IL93090A - Platinum compounds and pharmaceutical preparations containing them - Google Patents
Platinum compounds and pharmaceutical preparations containing themInfo
- Publication number
- IL93090A IL93090A IL9309090A IL9309090A IL93090A IL 93090 A IL93090 A IL 93090A IL 9309090 A IL9309090 A IL 9309090A IL 9309090 A IL9309090 A IL 9309090A IL 93090 A IL93090 A IL 93090A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- platinum
- cis
- water
- cancer
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 8
- 229940045985 antineoplastic platinum compound Drugs 0.000 title description 2
- 150000003058 platinum compounds Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 86
- 229910052757 nitrogen Inorganic materials 0.000 claims description 27
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 claims description 26
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 150000002016 disaccharides Chemical class 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 125000001483 monosaccharide substituent group Chemical group 0.000 claims description 8
- 150000002772 monosaccharides Chemical class 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 206010033128 Ovarian cancer Diseases 0.000 claims description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 150000002367 halogens Chemical class 0.000 claims description 5
- 201000010536 head and neck cancer Diseases 0.000 claims description 5
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 5
- 125000001841 imino group Chemical group [H]N=* 0.000 claims description 5
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 4
- 206010057644 Testis cancer Diseases 0.000 claims description 4
- 125000002619 bicyclic group Chemical group 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 201000003120 testicular cancer Diseases 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 3
- 150000002431 hydrogen Chemical class 0.000 claims description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 72
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 69
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 52
- 239000000203 mixture Substances 0.000 description 50
- 239000000243 solution Substances 0.000 description 31
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 30
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 26
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 26
- 229940093499 ethyl acetate Drugs 0.000 description 24
- 235000019439 ethyl acetate Nutrition 0.000 description 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 21
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 20
- 239000002552 dosage form Substances 0.000 description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- 239000000706 filtrate Substances 0.000 description 17
- -1 N-acetylamino Chemical group 0.000 description 13
- RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 description 13
- 229910001863 barium hydroxide Inorganic materials 0.000 description 13
- 150000002540 isothiocyanates Chemical class 0.000 description 13
- 229910052697 platinum Inorganic materials 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- PBCJIPOGFJYBJE-UHFFFAOYSA-N acetonitrile;hydrate Chemical compound O.CC#N PBCJIPOGFJYBJE-UHFFFAOYSA-N 0.000 description 12
- 238000001704 evaporation Methods 0.000 description 12
- 230000008020 evaporation Effects 0.000 description 12
- 238000007912 intraperitoneal administration Methods 0.000 description 12
- 238000001990 intravenous administration Methods 0.000 description 12
- 238000004809 thin layer chromatography Methods 0.000 description 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 11
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 11
- 230000008034 disappearance Effects 0.000 description 11
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- 229940035423 ethyl ether Drugs 0.000 description 10
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- 238000002360 preparation method Methods 0.000 description 7
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- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 241001529936 Murinae Species 0.000 description 6
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- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 description 6
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- SSJXIUAHEKJCMH-UHFFFAOYSA-N cyclohexane-1,2-diamine Chemical compound NC1CCCCC1N SSJXIUAHEKJCMH-UHFFFAOYSA-N 0.000 description 5
- 238000000921 elemental analysis Methods 0.000 description 5
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 3
- 229910052788 barium Inorganic materials 0.000 description 3
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 3
- 210000001185 bone marrow Anatomy 0.000 description 3
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- 210000003734 kidney Anatomy 0.000 description 3
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- 239000008223 sterile water Substances 0.000 description 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
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- SGLJYTWMWIAGEU-UHFFFAOYSA-N cyclohexane-1,2-diamine;platinum(2+) Chemical compound [Pt+2].NC1CCCCC1N SGLJYTWMWIAGEU-UHFFFAOYSA-N 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- ISOLMABRZPQKOV-UHFFFAOYSA-N diethyl 2-acetamidopropanedioate Chemical compound CCOC(=O)C(NC(C)=O)C(=O)OCC ISOLMABRZPQKOV-UHFFFAOYSA-N 0.000 description 1
- 125000000600 disaccharide group Chemical group 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 125000003843 furanosyl group Chemical group 0.000 description 1
- 229950006191 gluconic acid Drugs 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229940060367 inert ingredients Drugs 0.000 description 1
- 239000006204 intramuscular dosage form Substances 0.000 description 1
- 239000006206 intraperitoneal dosage form Substances 0.000 description 1
- 239000006207 intravenous dosage form Substances 0.000 description 1
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- ZVYNEIVHNNYCSE-UHFFFAOYSA-N piperidine-4,4-dicarboxylic acid Chemical compound OC(=O)C1(C(O)=O)CCNCC1 ZVYNEIVHNNYCSE-UHFFFAOYSA-N 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 102200044872 rs387906892 Human genes 0.000 description 1
- 102220036716 rs587780004 Human genes 0.000 description 1
- HSNZZMHEPUFJNZ-SHUUEZRQSA-N sedoheptulose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO HSNZZMHEPUFJNZ-SHUUEZRQSA-N 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- YPNVIBVEFVRZPJ-UHFFFAOYSA-L silver sulfate Chemical compound [Ag+].[Ag+].[O-]S([O-])(=O)=O YPNVIBVEFVRZPJ-UHFFFAOYSA-L 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 229960005137 succinic acid Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000464 thioxo group Chemical group S=* 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29736889A | 1989-01-17 | 1989-01-17 | |
| US07/301,773 US4946954A (en) | 1989-01-17 | 1989-01-26 | Platinum pharmaceutical agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL93090A0 IL93090A0 (en) | 1990-11-05 |
| IL93090A true IL93090A (en) | 1995-10-31 |
Family
ID=26970120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9309090A IL93090A (en) | 1989-01-17 | 1990-01-17 | Platinum compounds and pharmaceutical preparations containing them |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4946954A (xx) |
| EP (1) | EP0462980A4 (xx) |
| JP (1) | JP2771326B2 (xx) |
| AU (2) | AU5039490A (xx) |
| CA (1) | CA2045120A1 (xx) |
| HU (1) | HUT59690A (xx) |
| IL (1) | IL93090A (xx) |
| NO (1) | NO180588C (xx) |
| NZ (1) | NZ232134A (xx) |
| PH (1) | PH26424A (xx) |
| RU (1) | RU2074861C1 (xx) |
| WO (1) | WO1990008157A1 (xx) |
| ZA (1) | ZA90336B (xx) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5041581A (en) * | 1985-10-18 | 1991-08-20 | The University Of Texas System Board Of Regents | Hydrophobic cis-platinum complexes efficiently incorporated into liposomes |
| US5384127A (en) * | 1985-10-18 | 1995-01-24 | Board Of Regents, The University Of Texas System | Stable liposomal formulations of lipophilic platinum compounds |
| WO1990012018A1 (en) * | 1989-04-04 | 1990-10-18 | Daikin Industries, Ltd. | New fluorocarbon platinum complexes |
| US5871710A (en) * | 1992-09-04 | 1999-02-16 | The General Hospital Corporation | Graft co-polymer adducts of platinum (II) compounds |
| AU2701395A (en) * | 1994-06-27 | 1996-01-19 | General Hospital Corporation, The | Graft co-polymer adducts of platinum (ii) compounds |
| ATE246696T1 (de) * | 1995-05-09 | 2003-08-15 | Kreatech Biotech Bv | Verfahren zur herstellung von linkern zwischen markierungsgruppen und bio-organischen molekülen auf der basis von platin für die markierung von bio-organischen molekülen zur entdeckung interessanter biologischer substanzen |
| US5843475A (en) * | 1996-12-06 | 1998-12-01 | Board Of Regents, The University Of Texas System | Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes |
| US6235776B1 (en) | 1998-11-12 | 2001-05-22 | Cell Pathways, Inc. | Method for treating a patient with neoplasia by treatment with a paclitaxel derivative |
| US6235782B1 (en) | 1998-11-12 | 2001-05-22 | Rifat Pamukcu | Method for treating a patient with neoplasia by treatment with a platinum coordination complex |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| AU2006222657B2 (en) * | 2000-01-04 | 2009-01-15 | Access Pharmaceuticals, Inc. | N,O-amidomalonate platinum complexes |
| US7166733B2 (en) * | 2000-01-04 | 2007-01-23 | Access Pharmaceuticals, Inc. | O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes |
| KR100729015B1 (ko) * | 2000-01-04 | 2007-06-14 | 어섹스 팔마큐티칼스 인코포레이티드 | Ｎ,ｏ-아미도말로네이트 백금 착화합물 |
| KR20040074857A (ko) * | 2003-02-19 | 2004-08-26 | 학교법인 이화학당 | Ｎ-치환 아미노디카복실산의 백금(ⅱ) 착물 및 그 제조방법 |
| KR100499340B1 (ko) * | 2003-04-29 | 2005-07-04 | 학교법인 이화학당 | 암 조직 선택성과 생분해성을 갖는폴리포스파젠-백금(ⅱ)착물 복합체 항암제 및 그 제조방법 |
| WO2006091790A1 (en) * | 2005-02-23 | 2006-08-31 | Xenoport, Inc. | Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use |
| RU2319491C1 (ru) | 2006-07-12 | 2008-03-20 | Бадулин Николай Александрович | Противоопухолевая, антибактериальная и антивирусная фармацевтическая композиция (ее варианты) |
| US8389506B2 (en) * | 2007-12-07 | 2013-03-05 | Prana Biotechnology Ltd. | Compounds for therapy and diagnosis |
| ES2704303T3 (es) | 2010-08-24 | 2019-03-15 | Dana Farber Cancer Inst Inc | Procedimientos para la predicción de una respuesta contra el cáncer |
| EP3693473A1 (en) | 2011-06-17 | 2020-08-12 | Myriad Genetics, Inc. | Methods and materials for assessing allelic imbalance |
| CN102863474A (zh) | 2011-07-09 | 2013-01-09 | 陈小平 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
| CN102993239A (zh) * | 2011-09-19 | 2013-03-27 | 陈小平 | 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物 |
| CN103703011B (zh) * | 2011-12-07 | 2016-06-22 | 北京市丰硕维康技术开发有限责任公司 | 一类离去基团是含氨基或烷氨基的羟基酸衍生物的铂类化合物及其制备方法和应用 |
| AU2012358244A1 (en) | 2011-12-21 | 2014-06-12 | Myriad Genetics, Inc. | Methods and materials for assessing loss of heterozygosity |
| CA3080441A1 (en) | 2012-02-23 | 2013-09-06 | The Children's Hospital Corporation | Methods for predicting anti-cancer response |
| NZ630278A (en) | 2012-06-07 | 2017-02-24 | Inst Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| WO2014160080A1 (en) | 2013-03-14 | 2014-10-02 | Children's Medical Center Corporation | Cancer diagnosis, treatment selection and treatment |
| EP3007709B1 (en) | 2013-06-14 | 2021-12-08 | Akamara Therapeutics, Inc. | Lipid-based platinum compounds and nanoparticles |
| WO2014203691A1 (ja) * | 2013-06-18 | 2014-12-24 | 株式会社ヤクルト本社 | 白金錯体を含有する新規医薬 |
| WO2015086473A1 (en) | 2013-12-09 | 2015-06-18 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| EP3686288B1 (en) | 2014-08-15 | 2023-03-08 | Myriad Genetics, Inc. | Methods and materials for assessing homologous recombination deficiency |
| CN107847457B (zh) | 2015-05-19 | 2022-07-05 | 阿卡马拉医疗公司 | 制备超分子铂基化合物的方法 |
| US20210137874A1 (en) * | 2017-03-22 | 2021-05-13 | The Regents Of The University Of California | Modified platinum compounds and therapeutic uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4115418A (en) * | 1976-09-02 | 1978-09-19 | Government Of The United States Of America | 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity |
| US4284579A (en) * | 1979-07-17 | 1981-08-18 | The United States Of America As Represented By The Of The Department Of Health & Human Services | (N-Phosphonacetyl-L-aspartato)(1,2-diaminocyclchexane)platinum(II) or alkali metal salt |
| JPS57123198A (en) * | 1981-01-23 | 1982-07-31 | Shionogi & Co Ltd | Novel platinum complex |
| JPS5921697A (ja) * | 1982-06-24 | 1984-02-03 | Yoshinori Kitani | 新規な白金錯体 |
| US4673754A (en) * | 1983-10-14 | 1987-06-16 | Inco Alloys International, Inc. | Platinum and palladium complexes |
| IL73337A (en) * | 1984-10-28 | 1988-09-30 | Yissum Res Dev Co | Antitumor steroid-platinum complexes and method for the preparation thereof |
| US4587331A (en) * | 1984-12-17 | 1986-05-06 | American Cyanamid Company | Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes |
| US4882447A (en) * | 1987-02-20 | 1989-11-21 | Tanabe Seiyaku Co., Ltd. | Novel organic platinum complex and process for the preparation thereof |
| ATE87314T1 (de) * | 1987-07-17 | 1993-04-15 | Univ Georgetown | Platin-arzneimittel. |
-
1989
- 1989-01-26 US US07/301,773 patent/US4946954A/en not_active Expired - Fee Related
-
1990
- 1990-01-16 PH PH39898A patent/PH26424A/en unknown
- 1990-01-17 CA CA002045120A patent/CA2045120A1/en not_active Abandoned
- 1990-01-17 HU HU901456A patent/HUT59690A/hu unknown
- 1990-01-17 WO PCT/US1990/000171 patent/WO1990008157A1/en not_active Application Discontinuation
- 1990-01-17 NZ NZ232134A patent/NZ232134A/en unknown
- 1990-01-17 AU AU50394/90A patent/AU5039490A/en not_active Abandoned
- 1990-01-17 IL IL9309090A patent/IL93090A/en not_active IP Right Cessation
- 1990-01-17 JP JP2503681A patent/JP2771326B2/ja not_active Expired - Lifetime
- 1990-01-17 RU SU905001256A patent/RU2074861C1/ru active
- 1990-01-17 EP EP19900902930 patent/EP0462980A4/en not_active Withdrawn
- 1990-01-17 ZA ZA90336A patent/ZA90336B/xx unknown
-
1991
- 1991-07-11 NO NO912732A patent/NO180588C/no unknown
-
1994
- 1994-01-31 AU AU54792/94A patent/AU674185B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU674185B2 (en) | 1996-12-12 |
| AU5479294A (en) | 1994-03-31 |
| NZ232134A (en) | 1992-09-25 |
| HUT59690A (en) | 1992-06-29 |
| US4946954A (en) | 1990-08-07 |
| IL93090A0 (en) | 1990-11-05 |
| NO180588C (no) | 1997-05-14 |
| NO912732D0 (no) | 1991-07-11 |
| CA2045120A1 (en) | 1990-07-18 |
| WO1990008157A1 (en) | 1990-07-26 |
| JPH04502767A (ja) | 1992-05-21 |
| JP2771326B2 (ja) | 1998-07-02 |
| PH26424A (en) | 1992-07-15 |
| RU2074861C1 (ru) | 1997-03-10 |
| NO180588B (no) | 1997-02-03 |
| EP0462980A1 (en) | 1992-01-02 |
| AU5039490A (en) | 1990-08-13 |
| ZA90336B (en) | 1990-10-31 |
| EP0462980A4 (en) | 1992-03-11 |
| NO912732L (no) | 1991-07-11 |
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| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |