IL99165A - Azabicycloalkane (and alkene) derivatives of 1,2,5-oxa- and thiadiazoles, their preparation and pharmaceutical compositions containing them - Google Patents
Azabicycloalkane (and alkene) derivatives of 1,2,5-oxa- and thiadiazoles, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL99165A IL99165A IL99165A IL9916591A IL99165A IL 99165 A IL99165 A IL 99165A IL 99165 A IL99165 A IL 99165A IL 9916591 A IL9916591 A IL 9916591A IL 99165 A IL99165 A IL 99165A
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical compositions
- azabicycloalkane
- thiadiazoles
- oxa
- alkene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK198590A DK198590D0 (da) | 1990-08-21 | 1990-08-21 | Heterocykliske forbindelser, deres fremstilling og anvendelse |
Publications (2)
Publication Number | Publication Date |
---|---|
IL99165A0 IL99165A0 (en) | 1992-07-15 |
IL99165A true IL99165A (en) | 1997-11-20 |
Family
ID=8109272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL99165A IL99165A (en) | 1990-08-21 | 1991-08-12 | Azabicycloalkane (and alkene) derivatives of 1,2,5-oxa- and thiadiazoles, their preparation and pharmaceutical compositions containing them |
Country Status (23)
Country | Link |
---|---|
US (1) | US5260314A (xx) |
EP (1) | EP0544779B1 (xx) |
JP (1) | JP3100160B2 (xx) |
KR (1) | KR100247121B1 (xx) |
AT (1) | ATE174027T1 (xx) |
AU (1) | AU662105B2 (xx) |
CA (1) | CA2089769C (xx) |
CZ (1) | CZ282606B6 (xx) |
DE (1) | DE69130570T2 (xx) |
DK (2) | DK198590D0 (xx) |
ES (1) | ES2124707T3 (xx) |
FI (1) | FI930747A (xx) |
GR (1) | GR3029289T3 (xx) |
HU (2) | HU221433B (xx) |
IE (1) | IE912960A1 (xx) |
IL (1) | IL99165A (xx) |
NO (1) | NO301883B1 (xx) |
NZ (1) | NZ239450A (xx) |
PT (1) | PT98736B (xx) |
SG (1) | SG68567A1 (xx) |
SK (1) | SK283219B6 (xx) |
WO (1) | WO1992003433A1 (xx) |
ZA (1) | ZA916581B (xx) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527813A (en) * | 1990-08-21 | 1996-06-18 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
US5418240A (en) * | 1990-08-21 | 1995-05-23 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
US5641791A (en) * | 1991-08-13 | 1997-06-24 | Novo Nordisk A.S | Heterocyclic compounds and their preparation and use |
WO1993014089A1 (en) * | 1992-01-13 | 1993-07-22 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
MX9300875A (es) | 1992-02-20 | 1993-08-31 | Smithkline Beecham Plc | Procedimiento para la preparacion de compuestos azabiciclicos. |
US5554626A (en) * | 1992-12-23 | 1996-09-10 | Neurosearch A/S | Substituted heterocyclic compounds as dopamine-reuptake inhibitors |
AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
AU671163B2 (en) * | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
AU672644B2 (en) * | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
US6271229B1 (en) | 1993-08-19 | 2001-08-07 | Novo Nordisk A/S | Method of treating gastrointestinal motility disorders |
CA2169838C (en) * | 1993-08-19 | 2002-06-11 | Franklin Porter Bymaster | Antipsychotic method |
US6265419B1 (en) * | 1993-12-21 | 2001-07-24 | Novo Nordisk A/S | Method of treating gastrointestinal motility disorders |
US5663182A (en) * | 1993-08-19 | 1997-09-02 | Bymaster; Franklin Porter | Antipsychotic method |
GB9409705D0 (en) * | 1994-05-14 | 1994-07-06 | Smithkline Beecham Plc | Novel compounds |
US5998404A (en) * | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
US5821371A (en) * | 1994-10-24 | 1998-10-13 | Eli Lilly And Comany | Heterocyclic compounds and their preparation and use |
US5605908A (en) * | 1994-10-24 | 1997-02-25 | Eli Lilly And Company | Heterocyclic compounds and their use |
US5488056A (en) * | 1994-10-31 | 1996-01-30 | Eli Lilly And Company | Method for treating anxiety |
US5574028A (en) * | 1994-10-31 | 1996-11-12 | Eli Lilly And Company | Method for treating anxiety |
US5484794A (en) * | 1994-11-09 | 1996-01-16 | Eli Lilly And Company | Method for treating anxiety |
US5726193A (en) * | 1994-10-31 | 1998-03-10 | Eli Lilly And Company | Method for treating anxiety |
US5612351A (en) * | 1994-11-08 | 1997-03-18 | Novo Nordisk A/S | Method of treating urinary bladder dysfunctions |
TW390883B (en) * | 1994-11-21 | 2000-05-21 | Novo Nordisk As | Azacyclic or azabicyclic compounds for treating diseases in the central nervous system, their preparation and pharmaceutical composition thereof |
TW304167B (xx) * | 1995-01-30 | 1997-05-01 | Lilly Co Eli | |
WO1996025160A1 (en) * | 1995-02-17 | 1996-08-22 | Novo Nordisk A/S | The use of heterocyclic compounds |
PE17897A1 (es) * | 1995-02-17 | 1997-06-12 | Lilly Co Eli | Formulacion transdermica en parche del 3-(4-butiltio)-1,2,5-tiadiazol-3-il)-1-azabiciclo (2,2,2) octano |
US5767280A (en) * | 1995-06-01 | 1998-06-16 | Eli Lilly And Company | Process for making heterocyclic compounds |
US6040442A (en) * | 1995-06-01 | 2000-03-21 | Eli Lilly And Company | Process for preparing 1,2,5-thiadiazole containing ethers |
ATE362931T1 (de) * | 1995-10-13 | 2007-06-15 | Neurosearch As | 8-azabicyclo(3.2.1)oct-2en-derivate, deren herstellung und anwendung |
US5852037A (en) * | 1995-11-13 | 1998-12-22 | Eli Lilly And Company | Method for treating anxiety |
US5889019A (en) * | 1995-11-29 | 1999-03-30 | Eli Lilly And Company | Heterocyclic compounds and their use |
JP2000501097A (ja) * | 1995-11-29 | 2000-02-02 | イーライ・リリー・アンド・カンパニー | ヘテロ環式化合物およびそれらの使用 |
US5998434A (en) * | 1995-12-06 | 1999-12-07 | Eli Lilly And Company | Composition for treating pain |
JP2000501711A (ja) * | 1995-12-07 | 2000-02-15 | イーライ・リリー・アンド・カンパニー | 疼痛を処置する方法 |
JP2000502716A (ja) * | 1996-01-04 | 2000-03-07 | ノボ ノルディスク アクティーゼルスカブ | 高コレステロール血症及び関連する疾患を治療する方法 |
EP0888355A1 (en) | 1996-03-19 | 1999-01-07 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
US5914338A (en) * | 1996-04-02 | 1999-06-22 | Novo Nordisk | Heterocyclic compounds and their preparation and use |
CA2250472A1 (en) * | 1996-04-23 | 1997-10-30 | Steven James Quimby | Heterocyclic compounds |
WO1997040043A1 (en) * | 1996-04-23 | 1997-10-30 | Eli Lilly And Company | Heterocyclic compounds |
AU3055397A (en) * | 1996-04-23 | 1997-11-12 | Eli Lilly And Company | Heterocyclic compounds |
EP0900217A4 (en) * | 1996-04-23 | 2001-05-23 | Lilly Co Eli | HETEROCYCLIC COMPOUNDS |
ATE250055T1 (de) * | 1996-04-24 | 2003-10-15 | Novo Nordisk As | Heterozyklische verbindungen, ihre herstellung und ihre anwendung |
US5834458A (en) * | 1996-10-09 | 1998-11-10 | Eli Lilly And Company | Heterocyclic compounds and their use |
US5733912A (en) * | 1997-02-19 | 1998-03-31 | Abbott Laboratories | 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission |
GB9805557D0 (en) * | 1998-03-16 | 1998-05-13 | Merck Sharp & Dohme | A combination of therapeutic agents |
CA2448913A1 (en) | 2001-07-06 | 2003-01-16 | Neurosearch A/S | Sulfone containing bicyclic aromatic ring compounds, their preparation and use as nicotinic acetyl-chloine receptors |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
EP1928437A2 (en) * | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
WO2008030651A1 (en) * | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ219646A (en) * | 1986-03-27 | 1990-10-26 | Merck Sharp & Dohme | Oxadiazole derivatives of azacyclics for treating cns disorders |
