IL99905A - Topical compositions for transdermal delivery of morphine prodrugs - Google Patents

Topical compositions for transdermal delivery of morphine prodrugs

Info

Publication number
IL99905A
IL99905A IL9990591A IL9990591A IL99905A IL 99905 A IL99905 A IL 99905A IL 9990591 A IL9990591 A IL 9990591A IL 9990591 A IL9990591 A IL 9990591A IL 99905 A IL99905 A IL 99905A
Authority
IL
Israel
Prior art keywords
morphine
transdermal delivery
hydrogen
formula
topical
Prior art date
Application number
IL9990591A
Other languages
English (en)
Other versions
IL99905A0 (en
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of IL99905A0 publication Critical patent/IL99905A0/xx
Publication of IL99905A publication Critical patent/IL99905A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL9990591A 1990-11-16 1991-10-30 Topical compositions for transdermal delivery of morphine prodrugs IL99905A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs

Publications (2)

Publication Number Publication Date
IL99905A0 IL99905A0 (en) 1992-08-18
IL99905A true IL99905A (en) 1995-06-29

Family

ID=20380936

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9990591A IL99905A (en) 1990-11-16 1991-10-30 Topical compositions for transdermal delivery of morphine prodrugs

Country Status (18)

Country Link
US (1) US5908846A (de)
EP (1) EP0557385B1 (de)
JP (1) JP3493434B2 (de)
AT (1) ATE168560T1 (de)
AU (1) AU655612B2 (de)
CA (1) CA2095223C (de)
DE (1) DE69129861T2 (de)
DK (1) DK0557385T3 (de)
ES (1) ES2121793T3 (de)
FI (1) FI932212A0 (de)
IE (1) IE913682A1 (de)
IL (1) IL99905A (de)
NO (1) NO931766L (de)
NZ (1) NZ240349A (de)
PT (1) PT99513B (de)
SE (1) SE9003665D0 (de)
WO (1) WO1992008459A1 (de)
ZA (1) ZA918512B (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
DE4403709A1 (de) * 1994-02-07 1995-08-10 Lohmann Therapie Syst Lts Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
JPH07267862A (ja) * 1994-03-29 1995-10-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
DE19508664C2 (de) * 1995-03-14 2001-08-23 Christian Mignat Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung
AU5108596A (en) * 1995-03-14 1996-10-02 Mundipharma Gmbh Morphine-3-esters
GB9519363D0 (en) 1995-09-22 1995-11-22 Euro Celtique Sa Pharmaceutical formulation
DE19602964A1 (de) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung
DE19923551A1 (de) * 1999-05-21 2000-11-30 Lohmann Therapie Syst Lts Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht
ES2374717T3 (es) 1999-10-29 2012-02-21 Euro-Celtique S.A. Formulaciones de hidrocodona de liberación controlada.
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
JP2004512354A (ja) 2000-10-30 2004-04-22 ユーロ−セルティーク，エス．エイ． ヒドロコドン放出制御製剤
US6569449B1 (en) * 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
AUPR549901A0 (en) * 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
JP2004513183A (ja) * 2000-11-14 2004-04-30 バイタル　ヘルス　サイエンシズ　プロプライアタリー　リミティド リン酸誘導体の複合体
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
CN1514729B (zh) * 2001-06-05 2012-09-05 控制释放系统公司 缓释的止痛化合物
JP4745608B2 (ja) * 2001-07-27 2011-08-10 バイタル ヘルス サイエンシズ プロプライアタリー リミティド 電子伝達剤のリン酸誘導体を用いた皮膚治療
AU2002350272B1 (en) * 2001-12-13 2003-06-23 Vital Health Sciences Pty Ltd Transdermal transport of compounds
AU2002950713A0 (en) * 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
ATE444296T1 (de) * 2002-10-25 2009-10-15 Euro Celtique Sa Analoga und prodrugs von buprenorphin
US20040152769A1 (en) * 2002-11-09 2004-08-05 Ekwuribe Nnochiri Nkem Modified carbamate-containing prodrugs and methods of synthesizing same
JP4690305B2 (ja) * 2003-01-17 2011-06-01 バイタル ヘルス サイエンシズ プロプライアタリー リミティド 抗増殖性質を有する化合物
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
PT1638492E (pt) * 2003-07-25 2008-03-17 Euro Celtique Sa Tratamento pré-operatório da dor pós-operatória
EP2194059A3 (de) * 2004-02-06 2010-09-22 Euro-Celtique S.A. Verfahren zur Herstellung 3-O-geschützter Morphinone und 3-O-geschützter Morphinon-Dienol-Carboxylate
ME02661B (de) 2004-02-23 2017-06-20 Euro Celtique Sa Missbrauchsichere Vorrichtung zur transdermalen Opioidverabreichung
WO2005084678A1 (en) * 2004-03-03 2005-09-15 Vital Health Sciences Pty Ltd Alkaloid formulations
CA2611831C (en) * 2005-06-17 2014-09-16 Vital Health Sciences Pty Ltd. A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
EP1973547A1 (de) * 2005-12-23 2008-10-01 Vital Health Sciences Pty Ltd. Verbindungen mit zytokin-modulierenden eigenschaften
EP2123274B1 (de) 2007-03-02 2016-08-24 Teika Pharmaceutical Co., Ltd. Medizinische zusammensetzung zur transdermalen absorption, aufbewahrungseinheit für eine medizinische zusammensetzung und diese verwendende transdermale absorptionszubereitung
US9511016B2 (en) * 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
US8354116B2 (en) * 2007-06-18 2013-01-15 Biochemics, Inc. Bifunctional synthetic molecules
US8784872B2 (en) 2007-11-19 2014-07-22 Comgenrx, Inc. Formulation for decreasing tobacco, alcohol, drug or food consumption
US20090130048A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical Composition for Treating Pain
US20100104614A1 (en) * 2008-06-27 2010-04-29 Oronsky Bryan T Providone compositions for wound healing
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
WO2011002995A1 (en) * 2009-07-02 2011-01-06 Kempharm, Inc. Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10071030B2 (en) 2010-02-05 2018-09-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
ES2829386T3 (es) 2010-03-30 2021-05-31 Phosphagenics Ltd Parche de administración transdérmica
WO2011130455A1 (en) 2010-04-13 2011-10-20 Najib Babul Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use
TWI590821B (zh) 2011-01-18 2017-07-11 輝瑞有限公司 固體分子分散液
EP2685992A4 (de) 2011-03-15 2014-09-10 Phosphagenics Ltd Aminochinoline als kinasehemmer
BR112017011069A2 (pt) 2014-11-25 2018-07-10 Kempharm Inc ácido benzóico, derivados e ácido benzóico e conjugados de ácido heteroaril carboxílico de oxicodona
AU2016367708B2 (en) 2015-12-09 2022-07-14 Phosphagenics Limited Pharmaceutical formulation
MX2019006845A (es) 2016-12-21 2019-10-15 Avecho Biotechnology Ltd Proceso.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4673679A (en) * 1986-05-14 1987-06-16 E. I. Du Pont De Nemours And Company Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
US4940586A (en) * 1987-02-26 1990-07-10 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4879297A (en) * 1987-06-01 1989-11-07 Warner-Lambert Company Fatty acids and their small chain esters as penetration enhancers in aqueous systems
US4891377A (en) * 1988-12-02 1990-01-02 Board Of Regents Acting For And On Behalf Of University Of Michigan Transdermal delivery of the narcotic analgesics etorphine and analogs
ES2094809T3 (es) * 1990-03-30 1997-02-01 Yasunori Morimoto Composicion absorbible por via percutanea del clorhidrato de morfina.
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine

Also Published As

Publication number Publication date
PT99513B (pt) 1999-04-30
NZ240349A (en) 1993-07-27
EP0557385A1 (de) 1993-09-01
AU655612B2 (en) 1995-01-05
DE69129861D1 (de) 1998-08-27
CA2095223C (en) 2002-12-17
DE69129861T2 (de) 1999-04-01
FI932212A (fi) 1993-05-14
JP3493434B2 (ja) 2004-02-03
WO1992008459A1 (en) 1992-05-29
SE9003665D0 (sv) 1990-11-16
CA2095223A1 (en) 1992-05-17
DK0557385T3 (da) 1999-04-26
IE913682A1 (en) 1992-05-20
ATE168560T1 (de) 1998-08-15
US5908846A (en) 1999-06-01
ZA918512B (en) 1992-08-26
ES2121793T3 (es) 1998-12-16
NO931766D0 (no) 1993-05-14
PT99513A (pt) 1992-09-30
IL99905A0 (en) 1992-08-18
EP0557385B1 (de) 1998-07-22
FI932212A0 (fi) 1993-05-14
NO931766L (no) 1993-05-14
AU8938191A (en) 1992-06-11
JPH06502422A (ja) 1994-03-17

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Legal Events

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