IL90267A - Enantiomeric glutaramide diuretic agents, process for their preparation and compositions containing them - Google Patents

Enantiomeric glutaramide diuretic agents, process for their preparation and compositions containing them

Info

Publication number
IL90267A
IL90267A IL90267A IL9026789A IL90267A IL 90267 A IL90267 A IL 90267A IL 90267 A IL90267 A IL 90267A IL 9026789 A IL9026789 A IL 9026789A IL 90267 A IL90267 A IL 90267A
Authority
IL
Israel
Prior art keywords
enantiomeric
preparation
compositions containing
diuretic agents
glutaramide
Prior art date
Application number
IL90267A
Other languages
English (en)
Other versions
IL90267A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL90267A0 publication Critical patent/IL90267A0/xx
Publication of IL90267A publication Critical patent/IL90267A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Detergent Compositions (AREA)
IL90267A 1988-05-19 1989-05-11 Enantiomeric glutaramide diuretic agents, process for their preparation and compositions containing them IL90267A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888811873A GB8811873D0 (en) 1988-05-19 1988-05-19 Therapeutic agents

Publications (2)

Publication Number Publication Date
IL90267A0 IL90267A0 (en) 1989-12-15
IL90267A true IL90267A (en) 1993-08-18

Family

ID=10637176

Family Applications (1)

Application Number Title Priority Date Filing Date
IL90267A IL90267A (en) 1988-05-19 1989-05-11 Enantiomeric glutaramide diuretic agents, process for their preparation and compositions containing them

Country Status (29)

Country Link
EP (1) EP0342850B1 (hu)
JP (1) JPH072699B2 (hu)
KR (1) KR920000561B1 (hu)
CN (1) CN1015361B (hu)
AT (1) ATE76399T1 (hu)
AU (1) AU602813B2 (hu)
CA (1) CA1331197C (hu)
CS (1) CS274502B2 (hu)
DD (1) DD283772A5 (hu)
DE (1) DE68901582D1 (hu)
DK (1) DK172032B1 (hu)
EG (1) EG19007A (hu)
ES (1) ES2037418T3 (hu)
FI (1) FI93541C (hu)
GB (1) GB8811873D0 (hu)
GR (1) GR3004968T3 (hu)
HU (1) HU205067B (hu)
IE (1) IE60724B1 (hu)
IL (1) IL90267A (hu)
MX (1) MX16067A (hu)
MY (1) MY104735A (hu)
NO (1) NO173647C (hu)
NZ (1) NZ229186A (hu)
PH (1) PH26740A (hu)
PL (1) PL154813B1 (hu)
PT (1) PT90584B (hu)
SU (1) SU1766251A3 (hu)
YU (1) YU47973B (hu)
ZA (1) ZA893696B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8812597D0 (en) * 1988-05-27 1988-06-29 Pfizer Ltd Therapeutic agents
GB8820844D0 (en) * 1988-09-05 1988-10-05 Pfizer Ltd Therapeutic agents
GB9000725D0 (en) * 1990-01-12 1990-03-14 Pfizer Ltd Therapeutic agents
ES2081183T3 (es) * 1993-09-22 1996-02-16 Pfizer Res & Dev Hidrogenacion.
US7468390B2 (en) 2002-01-17 2008-12-23 Novartis Ag Methods of treatment and pharmaceutical composition
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
AU2013304949C1 (en) 2012-08-24 2020-12-24 Novartis Ag NEP inhibitors for treating diseases characterized by atrial enlargement or remodeling
WO2017033128A1 (en) 2015-08-25 2017-03-02 Novartis Ag Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
US20180311241A1 (en) 2015-10-29 2018-11-01 Cadila Healthcare Limited Pharmaceutical synergistic combination

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제

Also Published As

Publication number Publication date
NO173647C (no) 1994-01-12
DE68901582D1 (de) 1992-06-25
MY104735A (en) 1994-05-31
DK240889D0 (da) 1989-05-18
GB8811873D0 (en) 1988-06-22
PH26740A (en) 1992-09-28
CN1037704A (zh) 1989-12-06
FI93541B (fi) 1995-01-13
FI892386A (fi) 1989-11-20
IE891613L (en) 1989-11-19
SU1766251A3 (ru) 1992-09-30
NZ229186A (en) 1990-10-26
HU205067B (en) 1992-03-30
FI93541C (fi) 1995-04-25
CS296589A2 (en) 1990-09-12
PL154813B1 (en) 1991-09-30
PT90584A (pt) 1989-11-30
CN1015361B (zh) 1992-02-05
ZA893696B (en) 1990-12-28
DD283772A5 (de) 1990-10-24
ES2037418T3 (es) 1993-06-16
IE60724B1 (en) 1994-08-10
PT90584B (pt) 1994-09-30
KR900017993A (ko) 1990-12-20
HUT53596A (en) 1990-11-28
AU3490489A (en) 1989-11-23
FI892386A0 (fi) 1989-05-18
NO173647B (no) 1993-10-04
NO892002D0 (no) 1989-05-18
CS274502B2 (en) 1991-04-11
IL90267A0 (en) 1989-12-15
AU602813B2 (en) 1990-10-25
YU47973B (sh) 1996-08-13
EP0342850B1 (en) 1992-05-20
JPH0222256A (ja) 1990-01-25
EG19007A (en) 1994-11-30
KR920000561B1 (ko) 1992-01-16
DK172032B1 (da) 1997-09-22
PL279491A1 (en) 1989-11-27
ATE76399T1 (de) 1992-06-15
GR3004968T3 (hu) 1993-04-28
YU102289A (en) 1991-06-30
CA1331197C (en) 1994-08-02
DK240889A (da) 1989-11-20
EP0342850A1 (en) 1989-11-23
NO892002L (no) 1989-11-20
JPH072699B2 (ja) 1995-01-18
MX16067A (es) 1993-10-01

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Legal Events

Date Code Title Description
KB Patent renewed
RH1 Patent not in force