IL86027A - 2-acylpyrrolidine derivatives,a process for the preparation thereof,compositions containing them,and their use - Google Patents

2-acylpyrrolidine derivatives,a process for the preparation thereof,compositions containing them,and their use

Info

Publication number
IL86027A
IL86027A IL86027A IL8602788A IL86027A IL 86027 A IL86027 A IL 86027A IL 86027 A IL86027 A IL 86027A IL 8602788 A IL8602788 A IL 8602788A IL 86027 A IL86027 A IL 86027A
Authority
IL
Israel
Prior art keywords
preparation
compositions containing
acylpyrrolidine derivatives
acylpyrrolidine
derivatives
Prior art date
Application number
IL86027A
Other languages
English (en)
Other versions
IL86027A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL86027A0 publication Critical patent/IL86027A0/xx
Publication of IL86027A publication Critical patent/IL86027A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL86027A 1987-04-11 1988-04-11 2-acylpyrrolidine derivatives,a process for the preparation thereof,compositions containing them,and their use IL86027A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873712365 DE3712365A1 (de) 1987-04-11 1987-04-11 Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung

Publications (2)

Publication Number Publication Date
IL86027A0 IL86027A0 (en) 1988-09-30
IL86027A true IL86027A (en) 1992-05-25

Family

ID=6325457

Family Applications (1)

Application Number Title Priority Date Filing Date
IL86027A IL86027A (en) 1987-04-11 1988-04-11 2-acylpyrrolidine derivatives,a process for the preparation thereof,compositions containing them,and their use

Country Status (14)

Country Link
US (1) US4912127A (hu)
EP (1) EP0286928A3 (hu)
JP (1) JPS63267755A (hu)
KR (1) KR880012543A (hu)
AU (1) AU607754B2 (hu)
DE (1) DE3712365A1 (hu)
DK (1) DK193088A (hu)
FI (1) FI881613A (hu)
HU (1) HU199784B (hu)
IL (1) IL86027A (hu)
NO (1) NO881544L (hu)
PH (1) PH25713A (hu)
PT (1) PT87195B (hu)
ZA (1) ZA882459B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3712364A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
DE3742431A1 (de) * 1987-12-15 1989-07-13 Hoechst Ag Neue derivate cyclischer aminosaeuren, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung
US5053414A (en) * 1988-04-08 1991-10-01 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
JPH0825995B2 (ja) * 1988-04-08 1996-03-13 小野薬品工業株式会社 複素環化合物
DE3817468A1 (de) * 1988-05-21 1989-11-30 Hoechst Ag Ethylenisch ungesaettigte harnstoffderivate und verfahren zu ihrer herstellung
US5254696A (en) * 1990-09-13 1993-10-19 Bayer Aktiengesellschaft N-acylpyrrolidine derivatives
DE4029054A1 (de) * 1990-09-13 1992-03-19 Bayer Ag N-acylpyrrolidin-derivate
HUT74687A (en) * 1993-12-02 1997-01-28 Merrell Pharma Inc Pyrrole and thiazolidine derivatives of prolyl endopeptidase inhibitor activity and pharmaceutical compositions containing the same
DE19527574A1 (de) * 1995-07-28 1997-01-30 Basf Ag Verfahren zur Herstellung vona-(N,N-Dialkyl)-aminocaarbonsäureamiden
AR038967A1 (es) * 2002-03-18 2005-02-02 Solvay Pharm Bv Derivados de 2,3 - diaril - pirazolidinas como inhibidores de enzimas que degradan la neurotensina
DE602004026289D1 (de) 2003-05-05 2010-05-12 Probiodrug Ag Glutaminylcyclase-hemmer
US20050137142A1 (en) * 2003-11-03 2005-06-23 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
EP1713780B1 (en) 2004-02-05 2012-01-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
US8524654B2 (en) 2007-05-21 2013-09-03 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1492640A (en) * 1975-07-08 1977-11-23 Ucb Sa L-pyroglutamyl-l-prolinamide
US4560795A (en) * 1979-04-10 1985-12-24 Merrell Dow France et Cie. α-Halomethyl derivatives of α-amino acids
US4499102A (en) * 1979-12-13 1985-02-12 Santen Pharmaceutical Co., Ltd. Thiazolidine and pyrrolidine compounds and pharmaceutical compositions containing them
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
GB2083030B (en) * 1980-08-23 1984-03-07 Merrell Toraude & Co Fluorinated pentene diamine derivatives
US4456594A (en) * 1981-11-06 1984-06-26 Smithkline Beckman Corporation N-Carboxyalkylproline-containing tripeptides
US4483991A (en) * 1983-01-17 1984-11-20 American Home Products Corporation Hypotensive agents
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0655758B2 (ja) * 1984-08-24 1994-07-27 味の素株式会社 アミノ酸誘導体
US4626545A (en) * 1984-08-27 1986-12-02 Merck & Co., Inc. Amino acid derivatives as enzyme inhibitors
US4762821A (en) * 1985-03-22 1988-08-09 Syntex (U.S.A.) Inc. N',N"-dialkylguanidino dipeptides
CA1309805C (en) * 1985-04-16 1992-11-03 Naoki Higuchi Dipeptide derivative and synthesis and use thereof
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
JPH0653757B2 (ja) * 1985-12-06 1994-07-20 味の素株式会社 プロリン誘導体の芳香族スルホン酸塩
JPH08806B2 (ja) * 1986-11-18 1996-01-10 サントリー株式会社 プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体
DE3712363A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue pyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
DE3712364A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung

Also Published As

Publication number Publication date
EP0286928A3 (de) 1991-05-08
DK193088D0 (da) 1988-04-08
FI881613A (fi) 1988-10-12
EP0286928A2 (de) 1988-10-19
NO881544D0 (no) 1988-04-08
KR880012543A (ko) 1988-11-28
DK193088A (da) 1988-10-12
IL86027A0 (en) 1988-09-30
FI881613A0 (fi) 1988-04-07
PT87195A (pt) 1988-05-01
PT87195B (pt) 1992-07-31
JPS63267755A (ja) 1988-11-04
HUT46888A (en) 1988-12-28
AU1446688A (en) 1988-10-13
NO881544L (no) 1988-10-12
PH25713A (en) 1991-09-18
HU199784B (en) 1990-03-28
US4912127A (en) 1990-03-27
ZA882459B (en) 1988-09-29
DE3712365A1 (de) 1988-10-27
AU607754B2 (en) 1991-03-14

Similar Documents

Publication Publication Date Title
AU627741B2 (en) Aminoacid derivatives, a process for their preparation, agents containing these compounds, and the use thereof
IL87116A0 (en) 9-halogen-(z)-prostaglandin derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ZA859756B (en) Peptide-aldehydes,process for the preparation thereof and pharmaceutical compositions containing the same
ZA87471B (en) Indolizine derivatives,process for preparing them and the compositions containing them
ZA881865B (en) Substituted 9-amino-tetrahydroacridines and related compounds,a process for their preparation and their use as medicaments
IL83760A (en) 3-pyrazoliomethyl-3- cephem-4-carboxylate derivatives, process for the preparation thereof, and pharmacetuical compositions containing the same
EP0254583A3 (en) Parasiticidal milbemicyn derivatives, a process for their production, and compositions containing the same
ZA888862B (en) 2,2-difluorocyclopropylethane derivatives,processes for their preparation and their use as pesticides
IL86027A (en) 2-acylpyrrolidine derivatives,a process for the preparation thereof,compositions containing them,and their use
EP0302793A3 (en) Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same
ZA901765B (en) Derivatives of thieno-triazolo-diazepine,a preparation process of the same and therapeutic compositions containing them
IL87563A (en) Isoxazole-b-carboline derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
ZA879043B (en) Carbamoylimidazole derivatives,a process for their preparation,and their use as fungicides
ZA897541B (en) Benzoxazolinone derivatives,process for the preparation thereof and pharmaceutical compositions containing them
ZA903305B (en) Thieno-triazolo-diazepine derivatives,a preparation process of the same and therapeutic compositions containing them
ZA884878B (en) Substituted benzimidazoles,a process for the preparation thereof,pharmaceutical formulations containing them,and the use thereof
EP0236929A3 (en) 1,2-dithiol-3-thione derivatives, a process for preparing them and a pharmaceutical composition containing them
ZA856431B (en) 1,6-naphthyridine derivatives,process for the preparation and the use thereof
IL84955A0 (en) Novel carbamoyloxylabdanes,process for the preparation thereof and pharmaceutical compositions containing them
IL86173A0 (en) Pyrrolidine derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
IL82294A0 (en) 1,3-dihydropyridine derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
IL90004A0 (en) 5-fluoromethyl pyrimidine-2-sulfonamides,process for their preparation and composition for their use as herbicides
IL90219A0 (en) Hydrazinocarbonyloxylabdanes,a process for their preparation and pharmaceutical compositions containing them
GB2213480B (en) Dioxazocine derivatives, their preparation and compositions containing them
EP0313081A3 (en) 2-oxa-isocephem compounds, compositions containing the same and processes for preparing the same