GB8610432D0 (en) * | 1986-04-29 | 1986-06-04 | Akzo Nv | Amino-thiazole & oxazole derivatives |
GB8714789D0 (en) * | 1987-06-24 | 1987-07-29 | Lundbeck & Co As H | Heterocyclic compounds |
GB8717446D0 (en) * | 1987-07-23 | 1987-08-26 | Merck Sharp & Dohme | Chemical compounds |
NZ225999A (en) * | 1987-09-10 | 1992-04-28 | Merck Sharp & Dohme | Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions |
IL88156A (en) * | 1987-11-13 | 1997-02-18 | Novo Nordisk As | Azacyclic compounds their preparation and pharmaceutical compositions containing them |
EP0322182A3 (en) * | 1987-12-22 | 1992-01-02 | Beecham Group Plc | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
IL88846A0 (en) * | 1988-01-08 | 1989-07-31 | Merck Sharp & Dohme | Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them |
NZ227841A (en) * | 1988-02-12 | 1991-08-27 | Merck Sharp & Dohme | Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions |
DK162892C (da) * | 1988-07-04 | 1992-05-11 | Novo Nordisk As | 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse |
US5043345A (en) * | 1989-02-22 | 1991-08-27 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
-
1990
- 1990-08-21 DK DK198590A patent/DK198590D0/da not_active Application Discontinuation
-
1991
- 1991-08-12 IL IL99165A patent/IL99165A/xx not_active IP Right Cessation
- 1991-08-13 US US07/744,160 patent/US5260314A/en not_active Expired - Lifetime
- 1991-08-19 NZ NZ239450A patent/NZ239450A/en not_active IP Right Cessation
- 1991-08-20 AT AT91915629T patent/ATE174027T1/de not_active IP Right Cessation
- 1991-08-20 AU AU84036/91A patent/AU662105B2/en not_active Ceased
- 1991-08-20 SK SK127-93A patent/SK283219B6/sk unknown
- 1991-08-20 HU HU9300464A patent/HU221433B/hu unknown
- 1991-08-20 CA CA002089769A patent/CA2089769C/en not_active Expired - Fee Related
- 1991-08-20 WO PCT/DK1991/000236 patent/WO1992003433A1/en active IP Right Grant
- 1991-08-20 ZA ZA916581A patent/ZA916581B/xx unknown
- 1991-08-20 KR KR1019930700496A patent/KR100247121B1/ko not_active IP Right Cessation
- 1991-08-20 EP EP91915629A patent/EP0544779B1/en not_active Expired - Lifetime
- 1991-08-20 ES ES91915629T patent/ES2124707T3/es not_active Expired - Lifetime
- 1991-08-20 DE DE69130570T patent/DE69130570T2/de not_active Expired - Fee Related
- 1991-08-20 JP JP03513857A patent/JP3100160B2/ja not_active Expired - Fee Related
- 1991-08-20 SG SG1996005511A patent/SG68567A1/en unknown
- 1991-08-20 CZ CS93244A patent/CZ282606B6/cs not_active IP Right Cessation
- 1991-08-20 DK DK91915629T patent/DK0544779T3/da active
- 1991-08-21 PT PT98736A patent/PT98736B/pt not_active IP Right Cessation
- 1991-08-21 IE IE296091A patent/IE912960A1/en not_active IP Right Cessation
-
1993
- 1993-02-19 FI FI930747A patent/FI930747A/fi not_active Application Discontinuation
- 1993-02-19 NO NO930601A patent/NO301883B1/no unknown
-
1995
- 1995-06-29 HU HU95P/P00608P patent/HU211861A9/hu unknown
-
1999
- 1999-02-03 GR GR990400369T patent/GR3029289T3/el unknown
Also Published As
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Publication | Publication Date | Title |
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IL99165A (en) | Azabicycloalkane (and alkene) derivatives of 1,2,5-oxa- and thiadiazoles, their preparation and pharmaceutical compositions containing them | |
IL99145A0 (en) | Heterocyclic compounds,their preparation and pharmaceutical compositions containing them | |
EP0384288A3 (en) | Piperidine compounds and their preparation and use | |
KR960701049A (ko) | 헤테로사이클릭 화합물, 이의 제조방법 및 이의 용도(Heterocyclic compounds and their preparation and use) | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |