2008021346A2 (en) * 2006-08-14 2008-02-21 Teva Pharmaceutical Industries Ltd. Pure paliperidone and processes for preparing thereof
US20080171876A1 (en) 2007-05-10 2008-07-17 Santiago Ini Pure paliperidone and processes for preparing thereof
WO2009118655A2 (en) * 2008-03-27 2009-10-01 Actavis Group Ptc Ehf Highly pure paliperidone or a pharmaceutically acceptable salt thereof substantially free of keto impurity
WO2009144288A1 (en) * 2008-05-29 2009-12-03 Inke, S.A. Process to prepare paliperidone and intermediates thereof
EP2300467A4 (en) 2008-06-16 2012-04-25 Msn Lab Ltd NEW AND IMPROVED METHODS FOR THE MANUFACTURE OF PALIPERIDONE
US20100010218A1 (en) * 2008-07-11 2010-01-14 Jiri Bartl Synthesis of paliperidone
EP2318405A2 (en) 2008-07-11 2011-05-11 Synthon B.V. Paliperidone ketone
ATE544766T1 (de) 2009-07-13 2012-02-15 Krka Verfahren zur synthese von paliperidon
CA2837251A1 (en) 2011-05-30 2012-12-06 Cipla Limited Process for the preparation of paliperidone

Also Published As

Publication number Publication date
AU2012264476B2 (en) 2016-12-08
WO2012164242A8 (en) 2013-12-27
WO2012164242A1 (en) 2012-12-06
CA2837251A1 (en) 2012-12-06
EP2714687B1 (en) 2017-02-15
AU2012264476A1 (en) 2013-12-12
JP2014515392A (ja) 2014-06-30
AU2012264476A8 (en) 2014-06-05
EP2714687A1 (en) 2014-04-09
US9062049B2 (en) 2015-06-23
US20140200228A1 (en) 2014-07-17
KR20140040766A (ko) 2014-04-03
ZA201309713B (en) 2014-11-26

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