GR3029289T3 - Heterocyclic compounds and their preparation and use - Google Patents

Heterocyclic compounds and their preparation and use

Info

Publication number
GR3029289T3
GR3029289T3 GR990400369T GR990400369T GR3029289T3 GR 3029289 T3 GR3029289 T3 GR 3029289T3 GR 990400369 T GR990400369 T GR 990400369T GR 990400369 T GR990400369 T GR 990400369T GR 3029289 T3 GR3029289 T3 GR 3029289T3
Authority
GR
Greece
Prior art keywords
preparation
compounds
heterocyclic compounds
forebrain
hippocampus
Prior art date
Application number
GR990400369T
Other languages
English (en)
Inventor
Per Sauerberg
Preben H Olesen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of GR3029289T3 publication Critical patent/GR3029289T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Lubricants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
GR990400369T 1990-08-21 1999-02-03 Heterocyclic compounds and their preparation and use GR3029289T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK198590A DK198590D0 (da) 1990-08-21 1990-08-21 Heterocykliske forbindelser, deres fremstilling og anvendelse
PCT/DK1991/000236 WO1992003433A1 (en) 1990-08-21 1991-08-20 Heterocyclic compounds and their preparation and use

Publications (1)

Publication Number Publication Date
GR3029289T3 true GR3029289T3 (en) 1999-05-28

Family

ID=8109272

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990400369T GR3029289T3 (en) 1990-08-21 1999-02-03 Heterocyclic compounds and their preparation and use

Country Status (23)

Country Link
US (1) US5260314A (el)
EP (1) EP0544779B1 (el)
JP (1) JP3100160B2 (el)
KR (1) KR100247121B1 (el)
AT (1) ATE174027T1 (el)
AU (1) AU662105B2 (el)
CA (1) CA2089769C (el)
CZ (1) CZ282606B6 (el)
DE (1) DE69130570T2 (el)
DK (2) DK198590D0 (el)
ES (1) ES2124707T3 (el)
FI (1) FI930747A (el)
GR (1) GR3029289T3 (el)
HU (2) HU221433B (el)
IE (1) IE912960A1 (el)
IL (1) IL99165A (el)
NO (1) NO301883B1 (el)
NZ (1) NZ239450A (el)
PT (1) PT98736B (el)
SG (1) SG68567A1 (el)
SK (1) SK283219B6 (el)
WO (1) WO1992003433A1 (el)
ZA (1) ZA916581B (el)

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US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
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AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
AU672644B2 (en) * 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
US5554626A (en) * 1992-12-23 1996-09-10 Neurosearch A/S Substituted heterocyclic compounds as dopamine-reuptake inhibitors
NZ271313A (en) * 1993-08-19 1999-09-29 Novo Nordisk As Pharmaceutical use of oxa-or thia-diazole-substd. azabicyclic ring compounds
US6265419B1 (en) * 1993-12-21 2001-07-24 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
US6271229B1 (en) 1993-08-19 2001-08-07 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
US5663182A (en) * 1993-08-19 1997-09-02 Bymaster; Franklin Porter Antipsychotic method
GB9409705D0 (en) * 1994-05-14 1994-07-06 Smithkline Beecham Plc Novel compounds
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5672709A (en) * 1994-10-24 1997-09-30 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5484794A (en) * 1994-11-09 1996-01-16 Eli Lilly And Company Method for treating anxiety
US5488056A (en) * 1994-10-31 1996-01-30 Eli Lilly And Company Method for treating anxiety
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
TW390883B (en) * 1994-11-21 2000-05-21 Novo Nordisk As Azacyclic or azabicyclic compounds for treating diseases in the central nervous system, their preparation and pharmaceutical composition thereof
TW304167B (el) * 1995-01-30 1997-05-01 Lilly Co Eli
EP0809494A1 (en) * 1995-02-17 1997-12-03 Novo Nordisk A/S The use of heterocyclic compounds
PE17897A1 (es) * 1995-02-17 1997-06-12 Lilly Co Eli Formulacion transdermica en parche del 3-(4-butiltio)-1,2,5-tiadiazol-3-il)-1-azabiciclo (2,2,2) octano
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
US5767280A (en) * 1995-06-01 1998-06-16 Eli Lilly And Company Process for making heterocyclic compounds
HUP9802433A3 (en) * 1995-10-13 2000-03-28 Neurosearch As 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use
US5852037A (en) * 1995-11-13 1998-12-22 Eli Lilly And Company Method for treating anxiety
US5889019A (en) * 1995-11-29 1999-03-30 Eli Lilly And Company Heterocyclic compounds and their use
AU1141497A (en) * 1995-11-29 1997-06-19 Eli Lilly And Company Heterocyclic compounds and their use
WO1997020819A1 (en) * 1995-12-06 1997-06-12 Eli Lilly And Company Composition for treating pain
HUP0000110A3 (en) * 1995-12-07 2000-09-28 Lilly Co Eli Pharmaceutical compositions comprising azacyclic, azabicyclic or tetrahydro-pyridine-derivatives suitable for treating pain
WO1997025043A1 (en) * 1996-01-04 1997-07-17 Novo Nordisk A/S A method of treating hypercholesterolemia and related disorders
EP0888355A1 (en) 1996-03-19 1999-01-07 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
JP2000509045A (ja) * 1996-04-23 2000-07-18 イーライ・リリー・アンド・カンパニー 複素環式化合物
EP0900218B1 (en) * 1996-04-23 2002-07-24 Eli Lilly And Company Heterocyclic compounds
EP0900217A4 (en) * 1996-04-23 2001-05-23 Lilly Co Eli HETEROCYCLIC COMPOUNDS
JP2000509042A (ja) * 1996-04-23 2000-07-18 イーライ・リリー・アンド・カンパニー ヘテロサイクリック化合物群
CA2252563A1 (en) * 1996-04-24 1997-10-30 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5834458A (en) * 1996-10-09 1998-11-10 Eli Lilly And Company Heterocyclic compounds and their use
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
GB9805557D0 (en) * 1998-03-16 1998-05-13 Merck Sharp & Dohme A combination of therapeutic agents
DE60215172T2 (de) * 2001-07-06 2007-08-30 Neurosearch A/S Neue verbindungen, deren herstellung und verwendung
EP2275095A3 (en) * 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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Also Published As

Publication number Publication date
HU221433B (en) 2002-10-28
IL99165A0 (en) 1992-07-15
ZA916581B (en) 1992-05-27
JPH06500542A (ja) 1994-01-20
SK283219B6 (sk) 2003-03-04
CA2089769A1 (en) 1992-02-22
EP0544779B1 (en) 1998-12-02
HU211861A9 (en) 1995-12-28
CZ282606B6 (cs) 1997-08-13
DK198590D0 (da) 1990-08-21
NO930601D0 (no) 1993-02-19
US5260314A (en) 1993-11-09
IE912960A1 (en) 1992-02-26
AU8403691A (en) 1992-03-17
DK0544779T3 (da) 1999-08-16
DE69130570T2 (de) 1999-04-29
EP0544779A1 (en) 1993-06-09
WO1992003433A1 (en) 1992-03-05
DE69130570D1 (de) 1999-01-14
PT98736A (pt) 1992-07-31
CZ24493A3 (en) 1994-01-19
NO301883B1 (no) 1997-12-22
SK12793A3 (en) 1993-09-09
FI930747A (fi) 1993-03-30
AU662105B2 (en) 1995-08-24
HU9300464D0 (en) 1993-05-28
ES2124707T3 (es) 1999-02-16
NZ239450A (en) 1994-12-22
NO930601L (no) 1993-04-16
CA2089769C (en) 2002-10-01
PT98736B (pt) 1999-01-29
KR100247121B1 (ko) 2000-08-01
SG68567A1 (en) 1999-11-16
ATE174027T1 (de) 1998-12-15
HUT66863A (en) 1995-01-30
JP3100160B2 (ja) 2000-10-16
IL99165A (en) 1997-11-20
FI930747A0 (fi) 1993-02-19

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