IL89693A - Production of 2', 3'-dideoxy-2', 3'-didehydronucleosides - Google Patents
Production of 2', 3'-dideoxy-2', 3'-didehydronucleosidesInfo
- Publication number
- IL89693A IL89693A IL8969389A IL8969389A IL89693A IL 89693 A IL89693 A IL 89693A IL 8969389 A IL8969389 A IL 8969389A IL 8969389 A IL8969389 A IL 8969389A IL 89693 A IL89693 A IL 89693A
- Authority
- IL
- Israel
- Prior art keywords
- deoxynucleoside
- dideoxy
- reacting
- formula
- anhydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL10557189A IL105571A (en) | 1988-03-24 | 1989-03-21 | Production of 2'-3'-dideoxy-2'3'- didehydronucleosides |
IL10557289A IL105572A (en) | 1988-03-24 | 1989-03-21 | Preparation of '2,' 3 - Dioxy - '2,' 3 - Didhydronucleicides |
IL10557089A IL105570A (en) | 1988-03-24 | 1989-03-21 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
IL105571A IL105571A0 (en) | 1988-03-24 | 1993-04-30 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
IL105570A IL105570A0 (en) | 1988-03-24 | 1993-04-30 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
IL105573A IL105573A0 (en) | 1988-03-24 | 1993-04-30 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
IL105572A IL105572A0 (en) | 1988-03-24 | 1993-04-30 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/173,473 US4904770A (en) | 1988-03-24 | 1988-03-24 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
Publications (2)
Publication Number | Publication Date |
---|---|
IL89693A0 IL89693A0 (en) | 1989-09-28 |
IL89693A true IL89693A (en) | 1994-08-26 |
Family
ID=22632190
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL8969389A IL89693A (en) | 1988-03-24 | 1989-03-21 | Production of 2', 3'-dideoxy-2', 3'-didehydronucleosides |
IL10557389A IL105573A (en) | 1988-03-24 | 1989-03-21 | Production of 2',3'-dideoxy-2', 2'-didehydronucleosides |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10557389A IL105573A (en) | 1988-03-24 | 1989-03-21 | Production of 2',3'-dideoxy-2', 2'-didehydronucleosides |
Country Status (14)
Country | Link |
---|---|
US (1) | US4904770A (no) |
EP (1) | EP0334368A3 (no) |
JP (1) | JPH02149595A (no) |
KR (2) | KR0140889B1 (no) |
AU (1) | AU622439B2 (no) |
CA (1) | CA1339448C (no) |
DK (1) | DK146489A (no) |
EG (1) | EG18661A (no) |
FI (1) | FI93111C (no) |
IL (2) | IL89693A (no) |
NO (1) | NO171367C (no) |
NZ (1) | NZ228390A (no) |
PT (1) | PT90099B (no) |
ZA (1) | ZA892166B (no) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5455339A (en) * | 1986-05-01 | 1995-10-03 | University Of Georgia Research Foundation, Inc. | Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides |
US5384396A (en) * | 1988-02-23 | 1995-01-24 | The University Of Georgia Research Foundation, Inc. | Process for the deoxygenation of nucleosides |
JPH02152976A (ja) * | 1988-05-06 | 1990-06-12 | Bristol Myers Co | 2´,3´―ジデヒドロ―2´,3´―ジデオキシヌクレオシドのプロドラッグ |
SE464168B (sv) * | 1989-07-19 | 1991-03-18 | Bo Fredrik Oeberg | Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt) |
US5200514A (en) * | 1990-01-19 | 1993-04-06 | University Of Georgia Research Foundation, Inc. | Synthesis of 2'-deoxypyrimidine nucleosides |
WO1992002516A1 (fr) * | 1990-07-27 | 1992-02-20 | Japan Tobacco Inc. | Procede de production de 2',3'-didesoxy-2',3'-dideshydronucleoside |
US5166327A (en) * | 1990-07-31 | 1992-11-24 | Yuki Gosei Kogyo Co., Ltd. | Process for producing 3'-deoxy-3-'-fluorothymidine |
JP3042073B2 (ja) * | 1991-06-19 | 2000-05-15 | 味の素株式会社 | ヌクレオシド誘導体とその製造方法 |
DE69208636T2 (de) * | 1991-06-21 | 1996-07-11 | Acic Canada Inc | Verfahren zur herstellung von zidovudine |
FR2688003B1 (fr) * | 1992-02-28 | 1995-06-30 | Univ Limoges | Derives de nucleosides, leur preparation et leurs applications biologiques. |
US5506349A (en) * | 1992-05-13 | 1996-04-09 | Ribozyme Pharmaceuticals, Inc. | Chemical synthesis of 2', 3'-dideoxycytidine |
US5539099A (en) * | 1993-11-15 | 1996-07-23 | Bristol-Myers Squibb Company | Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides |
US5608049A (en) * | 1995-03-10 | 1997-03-04 | Bristol-Myers Squibb Company | Preparation of d4T from 5-methyluridine |
US5608048A (en) * | 1995-06-05 | 1997-03-04 | Bristol-Myers Squibb Company | d4 T polymorphic Form 1 process |
US6635753B1 (en) | 1998-09-30 | 2003-10-21 | Brantford Chemicals Inc. | Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof |
US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
IT1318463B1 (it) * | 2000-04-12 | 2003-08-25 | Archimica S P A Ora Clariant L | Procedimento per la preparazione di 5'-acetilstavudina. |
IL157478A0 (en) * | 2001-03-01 | 2004-03-28 | Pharmasset Ltd | Method for the synthesis of 2', 3'-didehydronucleosides |
US20050131224A1 (en) * | 2003-12-15 | 2005-06-16 | Cti Pet Systems, Inc. | Method for preparing radiolabeled thymidine |
US7160537B2 (en) * | 2003-12-15 | 2007-01-09 | Siemens Medical Solutions Usa, Inc. | Method for preparing radiolabeled thymidine having low chromophoric byproducts |
US20050171126A1 (en) * | 2003-12-26 | 2005-08-04 | Ajinomoto Co., Inc. | Process for the production of purine nucleoside compounds |
US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
EP2305697A3 (en) | 2005-07-25 | 2011-07-27 | Intermune, Inc. | Macrocyclic inhibitors of Hepatitis C virus replication |
US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
CN101029068B (zh) * | 2007-04-09 | 2010-06-23 | 陆咏 | 一种2',3'-二脱氢-3'-脱氧胸苷的合成方法 |
MY163296A (en) | 2011-08-30 | 2017-09-15 | Astex Pharmaceuticals Inc | Drug formulations |
EP2986602A1 (en) * | 2013-04-16 | 2016-02-24 | Bristol-Myers Squibb Company | Method for producing festinavir using 5-methyluridine as starting material |
MX2018000016A (es) | 2015-07-02 | 2019-01-31 | Otsuka Pharma Co Ltd | Composiciones farmaceuticas liofilizadas. |
EP3661522A2 (en) | 2017-08-03 | 2020-06-10 | Otsuka Pharmaceutical Co., Ltd. | Drug compound and purification methods thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3322747A (en) * | 1965-04-01 | 1967-05-30 | Merck & Co Inc | Thionocarbonate nucleosides |
US3539550A (en) * | 1967-01-23 | 1970-11-10 | Syntex Corp | Process for the preparation of 2'-halo-2'-deoxy pyrimidine nucleosides |
US3792040A (en) * | 1970-03-19 | 1974-02-12 | Syntex Corp | Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing |
-
1988
- 1988-03-24 US US07/173,473 patent/US4904770A/en not_active Expired - Lifetime
-
1989
- 1989-03-15 CA CA000593738A patent/CA1339448C/en not_active Expired - Fee Related
- 1989-03-20 NZ NZ228390A patent/NZ228390A/en unknown
- 1989-03-20 NO NO891208A patent/NO171367C/no unknown
- 1989-03-21 IL IL8969389A patent/IL89693A/en not_active IP Right Cessation
- 1989-03-21 IL IL10557389A patent/IL105573A/en not_active IP Right Cessation
- 1989-03-21 FI FI891338A patent/FI93111C/fi not_active IP Right Cessation
- 1989-03-22 ZA ZA892166A patent/ZA892166B/xx unknown
- 1989-03-22 DK DK146489A patent/DK146489A/da not_active Application Discontinuation
- 1989-03-23 KR KR89003629A patent/KR0140889B1/ko not_active IP Right Cessation
- 1989-03-23 EP EP19890105269 patent/EP0334368A3/en not_active Ceased
- 1989-03-23 AU AU31673/89A patent/AU622439B2/en not_active Ceased
- 1989-03-23 JP JP1071592A patent/JPH02149595A/ja active Pending
- 1989-03-23 EG EG144/89A patent/EG18661A/xx active
- 1989-03-23 PT PT90099A patent/PT90099B/pt not_active IP Right Cessation
-
1997
- 1997-10-23 KR KR97054314A patent/KR0142109B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR0142109B1 (en) | 1998-07-01 |
EP0334368A3 (en) | 1991-12-27 |
DK146489D0 (da) | 1989-03-22 |
NZ228390A (en) | 1991-12-23 |
FI93111B (fi) | 1994-11-15 |
NO171367C (no) | 1993-03-03 |
FI93111C (fi) | 1995-02-27 |
US4904770A (en) | 1990-02-27 |
FI891338A0 (fi) | 1989-03-21 |
IL105573A (en) | 1994-04-12 |
NO891208L (no) | 1989-09-25 |
NO171367B (no) | 1992-11-23 |
AU622439B2 (en) | 1992-04-09 |
KR890014528A (ko) | 1989-10-24 |
CA1339448C (en) | 1997-09-09 |
FI891338A (fi) | 1989-09-25 |
PT90099B (pt) | 1994-07-29 |
IL89693A0 (en) | 1989-09-28 |
JPH02149595A (ja) | 1990-06-08 |
KR0140889B1 (en) | 1998-06-15 |
AU3167389A (en) | 1989-09-28 |
DK146489A (da) | 1989-09-25 |
PT90099A (pt) | 1989-11-10 |
EP0334368A2 (en) | 1989-09-27 |
ZA892166B (en) | 1992-02-26 |
NO891208D0 (no) | 1989-03-20 |
EG18661A (en) | 1993-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RH | Patent void |