IL95709A - תולדת פנוקסאטין, תהליך להכנתה ותכשירים תרופתיים המכילים אותה - Google Patents
תולדת פנוקסאטין, תהליך להכנתה ותכשירים תרופתיים המכילים אותהInfo
- Publication number
- IL95709A IL95709A IL9570990A IL9570990A IL95709A IL 95709 A IL95709 A IL 95709A IL 9570990 A IL9570990 A IL 9570990A IL 9570990 A IL9570990 A IL 9570990A IL 95709 A IL95709 A IL 95709A
- Authority
- IL
- Israel
- Prior art keywords
- dioxide
- ethylphenoxathiin
- mammal
- compound
- human
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 40
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- 239000000203 mixture Substances 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 23
- XJLRCPYQIPAQCA-UHFFFAOYSA-N phenoxathiine 10,10-dioxide Chemical compound C1=CC=C2S(=O)(=O)C3=CC=CC=C3OC2=C1 XJLRCPYQIPAQCA-UHFFFAOYSA-N 0.000 claims description 20
- HQSRQKBSOOZLHH-UHFFFAOYSA-N 1-ethylphenoxathiine 10,10-dioxide Chemical compound O1C2=CC=CC=C2S(=O)(=O)C2=C1C=CC=C2CC HQSRQKBSOOZLHH-UHFFFAOYSA-N 0.000 claims description 18
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- 238000011282 treatment Methods 0.000 claims description 10
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- PJLJUHYRWZCAJT-UHFFFAOYSA-N 1-ethylphenoxathiine Chemical compound O1C2=CC=CC=C2SC2=C1C=CC=C2CC PJLJUHYRWZCAJT-UHFFFAOYSA-N 0.000 claims 2
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- 229920006362 Teflon® Polymers 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 238000005644 Wolff-Kishner reduction reaction Methods 0.000 description 1
- XYDIMLHXEDSIDM-UHFFFAOYSA-N [Li]c1cccc2Oc3ccccc3S(=O)(=O)c12 Chemical compound [Li]c1cccc2Oc3ccccc3S(=O)(=O)c12 XYDIMLHXEDSIDM-UHFFFAOYSA-N 0.000 description 1
- ZBIKORITPGTTGI-UHFFFAOYSA-N [acetyloxy(phenyl)-$l^{3}-iodanyl] acetate Chemical compound CC(=O)OI(OC(C)=O)C1=CC=CC=C1 ZBIKORITPGTTGI-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 229940082992 antihypertensives mao inhibitors Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 208000025748 atypical depressive disease Diseases 0.000 description 1
- 238000010533 azeotropic distillation Methods 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 208000030963 borderline personality disease Diseases 0.000 description 1
- 150000001722 carbon compounds Chemical class 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 229940125904 compound 1 Drugs 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- IJKVHSBPTUYDLN-UHFFFAOYSA-N dihydroxy(oxo)silane Chemical compound O[Si](O)=O IJKVHSBPTUYDLN-UHFFFAOYSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 1
- 239000007919 dispersible tablet Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- HVTICUPFWKNHNG-UHFFFAOYSA-N iodoethane Chemical compound CCI HVTICUPFWKNHNG-UHFFFAOYSA-N 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 229940041476 lactose 100 mg Drugs 0.000 description 1
- 229940080428 lactose 200 mg Drugs 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000007932 molded tablet Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000002902 organometallic compounds Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 208000019906 panic disease Diseases 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 208000022821 personality disease Diseases 0.000 description 1
- 239000003444 phase transfer catalyst Substances 0.000 description 1
- 150000005030 phenoxathiins Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 208000028173 post-traumatic stress disease Diseases 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- 239000001944 prunus armeniaca kernel oil Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 239000011369 resultant mixture Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 229940080313 sodium starch Drugs 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- YRHRIQCWCFGUEQ-UHFFFAOYSA-N thioxanthen-9-one Chemical class C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 YRHRIQCWCFGUEQ-UHFFFAOYSA-N 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229960003741 tranylcypromine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
- C07D327/08—[b,e]-condensed with two six-membered carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898921069A GB8921069D0 (en) | 1989-09-18 | 1989-09-18 | Pharmaceutically active compound,preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL95709A true IL95709A (he) | 1995-03-30 |
Family
ID=10663238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9570990A IL95709A (he) | 1989-09-18 | 1990-09-17 | תולדת פנוקסאטין, תהליך להכנתה ותכשירים תרופתיים המכילים אותה |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5420156A (he) |
| EP (1) | EP0419157A3 (he) |
| JP (1) | JPH03145486A (he) |
| KR (1) | KR940000074B1 (he) |
| AU (1) | AU643701B2 (he) |
| CA (1) | CA2025524A1 (he) |
| DD (1) | DD295840A5 (he) |
| FI (1) | FI88794C (he) |
| GB (1) | GB8921069D0 (he) |
| HU (1) | HU207065B (he) |
| IE (1) | IE903355A1 (he) |
| IL (1) | IL95709A (he) |
| MC (1) | MC2152A1 (he) |
| MX (1) | MX9203221A (he) |
| NO (1) | NO175746C (he) |
| NZ (1) | NZ235343A (he) |
| PT (1) | PT95327A (he) |
| ZA (1) | ZA907398B (he) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8921069D0 (en) * | 1989-09-18 | 1989-11-01 | Wellcome Found | Pharmaceutically active compound,preparation and use |
| IE913256A1 (en) * | 1990-09-17 | 1992-02-25 | Wellcome Found | Pharmacologically active compounds and use |
| ES2082723B1 (es) * | 1994-07-20 | 1996-10-01 | Lilly Sa | Formulacion farmaceutica de fluoxetina en forma dispersable. |
| AU5531798A (en) * | 1996-09-11 | 1998-04-14 | Krenitsky Pharmaceutical, Inc. | Pharmacologically active compounds and use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2997422A (en) * | 1959-01-09 | 1961-08-22 | Smith Kline French Lab | Monoamine oxidase inhibition |
| GB1447032A (en) * | 1972-05-19 | 1976-08-25 | Wellcome Found | Tricyclic sulphones and pharmaceutical compositions containing them |
| AU2843377A (en) * | 1972-05-19 | 1979-03-08 | Wellcome Found | Phenoxathiin dioxides |
| US4091108A (en) * | 1972-09-06 | 1978-05-23 | Burroughs Wellcome Co. | Antiallergic pharmaceutical composition and use |
| FR2239025B1 (he) * | 1973-07-25 | 1982-07-02 | Souriau & Cie | |
| DE2339617A1 (de) * | 1973-08-04 | 1975-02-20 | Merck Patent Gmbh | Sulfoxide und sulfone sowie verfahren zu ihrer herstellung |
| US4012517A (en) * | 1975-01-24 | 1977-03-15 | Burroughs Wellcome Co. | Compositions and treatment |
| EP0068563A3 (en) * | 1981-06-23 | 1983-06-15 | THE PROCTER & GAMBLE COMPANY | Heterocyclic acetic acid compounds and compositions for treating bone diseases |
| EP0150891A1 (en) * | 1984-01-05 | 1985-08-07 | The Wellcome Foundation Limited | Tricyclic compounds, processes for their preparation, compositions containing such compounds and their use in medicine |
| EP0270252A3 (en) * | 1986-11-11 | 1990-04-04 | Imperial Chemical Industries Plc | Derivatives of propenoic acids used in agriculture |
| JPH01294718A (ja) * | 1987-12-15 | 1989-11-28 | Nippon Oil & Fats Co Ltd | 新規な透明樹脂、高屈折率透明光学用樹脂、塗料用樹脂及び単量体 |
| GB8921069D0 (en) * | 1989-09-18 | 1989-11-01 | Wellcome Found | Pharmaceutically active compound,preparation and use |
-
1989
- 1989-09-18 GB GB898921069A patent/GB8921069D0/en active Pending
-
1990
- 1990-09-10 KR KR1019900014272A patent/KR940000074B1/ko not_active Expired - Fee Related
- 1990-09-17 CA CA002025524A patent/CA2025524A1/en not_active Abandoned
- 1990-09-17 NO NO904034A patent/NO175746C/no unknown
- 1990-09-17 PT PT95327A patent/PT95327A/pt not_active Application Discontinuation
- 1990-09-17 HU HU905928A patent/HU207065B/hu not_active IP Right Cessation
- 1990-09-17 IE IE335590A patent/IE903355A1/en unknown
- 1990-09-17 ZA ZA907398A patent/ZA907398B/xx unknown
- 1990-09-17 MC MC902148A patent/MC2152A1/fr unknown
- 1990-09-17 FI FI904560A patent/FI88794C/fi not_active IP Right Cessation
- 1990-09-17 NZ NZ235343A patent/NZ235343A/en unknown
- 1990-09-17 IL IL9570990A patent/IL95709A/he not_active IP Right Cessation
- 1990-09-17 DD DD90344071A patent/DD295840A5/de not_active IP Right Cessation
- 1990-09-17 JP JP2246932A patent/JPH03145486A/ja active Pending
- 1990-09-17 EP EP19900310109 patent/EP0419157A3/en not_active Ceased
- 1990-09-18 AU AU62653/90A patent/AU643701B2/en not_active Ceased
-
1992
- 1992-06-24 MX MX9203221A patent/MX9203221A/es unknown
-
1993
- 1993-12-08 US US08/164,043 patent/US5420156A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2025524A1 (en) | 1991-03-19 |
| FI88794B (fi) | 1993-03-31 |
| HU207065B (en) | 1993-03-01 |
| FI904560A0 (fi) | 1990-09-17 |
| GB8921069D0 (en) | 1989-11-01 |
| US5420156A (en) | 1995-05-30 |
| NO904034D0 (no) | 1990-09-17 |
| MC2152A1 (fr) | 1992-03-10 |
| FI88794C (fi) | 1993-07-12 |
| ZA907398B (en) | 1992-05-27 |
| HU905928D0 (en) | 1991-03-28 |
| NZ235343A (en) | 1992-08-26 |
| AU6265390A (en) | 1991-03-21 |
| NO175746B (no) | 1994-08-22 |
| NO904034L (no) | 1991-03-19 |
| EP0419157A2 (en) | 1991-03-27 |
| EP0419157A3 (en) | 1991-08-28 |
| HUT58068A (en) | 1992-01-28 |
| KR910006270A (ko) | 1991-04-29 |
| NO175746C (no) | 1994-11-30 |
| MX9203221A (es) | 1992-07-01 |
| PT95327A (pt) | 1991-05-22 |
| JPH03145486A (ja) | 1991-06-20 |
| IE903355A1 (en) | 1991-04-10 |
| AU643701B2 (en) | 1993-11-25 |
| DD295840A5 (de) | 1991-11-14 |
| KR940000074B1 (ko) | 1994-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |