IL94991A - מעכבי אינזימים סטרואידיים ו/או אנטגוניסט לקולטן אנדרוגני, הכנתם והרכיבים פרמצבטיים לטיפול במחלות אנדרוגניים - Google Patents
מעכבי אינזימים סטרואידיים ו/או אנטגוניסט לקולטן אנדרוגני, הכנתם והרכיבים פרמצבטיים לטיפול במחלות אנדרוגנייםInfo
- Publication number
- IL94991A IL94991A IL9499190A IL9499190A IL94991A IL 94991 A IL94991 A IL 94991A IL 9499190 A IL9499190 A IL 9499190A IL 9499190 A IL9499190 A IL 9499190A IL 94991 A IL94991 A IL 94991A
- Authority
- IL
- Israel
- Prior art keywords
- inhibitor
- alkyl
- group
- hydrogen
- antiandrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37671089A | 1989-07-07 | 1989-07-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL94991A0 IL94991A0 (en) | 1991-06-10 |
IL94991A true IL94991A (he) | 1999-11-30 |
Family
ID=23486146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL9499190A IL94991A (he) | 1989-07-07 | 1990-07-06 | מעכבי אינזימים סטרואידיים ו/או אנטגוניסט לקולטן אנדרוגני, הכנתם והרכיבים פרמצבטיים לטיפול במחלות אנדרוגניים |
Country Status (17)
Country | Link |
---|---|
US (2) | US5593981A (he) |
EP (1) | EP0595796B1 (he) |
JP (1) | JP3350048B2 (he) |
KR (1) | KR920703065A (he) |
AT (1) | ATE230994T1 (he) |
AU (1) | AU5851690A (he) |
CA (1) | CA2062792C (he) |
DE (1) | DE69034035T2 (he) |
DK (1) | DK0595796T3 (he) |
ES (1) | ES2189784T3 (he) |
HU (1) | HUT60139A (he) |
IE (1) | IE902458A1 (he) |
IL (1) | IL94991A (he) |
MY (1) | MY106725A (he) |
NZ (2) | NZ234417A (he) |
WO (1) | WO1991000733A1 (he) |
ZA (1) | ZA905313B (he) |
Families Citing this family (60)
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US5300294A (en) * | 1990-06-27 | 1994-04-05 | Smithkline Beecham Corporation | Method of treating prostatic adenocarcinoma |
US5143909A (en) * | 1991-03-19 | 1992-09-01 | Merrell Dow Pharmaceuticals Inc. | Aminosteroids in a method for inhibiting c17-20 lyase |
IL101243A (he) * | 1991-03-20 | 1999-12-22 | Merck & Co Inc | תכשירי רוקחות לטיפול בהיפרפלזיה שפירה של הערמונה המכילים תולדות סטירואיד |
IL101245A0 (en) * | 1991-03-20 | 1992-11-15 | Merck & Co Inc | Pharmaceutical compositions for the treatment of prostatic cancer |
US5175155A (en) * | 1991-10-07 | 1992-12-29 | Sterling Winthrop Inc. | Win 49596-finasteride method of use and compositions |
US5994362A (en) * | 1992-03-11 | 1999-11-30 | Merck & Co., Inc. | Method of treatment for prostatic cancer |
ATE275957T1 (de) * | 1993-01-19 | 2004-10-15 | Endorech Inc | Therapeutische verwendungen und verabreichungsysteme von dehydroepiandrosteron |
DE4318371A1 (de) * | 1993-05-28 | 1994-12-01 | Schering Ag | Mittel, enthaltend eine Verbindung mit antiandrogener sowie eine Verbindung mit kompetitiver, progesteronantagonistischer Wirkung |
US5637310A (en) * | 1993-12-20 | 1997-06-10 | Smithkline Beecham Corporation | Method of treating prostatic adenocarcinoma |
EP0748220A4 (en) * | 1994-01-21 | 1997-09-10 | Sepracor Inc | METHOD AND COMPOSITIONS FOR TREATING ANDROGEN-DEPENDENT DISEASES USING OPTICALLY PURE R - (-) CASODEX |
DE19610645A1 (de) * | 1996-03-06 | 1997-09-11 | Schering Ag | Kombination von Dehydroepiandrosteron und Aromatasehemmern und Verwendung dieser Kombination zur Herstellung eines Arzeimittels zur Behandlung eines relativen und absoluten Androgenmangels beim Mann |
EP1321146A3 (en) * | 1998-03-11 | 2004-06-02 | Endorecherche Inc. | Inhibitors of type 5 and 3 17beta-hydroxysteroid dehydrogenase and methods for their use |
EP1094798A2 (en) | 1998-03-11 | 2001-05-02 | Endorecherche Inc. | INHIBITORS OF TYPE 5 AND TYPE 3 17beta-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE |
US20040186185A1 (en) * | 1998-05-07 | 2004-09-23 | Steiner Mitchell S. | Method for treatment and chemoprevention of prostate cancer |
US6165504A (en) * | 1998-09-23 | 2000-12-26 | Barr Laboratories, Inc. | Methods for treating hot flashes and improving the quality of life of castrated prostatic cancer patients |
US20070129282A1 (en) * | 1998-11-24 | 2007-06-07 | Ahlem Clarence N | Pharmaceutical treatments and compositions |
US20030083231A1 (en) * | 1998-11-24 | 2003-05-01 | Ahlem Clarence N. | Blood cell deficiency treatment method |
US6613758B1 (en) | 1999-04-02 | 2003-09-02 | Barr Laboratories, Inc. | Method for treating osteoporosis in castrated prostatic cancer patients |
PT1955700E (pt) | 1999-09-30 | 2011-05-04 | Harbor Biosciences Inc | Tratamento terap?utico de doen?as associadas ao receptor de androg?nios |
JP3908162B2 (ja) | 2000-06-30 | 2007-04-25 | 中外製薬株式会社 | 新規な抗アンドロゲン剤 |
US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
AU2002259147A1 (en) | 2001-05-08 | 2002-11-18 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
US20060287282A1 (en) * | 2001-06-25 | 2006-12-21 | Steiner Mitchell S | Compositions comprising a SARM ad GnRH agonist or a GnRH antagonist, and methods of use thereof |
NZ530810A (en) | 2001-09-06 | 2006-05-26 | Schering Corp | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
PE20030705A1 (es) | 2001-10-17 | 2003-08-21 | Schering Corp | Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades androgeno-dependientes |
US20040096510A1 (en) * | 2001-11-29 | 2004-05-20 | Steiner Mitchell S. | Prevention and treatment of androgen-deprivation induced osteoporosis |
US20080249183A1 (en) * | 2001-11-29 | 2008-10-09 | Steiner Mitchell S | Treatment of androgen-deprivation induced osteoporosis |
US20050080143A1 (en) * | 2001-11-29 | 2005-04-14 | Steiner Mitchell S. | Treatment of androgen-deprivation induced osteoporosis |
US20040214898A1 (en) * | 2001-11-29 | 2004-10-28 | Steiner Mitchell S. | Methods for treating hot flashes |
AU2002356928B2 (en) * | 2001-11-29 | 2008-04-17 | Gtx Inc. | Prevention and treatment of androgen-deprivation induced osteoporosis |
US20070197664A1 (en) * | 2001-11-29 | 2007-08-23 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
US20060269611A1 (en) * | 2001-11-29 | 2006-11-30 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
US7524866B2 (en) * | 2001-11-29 | 2009-04-28 | Gtx, Inc. | Prevention and treatment of androgen—deprivation induced osteoporosis |
JP2006501205A (ja) * | 2002-07-30 | 2006-01-12 | カリキオン インコーポレイテッド | エゼチミブ組成物、並びにコレステロールに関連した良性および悪性の腫瘍を治療する方法 |
AU2003290799A1 (en) | 2002-11-18 | 2004-06-15 | Schering Corporation | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
ES2312845T3 (es) | 2002-12-17 | 2009-03-01 | Schering Corporation | Inhibidores de la deshidrogenasa de 17 beta-hidroxiesteroides de tipo 3 para el tratamiento de enfermedades dependientes de androgenos. |
US7332525B2 (en) * | 2003-01-17 | 2008-02-19 | Castle Erik P | Method of treatment of prostate cancer and composition for treatment thereof |
EP1615944A4 (en) | 2003-04-01 | 2010-08-11 | Harbor Biosciences Inc | ANTI-ORANGE PROBLEMS WITH MARGINAL AGONIST EFFECT AND METHOD OF USE |
CN102357248A (zh) | 2004-10-20 | 2012-02-22 | 恩多研究公司 | 单独的性甾体前体或与选择性雌激素受体调节剂联合用于防治绝经后女性的阴道疾病和病症 |
US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
RS52671B (en) | 2005-10-12 | 2013-06-28 | Unimed Pharmaceuticals Llc | IMPROVED TESTOSTERON GEL AND USE PROCEDURE |
US20070141581A1 (en) * | 2005-12-15 | 2007-06-21 | University Of North Texas Health Science Center At Fort Worth | Membrane androgen receptor as a therapeutic target for the prevention/promotion of cell death |
US20080153792A1 (en) * | 2006-11-17 | 2008-06-26 | Frincke James M | Drug Identification and Treatment Method |
US20080221074A1 (en) * | 2006-11-17 | 2008-09-11 | Jaime Flores-Riveros | Drug Screen and Treatment Method |
US8486926B2 (en) * | 2006-11-17 | 2013-07-16 | Harbor Therapeutics, Inc. | Steroid tetrol solid state forms |
US8354396B2 (en) * | 2006-11-17 | 2013-01-15 | Harbor Therapeutics, Inc. | Drug identification and treatment method |
US8217025B2 (en) * | 2006-11-17 | 2012-07-10 | Harbor Therapeutics, Inc. | Drug screening and treatment methods |
GB0708376D0 (en) | 2007-05-01 | 2007-06-06 | Alligator Bioscience Ab | Novel polypeptides and uses thereof |
PT2532648E (pt) * | 2007-05-03 | 2014-04-24 | Univ Yale | Antiandrogénios «suaves» localmente activos |
US8268806B2 (en) | 2007-08-10 | 2012-09-18 | Endorecherche, Inc. | Pharmaceutical compositions |
GB0722779D0 (en) | 2007-11-20 | 2008-01-02 | Sterix Ltd | Compound |
WO2010036822A1 (en) * | 2008-09-24 | 2010-04-01 | Hollis-Eden Pharmaceuticals, Inc. | Patient populations and treatment methods |
US20100227841A1 (en) * | 2008-09-24 | 2010-09-09 | Harbor BioSciencs, Inc. | Patient populations and treatment methods |
US20100222315A1 (en) * | 2008-09-24 | 2010-09-02 | Harbor BioSciencs, Inc. | Patient populations and treatment methods |
JP5860399B2 (ja) * | 2009-08-14 | 2016-02-16 | オプコ ヘルス, インコーポレイテッド | ニューロキニン−1アンタゴニストの静脈内用製剤 |
WO2011066582A1 (en) * | 2009-11-30 | 2011-06-03 | Harbor Biosciences, Inc. | Anticancer compounds and screening method |
CN115505019B (zh) * | 2022-11-07 | 2024-01-26 | 南宁师范大学 | 7-酰胺取代雌甾类化合物及其制备方法和应用 |
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-
1990
- 1990-07-05 HU HU9248A patent/HUT60139A/hu unknown
- 1990-07-05 WO PCT/CA1990/000212 patent/WO1991000733A1/en active IP Right Grant
- 1990-07-05 CA CA002062792A patent/CA2062792C/en not_active Expired - Lifetime
- 1990-07-05 JP JP50926390A patent/JP3350048B2/ja not_active Expired - Fee Related
- 1990-07-05 AT AT90909601T patent/ATE230994T1/de not_active IP Right Cessation
- 1990-07-05 DE DE69034035T patent/DE69034035T2/de not_active Expired - Fee Related
- 1990-07-05 EP EP90909601A patent/EP0595796B1/en not_active Expired - Lifetime
- 1990-07-05 KR KR1019920700028A patent/KR920703065A/ko not_active Application Discontinuation
- 1990-07-05 ES ES90909601T patent/ES2189784T3/es not_active Expired - Lifetime
- 1990-07-05 AU AU58516/90A patent/AU5851690A/en not_active Abandoned
- 1990-07-05 DK DK90909601T patent/DK0595796T3/da active
- 1990-07-06 IL IL9499190A patent/IL94991A/he active IP Right Grant
- 1990-07-06 ZA ZA905313A patent/ZA905313B/xx unknown
- 1990-07-06 IE IE245890A patent/IE902458A1/en not_active IP Right Cessation
- 1990-07-07 MY MYPI90001140A patent/MY106725A/en unknown
- 1990-07-09 NZ NZ234417A patent/NZ234417A/en unknown
- 1990-07-09 NZ NZ272841A patent/NZ272841A/xx unknown
-
1993
- 1993-09-10 US US08/098,607 patent/US5593981A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/472,512 patent/US5610150A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ZA905313B (en) | 1992-02-26 |
DE69034035T2 (de) | 2004-01-22 |
IL94991A0 (en) | 1991-06-10 |
AU5851690A (en) | 1991-02-06 |
NZ234417A (en) | 1995-10-26 |
AU665311B2 (en) | 1995-12-21 |
NZ272841A (en) | 1999-06-29 |
IE902458A1 (en) | 1991-02-13 |
EP0595796B1 (en) | 2003-01-15 |
ES2189784T3 (es) | 2003-07-16 |
DK0595796T3 (da) | 2003-05-05 |
KR920703065A (ko) | 1992-12-17 |
HUT60139A (en) | 1992-08-28 |
HU9200048D0 (en) | 1992-06-29 |
MY106725A (en) | 1995-07-31 |
WO1991000733A1 (en) | 1991-01-24 |
US5593981A (en) | 1997-01-14 |
JP3350048B2 (ja) | 2002-11-25 |
CA2062792C (en) | 2006-03-21 |
DE69034035D1 (de) | 2003-02-20 |
ATE230994T1 (de) | 2003-02-15 |
EP0595796A1 (en) | 1994-05-11 |
CA2062792A1 (en) | 1991-01-08 |
US5610150A (en) | 1997-03-11 |
AU6342594A (en) | 1994-07-21 |
JPH04506799A (ja) | 1992-11-26 |
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KB | Patent renewed | ||
KB | Patent renewed |