IL88034A - Causes of a mutant acid fibroblast growth, its preparation and pharmaceutical preparations containing it - Google Patents

Causes of a mutant acid fibroblast growth, its preparation and pharmaceutical preparations containing it

Info

Publication number
IL88034A
IL88034A IL8803488A IL8803488A IL88034A IL 88034 A IL88034 A IL 88034A IL 8803488 A IL8803488 A IL 8803488A IL 8803488 A IL8803488 A IL 8803488A IL 88034 A IL88034 A IL 88034A
Authority
IL
Israel
Prior art keywords
growth factor
fibroblast growth
leu
acidic fibroblast
ser
Prior art date
Application number
IL8803488A
Other languages
English (en)
Hebrew (he)
Other versions
IL88034A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL88034A0 publication Critical patent/IL88034A0/xx
Publication of IL88034A publication Critical patent/IL88034A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL8803488A 1987-10-22 1988-10-13 Causes of a mutant acid fibroblast growth, its preparation and pharmaceutical preparations containing it IL88034A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11260087A 1987-10-22 1987-10-22
US24443188A 1988-09-16 1988-09-16

Publications (2)

Publication Number Publication Date
IL88034A0 IL88034A0 (en) 1989-06-30
IL88034A true IL88034A (en) 1994-06-24

Family

ID=26810140

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8803488A IL88034A (en) 1987-10-22 1988-10-13 Causes of a mutant acid fibroblast growth, its preparation and pharmaceutical preparations containing it

Country Status (13)

Country Link
EP (1) EP0319052B1 (da)
JP (1) JPH082309B2 (da)
KR (1) KR970009340B1 (da)
AT (1) ATE117723T1 (da)
AU (1) AU623351B2 (da)
CA (1) CA1340363C (da)
DE (1) DE3852870T2 (da)
DK (1) DK174961B1 (da)
ES (1) ES2070125T3 (da)
IE (1) IE65360B1 (da)
IL (1) IL88034A (da)
NZ (1) NZ226543A (da)
PT (1) PT88824B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0392605A1 (en) * 1989-04-13 1990-10-17 Merck & Co. Inc. Method of enhancing acidic fibroblast growth factor expression
EP0406738A3 (en) * 1989-07-03 1991-08-14 Takeda Chemical Industries, Ltd. Production of acidic fgf protein
CA2020720A1 (en) * 1989-07-13 1991-01-14 Shigeko Yamazaki Method for the purification of therapeutically active recombinant acidic fibroblast growth factor
US5126323A (en) * 1989-11-16 1992-06-30 Genetics Institute, Inc. Homogeneous purified k-fgf and compositions containing the same
WO1992011360A1 (en) * 1990-12-18 1992-07-09 Amgen Inc. Analogs of acidic fibroblast growth factor having enhanced stability and biological activity
US5348941A (en) * 1992-04-01 1994-09-20 Merck & Co., Inc. Stabilizers for fibroblast growth factors
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
JP4088111B2 (ja) * 2002-06-28 2008-05-21 日立電線株式会社 多孔質基板とその製造方法、GaN系半導体積層基板とその製造方法
JP5401312B2 (ja) * 2007-06-29 2014-01-29 第一三共株式会社 組換えC−末端α−アミド化酵素誘導体
PL221356B1 (pl) * 2012-04-21 2016-03-31 Wrocławskie Ct Badań Eit & Spółka Z Ograniczoną Odpowiedzialności Zmodyfikowany genetycznie, rekombinowany czynnik wzrostu fibroblastów (FGF1) skoniugowany z nanocząsteczkami metalu lub tlenku metalu, jego sekwencja DNA i aminokwasowa oraz zastosowanie
CH717226B1 (it) * 2020-07-14 2021-09-30 Contrad Swiss Sa Idrogel per applicazione topica efficace nel limitare la degenerazione di tendini e muscoli.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90047A (en) * 1982-10-19 1992-12-01 Cetus Oncology Corp Cysteine-depleted biologically active muteins other than interferon - '
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
EP0248819B2 (en) * 1985-09-12 2000-08-30 Scios Inc. Recombinant fibroblast growth factors
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor

Also Published As

Publication number Publication date
CA1340363C (en) 1999-02-02
DE3852870D1 (de) 1995-03-09
JPH02484A (ja) 1990-01-05
KR970009340B1 (en) 1997-06-10
EP0319052B1 (en) 1995-01-25
DK587488A (da) 1989-06-06
PT88824B (pt) 1993-04-30
EP0319052A3 (en) 1990-04-25
KR890006815A (ko) 1989-06-16
DE3852870T2 (de) 1995-08-17
IL88034A0 (en) 1989-06-30
JPH082309B2 (ja) 1996-01-17
NZ226543A (en) 1992-02-25
AU623351B2 (en) 1992-05-14
EP0319052A2 (en) 1989-06-07
IE65360B1 (en) 1995-10-18
ES2070125T3 (es) 1995-06-01
ATE117723T1 (de) 1995-02-15
DK587488D0 (da) 1988-10-21
IE883188L (en) 1989-04-22
DK174961B1 (da) 2004-03-29
AU2430588A (en) 1989-04-27

Similar Documents

Publication Publication Date Title
CA2055963C (en) Chimeric fibroblast growth factor
US5223483A (en) Cysteine-modified acidic fibroblast growth factor
EP0320148A1 (en) Analogs of fibroblast growth factor
EP0259953B1 (en) Cloning and expression of acidic fibroblast growth factor
CA1340363C (en) Mutant acidic fibroblast growth factor
JP3303211B2 (ja) bFGFムテインおよびその製造法
US5401832A (en) Brain derived and recombinant acidic fibroblast growth factor
US5312911A (en) Cysteine-modified acidic fibroblast growth factor
IL147575A (en) Method for purifying keratinocyte growth factors
WO1996022369A1 (en) Analogs of acidic fibroblast growth factor having enhanced stability and biological activity
AU663067B2 (en) Analogs of acidic fibroblast growth factor having enhanced stability and biological activity
CA2485587C (en) Muteins of placental growth factor type 1, preparation method and application thereof
US5656458A (en) Expression and processing of amino terminus acetylated FGF's in yeast
CA1340639C (en) Mutant acidic fibroblast growth factor
EP0392605A1 (en) Method of enhancing acidic fibroblast growth factor expression
MXPA97002475A (en) Analogues of the fibroblast acid growth factor that have stability and biological acticity improves

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXTN Extension order renewed