IL99165A - Azabicycloalkane (and alkene) derivatives of 1,2,5-oxa- and thiadiazoles, their preparation and pharmaceutical compositions containing them - Google Patents
Azabicycloalkane (and alkene) derivatives of 1,2,5-oxa- and thiadiazoles, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL99165A IL99165A IL99165A IL9916591A IL99165A IL 99165 A IL99165 A IL 99165A IL 99165 A IL99165 A IL 99165A IL 9916591 A IL9916591 A IL 9916591A IL 99165 A IL99165 A IL 99165A
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical compositions
- azabicycloalkane
- thiadiazoles
- oxa
- alkene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Lubricants (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK198590A DK198590D0 (da) | 1990-08-21 | 1990-08-21 | Heterocykliske forbindelser, deres fremstilling og anvendelse |
Publications (2)
Publication Number | Publication Date |
---|---|
IL99165A0 IL99165A0 (en) | 1992-07-15 |
IL99165A true IL99165A (en) | 1997-11-20 |
Family
ID=8109272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL99165A IL99165A (en) | 1990-08-21 | 1991-08-12 | Azabicycloalkane (and alkene) derivatives of 1,2,5-oxa- and thiadiazoles, their preparation and pharmaceutical compositions containing them |
Country Status (23)
Country | Link |
---|---|
US (1) | US5260314A (fr) |
EP (1) | EP0544779B1 (fr) |
JP (1) | JP3100160B2 (fr) |
KR (1) | KR100247121B1 (fr) |
AT (1) | ATE174027T1 (fr) |
AU (1) | AU662105B2 (fr) |
CA (1) | CA2089769C (fr) |
CZ (1) | CZ282606B6 (fr) |
DE (1) | DE69130570T2 (fr) |
DK (2) | DK198590D0 (fr) |
ES (1) | ES2124707T3 (fr) |
FI (1) | FI930747A (fr) |
GR (1) | GR3029289T3 (fr) |
HU (2) | HU221433B (fr) |
IE (1) | IE912960A1 (fr) |
IL (1) | IL99165A (fr) |
NO (1) | NO301883B1 (fr) |
NZ (1) | NZ239450A (fr) |
PT (1) | PT98736B (fr) |
SG (1) | SG68567A1 (fr) |
SK (1) | SK283219B6 (fr) |
WO (1) | WO1992003433A1 (fr) |
ZA (1) | ZA916581B (fr) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527813A (en) * | 1990-08-21 | 1996-06-18 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
US5418240A (en) * | 1990-08-21 | 1995-05-23 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
US5641791A (en) * | 1991-08-13 | 1997-06-24 | Novo Nordisk A.S | Heterocyclic compounds and their preparation and use |
WO1993014089A1 (fr) * | 1992-01-13 | 1993-07-22 | Novo Nordisk A/S | Composes heterocycliques, leur preparation et leur utilisation |
MX9300875A (es) * | 1992-02-20 | 1993-08-31 | Smithkline Beecham Plc | Procedimiento para la preparacion de compuestos azabiciclicos. |
US5554626A (en) * | 1992-12-23 | 1996-09-10 | Neurosearch A/S | Substituted heterocyclic compounds as dopamine-reuptake inhibitors |
AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
AU671163B2 (en) * | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
AU672644B2 (en) * | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
US5663182A (en) * | 1993-08-19 | 1997-09-02 | Bymaster; Franklin Porter | Antipsychotic method |
US6265419B1 (en) | 1993-12-21 | 2001-07-24 | Novo Nordisk A/S | Method of treating gastrointestinal motility disorders |
US6271229B1 (en) | 1993-08-19 | 2001-08-07 | Novo Nordisk A/S | Method of treating gastrointestinal motility disorders |
DK0714394T3 (da) * | 1993-08-19 | 2001-10-01 | Novo Nordisk As | Antipsykotisk fremgangsmåde |
GB9409705D0 (en) * | 1994-05-14 | 1994-07-06 | Smithkline Beecham Plc | Novel compounds |
US5998404A (en) * | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
US5605908A (en) * | 1994-10-24 | 1997-02-25 | Eli Lilly And Company | Heterocyclic compounds and their use |
US5821370A (en) * | 1994-10-24 | 1998-10-13 | Eli Lilly And Company | Heterocyclic compounds and their preparation and use |
US5488056A (en) * | 1994-10-31 | 1996-01-30 | Eli Lilly And Company | Method for treating anxiety |
US5574028A (en) * | 1994-10-31 | 1996-11-12 | Eli Lilly And Company | Method for treating anxiety |
US5726193A (en) * | 1994-10-31 | 1998-03-10 | Eli Lilly And Company | Method for treating anxiety |
US5484794A (en) * | 1994-11-09 | 1996-01-16 | Eli Lilly And Company | Method for treating anxiety |
US5612351A (en) * | 1994-11-08 | 1997-03-18 | Novo Nordisk A/S | Method of treating urinary bladder dysfunctions |
TW390883B (en) * | 1994-11-21 | 2000-05-21 | Novo Nordisk As | Azacyclic or azabicyclic compounds for treating diseases in the central nervous system, their preparation and pharmaceutical composition thereof |
TW304167B (fr) * | 1995-01-30 | 1997-05-01 | Lilly Co Eli | |
WO1996025160A1 (fr) * | 1995-02-17 | 1996-08-22 | Novo Nordisk A/S | Utilisation de composes heterocycliques |
PE17897A1 (es) * | 1995-02-17 | 1997-06-12 | Lilly Co Eli | Formulacion transdermica en parche del 3-(4-butiltio)-1,2,5-tiadiazol-3-il)-1-azabiciclo (2,2,2) octano |
US5767280A (en) * | 1995-06-01 | 1998-06-16 | Eli Lilly And Company | Process for making heterocyclic compounds |
US6040442A (en) * | 1995-06-01 | 2000-03-21 | Eli Lilly And Company | Process for preparing 1,2,5-thiadiazole containing ethers |
EP0859777B1 (fr) * | 1995-10-13 | 2007-05-23 | Neurosearch A/S | Derives de 8-azabicyclo(3.2.1)oct-2-ene, leur preparation et leur utilisation |
US5852037A (en) * | 1995-11-13 | 1998-12-22 | Eli Lilly And Company | Method for treating anxiety |
US5889019A (en) * | 1995-11-29 | 1999-03-30 | Eli Lilly And Company | Heterocyclic compounds and their use |
WO1997019669A2 (fr) * | 1995-11-29 | 1997-06-05 | Eli Lilly And Company | Composes heterocycliques et leur utilisation |
EP0874828A4 (fr) * | 1995-12-06 | 1999-09-01 | Lilly Co Eli | Compositions de traitement de la douleur |
EA199800535A1 (ru) * | 1995-12-07 | 1998-12-24 | Эли Лилли Энд Компани | Способ лечения боли |
JP2000502716A (ja) * | 1996-01-04 | 2000-03-07 | ノボ ノルディスク アクティーゼルスカブ | 高コレステロール血症及び関連する疾患を治療する方法 |
JP2000506871A (ja) | 1996-03-19 | 2000-06-06 | ノボ ノルディスク アクティーゼルスカブ | 複素環式化合物並びにその調製及び用途 |
US5914338A (en) * | 1996-04-02 | 1999-06-22 | Novo Nordisk | Heterocyclic compounds and their preparation and use |
WO1997040043A1 (fr) * | 1996-04-23 | 1997-10-30 | Eli Lilly And Company | Composes heterocycliques |
JP2000509042A (ja) * | 1996-04-23 | 2000-07-18 | イーライ・リリー・アンド・カンパニー | ヘテロサイクリック化合物群 |
JP2000509044A (ja) * | 1996-04-23 | 2000-07-18 | イーライ・リリー・アンド・カンパニー | ヘテロサイクリック化合物群 |
ATE221066T1 (de) * | 1996-04-23 | 2002-08-15 | Lilly Co Eli | Heterozyklische verbindungen |
JP2000513712A (ja) * | 1996-04-24 | 2000-10-17 | ノボ ノルディスク アクティーゼルスカブ | 複素環化合物およびその調製およびその使用 |
US5834458A (en) * | 1996-10-09 | 1998-11-10 | Eli Lilly And Company | Heterocyclic compounds and their use |
US5733912A (en) * | 1997-02-19 | 1998-03-31 | Abbott Laboratories | 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission |
GB9805557D0 (en) * | 1998-03-16 | 1998-05-13 | Merck Sharp & Dohme | A combination of therapeutic agents |
ATE341548T1 (de) | 2001-07-06 | 2006-10-15 | Neurosearch As | Neue verbindungen, deren herstellung und verwendung |
AU2006282896A1 (en) * | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2258358A3 (fr) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenèse avec un inhibiteur de l'acetylcholinestérase |
EP1940389A2 (fr) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation de la neurogenese par inhibition de la pde |
