DK0544779T3 - Heterocykliske forbindelser og deres fremstilling og anvendelse - Google Patents

Heterocykliske forbindelser og deres fremstilling og anvendelse

Info

Publication number
DK0544779T3
DK0544779T3 DK91915629T DK91915629T DK0544779T3 DK 0544779 T3 DK0544779 T3 DK 0544779T3 DK 91915629 T DK91915629 T DK 91915629T DK 91915629 T DK91915629 T DK 91915629T DK 0544779 T3 DK0544779 T3 DK 0544779T3
Authority
DK
Denmark
Prior art keywords
preparation
compounds
heterocyclic compounds
forebrain
hippocampus
Prior art date
Application number
DK91915629T
Other languages
English (en)
Inventor
Per Sauerberg
Preben H Olesen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of DK0544779T3 publication Critical patent/DK0544779T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
DK91915629T 1990-08-21 1991-08-20 Heterocykliske forbindelser og deres fremstilling og anvendelse DK0544779T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK198590A DK198590D0 (da) 1990-08-21 1990-08-21 Heterocykliske forbindelser, deres fremstilling og anvendelse
PCT/DK1991/000236 WO1992003433A1 (en) 1990-08-21 1991-08-20 Heterocyclic compounds and their preparation and use

Publications (1)

Publication Number Publication Date
DK0544779T3 true DK0544779T3 (da) 1999-08-16

Family

ID=8109272

Family Applications (2)

Application Number Title Priority Date Filing Date
DK198590A DK198590D0 (da) 1990-08-21 1990-08-21 Heterocykliske forbindelser, deres fremstilling og anvendelse
DK91915629T DK0544779T3 (da) 1990-08-21 1991-08-20 Heterocykliske forbindelser og deres fremstilling og anvendelse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK198590A DK198590D0 (da) 1990-08-21 1990-08-21 Heterocykliske forbindelser, deres fremstilling og anvendelse

Country Status (23)

Country Link
US (1) US5260314A (da)
EP (1) EP0544779B1 (da)
JP (1) JP3100160B2 (da)
KR (1) KR100247121B1 (da)
AT (1) ATE174027T1 (da)
AU (1) AU662105B2 (da)
CA (1) CA2089769C (da)
CZ (1) CZ282606B6 (da)
DE (1) DE69130570T2 (da)
DK (2) DK198590D0 (da)
ES (1) ES2124707T3 (da)
FI (1) FI930747A (da)
GR (1) GR3029289T3 (da)
HU (2) HU221433B (da)
IE (1) IE912960A1 (da)
IL (1) IL99165A (da)
NO (1) NO301883B1 (da)
NZ (1) NZ239450A (da)
PT (1) PT98736B (da)
SG (1) SG68567A1 (da)
SK (1) SK283219B6 (da)
WO (1) WO1992003433A1 (da)
ZA (1) ZA916581B (da)

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WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
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AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
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US5554626A (en) * 1992-12-23 1996-09-10 Neurosearch A/S Substituted heterocyclic compounds as dopamine-reuptake inhibitors
US6265419B1 (en) 1993-12-21 2001-07-24 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
UA43347C2 (uk) * 1993-08-19 2001-12-17 Ново Нордіск А/С Спосіб лікування психічних захворювань
US5663182A (en) * 1993-08-19 1997-09-02 Bymaster; Franklin Porter Antipsychotic method
US6281233B1 (en) 1993-08-19 2001-08-28 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
GB9409705D0 (en) * 1994-05-14 1994-07-06 Smithkline Beecham Plc Novel compounds
US5646289A (en) * 1994-10-24 1997-07-08 Eli Lilly And Company Heterocyclic compounds and their preparation and use
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US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5484794A (en) * 1994-11-09 1996-01-16 Eli Lilly And Company Method for treating anxiety
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
US5488056A (en) * 1994-10-31 1996-01-30 Eli Lilly And Company Method for treating anxiety
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
TW390883B (en) * 1994-11-21 2000-05-21 Novo Nordisk As Azacyclic or azabicyclic compounds for treating diseases in the central nervous system, their preparation and pharmaceutical composition thereof
TW304167B (da) * 1995-01-30 1997-05-01 Lilly Co Eli
PE17897A1 (es) * 1995-02-17 1997-06-12 Lilly Co Eli Formulacion transdermica en parche del 3-(4-butiltio)-1,2,5-tiadiazol-3-il)-1-azabiciclo (2,2,2) octano
AU4712696A (en) * 1995-02-17 1996-09-04 Novo Nordisk A/S The use of heterocyclic compounds
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
US5767280A (en) * 1995-06-01 1998-06-16 Eli Lilly And Company Process for making heterocyclic compounds
PL185357B1 (pl) * 1995-10-13 2003-04-30 Neurosearch As Pochodne 8-azabicyklo [3.2.1] okt-2-enowe, ich wytwarzanie i zastosowanie
US5852037A (en) * 1995-11-13 1998-12-22 Eli Lilly And Company Method for treating anxiety
JP2000501097A (ja) * 1995-11-29 2000-02-02 イーライ・リリー・アンド・カンパニー ヘテロ環式化合物およびそれらの使用
US5889019A (en) * 1995-11-29 1999-03-30 Eli Lilly And Company Heterocyclic compounds and their use
CA2239301A1 (en) * 1995-12-06 1997-06-12 Charles Howard Mitch Composition for treating pain
NZ324594A (en) * 1995-12-07 1999-09-29 Lilly Co Eli A method and composition for treating pain using a composition comprising an azacyclic azabicyclic or tetrahydropyridine compound and an analgesic
JP2000502716A (ja) * 1996-01-04 2000-03-07 ノボ ノルディスク アクティーゼルスカブ 高コレステロール血症及び関連する疾患を治療する方法
AU2152497A (en) * 1996-03-19 1997-10-10 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
AU2679497A (en) * 1996-04-23 1997-11-12 Eli Lilly And Company Heterocyclic compounds
WO1997040043A1 (en) * 1996-04-23 1997-10-30 Eli Lilly And Company Heterocyclic compounds
EP0900218B1 (en) * 1996-04-23 2002-07-24 Eli Lilly And Company Heterocyclic compounds
AU2991397A (en) * 1996-04-23 1997-11-12 Eli Lilly And Company Heterocyclic compounds
ATE250055T1 (de) * 1996-04-24 2003-10-15 Novo Nordisk As Heterozyklische verbindungen, ihre herstellung und ihre anwendung
US5834458A (en) * 1996-10-09 1998-11-10 Eli Lilly And Company Heterocyclic compounds and their use
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
GB9805557D0 (en) 1998-03-16 1998-05-13 Merck Sharp & Dohme A combination of therapeutic agents
AU2002320958B2 (en) * 2001-07-06 2008-02-28 Neurosearch A/S Novel compounds, their preparation and use
AU2006282896A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2010502722A (ja) * 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
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Also Published As

Publication number Publication date
CA2089769A1 (en) 1992-02-22
PT98736A (pt) 1992-07-31
NZ239450A (en) 1994-12-22
DE69130570D1 (de) 1999-01-14
JP3100160B2 (ja) 2000-10-16
HU221433B (en) 2002-10-28
NO930601D0 (no) 1993-02-19
EP0544779B1 (en) 1998-12-02
AU8403691A (en) 1992-03-17
NO930601L (no) 1993-04-16
CZ282606B6 (cs) 1997-08-13
SK283219B6 (sk) 2003-03-04
ATE174027T1 (de) 1998-12-15
EP0544779A1 (en) 1993-06-09
IL99165A (en) 1997-11-20
KR100247121B1 (ko) 2000-08-01
NO301883B1 (no) 1997-12-22
WO1992003433A1 (en) 1992-03-05
HU211861A9 (en) 1995-12-28
ZA916581B (en) 1992-05-27
FI930747A0 (fi) 1993-02-19
CZ24493A3 (en) 1994-01-19
ES2124707T3 (es) 1999-02-16
US5260314A (en) 1993-11-09
SG68567A1 (en) 1999-11-16
AU662105B2 (en) 1995-08-24
HU9300464D0 (en) 1993-05-28
DK198590D0 (da) 1990-08-21
DE69130570T2 (de) 1999-04-29
FI930747A (fi) 1993-03-30
GR3029289T3 (en) 1999-05-28
IL99165A0 (en) 1992-07-15
JPH06500542A (ja) 1994-01-20
HUT66863A (en) 1995-01-30
CA2089769C (en) 2002-10-01
SK12793A3 (en) 1993-09-09
IE912960A1 (en) 1992-02-26
PT98736B (pt) 1999-01-29

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