IL98988A - Enzymatic preparation of basic fibroblast growth factor - Google Patents
Enzymatic preparation of basic fibroblast growth factorInfo
- Publication number
- IL98988A IL98988A IL9898891A IL9898891A IL98988A IL 98988 A IL98988 A IL 98988A IL 9898891 A IL9898891 A IL 9898891A IL 9898891 A IL9898891 A IL 9898891A IL 98988 A IL98988 A IL 98988A
- Authority
- IL
- Israel
- Prior art keywords
- bfgf
- growth factor
- thr
- fibroblast growth
- adduct
- Prior art date
Links
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 title 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- 102000003908 Cathepsin D Human genes 0.000 abstract 1
- 108090000258 Cathepsin D Proteins 0.000 abstract 1
- 229920002971 Heparan sulfate Polymers 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- NURNJECQNNCRBK-FLBSBUHZSA-N Ile-Thr-Thr Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O NURNJECQNNCRBK-FLBSBUHZSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- 108090000284 Pepsin A Proteins 0.000 abstract 1
- 102100039652 Pepsin A-5 Human genes 0.000 abstract 1
- DSGIVWSDDRDJIO-ZXXMMSQZSA-N Thr-Thr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O DSGIVWSDDRDJIO-ZXXMMSQZSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229940066716 pepsin a Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909017008A GB9017008D0 (en) | 1990-08-02 | 1990-08-02 | Process for the enzymatic preparation of basic fibroblast growth factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL98988A0 IL98988A0 (en) | 1992-07-15 |
| IL98988A true IL98988A (en) | 1997-02-18 |
Family
ID=10680087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9898891A IL98988A (en) | 1990-08-02 | 1991-07-29 | Enzymatic preparation of basic fibroblast growth factor |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5348863A (cs) |
| EP (1) | EP0495049B1 (cs) |
| JP (1) | JPH05501655A (cs) |
| KR (1) | KR100191697B1 (cs) |
| CN (1) | CN1033810C (cs) |
| AT (1) | ATE152122T1 (cs) |
| AU (1) | AU643822B2 (cs) |
| CA (1) | CA2066174A1 (cs) |
| CZ (1) | CZ286237B6 (cs) |
| DE (1) | DE69125810T2 (cs) |
| DK (1) | DK0495049T3 (cs) |
| ES (1) | ES2103822T3 (cs) |
| FI (1) | FI921428A (cs) |
| GB (1) | GB9017008D0 (cs) |
| GR (1) | GR3024111T3 (cs) |
| HU (1) | HU212671B (cs) |
| IE (1) | IE912729A1 (cs) |
| IL (1) | IL98988A (cs) |
| MY (1) | MY107334A (cs) |
| NO (1) | NO301480B1 (cs) |
| NZ (1) | NZ239204A (cs) |
| PH (1) | PH31240A (cs) |
| PT (1) | PT98544B (cs) |
| RU (1) | RU2093519C1 (cs) |
| WO (1) | WO1992002539A1 (cs) |
| YU (1) | YU48309B (cs) |
| ZA (1) | ZA916026B (cs) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993015753A1 (fr) * | 1992-02-14 | 1993-08-19 | Kaken Pharmaceutical Co., Ltd. | Medicament contre les maladies des voies aeriennes |
| WO1995028949A1 (en) * | 1994-04-21 | 1995-11-02 | Novo Nordisk A/S | Heparin-binding protein for the treatment of sepsis and processes for its preparation |
| US5939390A (en) * | 1995-03-09 | 1999-08-17 | Novo Nordisk A/S | Pharmaceutical composition |
| US6274712B1 (en) | 1997-12-23 | 2001-08-14 | 3-Dimensional Pharmaceuticals, Inc. | Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137 |
| IL141647A0 (en) | 2001-02-26 | 2002-03-10 | Yeda Res & Dev | Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus |
| WO2004060403A2 (en) | 2003-01-06 | 2004-07-22 | Angiochem Inc. | Aprotinin and anglos as carriers across the blood-brain barrier |
| MXPA05007552A (es) | 2003-01-14 | 2006-05-19 | Teva Pharma | Formulaciones parenterales de un peptido para el tratamiento de lupus sistemico eritematoso. |
| US8618054B2 (en) | 2004-05-05 | 2013-12-31 | Valorisation-Rechereche Société en Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
| PL1751175T3 (pl) | 2004-05-05 | 2013-03-29 | Valorisation Recherche Soc En Commandite | Antagoniści receptora IL-1, kompozycje i sposoby leczenia |
| EP2366786A3 (en) | 2005-05-05 | 2012-08-29 | VALORISATION HSJ, Société en Commandite | Cytokine receptor modulators and uses thereof |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| EP2164866B1 (en) | 2007-05-29 | 2014-05-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| CN102026667B (zh) | 2008-04-18 | 2014-06-25 | 安吉奥开米公司 | 紫杉醇、紫杉醇类似物或紫杉醇结合物的药物组合物及相关制备方法和用途 |
| JP2012505637A (ja) | 2008-10-15 | 2012-03-08 | アンジオケム，インコーポレーテッド | Ｇｌｐ−１アゴニストのコンジュゲート及びその使用 |
| MX2011004019A (es) | 2008-10-15 | 2011-06-24 | Angiochem Inc | Conjugados de etoposido y doxorubicina para entrega de farmacos. |
| CA2745524C (en) | 2008-12-05 | 2020-06-09 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
| BRPI0922611A2 (pt) | 2008-12-17 | 2018-11-06 | Angiochem Inc | inibidores de metaloproteína de matriz de membrana tipo 1 e usos dos mesmos |
| CA2759129C (en) | 2009-04-20 | 2018-12-11 | Angiochem Inc. | Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog |
| MX2012000016A (es) | 2009-07-02 | 2012-03-26 | Angiochem Inc | Conjugados de peptidos multimericos y sus usos. |
| CA2803646A1 (en) | 2010-07-02 | 2012-01-05 | Angiochem Inc. | Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof |
| SG11201509430WA (en) * | 2013-05-16 | 2015-12-30 | Agency Science Tech & Res | Heparan sulphates |
| US10493012B2 (en) | 2014-11-19 | 2019-12-03 | Agency For Science, Technology And Research | Cosmetic use of heparan sulphate |
| JP6709217B2 (ja) | 2014-11-19 | 2020-06-10 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 皮膚の修復および／または再生において使用するためのヘパラン硫酸 |
| ES2826827T3 (es) | 2015-06-15 | 2021-05-19 | Angiochem Inc | Métodos para el tratamiento de carcinomatosis leptomeníngea |
| CN105294851B (zh) * | 2015-12-07 | 2019-02-12 | 中国科学院长春应用化学研究所 | 与几丁质特异结合的碱性成纤维细胞生长因子及其编码基因、制备方法与应用 |
| CN114965839A (zh) * | 2022-05-11 | 2022-08-30 | 朗肽生物制药股份有限公司 | 人碱性成纤维细胞生长因子的肽图分析方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4956455A (en) * | 1984-03-05 | 1990-09-11 | The Salk Institute For Biological Studies | Bovine fibroblast growth factor |
| US4785079A (en) * | 1984-11-09 | 1988-11-15 | The Salk Institute For Biological Studies | Isolation of fibroblast growth factor |
| US5026839A (en) * | 1985-12-17 | 1991-06-25 | Synergen, Inc | DNA encoding a basic fibroblast growth factor |
| DE3811921A1 (de) * | 1988-04-09 | 1989-10-19 | Hoechst Ag | Verfahren zur herstellung von proteinen, die n-terminal mit prolin beginnen |
| US5136025A (en) * | 1990-04-04 | 1992-08-04 | California Biotechnology Inc. | Method to purify basic fibroblast growth factor |
-
1990
- 1990-08-02 GB GB909017008A patent/GB9017008D0/en active Pending
-
1991
- 1991-07-29 CZ CS19912362A patent/CZ286237B6/cs not_active IP Right Cessation
- 1991-07-29 YU YU131991A patent/YU48309B/sh unknown
- 1991-07-29 IL IL9898891A patent/IL98988A/xx not_active IP Right Cessation
- 1991-07-30 CA CA002066174A patent/CA2066174A1/en not_active Abandoned
- 1991-07-30 US US07/842,177 patent/US5348863A/en not_active Expired - Fee Related
- 1991-07-30 ES ES91913996T patent/ES2103822T3/es not_active Expired - Lifetime
- 1991-07-30 DK DK91913996.4T patent/DK0495049T3/da active
- 1991-07-30 WO PCT/EP1991/001428 patent/WO1992002539A1/en active IP Right Grant
- 1991-07-30 HU HU9201101A patent/HU212671B/hu not_active IP Right Cessation
- 1991-07-30 AU AU83044/91A patent/AU643822B2/en not_active Ceased
- 1991-07-30 AT AT91913996T patent/ATE152122T1/de not_active IP Right Cessation
- 1991-07-30 EP EP91913996A patent/EP0495049B1/en not_active Expired - Lifetime
- 1991-07-30 KR KR1019920700725A patent/KR100191697B1/ko not_active IP Right Cessation
- 1991-07-30 JP JP3513137A patent/JPH05501655A/ja active Pending
- 1991-07-30 DE DE69125810T patent/DE69125810T2/de not_active Expired - Fee Related
- 1991-07-30 PH PH42854A patent/PH31240A/en unknown
- 1991-07-30 RU SU915011557A patent/RU2093519C1/ru active
- 1991-07-31 ZA ZA916026A patent/ZA916026B/xx unknown
- 1991-07-31 MY MYPI91001378A patent/MY107334A/en unknown
- 1991-07-31 NZ NZ239204A patent/NZ239204A/xx unknown
- 1991-08-01 PT PT98544A patent/PT98544B/pt not_active IP Right Cessation
- 1991-08-01 IE IE272991A patent/IE912729A1/en unknown
- 1991-08-02 CN CN91105269A patent/CN1033810C/zh not_active Expired - Fee Related
-
1992
- 1992-03-30 NO NO921236A patent/NO301480B1/no not_active IP Right Cessation
- 1992-04-01 FI FI921428A patent/FI921428A/fi unknown
-
1997
- 1997-07-16 GR GR970401761T patent/GR3024111T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH | Patent void |