IL95133A - אנלוג למילבמיצין, תהליך להכנתו ותכשירים תרופתיים המכילים אותו - Google Patents
אנלוג למילבמיצין, תהליך להכנתו ותכשירים תרופתיים המכילים אותוInfo
- Publication number
- IL95133A IL95133A IL9513390A IL9513390A IL95133A IL 95133 A IL95133 A IL 95133A IL 9513390 A IL9513390 A IL 9513390A IL 9513390 A IL9513390 A IL 9513390A IL 95133 A IL95133 A IL 95133A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- agar
- gray
- animals
- growth
- Prior art date
Links
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- 239000003651 drinking water Substances 0.000 description 1
- 230000001984 ectoparasiticidal effect Effects 0.000 description 1
- 239000013057 ectoparasiticide Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 244000079386 endoparasite Species 0.000 description 1
- RJQHFINBSUAZAI-UHFFFAOYSA-N ethane;methane;sulfuric acid Chemical compound C.CC.OS(O)(=O)=O RJQHFINBSUAZAI-UHFFFAOYSA-N 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 244000000050 gastrointestinal parasite Species 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 244000000013 helminth Species 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000003898 horticulture Methods 0.000 description 1
- 210000004276 hyalin Anatomy 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000001418 larval effect Effects 0.000 description 1
- 235000020997 lean meat Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 1
- 229940043265 methyl isobutyl ketone Drugs 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 238000012746 preparative thin layer chromatography Methods 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000028070 sporulation Effects 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229940035024 thioglycerol Drugs 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pest Control & Pesticides (AREA)
- Food Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Animal Husbandry (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898917064A GB8917064D0 (en) | 1989-07-26 | 1989-07-26 | Antiparasitic agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL95133A true IL95133A (he) | 1994-11-11 |
Family
ID=10660639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9513390A IL95133A (he) | 1989-07-26 | 1990-07-19 | אנלוג למילבמיצין, תהליך להכנתו ותכשירים תרופתיים המכילים אותו |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5073567A (he) |
| EP (1) | EP0410615B1 (he) |
| JP (1) | JPH0692414B2 (he) |
| KR (1) | KR930005872B1 (he) |
| AT (1) | ATE100106T1 (he) |
| AU (1) | AU615620B2 (he) |
| CA (1) | CA2021894C (he) |
| DE (1) | DE69005935T2 (he) |
| DK (1) | DK0410615T3 (he) |
| ES (1) | ES2062378T3 (he) |
| FI (1) | FI94262C (he) |
| GB (1) | GB8917064D0 (he) |
| HU (1) | HUT57832A (he) |
| IE (1) | IE63136B1 (he) |
| IL (1) | IL95133A (he) |
| NO (1) | NO903312L (he) |
| NZ (1) | NZ234644A (he) |
| PT (1) | PT94805B (he) |
| ZA (1) | ZA905842B (he) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9125818D0 (en) * | 1991-12-04 | 1992-02-05 | Pfizer Ltd | Antiparasitic agents |
| GB9205007D0 (en) * | 1992-03-07 | 1992-04-22 | Pfizer Ltd | Antiparasitic agents |
| US5707817A (en) * | 1993-02-05 | 1998-01-13 | Colorado State University Research Foundation | Carbohydrate-based vaccine and diagnostic reagent for trichinosis |
| US5541075A (en) * | 1993-02-05 | 1996-07-30 | Heska Corporation | Carbohydrate-based vaccine and diagnostic reagent for trichinosis |
| US5801023A (en) * | 1994-01-14 | 1998-09-01 | Pfizer Inc. | Antiparasitic pyrrolobenzoxazine compounds |
| GB9402916D0 (en) * | 1994-02-16 | 1994-04-06 | Pfizer Ltd | Antiparasitic agents |
| FR2754541B1 (fr) * | 1996-10-15 | 1998-12-24 | Air Liquide | Procede et installation pour la separation d'un melange d'hydrogene et/ou d'au moins un hydrocarbure et/ou d'azote et/ou d'oxyde de carbone |
| WO1999017760A2 (en) | 1997-10-02 | 1999-04-15 | Microcide Pharmaceuticals, Inc. | Fungal or mammalian cell efflux pump inhibitors for enhancing susceptibility of the cell to a drug |
| GB9825402D0 (en) | 1998-11-19 | 1999-01-13 | Pfizer Ltd | Antiparasitic formulations |
| WO2003024223A1 (en) | 2001-09-17 | 2003-03-27 | Eli Lilly And Company | Pesticidal formulations |
| EP2327410A1 (en) * | 2009-10-28 | 2011-06-01 | Consiglio Nazionale Delle Ricerche - Infm Istituto Nazionale Per La Fisica Della Materia | Avermectins and milbemycins for the treatment of flavivirus infections |
| EP2886640A1 (en) | 2013-12-18 | 2015-06-24 | Riga Technical University | Process for isolation of milbemycins A3 and A4 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4914624A (he) * | 1972-06-08 | 1974-02-08 | ||
| DE3519834C2 (de) * | 1984-06-05 | 1993-12-16 | American Cyanamid Co | Neue antibiotische Wirkstoffe, Verfahren zu ihrer Gewinnung und ihre Anwendung zur Bekämpfung von Infektionen bei Tieren und Pflanzen |
| US4587247A (en) * | 1985-02-25 | 1986-05-06 | Merck & Co., Inc. | Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use |
| NZ215917A (en) * | 1985-05-02 | 1989-10-27 | Merck & Co Inc | 22-oh milbemycin derivatives and parasiticidal compositions |
| JP2587241B2 (ja) * | 1986-07-24 | 1997-03-05 | ビ−チヤム・グル−プ・ピ−エルシ− | 新規化合物、その製法及びそれを含む医薬組成物 |
-
1989
- 1989-07-26 GB GB898917064A patent/GB8917064D0/en active Pending
-
1990
- 1990-07-13 ES ES90307708T patent/ES2062378T3/es not_active Expired - Lifetime
- 1990-07-13 EP EP90307708A patent/EP0410615B1/en not_active Expired - Lifetime
- 1990-07-13 DK DK90307708.9T patent/DK0410615T3/da active
- 1990-07-13 DE DE90307708T patent/DE69005935T2/de not_active Expired - Fee Related
- 1990-07-13 AT AT90307708T patent/ATE100106T1/de not_active IP Right Cessation
- 1990-07-19 IL IL9513390A patent/IL95133A/he not_active IP Right Cessation
- 1990-07-24 PT PT94805A patent/PT94805B/pt not_active IP Right Cessation
- 1990-07-24 CA CA002021894A patent/CA2021894C/en not_active Expired - Fee Related
- 1990-07-25 KR KR1019900011286A patent/KR930005872B1/ko not_active Expired - Fee Related
- 1990-07-25 FI FI903727A patent/FI94262C/fi not_active IP Right Cessation
- 1990-07-25 IE IE269490A patent/IE63136B1/en not_active IP Right Cessation
- 1990-07-25 AU AU59849/90A patent/AU615620B2/en not_active Ceased
- 1990-07-25 NZ NZ234644A patent/NZ234644A/xx unknown
- 1990-07-25 US US07/557,885 patent/US5073567A/en not_active Expired - Fee Related
- 1990-07-25 ZA ZA905842A patent/ZA905842B/xx unknown
- 1990-07-25 NO NO90903312A patent/NO903312L/no unknown
- 1990-07-26 HU HU904642A patent/HUT57832A/hu unknown
- 1990-07-26 JP JP2198945A patent/JPH0692414B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2062378T3 (es) | 1994-12-16 |
| NO903312L (no) | 1991-01-28 |
| PT94805A (pt) | 1991-03-20 |
| NO903312D0 (no) | 1990-07-25 |
| AU5984990A (en) | 1991-01-31 |
| EP0410615A1 (en) | 1991-01-30 |
| DK0410615T3 (da) | 1994-02-14 |
| HU904642D0 (en) | 1991-01-28 |
| FI94262C (fi) | 1995-08-10 |
| FI903727A0 (fi) | 1990-07-25 |
| EP0410615B1 (en) | 1994-01-12 |
| ZA905842B (en) | 1992-03-25 |
| ATE100106T1 (de) | 1994-01-15 |
| NZ234644A (en) | 1991-11-26 |
| AU615620B2 (en) | 1991-10-03 |
| GB8917064D0 (en) | 1989-09-13 |
| FI94262B (fi) | 1995-04-28 |
| KR910003111A (ko) | 1991-02-26 |
| JPH0692414B2 (ja) | 1994-11-16 |
| US5073567A (en) | 1991-12-17 |
| KR930005872B1 (ko) | 1993-06-25 |
| HUT57832A (en) | 1991-12-30 |
| JPH0368581A (ja) | 1991-03-25 |
| DE69005935D1 (de) | 1994-02-24 |
| PT94805B (pt) | 1997-05-28 |
| CA2021894C (en) | 1996-09-17 |
| CA2021894A1 (en) | 1991-01-27 |
| IE902694A1 (en) | 1991-02-27 |
| IE63136B1 (en) | 1995-03-22 |
| DE69005935T2 (de) | 1994-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |