IL99306A - תולדות אלקילאמידים הטרוציקליים, אגוניסטי שם סרוטונין a1th5 תהליך להכנתם ותכשירים תרופתיים המכילים אותן - Google Patents

תולדות אלקילאמידים הטרוציקליים, אגוניסטי שם סרוטונין a1th5 תהליך להכנתם ותכשירים תרופתיים המכילים אותן

Info

Publication number
IL99306A
IL99306A IL9930691A IL9930691A IL99306A IL 99306 A IL99306 A IL 99306A IL 9930691 A IL9930691 A IL 9930691A IL 9930691 A IL9930691 A IL 9930691A IL 99306 A IL99306 A IL 99306A
Authority
IL
Israel
Prior art keywords
compound according
phenyl
represented
ppm
nmr
Prior art date
Application number
IL9930691A
Other languages
English (en)
Other versions
IL99306A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL99306A0 publication Critical patent/IL99306A0/xx
Publication of IL99306A publication Critical patent/IL99306A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
IL9930691A 1990-08-29 1991-08-26 תולדות אלקילאמידים הטרוציקליים, אגוניסטי שם סרוטונין a1th5 תהליך להכנתם ותכשירים תרופתיים המכילים אותן IL99306A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57471090A 1990-08-29 1990-08-29
US07/735,700 US5189179A (en) 1990-08-29 1991-07-30 Serotonin 5ht1a agonists

Publications (2)

Publication Number Publication Date
IL99306A0 IL99306A0 (en) 1992-07-15
IL99306A true IL99306A (he) 1995-03-30

Family

ID=27076473

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9930691A IL99306A (he) 1990-08-29 1991-08-26 תולדות אלקילאמידים הטרוציקליים, אגוניסטי שם סרוטונין a1th5 תהליך להכנתם ותכשירים תרופתיים המכילים אותן

Country Status (21)

Country Link
US (3) US5189179A (he)
EP (1) EP0478954B1 (he)
JP (1) JPH04270264A (he)
KR (1) KR920004345A (he)
CN (1) CN1030766C (he)
AT (1) ATE197040T1 (he)
AU (1) AU641535B2 (he)
CA (1) CA2049803A1 (he)
DE (1) DE69132450T2 (he)
DK (1) DK0478954T3 (he)
ES (1) ES2153346T3 (he)
FI (1) FI914065A (he)
GR (1) GR3035062T3 (he)
HU (1) HU208955B (he)
IE (1) IE913036A1 (he)
IL (1) IL99306A (he)
NO (1) NO175430C (he)
NZ (1) NZ239521A (he)
PH (1) PH30242A (he)
PT (1) PT98800B (he)
TW (1) TW200457B (he)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189179A (en) * 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
US5892112A (en) * 1990-11-21 1999-04-06 Glycomed Incorporated Process for preparing synthetic matrix metalloprotease inhibitors
USRE38506E1 (en) 1991-10-04 2004-04-20 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US6406859B1 (en) 1992-01-08 2002-06-18 Synaptic Pharmaceutical Corporation DNA encoding a 5-HT 1F receptor and uses thereof
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9304632D0 (en) * 1993-03-06 1993-04-21 Wyeth John & Brother Ltd Amide derivatives
FR2707294B1 (fr) * 1993-07-06 1995-09-29 Pf Medicament Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine.
US5478572A (en) * 1994-09-06 1995-12-26 Bristol-Myers Squibb Co. Gepirone dosage form
AU706839B2 (en) 1996-03-29 1999-06-24 Pfizer Inc. Benzyl(idene)-lactam derivatives, their preparation and their use as selective (ANT)agonists of 5-HT1A- and/or 5-HT1D receptors
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6121307A (en) * 1998-04-08 2000-09-19 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
CN1304409A (zh) * 1998-04-08 2001-07-18 美国家用产品公司 用于治疗抑郁症的吲哚－3－基－环己胺衍生物(5－ht1受体拮抗剂)
AU3386199A (en) * 1998-04-08 1999-10-25 American Home Products Corporation N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents)
ATE227718T1 (de) * 1998-04-08 2002-11-15 Wyeth Corp N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen
US7588029B2 (en) * 2000-03-21 2009-09-15 Fisher & Paykel Healthcare Limited Humidified gases delivery apparatus
AU2002325712C1 (en) 2001-08-30 2008-07-31 Stem Cell Therapeutics Inc. Differentiation of neural stem cells and therapeutic use theeof
JP4906231B2 (ja) * 2001-09-14 2012-03-28 ステム セル セラピューティクス インコーポレイテッド プロラクチン誘導性の神経幹細胞数の増加ならびにその治療用途
US20030054551A1 (en) * 2001-09-18 2003-03-20 Stem Cell Therapeutics Inc. Effect of growth hormone and IGF-1 on neural stem cells
CA2492442A1 (en) * 2002-07-31 2004-02-05 Stem Cell Therapeutics Inc. Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (pacap)
ES2380827T3 (es) * 2002-12-26 2012-05-18 Pozen, Inc. Formas de dosificación con múltiples capas que contienen naproxeno y triptanes
BRPI0410807A (pt) * 2003-06-06 2006-06-27 Glaxo Group Ltd composição farmacêutica, e, método pata tratar um mamìfero sofrendo de ou susceptìvel a condições associadas com dor cefálica
WO2005018541A2 (en) * 2003-07-11 2005-03-03 Pharmacia Corporation Cox-2 inhibitor and serotonin modulator for treating cns damage
US20070111932A1 (en) * 2003-07-31 2007-05-17 Stem Cell Therapeutics Inc. Method of enhancing and/or inducing neuronal migration using erythropoietin
JP2007503396A (ja) * 2003-08-22 2007-02-22 ファルマシア コーポレイション 新形成の治療のためのシクロオキシゲナーゼ−２選択的阻害剤及びセロトニン−調節剤の組成物
CN1325673C (zh) * 2003-12-30 2007-07-11 上海交通大学 利用废旧紫铜生产无氧铜的装置
AU2005211847B2 (en) * 2004-02-13 2011-02-24 Stem Cell Therapeutics Corp. Use of luteinizing hormone (LH) and chorionic gonadotropin (hCG) for proliferation of neural stem cells and neurogenesis
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
US8283478B2 (en) 2005-05-20 2012-10-09 Janssen Pharmaceutica Nv Process for preparation of sulfamide derivatives
JP2009509943A (ja) 2005-09-27 2009-03-12 ステム セル セラピューティクス コーポレイション プロラクチンにより制御される乏突起膠細胞前駆体細胞の増殖
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8492431B2 (en) 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US20070191474A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
WO2007106987A1 (en) * 2006-03-17 2007-09-27 Stem Cell Therapeutics Corp. Continuous dosing regimens for neural stem cell proliferating agents and neural stem cell differentiating agents
JP2009537635A (ja) 2006-05-19 2009-10-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 癲癇の処置のための共同−療法
US8809385B2 (en) 2008-06-23 2014-08-19 Janssen Pharmaceutica Nv Crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
CN111116451A (zh) * 2020-01-16 2020-05-08 宁波大学 一种多取代色胺基苯甲酰胺类化合物及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2725386A (en) * 1953-02-13 1955-11-29 Fond Emanuele Paterno 2-(1, 4-benzodioxan) methyl derivatives of amino-lower fatty acid amides and preparation thereof
FR2463765A1 (fr) * 1979-08-17 1981-02-27 Clin Midy Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire
US4684739A (en) * 1980-12-15 1987-08-04 Mitsubishi Chemical Industries Limited Alkylenedioxybenzene derivatives and acid addition salts thereof
US4614807A (en) * 1984-10-04 1986-09-30 Eli Lilly And Company 6,7-dihalomelatonins
ATE65084T1 (de) * 1986-06-26 1991-07-15 Ciba Geigy Ag Hydrierte 1-benzooxacycloalkylpyridincarbons|ureverbindungen.
DE3642497A1 (de) * 1986-12-12 1988-06-23 Hoechst Ag Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
US4956382A (en) * 1987-02-07 1990-09-11 Pfizer Inc. Sulfonamide anti-arrhythmic agents
US5189179A (en) * 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
US5120758A (en) * 1991-02-08 1992-06-09 Ciba-Geigy Corporation Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors

Also Published As

Publication number Publication date
NZ239521A (en) 1993-07-27
KR920004345A (ko) 1992-03-27
DK0478954T3 (da) 2001-01-08
PH30242A (en) 1997-02-05
PT98800A (pt) 1992-08-31
HU208955B (en) 1994-02-28
ES2153346T3 (es) 2001-03-01
CA2049803A1 (en) 1992-03-01
EP0478954A1 (en) 1992-04-08
NO175430B (no) 1994-07-04
IE913036A1 (en) 1992-03-11
GR3035062T3 (en) 2001-03-30
CN1059717A (zh) 1992-03-25
EP0478954B1 (en) 2000-10-18
US5559143A (en) 1996-09-24
HUT59092A (en) 1992-04-28
AU8266491A (en) 1992-03-05
DE69132450D1 (de) 2000-11-23
ATE197040T1 (de) 2000-11-15
DE69132450T2 (de) 2001-05-03
TW200457B (he) 1993-02-21
FI914065A (fi) 1992-03-01
US5189179A (en) 1993-02-23
NO175430C (no) 1994-10-12
PT98800B (pt) 1999-01-29
CN1030766C (zh) 1996-01-24
FI914065A0 (fi) 1991-08-28
NO913384D0 (no) 1991-08-28
NO913384L (no) 1992-03-02
US5387604A (en) 1995-02-07
JPH04270264A (ja) 1992-09-25
IL99306A0 (en) 1992-07-15
AU641535B2 (en) 1993-09-23

Similar Documents

Publication Publication Date Title
EP0478954B1 (en) Serotonin 5HT1A and 5HT1D agonists
US5604261A (en) Arylalkyl (thio)amides
JPH0428698B2 (he)
FR2903101A1 (fr) Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2004255191A1 (en) Phenylcarboxylate beta-secretase inhibitors for the treatment of Alzheimer's disease
PL128296B1 (en) Process for preparing novel 3-/1-imidazolylalkyl/-indoles
PL191876B1 (pl) Nowe kwasy sulfonyloaminokarboksylowe i sposób ich wytwarzania, środek farmaceutyczny i ich zastosowanie do wytwarzania leku
JPS61249960A (ja) Ｎ―インドリルエチル―スルホン酸アミド類、その製法及び用途
BG63940B1 (bg) Бифенилсулфонамидни инхибитори на металопротеиназата на матрикса
EP0406734A2 (en) 2-(Aminoaryl)indoles and indolines, a process for their preparation and their use as medicaments
FR2635104A1 (fr) Derives d'indolone, leur preparation et leur application en therapeutique
FR2630328A1 (fr) Derive de l'histamine, sa preparation et son application en therapeutique
IL203956A (he) נגזרות אינדול – 2 – און דו–מותמרות בעמדה 3, הכנתן ושימוש שלהן להכנת תרופות
KR900004385B1 (ko) 카복사미드 유도체 및 그의 제조방법
NO311257B1 (no) Indoler med brostruktur som matriksmetallproteaseinhibitorer, samt farmasöytiske preparater som omfatter dem
EP0526478B1 (en) 3-indolyl thioacetate derivatives
NZ524404A (en) Indole derivatives and their use as medicaments
FR2680172A1 (fr) Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique.
JPH0625128A (ja) 新規なナフタレンアミドおよびナフタレンスルホンアミド化合物
EP0841330B1 (fr) Nouveaux dérivés aminométhyl hétérocycliques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
KR20060036091A (ko) 신규 화합물
EP0782568B1 (fr) Ethers aromatiques derives d'indoles comme "5ht1-like" ligands
BG62349B2 (bg) N-заместени производни на 3-азабицикло/3.2.0/хептан като невролептици
AU2002300093B2 (en) New benzenesulphonamide compounds, a process for their preparation and pharmaceutical compositions containing them
JP2003523343A (ja) アミノ酸化合物、ならびにｎｅｐ、ａｃｅおよびｅｃｅ阻害剤としてのその使用

Legal Events

Date Code Title Description
KB Patent renewed
HC Change of name of proprietor(s)
HC Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PARMACEUTICALS, INC.