CA2625210A1 (fr) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Modulation de la neurogenese dont la mediation est assuree par recepteur gaba |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
EP2382975A3 (fr) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogénèse par modulation d'angiotensine |
JP2010502722A (ja) * | 2006-09-08 | 2010-01-28 | ブレインセルス,インコーポレイティド | 4−アシルアミノピリジン誘導体を含む組み合わせ |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2010099217A1 (fr) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ219646A (en) * | 1986-03-27 | 1990-10-26 | Merck Sharp & Dohme | Oxadiazole derivatives of azacyclics for treating cns disorders |
GB8610432D0 (en) * | 1986-04-29 | 1986-06-04 | Akzo Nv | Amino-thiazole & oxazole derivatives |
GB8714789D0 (en) * | 1987-06-24 | 1987-07-29 | Lundbeck & Co As H | Heterocyclic compounds |
GB8717446D0 (en) * | 1987-07-23 | 1987-08-26 | Merck Sharp & Dohme | Chemical compounds |
NZ225999A (en) * | 1987-09-10 | 1992-04-28 | Merck Sharp & Dohme | Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions |
IE63906B1 (en) * | 1987-11-13 | 1995-06-14 | Novo Nordisk As | Azabicyclic compounds and their preparation and use |
EP0322182A3 (fr) * | 1987-12-22 | 1992-01-02 | Beecham Group Plc | Composés azabicycliques, procédé pour leur préparation et compositions pharmaceutiques les contenant |
IL88846A0 (en) * | 1988-01-08 | 1989-07-31 | Merck Sharp & Dohme | Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them |
NZ227841A (en) * | 1988-02-12 | 1991-08-27 | Merck Sharp & Dohme | Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions |
DK162892C (da) * | 1988-07-04 | 1992-05-11 | Novo Nordisk As | 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse |
US5043345A (en) * | 1989-02-22 | 1991-08-27 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
-
1990
- 1990-08-21 DK DK198590A patent/DK198590D0/da not_active Application Discontinuation
-
1991
- 1991-08-12 IL IL99165A patent/IL99165A/xx not_active IP Right Cessation
- 1991-08-13 US US07/744,160 patent/US5260314A/en not_active Expired - Lifetime
- 1991-08-19 NZ NZ239450A patent/NZ239450A/en not_active IP Right Cessation
- 1991-08-20 SK SK127-93A patent/SK283219B6/sk unknown
- 1991-08-20 AT AT91915629T patent/ATE174027T1/de not_active IP Right Cessation
- 1991-08-20 CA CA002089769A patent/CA2089769C/fr not_active Expired - Fee Related
- 1991-08-20 AU AU84036/91A patent/AU662105B2/en not_active Ceased
- 1991-08-20 CZ CS93244A patent/CZ282606B6/cs not_active IP Right Cessation
- 1991-08-20 ES ES91915629T patent/ES2124707T3/es not_active Expired - Lifetime
- 1991-08-20 DE DE69130570T patent/DE69130570T2/de not_active Expired - Fee Related
- 1991-08-20 SG SG1996005511A patent/SG68567A1/en unknown
- 1991-08-20 WO PCT/DK1991/000236 patent/WO1992003433A1/fr active IP Right Grant
- 1991-08-20 EP EP91915629A patent/EP0544779B1/fr not_active Expired - Lifetime
- 1991-08-20 KR KR1019930700496A patent/KR100247121B1/ko not_active IP Right Cessation
- 1991-08-20 ZA ZA916581A patent/ZA916581B/xx unknown
- 1991-08-20 DK DK91915629T patent/DK0544779T3/da active
- 1991-08-20 HU HU9300464A patent/HU221433B/hu unknown
- 1991-08-20 JP JP03513857A patent/JP3100160B2/ja not_active Expired - Fee Related
- 1991-08-21 IE IE296091A patent/IE912960A1/en not_active IP Right Cessation
- 1991-08-21 PT PT98736A patent/PT98736B/pt not_active IP Right Cessation
-
1993
- 1993-02-19 NO NO930601A patent/NO301883B1/no unknown
- 1993-02-19 FI FI930747A patent/FI930747A/fi not_active Application Discontinuation
-
1995
- 1995-06-29 HU HU95P/P00608P patent/HU211861A9/hu unknown
-
1999
- 1999-02-03 GR GR990400369T patent/GR3029289T3/el unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |