IL90075A - Preparations and methods for repairing cartilage and bone - Google Patents
Preparations and methods for repairing cartilage and boneInfo
- Publication number
- IL90075A IL90075A IL9007589A IL9007589A IL90075A IL 90075 A IL90075 A IL 90075A IL 9007589 A IL9007589 A IL 9007589A IL 9007589 A IL9007589 A IL 9007589A IL 90075 A IL90075 A IL 90075A
- Authority
- IL
- Israel
- Prior art keywords
- cells
- briv
- serum
- chondrocytes
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 31
- 210000000988 bone and bone Anatomy 0.000 title claims description 21
- 238000000034 method Methods 0.000 title claims description 17
- 210000000845 cartilage Anatomy 0.000 title description 14
- 230000008439 repair process Effects 0.000 title description 9
- 210000004027 cell Anatomy 0.000 claims description 106
- 210000001612 chondrocyte Anatomy 0.000 claims description 38
- 239000007943 implant Substances 0.000 claims description 36
- 210000002966 serum Anatomy 0.000 claims description 24
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 19
- 108090000190 Thrombin Proteins 0.000 claims description 18
- 229960004072 thrombin Drugs 0.000 claims description 18
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 17
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 16
- 108010049003 Fibrinogen Proteins 0.000 claims description 16
- 102000008946 Fibrinogen Human genes 0.000 claims description 16
- 239000012894 fetal calf serum Substances 0.000 claims description 16
- 229940012952 fibrinogen Drugs 0.000 claims description 16
- 210000001185 bone marrow Anatomy 0.000 claims description 15
- 210000003205 muscle Anatomy 0.000 claims description 12
- 210000001188 articular cartilage Anatomy 0.000 claims description 11
- 210000001519 tissue Anatomy 0.000 claims description 11
- 210000002950 fibroblast Anatomy 0.000 claims description 9
- 230000035755 proliferation Effects 0.000 claims description 9
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 8
- 230000002648 chondrogenic effect Effects 0.000 claims description 8
- 238000002513 implantation Methods 0.000 claims description 8
- 229920001817 Agar Polymers 0.000 claims description 7
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- 229910001628 calcium chloride Inorganic materials 0.000 claims description 7
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims description 7
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims description 5
- 230000002188 osteogenic effect Effects 0.000 claims description 5
- 230000002062 proliferating effect Effects 0.000 claims description 5
- 239000000316 bone substitute Substances 0.000 claims description 4
- 210000000963 osteoblast Anatomy 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
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- 108010039627 Aprotinin Proteins 0.000 claims description 3
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- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 claims 2
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 239000003102 growth factor Substances 0.000 description 5
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- 230000004663 cell proliferation Effects 0.000 description 4
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- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 235000010378 sodium ascorbate Nutrition 0.000 description 4
- 229960005055 sodium ascorbate Drugs 0.000 description 4
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 4
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 4
- 239000012588 trypsin Substances 0.000 description 4
- 241000307523 Xenostegia media Species 0.000 description 3
- 239000006285 cell suspension Substances 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
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- 239000000463 material Substances 0.000 description 3
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
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- 101000635938 Homo sapiens Transforming growth factor beta-1 proprotein Proteins 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
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- 238000004458 analytical method Methods 0.000 description 2
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- 230000008901 benefit Effects 0.000 description 2
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- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000003321 cartilage cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000005786 degenerative changes Effects 0.000 description 2
- 210000002745 epiphysis Anatomy 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 210000000968 fibrocartilage Anatomy 0.000 description 2
- 230000001744 histochemical effect Effects 0.000 description 2
- 210000003035 hyaline cartilage Anatomy 0.000 description 2
- 230000002055 immunohistochemical effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 210000000412 mechanoreceptor Anatomy 0.000 description 2
- 108091008704 mechanoreceptors Proteins 0.000 description 2
- 230000011164 ossification Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
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- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000055008 Matrilin Proteins Human genes 0.000 description 1
- 108010072582 Matrilin Proteins Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000219061 Rheum Species 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
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- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 230000000636 anti-proteolytic effect Effects 0.000 description 1
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- 235000010323 ascorbic acid Nutrition 0.000 description 1
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- 238000010876 biochemical test Methods 0.000 description 1
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- 230000012292 cell migration Effects 0.000 description 1
- 239000013000 chemical inhibitor Substances 0.000 description 1
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- 210000000991 chicken egg Anatomy 0.000 description 1
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- 238000007710 freezing Methods 0.000 description 1
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- 210000004349 growth plate Anatomy 0.000 description 1
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- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/838—Marrow; spleen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/84—Bones; tendons; teeth; cartilage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/187,730 US5053050A (en) | 1988-04-29 | 1988-04-29 | Compositions for repair of cartilage and bone |
| US07/280,122 US4904259A (en) | 1988-04-29 | 1988-12-05 | Compositions and methods for repair of cartilage and bone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL90075A true IL90075A (en) | 1994-08-26 |
Family
ID=26883341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9007589A IL90075A (en) | 1988-04-29 | 1989-04-25 | Preparations and methods for repairing cartilage and bone |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4904259A (ja) |
| EP (1) | EP0339607B1 (ja) |
| JP (1) | JP2858782B2 (ja) |
| AU (1) | AU625913B2 (ja) |
| DE (1) | DE68904800T2 (ja) |
| ES (1) | ES2051914T3 (ja) |
| IL (1) | IL90075A (ja) |
Families Citing this family (150)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5759830A (en) * | 1986-11-20 | 1998-06-02 | Massachusetts Institute Of Technology | Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo |
| US5041138A (en) * | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
| US6309635B1 (en) | 1986-11-20 | 2001-10-30 | Children's Medical Center Corp. | Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo |
| US5567612A (en) * | 1986-11-20 | 1996-10-22 | Massachusetts Institute Of Technology | Genitourinary cell-matrix structure for implantation into a human and a method of making |
| US5376118A (en) * | 1989-05-10 | 1994-12-27 | United States Surgical Corporation | Support material for cell impregnation |
| WO1991001720A1 (en) * | 1989-08-07 | 1991-02-21 | Herman Wade Schlameus | Composition and method of promoting hard tissue healing |
| US20030077825A1 (en) * | 1994-07-22 | 2003-04-24 | Bhatnagar Rajendra S. | Structures useful for bone engineering and methods |
| US5425769A (en) * | 1990-04-23 | 1995-06-20 | Snyders, Jr.; Robert V. | Composition of material for osseous repair |
| US5269785A (en) * | 1990-06-28 | 1993-12-14 | Bonutti Peter M | Apparatus and method for tissue removal |
| US6990982B1 (en) * | 1990-06-28 | 2006-01-31 | Bonutti Ip, Llc | Method for harvesting and processing cells from tissue fragments |
| US5618531A (en) * | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
| US5811094A (en) * | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5197985A (en) * | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US6117425A (en) | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
| US7208179B1 (en) | 1990-11-27 | 2007-04-24 | The American National Red Cross | Methods for treating disease and forming a supplemented fibrin matrix |
| US6054122A (en) | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US6197325B1 (en) | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US5197973A (en) * | 1990-12-14 | 1993-03-30 | Creative Biomolecules, Inc. | Synthetic bioadhesive |
| US5853746A (en) * | 1991-01-31 | 1998-12-29 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier |
| US5284830A (en) * | 1991-02-13 | 1994-02-08 | The Board Of Trustees Of The Leland Stanford Junior University | Thyroid-derived chondrocyte-stimulating factor |
| US6211146B1 (en) * | 1991-03-11 | 2001-04-03 | Curis, Inc. | 60A protein-induced morphogenesis |
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
| CA2104678C (en) * | 1991-03-11 | 2002-05-14 | Charles M. Cohen | Protein-induced morphogenesis |
| DE4121043A1 (de) * | 1991-06-26 | 1993-01-07 | Merck Patent Gmbh | Knochenersatzmaterial mit fgf |
| US6503277B2 (en) * | 1991-08-12 | 2003-01-07 | Peter M. Bonutti | Method of transplanting human body tissue |
| US6033437A (en) | 1991-09-30 | 2000-03-07 | Orbital Implant Technology | Pegs for orbital implants |
| WO1993007913A1 (en) * | 1991-10-24 | 1993-04-29 | Children's Medical Center Corporation | Neomorphogenesis of urological structures in vivo from cell culture |
| GB9125052D0 (en) * | 1991-11-26 | 1992-01-22 | Isis Innovation | Culture of bone cells |
| US5326357A (en) * | 1992-03-18 | 1994-07-05 | Mount Sinai Hospital Corporation | Reconstituted cartridge tissue |
| WO1994002182A1 (en) * | 1992-07-18 | 1994-02-03 | Opperbas Holding B.V. | A two component fibrin-glue composition for improving in vitro fertilization |
| WO1994014390A1 (en) * | 1992-12-24 | 1994-07-07 | Orbital Implant Technology | Device for orbital implant |
| DK0691858T3 (da) * | 1993-03-30 | 2000-05-08 | Omrix Biopharm Sa | Tokomponent fibrinklæber |
| US5709854A (en) * | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
| EP2025353A2 (en) * | 1993-04-30 | 2009-02-18 | Massachusetts Institute of Technology | Injectable polysaccharide-cell compositions |
| US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| US5411885A (en) * | 1993-12-17 | 1995-05-02 | New York Blood Center, Inc. | Methods for tissue embedding and tissue culturing |
| AU2435495A (en) * | 1994-05-05 | 1995-11-29 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
| US5723331A (en) * | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
| AU3145795A (en) * | 1994-07-26 | 1996-02-22 | Children's Medical Center Corporation | Fibrin-cell suspension for construction of new tissue |
| US5769899A (en) * | 1994-08-12 | 1998-06-23 | Matrix Biotechnologies, Inc. | Cartilage repair unit |
| US5972703A (en) * | 1994-08-12 | 1999-10-26 | The Regents Of The University Of Michigan | Bone precursor cells: compositions and methods |
| US5716404A (en) | 1994-12-16 | 1998-02-10 | Massachusetts Institute Of Technology | Breast tissue engineering |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US6974571B2 (en) | 1995-03-28 | 2005-12-13 | Thomas Jefferson University | Isolated stromal cells and methods of using the same |
| US6653134B2 (en) | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| US5716616A (en) * | 1995-03-28 | 1998-02-10 | Thomas Jefferson University | Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects |
| ATE241369T1 (de) * | 1995-03-28 | 2003-06-15 | Univ Jefferson | Isolierte stromazellen und methoden zu deren verwendung |
| US5904716A (en) * | 1995-04-26 | 1999-05-18 | Gendler; El | Method for reconstituting cartilage tissue using demineralized bone and product thereof |
| US6123727A (en) | 1995-05-01 | 2000-09-26 | Massachusetts Institute Of Technology | Tissue engineered tendons and ligaments |
| US5855610A (en) | 1995-05-19 | 1999-01-05 | Children's Medical Center Corporation | Engineering of strong, pliable tissues |
| US5741685A (en) * | 1995-06-07 | 1998-04-21 | Children's Medical Center Corporation | Parenchymal cells packaged in immunoprotective tissue for implantation |
| US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
| EP0801676A2 (de) * | 1995-10-20 | 1997-10-22 | Michael Sittinger | Neue künstliche gewebe, verfahren zu ihrer herstellung und ihre verwendung |
| US6464729B1 (en) | 1995-11-06 | 2002-10-15 | Mount Sinai Hospital Corporation | Reconstituted mineralized cartilage tissue |
| US20020111695A1 (en) * | 1995-11-06 | 2002-08-15 | Mount Sinai Hospital Corporation | Reconstituted mineralized cartilage tissue |
| ATE295875T1 (de) * | 1996-03-01 | 2005-06-15 | Isotis Nv | Verfahren zur in vitro herstellung von knochen |
| ATE250666T1 (de) * | 1996-06-04 | 2003-10-15 | Sulzer Orthopedics Ltd | Verfahren zur herstellung von knorpelgewebe und von implantaten |
| US5718717A (en) | 1996-08-19 | 1998-02-17 | Bonutti; Peter M. | Suture anchor |
| US20020173806A1 (en) * | 1996-08-30 | 2002-11-21 | Verigen Transplantation Service International (Vtsi) Ag | Method for autologous transplantation |
| US20060025786A1 (en) * | 1996-08-30 | 2006-02-02 | Verigen Transplantation Service International (Vtsi) Ag | Method for autologous transplantation |
| US6569172B2 (en) * | 1996-08-30 | 2003-05-27 | Verigen Transplantation Service International (Vtsi) | Method, instruments, and kit for autologous transplantation |
| US5989269A (en) * | 1996-08-30 | 1999-11-23 | Vts Holdings L.L.C. | Method, instruments and kit for autologous transplantation |
| US5759190A (en) * | 1996-08-30 | 1998-06-02 | Vts Holdings Limited | Method and kit for autologous transplantation |
| US6475230B1 (en) * | 1997-08-01 | 2002-11-05 | Peter M. Bonutti | Method and apparatus for securing a suture |
| DE69714035T2 (de) | 1997-08-14 | 2003-03-06 | Sulzer Innotec Ag, Winterthur | Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren |
| CA2307743A1 (en) | 1997-10-30 | 1999-05-14 | The General Hospital Corporation | Bonding of cartilaginous matrices using isolated chondrocytes |
| US6197586B1 (en) * | 1997-12-12 | 2001-03-06 | The Regents Of The University Of California | Chondrocyte-like cells useful for tissue engineering and methods |
| US6045551A (en) | 1998-02-06 | 2000-04-04 | Bonutti; Peter M. | Bone suture |
| US6551355B1 (en) | 1998-08-14 | 2003-04-22 | Cambridge Scientific, Inc. | Tissue transplant coated with biocompatible biodegradable polymer |
| EP1656960A1 (en) * | 1998-08-14 | 2006-05-17 | Verigen AG | Methods, instruments and materials for chondrocyte cell transplantation |
| CN1323228A (zh) * | 1998-08-14 | 2001-11-21 | 维里根国际移植服务(Vtsi)股份公司 | 用于软骨细胞移植的方法、器械和材料 |
| US6190893B1 (en) * | 1998-09-18 | 2001-02-20 | Massachusetts Institute Of Technology | Electroactive materials for stimulation of biological activity of bone marrow stromal cells |
| US6197061B1 (en) | 1999-03-01 | 2001-03-06 | Koichi Masuda | In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage |
| US6251143B1 (en) | 1999-06-04 | 2001-06-26 | Depuy Orthopaedics, Inc. | Cartilage repair unit |
| DE19926083A1 (de) * | 1999-06-08 | 2000-12-14 | Universitaetsklinikum Freiburg | Biologisches Gelenkkonstrukt |
| US20020116063A1 (en) * | 1999-08-02 | 2002-08-22 | Bruno Giannetti | Kit for chondrocyte cell transplantation |
| US6368343B1 (en) | 2000-03-13 | 2002-04-09 | Peter M. Bonutti | Method of using ultrasonic vibration to secure body tissue |
| US6447516B1 (en) | 1999-08-09 | 2002-09-10 | Peter M. Bonutti | Method of securing tissue |
| MXPA02005863A (es) | 1999-12-17 | 2003-10-14 | Cartificial As | Dispositivo de protesis. |
| US6635073B2 (en) | 2000-05-03 | 2003-10-21 | Peter M. Bonutti | Method of securing body tissue |
| WO2001082994A1 (en) * | 2000-04-28 | 2001-11-08 | Curis, Inc. | Methods and reagents for tissue engineering of cartilage in vitro |
| AU2001249704A1 (en) * | 2000-04-28 | 2001-11-12 | The Regents Of The University Of California | Structures useful for bone engineering and methods |
| US7144729B2 (en) | 2000-09-01 | 2006-12-05 | Dfb Pharmaceuticals, Inc. | Methods and compositions for tissue regeneration |
| US6673603B2 (en) * | 2000-09-01 | 2004-01-06 | Modex Therapeutiques, S.A. | Cell paste comprising keratinocytes and fibroblasts |
| JP2002233567A (ja) * | 2000-12-06 | 2002-08-20 | Mitsuo Ochi | 移植用組織等価物及びその製造方法 |
| EP1356024A2 (en) * | 2001-01-31 | 2003-10-29 | Interface Biotech A/S | An improved in vitro method of culturing mammalian cells for autologous cell implantation/transplantation methods |
| US6911202B2 (en) * | 2001-02-06 | 2005-06-28 | Abraham Amir | Cosmetic repair using cartilage producing cells and medical implants coated therewith |
| AU2002335747B2 (en) * | 2001-09-15 | 2009-01-29 | Rush University Medical Center | Stratified cartilage tissue and methods to engineer same |
| US20030165473A1 (en) * | 2001-11-09 | 2003-09-04 | Rush-Presbyterian-St. Luke's Medical Center | Engineered intervertebral disc tissue |
| US7160725B2 (en) * | 2001-11-13 | 2007-01-09 | Curis, Inc. | Hedgehog signaling promotes the formation of three dimensional cartilage matrices |
| US6719765B2 (en) | 2001-12-03 | 2004-04-13 | Bonutti 2003 Trust-A | Magnetic suturing system and method |
| US20030138873A1 (en) * | 2002-01-22 | 2003-07-24 | Koichi Masuda | Tissue engineered cartilage for drug discovery |
| US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| US20040136968A1 (en) * | 2002-09-27 | 2004-07-15 | Verigen Ag | Autologous cells on a support matrix for tissue repair |
| US7067123B2 (en) * | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US20050222687A1 (en) * | 2004-04-02 | 2005-10-06 | Gordana Vunjak-Novakovic | Cartilage implant assembly and method for implantation |
| US20050064042A1 (en) * | 2003-04-29 | 2005-03-24 | Musculoskeletal Transplant Foundation | Cartilage implant plug with fibrin glue and method for implantation |
| US20090291112A1 (en) * | 2003-05-16 | 2009-11-26 | Truncale Katherine G | Allograft osteochondral plug combined with cartilage particle mixture |
| US7901457B2 (en) * | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US8257963B2 (en) | 2007-06-01 | 2012-09-04 | Depuy Mitek, Inc. | Chondrocyte container and method of use |
| US7897384B2 (en) * | 2003-09-08 | 2011-03-01 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| US7927599B2 (en) * | 2003-09-08 | 2011-04-19 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| EP1684815B1 (en) * | 2003-10-10 | 2008-12-17 | KW2 Implantattechnologie GmbH | Cartilage regeneration by generation of chondrons under high concentrations of magnesium |
| EP2338441B1 (en) | 2003-12-11 | 2013-01-23 | Isto Technologies Inc. | Particulate cartilage system |
| KR100531922B1 (ko) * | 2003-12-23 | 2005-11-29 | 주식회사 셀론텍 | 연골치료제 조성물 및 그 사용방법 |
| ATE553186T1 (de) * | 2004-02-20 | 2012-04-15 | Isto Technologies Inc | Bandscheibenreparatur und verfahren dafür |
| US8512730B2 (en) | 2004-07-12 | 2013-08-20 | Isto Technologies, Inc. | Methods of tissue repair and compositions therefor |
| US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20080220044A1 (en) * | 2007-03-06 | 2008-09-11 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
| US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| JP4279233B2 (ja) * | 2004-10-25 | 2009-06-17 | 国立大学法人広島大学 | 間葉系組織再生誘導用シート及びその製造方法 |
| WO2006050213A2 (en) * | 2004-10-29 | 2006-05-11 | Michalow Alexander E | Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway |
| WO2007007062A2 (en) * | 2005-07-08 | 2007-01-18 | Depuy International Limited | Cartilage repair implant |
| US7815926B2 (en) * | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| WO2007025290A2 (en) | 2005-08-26 | 2007-03-01 | Isto Technologies, Inc. | Implants and methods for repair, replacement and treatment of joint disease |
| CA2623106C (en) | 2005-09-19 | 2013-12-24 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
| EP1764117A1 (en) | 2005-09-20 | 2007-03-21 | Zimmer GmbH | Implant for the repair of a cartilage defect and method for manufacturing the implant |
| US7371260B2 (en) * | 2005-10-26 | 2008-05-13 | Biomet Sports Medicine, Inc. | Method and instrumentation for the preparation and transplantation of osteochondral allografts |
| NZ571113A (en) * | 2005-11-17 | 2012-02-24 | Biomimetic Therapeutics Inc | Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix |
| CA2641860C (en) * | 2006-02-09 | 2015-07-14 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating bone |
| CA2646488A1 (en) | 2006-03-20 | 2007-09-27 | Tigenix N.V. | Methods to maintain, improve and restore the cartilage phenotype of chondrocytes |
| US20070276506A1 (en) * | 2006-05-25 | 2007-11-29 | Biomet Manufacturing Corp. | Demineralized osteochondral plug |
| CA2656278C (en) | 2006-06-30 | 2016-02-09 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating rotator cuff injuries |
| US9161967B2 (en) * | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| WO2008073628A2 (en) | 2006-11-03 | 2008-06-19 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
| US8435551B2 (en) * | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| AU2008240191B2 (en) | 2007-04-12 | 2013-09-19 | Zimmer, Inc. | Compositions and methods for tissue repair |
| US8303592B2 (en) * | 2007-10-05 | 2012-11-06 | Biomet Manufacturing Corp. | System for forming a tendon-bone graft |
| US8322256B2 (en) * | 2007-10-05 | 2012-12-04 | Biomet Manufacturing Corp. | System for forming a tendon-bone graft |
| CA2708147A1 (en) * | 2007-12-05 | 2009-06-18 | Musculoskeletal Transplant Foundation | Cancellous bone implant for cartilage repair |
| AU2009212151C1 (en) * | 2008-02-07 | 2015-09-17 | Biomimetic Therapeutics, Llc | Compositions and methods for distraction osteogenesis |
| EP2265220A1 (en) * | 2008-03-05 | 2010-12-29 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| NZ602861A (en) * | 2008-09-09 | 2014-03-28 | Biomimetic Therapeutics Llc | Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries |
| US8790638B2 (en) * | 2009-02-04 | 2014-07-29 | Stemedica Cell Technologies, Inc. | Compositions of stem cells and stem cell factors and methods for their use and manufacture |
| WO2010102266A1 (en) * | 2009-03-05 | 2010-09-10 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects |
| ES2340657B1 (es) * | 2010-02-19 | 2011-01-21 | Bnac De Sang I Teixtits | Procedimiento para la obtencion de un producto de ingenieria tisular orientado a la regeneracion de tejido oseo. |
| EP2538791B1 (en) | 2010-02-22 | 2015-04-08 | BioMimetic Therapeutics, LLC | Platelet-derived growth factor compositions and methods for the treatment of tendinopathies |
| IL207586A0 (en) * | 2010-08-12 | 2010-12-30 | Omrix Biopharmaceuticals Ltd | A fibrin based therapeutic preparation and use thereof |
| US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| DE102011018365A1 (de) | 2011-04-20 | 2012-10-25 | Bernhard Hildebrandt | Biologischer, implantierbarer Gelenkersatz |
| US10245306B2 (en) | 2012-11-16 | 2019-04-02 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
| US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| US10179191B2 (en) | 2014-10-09 | 2019-01-15 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| FR3035407B1 (fr) | 2015-04-23 | 2022-06-17 | Francais Du Sang Ets | Procede de conservation de cellules, tissus ou organes en hypothermie |
| WO2019151597A1 (ko) * | 2018-01-31 | 2019-08-08 | 주식회사 로킷헬스케어 | 연골 재생용 바이오 잉크 조성물, 이를 이용한 맞춤형 연골 재생용 스캐폴드의 제조방법, 및 상기 제조방법을 이용하여 제조된 맞춤형 연골 재생용 스캐폴드 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
| US4846835A (en) * | 1987-06-15 | 1989-07-11 | Grande Daniel A | Technique for healing lesions in cartilage |
-
1988
- 1988-12-05 US US07/280,122 patent/US4904259A/en not_active Expired - Lifetime
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1989
- 1989-04-25 IL IL9007589A patent/IL90075A/en not_active IP Right Cessation
- 1989-04-26 EP EP89107552A patent/EP0339607B1/en not_active Expired - Lifetime
- 1989-04-26 ES ES89107552T patent/ES2051914T3/es not_active Expired - Lifetime
- 1989-04-26 DE DE8989107552T patent/DE68904800T2/de not_active Expired - Fee Related
- 1989-04-27 AU AU33808/89A patent/AU625913B2/en not_active Ceased
- 1989-05-01 JP JP1112799A patent/JP2858782B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0339607A3 (en) | 1990-03-28 |
| EP0339607B1 (en) | 1993-02-10 |
| AU625913B2 (en) | 1992-07-16 |
| EP0339607A2 (en) | 1989-11-02 |
| JPH02209811A (ja) | 1990-08-21 |
| US4904259A (en) | 1990-02-27 |
| JP2858782B2 (ja) | 1999-02-17 |
| ES2051914T3 (es) | 1994-07-01 |
| AU3380889A (en) | 1989-11-02 |
| DE68904800T2 (de) | 1993-08-05 |
| DE68904800D1 (de) | 1993-03-25 |
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| CB | Opposition filed against grant of patent | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
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